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Food Science and Human Wellness 2024年第1期13卷 360-369页

作者： Xiangxin Li Yijing Pu Haitao Jiang Wenxiao Jiao Wenjun Peng Wenli Tian Weibo Jiang Xiaoming Fang Institute of Apicultural research Chinese Academy of Agricultural SciencesBeijing 100093China College of Food Science and Nutritional Engineering China Agricultural UniversityBeijing 100083China College of Food Science and Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

This study was aimed to analyze the effect of procyanidin B2(PC)and tannin acid(TA)on the activities of cholesterol esterase(CEase)and the inhibitory mechanisms of enzymatic *** interaction mechanisms were investigated by enzymatic kinetics,multi-spectroscopy methods,thermodynamics analysis,molecular docking,and dynamic *** and TA could bind with CEase and inhibit the activity of enzyme in a mixed-competitive manner and non-competitive manner,which was verified by molecular docking simulations and dynamics ***,PC and TA showed the synergistic inhibition with ***,UVvis and the thermodynamic analysis revealed that the complexes were formed from CEase and inhibitors by noncovalent *** revealed by the circular dichroism results,both PC and TA decreased enzymatic activities by altering the conformations of *** inhibition of PC and TA on CEase might be one mechanism for its cholesterol-lowering effect.

关键词： Cholesterol esterase Polyphenols Interaction mechanisms Molecular dynamic simulation Synergistic effect

Preparation and Photostriction Properties of BiFeO_(3)-BaTiO_(3)Ceramics

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1079-1086页

作者： ZHENG Zewei ZHANG Liqiang CHEN Chen CAO Minghe YI Zhiguo LIU Hanxing School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Microelectronics Shanghai UniversityShanghai 200444China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

Under illumination by 405,520 and 655 nm monochromatic visible light(light intensity of 30 kW/m^(2)),large photostriction(ΔL/L)of 0.19%,0.13%and 0.26%for 67BiFeO_(3)-33BaTiO_(3)(67BF-33BT)lead-free ferroelectric ceramics are obtained,*** studying the ferroelectric and photoelectric properties in conjunction with in situ Raman spectroscopy,it is found that the photostrictive effect of 67BF-33BT is not caused by the electrical strain induced by abnormal photovoltaic voltage,but related to the optical induced oxygen octahedral *** 67BF-33BT lead-free ferroelectric material with excellent photostrictive response in the visible light region is expected to play an important role in the field of optical drive electromechanical devices.

关键词： ferroelectric ceramics photostrictive effect visible light response

Insulation Design Rule for a Spacer in SF_(6)/N_(2)-filled DC Gas Insulated Apparatus

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 727-735页

作者： Hongyang Zhou Guoming Ma Meng Zhang Cong Wang Youping Tu Chengrong Li State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources and the Beijing Key Laboratory of High Voltage and EMC North China Electric Power UniversityBeijing 102206China

A recurring challenge of a DC SF_(6)/N_(2)-filled GIS/GIL apparatus is the charge accumulation at DC *** conventional design rules and knowledge of AC spacers may not be applicable for this new type of apparatus.A novel design rule is proposed considering the effect of accumulated charge on the threshold of electric field strength being resistant to the superposed voltage.A surface charge accumulation simulation model is introduced,and the key parameters in the simulation model are *** addition,an experimental platform for a 100 kV spacer flashover test is *** flashover tests under superimposed voltage with opposing polarities are carried out,and the withstanding voltage of the spacer is ***,based on the proposed model,the threshold of the surface electric field strength(tangential component)on the DC spacer in SF_(6)/N_(2) mixed gases is *** a reliable insulation design of a DC GIS/GIL apparatus filled with 0.7 MPa SF_(6)/N_(2),the threshold of surface electric field strength on the DC spacer is 12 kV/*** insulation design rule can be referenced in the design of a high-voltage DC SF_(6)/N_(2)-filled GIS/GIL apparatus.

关键词： Charge accumulation DC spacer flashover voltage SF_(6)/N_(2) threshold of surface electric field strength

Long-Chain Alkenones in the South Yellow Sea Sediments and Their Indicative Significance for Haptophytes Species

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Journal of Ocean University of China 2024年第5期23卷 1287-1296页

作者： XU Yakun YANG Xinxin XIAO Rui XING Lei Key Laboratory of Marine Chemistry Theory and Engineering Technology Ministry of EducationOcean University of ChinaQingdao 266100China Laboratory of Marine Ecology and Environment Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China

