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The diagnostic value of tenascin-C in acute aortic syndrome

Journal of Geriatric Cardiology 2024年第3期21卷 359-368页

作者： Ming MA Wei CHEN Hai-Long CAO Jun PAN Qing ZHOU Xin-Long TANG Dong-Jin WANG Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjingChina Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina Department of Thoracic surgery Kunshan Hospital of Traditional Chinese MedicineJiangsuChina

OBJECTIVES Misdiagnosis of acute aortic syndrome(AAS)significantly increases ***-C(TN-C)is an extracellular matrix glycoprotein related to cardiovascular *** elevation of TN-C in AAS and whether it can discriminate suddenonset of acute chest pain in Chinese remains *** We measured the plasma concentration of TN-C by ELISA in a cohort of 376 patients with chest or back *** to discriminate AAS from acute coronary syndrome(ACS)were compared and *** From October 2016 to September 2021,376 undiagnosed patients with chest or back pain were enrolled.166 of them were finally diagnosed as AAS,100 were ACS and 110 without cardiovascular diseases(NCV).TN-C was significantly elevated in AAS at 18.18 ng/mL(IQR:13.10–27.68)compared with 7.51 ng/mL(IQR:5.67–11.38)in ACS(P<0.001)and 3.68 ng/mL(IQR:2.50–5.29)in NCV(P<0.001).There was no significant difference in TN-C level among the subtypes of *** the 166 AAS patients,the peaked level of TN-C was at acute stage(P=0.012),then a slight of decrease was observed at subacute *** area under receiver operating characteristic curve for AAS patients versus NCV was 0.979(95%CI:0.964-0.994)for *** a cutoff level of 11.474 ng/mL,TN-C has a sensitivity of 76.0%,specificity of 85.5%,accuracy of 82.0%,positive predictive value(PPV)of 76.0%,negative predictive value(NPV)of 85.5%.Diagnostic performance of TN-C was superior to D-dimer and *** The concentration of serum TN-C in AAS patients was significantly higher than that in ACS patients and ***-C could be a new biomarker to distinguish AAS patients in the early stage after symptoms onset from other pain diseases.

关键词： acute cardiovascular elevated

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Alleviating experimental pulmonary hypertension via co-delivering FoxO1 stimulus and apoptosis activator to hyperproliferating pulmonary arteries

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Acta Pharmaceutica Sinica B 2023年第6期13卷 2369-2382页

作者： Bingbing Li Chao Teng Huiling Yu Xiaohong Jiang Xuyang Xing Qi Jiang Chenshi Lin Zongmin Zhao Ruifeng Zhang Wei He School of Pharmacy China Pharmaceutical UniversityNanjing 211198China Department of Anesthesiology Affiliated Drum Tower of Nanjing UniversityNanjing 210008China Department of Pharmaceutical sciences College of PharmacyUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Respiratory Medicine Zhongda Hospital of Southeast UniversityNanjing 210009China Department of Anesthesiology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjing 210004China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Pulmonary hypertension(PH)is an insidious pulmonary vasculopathy with high mortality and morbidity and its underlying pathogenesis is still poorly *** hyperproliferation and apoptosis resistance of pulmonary artery smooth muscle cells(PASMCs)contributes to pulmonary vascular remodeling in pulmonary hypertension,which is closely linked to the downregulation of forkhead box transcriptional factor O1(FoxO1)and apoptotic protein caspase 3(Cas-3).Here,PA-targeted co-delivery of a FoxO1 stimulus(paclitaxel,PTX)and Cas-3 was exploited to alleviate monocrotaline-induced pulmonary *** co-delivery system is prepared by loading the active protein on paclitaxel-crystal nanoparticles,followed by a glucuronic acid coating to target the glucose transporter-1 on the *** co-loaded system(170 nm)circulates in the blood over time,accumulates in the lung,effectively targets the PAs,and profoundly regresses the remodeling of pulmonary arteries and improves hemodynamics,leading to a decrease in pulmonary arterial pressure and Fulton's *** mechanistic studies suggest that the targeted co-delivery system alleviates experimental pulmonary hypertension primarily via the regression of PASMC proliferation by inhibiting cell cycle progression and promoting *** together,this targeted co-delivery approach offers a promising avenue to target PAs and cure the intractable vasculopathy in pulmonary hypertension.

