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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 351-357页

作者： Woro Riyadina Alifa Syamantha Putri Sulistyowati Tuminah Ika Suswanti Yuda Turana research Center for Public health and Nutrition Organization Research for HealthNational Research and Innovation AgencyCenter JakartaIndonesia StiKes Widya Dharma Husada Tangerang South TangerangIndonesia School of Medicine and health Sciences Atma Jaya Catholic University of IndonesiaNorth JakartaIndonesia

Objective:To determine the stroke predictors for the 10-year of follow-up in Bogor City,***:The prospective study analyzed the data of 4445 stroke-free subjects aged 25 years and above that was part of"the Bogor Cohort Study on Non-Communicable Disease Risk Factors".Data were collected by interview method with structured questionnaires,physical measurements three times a year,and laboratory examination every two years during a 10-year follow-up(2011-2021,without examination in 2020).The incidence of stroke is based on anamnesis results and examination by a *** stroke predictor variables include characteristics,biological conditions,and risk *** analysed 4445 stroke-free samples with Cox proportional hazard regression ***:During the 10-year observation,stroke incidence was 440 person-years per 100000 population(95%CI 370-530).During the follow-up of ten years,the main predictor of stroke was mental-emotional disorders with HR 4.2(95%CI 2.8-6.3)after adjustment by age,hypertension,obesity,abdominal obesity,and high LDL-cholesterol ***:Mental-emotional disorders are the strongest predictor of stroke ***,psychological factors must be controlled in a stroke prevention program.

关键词： Adult Cohort Mental-emotional disorder Stroke predictor

Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy?

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Stroke & Vascular Neurology 2024年第3期9卷 279-288,I0247页

作者： Adam Ingleton Marko Raseta Rui-En Chung Kevin Jun Hui Kow Jake Weddell Sanjeev Nayak Changez Jadun Zafar Hashim Noman Qayyum Phillip Ferdinand Indira Natarajan Christine Roffe Neurosciences University Hospitals of North Midlands NHS TrustStoke-on TrentUK Statistics and Mathematical Modelling Department of Molecular GeneticsErasmus Medical CenterRotterdamZuid-HollandThe Netherlands Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK School of Medicine Keele UniversityKeeleUK Interventional Radiology University Hospitals of North Midlands NHS TrustStoke-on TrentUK Stroke research Keele UniversityKeeleUK

Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy(MT).Most patients undergoing MT are also given *** agents are contraindicated within 24 hours of *** evaluated outcomes and complications of patients stented with and without intravenous aspirin during *** All patients who underwent emergent extracranial stenting during MT at the Royal Stoke University Hospital,UK between 2010 and 2020,were *** were thrombolysed before MT,unless *** 500 mg intravenously was given intraoperatively at the discretion of the *** intracranial haemorrhage(sICH)and the national institutes for health Stroke Scale score(NIHSS)were recorded at 7 days,and mortality and functional recovery(modified Rankin Scale:mRS≤2)at 90 *** Out of 565 patients treated by MT 102 patients(median age 67 IQR 57–72 years,baseline median NIHSS 18 IQR 13–23,76(75%)thrombolysed)had a stent *** these 49(48%)were given aspirin and 53(52%)were *** treated with aspirin had greater NIHSS improvement(median 8 IQR 1–16 vs median 3 IQR-9–8 points,p=0.003),but there were no significant differences in sICH(2/49(4%)vs 9/53(17%)),mRS≤2(25/49(51%)vs 19/53(36%))and mortality(10/49(20%)vs 12/53(23%))with and without *** improvement(median 12 IQR 4–18 vs median 7 IQR-7–10,p=0.01)was greater,and mortality was lower(4/33(12%)vs 6/15(40%),p=0.05)when aspirin was combined with thrombolysis,than for aspirin alone,with no increase in *** Our findings based on registry data derived from routine clinical care suggest that intraprocedural intravenous aspirin in patients undergoing emergent stenting during MT does not increase sICH and is associated with good clinical outcomes,even when combined with intravenous thrombolysis.