Long-chain alkenones(LCAs)have been widely used as important biomarkers in palaeoceanographic ***,the commonly used LCAs proxies are mainly based on C_(37) alkenones,and it is still lack of the studies about the distribution and in-dications of LCAs with different chain lengths other than C_(37) ***,the composition and distribution of LCAs were ana-lyzed in surface sediments from the southern Yellow Sea(SYS)and a sedimentary core(A02-C)from the central Yellow Sea(YS)mud *** results showed that C_(37),C_(38) and C_(39) alkenones were the major LCAs in surface sediments of the SYS,and the relative contents of C_(38:2)Et,C_(37:2)Me,C_(37:3)Me,C_(38:2)Me,C_(38:3)Et,C_(38:3)Me,C_(39:2)Et and C_(39:3)Et were 18.3%-59.8%,22.6%-41.2%,7.4%-23.0%,6.6%-15.4%,3.8%-13.3%,3.6%-8.7%,2.8%-6.0% and 0.7%-3.0%,*** the relationships of U_(38Me)^(K)-U_(38Et)^(K) and U_(37)^(K')-U_(38Et)^(K) indicate that LCAs are mainly derived from Emiliania huxleyi(***).High ratios of total C_(37) alkenones to total C_(38) alkenones(K_(37)/K_(38))(1-1.2)were found in the central SYS,corresponding to the relatively high abundance of ***;while low ratios of K_(37)/K_(38)(0.7-0.9)were observed at nearshore area of the SYS where Gephyrocapsa oceanica(***)has rela-tively high *** spatial distribution of K_(37)/K_(38) ratio is also consistent with that of coccolithophores nannofossil in the *** addition,K_(37)/K_(38) ratio in core A02-C varied from 0.7 to 1.1 with a gradual decreasing trend during the past 5.5 *** suggests that the relative abundance of *** decreased gradually,caused by the changes in the Yellow Sea Warm Current(YSWC)and the East Asian Winter Monsoon(EAWM)during this period.

关键词： alkenones southern Yellow Sea sediment Yellow Sea Warm Current

CD87-targeted BiTE and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas

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Science China(Life Sciences) 2024年第10期67卷 2169-2185页

作者： Yuan Ren Xinjie Bao Ming Feng Bing Xing Wei Lian Yong Yao Renzhi Wang Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Recently,bispecific T-cell engagers(BiTEs)and chimeric antigen receptor-modified T cells(CAR-Ts)have been shown to have high therapeutic efficacy in hematological ***87 is highly expressed in solid tumors with an oncogenic *** assess their cytotoxic effects on invasive nonfunctioning pituitary adenomas(iNFPAs),we first examined CD87 expression and its effects on the metabolism of iNFPA *** generated CD87-specific BiTE and CAR/IL-12 T cells,and their cytotoxic effects on iNFPAs cells and in mouse models were ***87 had high expression in i NFPA tissue and cell samples but was undetected in noncancerous brain ***87×CD3 BiTE and CD87 CAR/IL-12 T-cells showed antigenic specificity and exerted satisfactory cytotoxic effects,decreasing tumor cell proliferation in vitro and reducing existing tumors in experimental ***,the above findings suggest that CD87 is a promising target for the immunotherapeutic management of iNFPAs using anti-CD87 BiTE and CD87-specific CAR/IL-12 T cells.

关键词： CD87 chimeric antigen receptor T cells invasive non-functional pituitary adenomas bispecific T cell engager Warburg effect

Temporal-spatial Generation of Astrocytes in the Developing Diencephalon

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Neuroscience Bulletin 2024年第1期40卷 1-16页

作者： Wentong Hong Pifang Gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song Qin Department of Anatomy Histology and EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Chinese Institute for Brain research Beijing 102206China School of basic Medical Sciences Capital Medical UniversityBeijing 100069China Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTexas 75390-9148USA Department of Neurobiology Key Laboratory of Medical Neurobiology of Ministry of Health of ChinaZhejiang University School of MedicineHangzhou 310058China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200032China

tAstrocytes are the largest glial population in the mammalian ***,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the *** lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V ***,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the *** genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the *** occurs at an early time point in the dorsal region relative to that in the ventral region of the developing *** transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal ***,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon.

关键词： Radial glia Astrocyte specification Lineage tracing Diencephalon Third ventricle

Preparation and Properties of Magnesium Oxysulfide Cement Based Foam Board Absorbing Material

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 118-125页

作者：刘军崔宝栋庞博 School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China

In order to better solve the problem of electromagnetic pollution in the civil building cement,to improve the absorption capacity of magnesium oxysulfide cement based materials,and to better use sulfur oxide magnesium cement foamed sheet for improvement of electromagnetic industry,this paper uses the excellent microwave absorbing properties of ferrite and the modified sulfur oxide magnesium cement foam board,and discusses the microwave absorbing performance,aiming at improving the electromagnetic pollution in daily *** effects of ferrite and silicon carbide doping on microwave absorption properties of modified magnesium oxysulfate cement were *** the same time,the wave absorbing properties of the corresponding samples were detected by bow method,and the causes of the corresponding phenomena were analyzed by scanning electron microscopy (SEM).The results show that the lowest reflectance of the material is-17.9 dB at 34.1 GHz and the average reflectance of the whole band is-15.9 dB under the target frequency band of 26.5-40 *** the action of external magnetic field,the absorbing particles are affected by magnetization force,magnetic dipole and resistance coupling,and play the absorbing effect in the cement base solidified completely in the electromagnetic field *** lowest reflectance is-17.3dB at 36.4GHz and the average reflectance is-14.3dB for the whole band.