关键词： Pulmonary hypertension Pulmonary artery smooth muscle cells Fork-head box transcriptional factor O1 Caspase 3 Co-delivery

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Transplantation of Mesenchymal Stem Cells Attenuates Acute Liver Failure in Mice via an Interleukin-4-dependent Switch to the M2 Macrophage Anti-inflammatory Phenotype

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 669-679页

作者： Jinglin Wang Haoran Ding Jingchao Zhou Senzhe Xia Xiaolei Shi Haozhen Ren nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital of Nanjing Univer-sity Medical SchoolNanjingJiangsuChina Department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityJiangsuChina Department of Hepatobiliary Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu UniversityNanjingJiangsuChina

Background and Aims:Transplantation of mesenchymal stem cells(MSCs)derived from bone marrow(BM)is an alternative treatment of acute liver failure(ALF)mainly be-cause of the resulting anti-inflammatory *** is not known how MSCs regulate local immune responses and liver *** study explored the effects of MSCs on hepatic macrophages and the Wnt signaling pathway in ***:MSCs were isolated from BM aspirates of C57BL/6J mice,and transplanted in mice with ALF induced by D-galactosamine(D-Gal).The proliferation of hepato-cytes was assayed by immunohistochemical(IHC)staining of Ki-67 and proliferating cell nuclear antigen(PCNA).The levels of key proteins in the Wnt signaling pathway were assayed by western blotting and cytokines were determined enzyme-linked immunosorbent assays(ELISAs).A mac-rophage polarization assay characterized the M1/M2 *** potential role of interleukin-4(IL-4)in the biological ac-tivity of MSCs was determined by silencing of ***:Transplantation of allogeneic MSCs significantly attenuated D-Gal-induced hepatic inflammation and promoted liver *** transplantation significantly promoted a phenotypic switch from proinflamatory M1 macrophages to anti-inflammatory M2 macrophages,leading to significant Wnt-3a induction and activation of the Wnt signaling path-way in mice with D-Gal-induced *** the paracrine fac-tors secreted by MSCs(G-CSF,IL-6,IL-1 beta,IL-4,and IL-17A),IL-4 was specifically induced following transplantation in the ALF model *** silencing of IL-4 significantly ab-rogated the phenotypic switch to M2 macrophages and the protective effects of MSCs in both the ALF model mice and a co-culture model in an IL-4 dependent ***-sions:In vivo and in vitro studies showed that MSCs ame-liorated ALF through an IL-4-dependent macrophage switch toward the M2 anti-inflammatory *** findings may have clinical implications in that overexpression of IL-4 may enhance the therapeu

关键词： Acute liver failure Mesenchymal stem cells Interleukin 4 Macrophage Wnt signaling pathway

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Increasing prevalence and influencing factors of childhood asthma: a cross-sectional study in Shanghai, China

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World Journal of Pediatrics 2021年第4期17卷 419-428页

作者： Ya-Bin Hu Yi-Ting Chen Shi-Jian Liu Fan Jiang Mei-Qin Wu Chong-Huai Yan Jian-Guo Tan Guang-Jun Yu Yi Hu Yong Yin Jia-Jie Qu Sheng-Hui Li Shi-Lu Tong Department of Clinical Epidemiology and Biostatistics Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Child health Advocacy Institute China Hospital Development InstituteShanghai Jiao Tong UniversityShanghaiChina School of Public health Shanghai Jiao Tong University School of Medicine227 South Chongqing RoadHuangpuShanghai200025China Department of Developmental and Behavioral Pediatrics Pediatric Translational Medicine InstitutionShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina MOE-Shanghai key Laboratory of Children’s Environmental health Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai key Laboratory of Meteorology and health(Shanghai Meteorological Service) ShanghaiChina Center for Biomedical Informatics Shanghai Children’s HospitalShanghaiChina Department of Respiratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai municipal education Commission ShanghaiChina School of Public health Institute of Environment and Population HealthAnhui Medical UniversityHefeiChina Center for Global health School of Public HealthNanjing Medical UniversityNanjingChina School of Public health and Social Work Institute of Health and Biomedical InnovationQueensland University of TechnologyBrisbaneAustralia