关键词： patients aspirin intravenous

Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan Dal-Fabbro Minzhi Yu Ling Mei Hajime Sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory ***,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm^(3) and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm^(3)(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

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Protein-nucleic acid hybrid nanostructures for molecular diagnostic applications

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Nano research 2024年第10期17卷 9003-9014页

作者： Noah R.Sundah Yuxuan Seah Auginia Natalia Xiaoyan Chen Panida Cen Yu Liu Huilin Shao institute for health Innovation and Technology National University of SingaporeSingapore 117599Singapore Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore 117583Singapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore 119077Singapore institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore

Molecular diagnostic technologies empower new clinical opportunities in precision ***,existing approaches face limitations with respect to performance,operation and *** molecules including proteins and nucleic acids are being increasingly adopted as tools in the development of new molecular diagnostic *** particular,leveraging their complementary properties—the functional diversity of proteins and the precision programmability of nucleic acids—a wide range of protein–nucleic acid hybrid nanostructures have been *** hybrid structures take diverse forms,ranging from one-dimensional to three-dimensional hybrids,as static assemblies to dynamic machines,and possess myriad functions to recognize target biomarkers,encode vast information and execute catalytic *** by recent advances in this area of molecular nanotechnology,we review the state-of-art design and application of various types of protein–nucleic acid hybrid nanostructures for molecular diagnostics,and present an outlook on the challenges and opportunities for emerging pre-clinical and clinical applications,highlighting the promise for earlier detection,more refined diagnosis and highly tailored treatment decision that ultimately lead to improved patient outcomes.

关键词： molecular nanotechnology DNA-protein hybrid molecular diagnostics precision medicine

Endoplasmic reticulum stress,autophagy,neuroinflammation,and sigma 1 receptors as contributors to depression and its treatment

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Neural Regeneration research 2024年第10期19卷 2202-2211页

作者： Chika Fujii Charles F.Zorumski Yukitoshi Izumi Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family institute for Innovative Psychiatric research Washington University School of MedicineSt.LouisMOUSA

The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving cellular stress and are possible targets for the pathophysiology and treatment of psychiatric and neurologic illnesses. An increasing number of studies indicate the involvement of endoplasmic reticulum stress and autophagy in the control of neuroinflammation, a contributing factor to multiple neuropsychiatric illnesses. Initial inflammatory triggers induce endoplasmic reticulum stress, leading to neuroinflammatory responses. Subsequently, induction of autophagy by neurosteroids and other signaling pathways that converge on autophagy induction are thought to participate in resolving neuroinflammation. The aim of this review is to summarize our current understanding of the molecular mechanisms governing the induction of endoplasmic reticulum stress, autophagy, and neuroinflammation in the central nervous system. Studies focused on innate immune factors, including neurosteroids with anti-inflammatory roles will be reviewed. In the context of depression, animal models that led to our current understanding of molecular mechanisms underlying depression will be highlighted, including the roles of sigma 1 receptors and pharmacological agents that dampen endoplasmic reticulum stress and associated neuroinflammation.

关键词： allopregnanolone fluvoxamine ketamine neurosteroids postpartum depression quercetin

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Impact of Proteinuria on Liver Enzyme Levels

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Journal of Clinical and Translational Hepatology 2024年第9期12卷 759-760页

作者： David Yardeni Asif Hitawala Lilian Howard Theo Heller Meryl Waldman Department of Gastroenterology and Liver Diseases Soroka University Medical CenterBeer-ShevaIsrael Liver Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Kidney Diseases Branch National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA

Dear Editors,We read with great interest the recently published article“Subnormal Serum Liver Enzyme Levels:A Review of Pathophysiology and Clinical Significance”by Youssef and colleagues.1 While much attention is given to elevations of liver enzymes,the authors highlight clinically important,often unrecognized reasons leading to low liver enzyme *** example,chronic kidney disease was cited as a cause of low serum aspartate aminotransferase(AST)proportional to the progression of the disease,but the cause(s)are not well *** is known about the possible influence of nephrotic syndrome(NS)on liver enzymes.