关键词： magnesium oxysulfide cement silicon carbide ferrite absorption properties

Responding of zooplankton to environmental factor changes in the Changjiang River estuarine regions in spring-summer from 2016 to 2020

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Journal of Oceanology and Limnology 2024年第2期42卷 544-559页

作者： Jieqing YANG Dongrong ZHANG Yuange CHEN Longling OUYANG Yangyang YANG Jin ZHOU Yunrong SHI East China Sea Fisheries research Institute Chinese Academy of Fishery SciencesKey Laboratory of East China Sea Fishery Resources ExploitationMinistry of Agriculture and Rural AffairsShanghai 200090China Key Laboratory of Engineering Oceanography Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China College of Marine Ecology and Environment Shanghai Ocean UniversityShanghai 201306China

The estuarine areas are under frequent influence from freshwater intrusion and ocean currents,in which zooplankton species are diversified and variable as they are sensitive to physio-chemical variations in ***,understanding the relationships between zooplankton and environmental factors help us know the water *** achieve co-existence with species in similar ecological group or habit,they could inevitably alter themselves to fit the ecology and adjust the function according to the competitive exclusion in ecological ***,information of the co-existence of dominant species in the Changjiang(Yangtze)River estuary(CRE)and adjacent waters remains *** explored the relationships between dominant zooplankton and environmental factors in the study region in spring-summer from 2016 to 2020,involving particularly the composition of dominant species,ecological groups,their relationships with environmental factors,and co-existence of important species,using the non-multidimensional scale analysis(nMDS)method and redundancy *** show that Labidocera euchaeta and Tortanus vermiculus were dominant species in the study *** turnover rate of dominant zooplankton was greater(>50%)in spring while the species number was higher in *** dominant species were estuarine,offshore,and eurytopic based on the adaptation to *** spring,the ecological groups were dominated by estuarine species,while in summer by estuarine and offshore *** addition,the nMDS showed that the dominant species in the same ecological group were more dispersed and not prominently clustered;the dominant species were staggered among different ecological *** temperature,salinity,pH,dissolved oxygen,and chlorophyll a were the main environmental factors on the distribution of the dominant species in spring,while in summer were dissolved oxygen,temperature,salinity,and *** domination of medusae of Nemopsis bachei and Pleurobrachia globosa in zo

关键词： Changjiang River estuary(CRE) zooplankton dominant species ecological group environmental factor co-existence

Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities

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Science China Chemistry 2024年第3期67卷 953-962页

作者： Yuan-Qing Gu Hong-Xin Long Dan-Dan Zhang Mei-Feng Ruan Guo-Kai Liu School of Pharmacy Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518055China

Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low ***,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) *** use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA ***,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished.

关键词： difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation difluorocarbene

DOA estimation of high-dimensional signals based on Krylov subspace and weighted l_(1)-norm

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Journal of Systems Engineering and Electronics 2024年第3期35卷 532-540,F0002页

作者： YANG Zeqi LIU Yiheng ZHANG Hua MA Shuai CHANG Kai LIU Ning LYU Xiaode Aerospace Information research Institute Chinese Academy of SciencesBeijing 100094China national Key Laboratory of Microwave Imaging Technology Beijing 100190China School of Electronic Electrical and Communication Engineering University of Chinese Academy of SciencesBeijing 100049China Northern Institute of Electronic Equipment Beijing 100191China

With the extensive application of large-scale array antennas,the increasing number of array elements leads to the increasing dimension of received signals,making it difficult to meet the real-time requirement of direction of arrival(DOA)estimation due to the computational complexity of *** subspace algorithms require estimation of the covariance matrix,which has high computational complexity and is prone to producing spurious *** order to reduce the computational complexity of DOA estimation algorithms and improve their estimation accuracy under large array elements,this paper proposes a DOA estimation method based on Krylov subspace and weighted l_(1)-*** method uses the multistage Wiener filter(MSWF)iteration to solve the basis of the Krylov subspace as an estimate of the signal subspace,further uses the measurement matrix to reduce the dimensionality of the signal subspace observation,constructs a weighted matrix,and combines the sparse reconstruction to establish a convex optimization function based on the residual sum of squares and weighted l_(1)-norm to solve the target *** results show that the proposed method has high resolution under large array conditions,effectively suppresses spurious peaks,reduces computational complexity,and has good robustness for low signal to noise ratio(SNR)environment.

关键词： direction of arrival(DOA) compressed sensing(CS) Krylov subspace l_(1)-norm dimensionality reduction