Background Asthma has been a global problem,especially in *** aim to evaluate the contemporary prevalence and influencing factors of asthma among children aged 3–7 years in Shanghai,*** A random sample of preschool children was included in this *** International Study of Asthma and Allergies in Childhood questionnaire was adopted to assess the childhood *** logistic regression models were used to evaluate the associations between independent variables and childhood *** Of 6389 preschool children who were invited to take part in this study,6163(response rate:96.5%)completed the questionnaire and were included in the *** overall prevalence of asthma was 14.6%which increased more than six folds from 2.1%in *** male,younger age,preterm delivery,being born in spring or autumn,being delivered by elective cesarean section without indication,miscarriage,high socioeconomic status,having allergy history,and exposure to passive smoking,latex paint,and dust were potential risk factors for childhood *** more time outdoors(>30 min/day),having indoor plants,and cleaning rooms more frequently were potential protective *** The prevalence of childhood asthma in Shanghai has increased dramatically during the past three *** findings about risk and protective factors of childhood asthma could be used to develop appropriate strategies to prevent and control childhood asthma in Shanghai and in other similar metropolitan cities.

关键词： Asthma Children Prevalence Risk/protective factors

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Longitudinal proteomic investigation of cOVID-19 vaccination

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Protein & Cell 2023年第9期14卷 668-682页

作者： Yingrui Wang Qianru Zhu Rui Sun Xiao Yi Lingling Huang Yifan Hu Weigang Ge Huanhuan Gao Xinfu Ye Yu Song Li Shao Yantao Li Jie Li Tiannan Guo Junping Shi Marker Lab Westlake Laboratory of Life Sciences and BiomedicineKey Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Basic Medical sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China Research Centerfor Industries of theFuture WestlakeUniversity600D unyu RoadHangzhou 310030China Center for Infectious Disease Research Westlake University18 Shilongshan RoadHangzhou 310024China Westlake Omics(Hangzhou)Biotechnology Co. Ltd.Hangzhou 310024China Department of Translational Medicine Platform The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015China The Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053China Medical college of Hangzhou Normal University Hangzhou 311121China Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjing 210093China Department of Infectious and Hepatology Diseases The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015China

Although the development of covID-19 vaccines has been a remarkable success,the heterogeneous individual antibody generation and decline over time are unknown and still hard to *** this study,blood samples were collected from 163 participants who next received two doses of an inactivated COvVID-19 vaccine(CoronaVac)at a 28-day *** TMT-based proteomics,we identified 1,715 serum and 7,342 peripheral blood mononuclear cells(PBMCs)*** proposed two sets of potential biomarkers(seven from serum,five from PBMCs)at baseline using machine learning,and predicted the individual seropositivity 57 days after vaccination(AUC=0.87).Based on the four PBMC's potential biomarkers,we predicted the antibody persistence until 180 days after vaccination(AUC=0.79).Our data highlighted characteristic hematological host responses,including altered lymphocyte migration regulation,neutrophil degranulation,and humoral immune *** study proposed potential blood-derived protein biomarkers before vaccination for predicting heterogeneous antibody generation and decline after coVID-19 vaccination,shedding light on immunization mechanisms and individual booster shot planning.

关键词： COVID-19 vaccination proteomics neutralizing antibodies(NAbs) machine learning

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The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy

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Cellular & Molecular Immunology 2016年第1期13卷 73-81页

作者： Yan-Hong Li Wen-Hui Zhou Yu Tao Song-Cun Wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and Gynecology Fudan University Shanghai Medical College Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai China Medical Center for Human Reproduction Beijing Chaoyang HospitalCapital Medical University Beijing China Maternal and Child Care Hospital Of Huangpu District Shanghai China These authors contributed equally to this work