关键词： Impact Liver Levels

Sexual and Reproductive Service Interventions for Menstrual Regulation, Safe Abortion, and Post-abortion Care and Their Effectiveness During Disaster Response: A Global Systematic Review

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International Journal of Disaster Risk Science 2024年第3期15卷 359-373页

作者： Nibedita S.Ray-Bennett Winifred Ekezie Isha Biswas Nimra Iqbal Choudhary David Cowie Lasith Dissanayake Lauren Macleod Azukaeogo Nnaji Madhulika Sahoo School of Business University of Leicester Avoidable Deaths Network University of Leicester Diabetes research Centre Leicester General Hospital University of Leicester School of Social Sciences and Humanities Aston University Lifespan and Population health School of Medicine University of Nottingham School of Public health and Interdisciplinary Studies Auckland University of Technology Faculty of Life Sciences and Education University of South Wales West African Regional ECHO (WARE) APIN Public Health Initiatives Department of Anthropology Kalahandi University

Sexual and reproductive health(SRH) services are crucial for women especially during disasters, to reduce maternal mortality and morbidity from miscarriages, unsafe abortions, and post-abortion complications. This study explored the SRH interventions provided during disaster response. A systematic review was conducted to identify what menstrual regulation(MR), safe abortion(SA), and post-abortion care(PAC) approaches/interventions exist to promote resilience in the health system in disaster settings; what intervention components were most eff ective; and challenges and opportunities to meeting SRH rights. Five electronic databases were searched, resulting in 4194 records. Following the screening process, seven publications were included. The intervention-related information in each publication was assessed based on availability,accessibility, acceptability, and quality. Two SRH approaches/interventions were found. The eff ectiveness of intervention components could not be conducted due to the limited number of relevant studies. Challenges were found at facility and community levels, and opportunities included overcoming them, making MR, SA, and PAC integral to the mitigation phase,and policy change to overcome barriers related to unaff ordability and inaccessibility. Recommendations are provided to encourage research and policy towards improving neglected SRH in disaster settings to realize Sustainable Development Goal 3 and the Global Strategy and Sendai Framework's priority to promote disaster-resilient health systems.

关键词： Abortion Disasters Sendai framework Sexual and reproductive health Sustainable development goal

Influence of previous plane of nutrition on molecular mechanisms regulating the expression of urea and water metabolism related genes in the rumen and kidney of finishing crossbred Angus steers

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Animal Nutrition 2024年第2期17卷 232-243页

作者： Aghata E.Moreira da Silva Arturo Macias Franco Bradley S.Ferguson Mozart A.Fonseca College of Agriculture Biotechnology&Natural Resources University of Nevada Department of Animal and Range Sciences Clayton Livestock Research Center New Mexico State University