Decidual natural killer （dNK） cells actively participate in the establishment and maintenance of maternal-fetal immune tolerance and act as local guardians against infection. However, how dNK cells maintain the immune balance between tolerance and anti-infection immune responses during pregnancy remains unknown. Here, we demonstrated that the inhibitory molecule T-cell immunoglobulin domain and mucin domain-containing molecule-3 （Tim-3） are expressed on over 60% of dNK cells. Tim-3^＋ dNK cells display higher interleukin （IL）-4 and lower tumor necrosis factor （TNF）-α and perforin production. Human trophoblast cells can induce the transformation of peripheral NK cells into a dNK-like phenotype via the secretion of galectin-9 （Gal-9） and the interaction between Gal-9 and Tim-3. In addition, trophoblasts inhibit lipopolysaccharide （LPS）-induced pro-inflammatory cytokine and perforin production by dNK cells, which can be attenuated by Tim-3 neutralizing antibodies. Interestingly, a decreased percentage of Tim-3-expressing dNK cells were observed in human miscarriages and murine abortion-prone models. Moreover, T helper （Th）2-type cytokines were decreased and Thl-type cytokines were increased in Tim-3^＋ but not Tim-3- dNK cells from human and mouse miscarriages. Therefore, our results suggest that the Gal-9/Tim-3 signal is important for the regulation of dNK cell function, which is beneficial for the maintenance of a normal pregnancy.

关键词： cytotoxicity galectin-9/Tim-3 NK cells pregnancy Th2

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New Genus and Species of Rhyacophilidae (Insecta:Trichoptera) from the Middle Jurassic of China

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Acta Geologica Sinica(English Edition) 2013年第6期87卷 1495-1500页

作者： GAO Yan YAO Yunzhi REN Dong key Laboratory of Insect Evolution and Environmental Changes Capital Normal University State key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology CAS

One new genus with a new fossil species,Declinimodus setulosus *** *** was found in the Middle Jurassic Jiulongshan Formation of Daohugou,Inner Mongolia,China,are described and *** new species is assigned to the Rhyacophilidae according to buttonshaped of the 2nd segment of maxillary palp,and the forked R1 （in the forewing,located near apex）.These new discovery are the earliest fossil records of Rhyacophilidae,which providing important evident for the study of the origin and early evolution of Trichoptera.

关键词： Trichoptera Rhyacophilidae fossil Jiulongshan Formation

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“In situ bone flap” combined with vascular pedicled mucous flap to reconstruction of skull base defect

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World Journal of Clinical Cases 2023年第29期11卷 7053-7060页

作者： Ming Qian Xi Chen Long-Yao Zhang Zhi-Feng Wang Yi Zhang Xue-Jian Wang Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Nursing Affiliated Hospital 2 of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Neurosurgery Nantong Clinical Medical CollegeKangda CollegeNanjing Medical UniversityNantong 226000Jiangsu ProvinceChina

BACKGROUND At present,neuroendoscopy technology has made rapid development,and great progress has been made in the operation of lesions in the saddle area of the skull ***,the complications of cerebrospinal fluid and intracranial infection after the operation are still important and life-threatening complications,which may lead to poor *** To investigate the method of in situ bone flap combined with nasal septum mucosal flap for reconstruction of enlarged skull base defect by endonasal sphenoidal approach and to discuss its application *** Clinical data of 24 patients undergoing transnasal sphenoidal endoscopic approach in the Department of Neurosurgery,Affiliated 2 Hospital of Nantong University from January 2019 to December 2022 were retrospectively *** patients underwent multi-layer reconstruction of skull base using in situ bone flap combined with nasal septum mucosa *** incidence of intraoperative and postoperative cerebrospinal fluid leakage and intracranial infection were analyzed,and the application effect and technical key points of in situ bone flap combined with nasal septum mucosa flap for skull base bone reconstruction were *** There were 5 cases of high flow cerebrospinal fluid(CSF)leakage and 7 cases of low flow CSF *** cerebrospinal fluid leakage occurred in 2 patients(8.3%)and intracranial infection in 2 patients(8.3%),which were cured after strict bed rest,continuous drainage of lumbar cistern combined with antibiotic treatment,and no secondary surgical repair was *** patients were followed up for 8 to 36 months after the operation,and no delayed cerebrospinal fluid leakage or intracranial infection occurred during the *** tomography reconstruction of skull base showed satisfactory reconstruction after *** The use of in situ bone flap combined with vascular pedicled mucous flap to reconstruction of skull base defect after endonasal sphe

关键词： In situ bone flap Nasal septum mucosa flap Multilayer reconstruction Skull base reconstruction Neuroendoscopy Endonasal sphenoidal approach

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DP-Share: Privacy-Preserving Software Defect Prediction Model Sharing Through Differential Privacy