This study aimed to understand how molecular mechanisms controlling water and urea metabolism at the finishing phase can be affected by previous plane of nutrition of crossbred Angus beef steers. Twentyfour(n = 24) animals were randomly distributed into either a moderate(MP) or high plane of nutrition during the background phase for 85 d. Animals were then blocked by their previous plane and were moved onto a 105-d finishing phase in a 2 × 2 factorial arrangement. The forage-finished group received only high-quality alfalfa hay, whereas the grain-fed group received a high grain diet(80% whole corn and20% alfalfa hay). By the end of the finishing phase, animals were harvested and tissue samples from the rumen and kidney were collected. Changes in gene expression of aquaporins(AQP)-2,-3,-4,-7, ATP1A1,ATP1B1, SGK1, CLIC1(kidney and rumen), UT-A1(kidney only) and UT-B(rumen only), were assayed via real-time q PCR; 18S r RNA was used as an endogenous control. One-way ANOVA followed by Tukey's post hoc analysis was conducted. When animals were from MP, forage-finishing increased the relative abundance of AQP3(P ≤ 0.05), AQP7(P ≤ 0.05), ATP1B1(P ≤ 0.05), and SGK1(P ≤ 0.05) in the kidney when compared to grain-fed animals. In the rumen, for the MP group, AQP7 was differentially expressed in both treatments at the finishing phase(P ≤ 0.01), with forage-finished steers having the highest expression of AQP7. For the MP group, UT-B had a tendency of presenting a higher expression on grainfed animals(P = 0.075). Overall, these results suggest that previous plane can impact expression of genes associated with water and urea metabolism during the finishing phase, namely AQP3, AQP7, ATP1B1, and SGK1 in the kidney, and AQP7 and UT-B in the rumen. The greatest impact observed on gene expression changes of investigated genes at the finishing phase was reflective of animals backgrounded on the moderate previous plane.

关键词： Gene expression Aquaporin Sodium channel Urea transporter

Immune cell pair ratio captured by imaging mass cytometry has superior predictive value for prognosis of non-small cell lung cancer than cell fraction and density

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Cancer Communications 2024年第5期44卷 589-592页

作者： Jian-Rong Li Chao Cheng institute for Clinical and Translational research Baylor College of MedicineHoustonTexasUSA Section of Epidemiology and Population Sciences Department of MedicineBaylor College of MedicineHoustonTexasUSA Dan L Duncan Comprehensive Cancer Center Baylor College of MedicineHoustonTexasUSA

Infiltrating immune cells in the tumor microenvironment(TME)play critical roles in the initiation,progression,and metastasis of cancer[1].Previous studies have reported that the infiltration levels of various immune cell types are significantly associated with patient prognosis in different cancers[2,3].Specifically,in non-small cell lung cancer(NSCLC)the prognostic associations of major immune cell types have been investigated[4–6],however,some of the reported associations are inconsistent and remain debated[7].Limited by technical issues,most studies focused on a few immune cell lineages or relied on inferred immune cell levels from computational *** investigate the prognostic effects of all major immune cell types unbiasedly,more systematic high-quality immune cell profiling data with matched patient survival information are needed.

关键词： prognosis cancer lung

Bioinspired nanomaterials for the treatment of bacterial infections

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Nano research 2024年第2期17卷 691-714页

作者： Xiaojing Ma Wenjing Tang Rong Yang Robert F.Smith School of Chemical&Biomolecular Engineering Cornell UniversityIthacaNY 14853USA

Infectious diseases pose a serious threat to global *** immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates of illness and ***,the creation of new antibiotics has come to a grinding halt in the last ten *** response to this crisis,nanotechnology has emerged as a hopeful solution to tackle drug resistance and enhance treatment results.A large variety of biomimetic nanomaterials,termed nanozymes,have demonstrated strong antimicrobial *** the inherent toxicity of nanomaterials is a concern,recent studies have harnessed the stimuli-responsiveness of nanomaterials to enable local and/or targeted delivery to reduce the treatment side ***,the physicochemical versatility of nanomaterials affords many degrees of freedom that enable rational design of smart or autonomous therapeutics,which cannot be achieved using conventional *** design straddles the fields of catalysis,nanoscience,microbiology,and translational *** provide an overview of this interdisciplinary landscape,this review is organized based on composition into lipid,metal,metal oxide,and non-metallic *** as a delivery vehicle enhance bioavailability and reduce ***-and metal oxide-based nanomaterials inhibit bacterial growth by mimicking natural enzymatic activities such as peroxidase(POD)and ***,carbon-,polymer-,and cell membrane-based nanomaterials are combined into a discussion on non-metallic *** the end of this review,potentially fruitful directions for future bioinspired nanomaterials in infectious disease treatment are included.

关键词： bioinspired nanomaterial bacteria infectious disease antimicrobial liposome nanozyme