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Journal of Computer science & Technology 2019年第5期34卷 1020-1038页

作者： Xiang Chen Dun Zhang Zhan-Qi Cui Qing Gu Xiao-Lin Ju School of Information science and Technology Nantong UniversityNantong 226019China State key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China School of Computer science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Computer School Beijing Information Science and Technology UniversityBeijing 100101China

In current software defect prediction (SDP) research, most previous empirical studies only use datasets provided by PROMISE repository and this may cause a threat to the external validity of previous empirical results. Instead of SDP dataset sharing, SDP model sharing is a potential solution to alleviate this problem and can encourage researchers in the research community and practitioners in the industrial community to share more models. However, directly sharing models may result in privacy disclosure, such as model inversion attack. To the best of our knowledge, we are the first to apply differential privacy (DP) to privacy-preserving SDP model sharing and then propose a novel method DP-Share, since DP mechanisms can prevent this attack when the privacy budget is carefully selected. In particular, DP-Share first performs data preprocessing for the dataset, such as over-sampling for minority instances (i.e., defective modules) and conducting discretization for continuous features to optimize privacy budget allocation. Then, it uses a novel sampling strategy to create a set of training sets. Finally it constructs decision trees based on these training sets and these decision trees can form a random forest (i.e., model). The last phase of DP-Share uses Laplace and exponential mechanisms to satisfy the requirements of DP. In our empirical studies, we choose nine experimental subjects from real software projects. Then, we use AUC (area under ROC curve) as the performance measure and holdout as our model validation technique. After privacy and utility analysis, we find that DP-Share can achieve better performance than a baseline method DF-Enhance in most cases when using the same privacy budget. Moreover, we also provide guidelines to effectively use our proposed method. Our work attempts to fill the research gap in terms of differential privacy for SDP, which can encourage researchers and practitioners to share more SDP models and then effectively advance the state of

关键词： software defect prediction model sharing differential privacy cross project defect prediction empirical study

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Exercise promotes osteogenic differentiation by activating the long non-coding RNA H19/microRNA-149 axis

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World Journal of Orthopedics 2024年第4期15卷 363-378页

作者： Xu-Chang Zhou Dong-Xue Wang Chun-Yu Zhang Ya-Jing Yang Ruo-Bing Zhao Sheng-Yao Liu Guo-Xin Ni School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China Department of Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430065Hubei ProvinceChina Department of Spinal Surgery The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510260Guangdong ProvinceChina Department of Rehabilitation Medicine The First Affiliated Hospital of Xiamen UniversityXiamen 361003Fujian ProvinceChina

BACKGROUND Regular physical activity during childhood and adolescence is beneficial to bone development,as evidenced by the ability to increase bone density and peak bone mass by promoting bone *** To investigate the effects of exercise on bone formation in growing mice and to investigate the underlying *** 20 growing mice were randomly divided into two groups:Con group(control group,n=10)and Ex group(treadmill exercise group,n=10).Hematoxylin-eosin staining,immunohistochemistry,and micro-CT scanning were used to assess the bone formation-related indexes of the mouse *** analysis was used to find potential miRNAs targets of long non-coding RNA H19(lncRNA H19).RT-qPCR and Western Blot were used to confirm potential miRNA target genes of lncRNA H19 and the role of lncRNA H19 in promoting osteogenic *** Compared with the Con group,the expression of bone morphogenetic protein 2 was also significantly *** micro-CT results showed that 8 wk moderate-intensity treadmill exercise significantly increased bone mineral density,bone volume fraction,and the number of trabeculae,and decreased trabecular segregation in the femur of *** of lncRNA H19 significantly upregulated the expression of miR-149 and suppressed the expression of markers of osteogenic *** addition,knockdown of lncRNA H19 significantly downregulated the expression of autophagy markers,which is consistent with the results of autophagy-related protein changes detected in mouse femurs by *** Appropriate treadmill exercise can effectively stimulate bone formation and promote the increase of bone density and bone volume in growing mice,thus enhancing the peak bone mass of *** lncRNA H19/miR-149 axis plays an important regulatory role in osteogenic differentiation.

关键词： Exercise Osteogenic differentiation Bone formation Bone mesenchymal stem cells Autophagy

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