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Journal of Mountain Science 2008年第4期5卷 279-298页

作者： Ganesh Raj JOSHI Daigoro HAyASHI Simulation Tectonics Laboratory Faculty of ScienceUniversity of the RyukyusOkinawa 903-0213Japan

This paper presents finite element modeling （FEM） to simulate the present-day stress field and crustal deformation using nE-SW structural section in the central Seismic Gap region of the Garhwal Himalaya. Our study deals with the effect of geometrical characteristics and rock layer parameters on the upper crust. Modeling results show that two types of tectonic regimes developed in the central Seismic Gap region： the geotectonics of the northern part has been controlled by regional compression, whereas southern part is characterized by regional extension. Correspondingly, thrust faults are induced in the northern part and normal faults are extensively developed in the southern front. Those evidences noticeably indicate that the compressive tectonic environment of the Himalaya becomes change into the extensional tectonic regime in its front. The computed shear stress accumulation along the northern fiat of Main Himalayan Thrust （MHT） implies that considerable amount of interseismic stress is building up along the MHT system in the Himalaya, which ultimately release through the possible future great Himalayan earthquake （M 〉 8）. The comparison between our modeled stress field, faulting pattern and horizontal shortening rate with the distribution of the microseismic events, focal mechanism solutions, active faulting and GPS data in the central Seismic Gap region shows good agreement.

关键词： neotectonic deformation stress distribution FE modeling central Seismic Gap nW-Himalaya

SynERGISTIC MODIFICATIOn OF EPDM AnD CROSSLInKInG AGEnT In IMMISCIBLE BLEnDS OF POLyVInyL CHLORIde WITH LOW denSITy POLyETHyLEnE

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Chinese Journal of Polymer Science 2006年第2期24卷 147-154页

作者：方征平 Institute of Polymer Composites Zhejiang University

The synergism of ethylene-propylene-diene monomer copolymer （EPDM） and dicumyl peroxide （DCP, a crosslinking agent） in low density polyethylene （LDPE）/poly（vinyl chloride）（PVC） blends was investigated. When EDPM and DCP are added to the blends simultaneously, the tensile properties could be improved significantly, especially for the blends with LDPE matrix. For example, incorporation of 10/1 （mass ratio） EPDM/DCP improves the tensile strength of the LDPE/PVC （mass ratio 80/20） blend from 7.9 MPa to 8.5 MPa and the elongation at break from 25% to 503%. Results from selective extraction, phase-contrast microscopy and thermal analysis reveal that the improvement in the tensile properties of the blends with LDPE matrix is principally due to the formation of a fine crosslinking network of the LDPE and EPDM phase. The outstanding modification effect of EPDM is explained by its dual functions： molecular entanglement with LDPE and the enhanced efficiency of DCP in the blends.

关键词： Polyvinyl chloride Polyethylene EPDM Blend Crosslinking

Genesis of continental seismogenic zone and a new fault zone model

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Chinese Science Bulletin 2000年第20期45卷 1886-1892页

作者： LIU Junlai & M. Shimada1. department of Earth Sciences, Changchun University of Science and Technology, Changchun 130026, China 2. RCEP, Disaster Prevention Research Institute, Kyoto University, Uji, Kyoto, 611-0011, Japan Correspondence should be addressed to Liu Junlai i department of Earth Sciences Changchun University of Science and Technology Changchun China RCEP Disaster Prevention Research Institute Kyoto University Uji Kyoto Japan

Experiments were conducted repeatedly on Mannari granite under different temperature and confining pressure conditions. Systematic micro- and submicro-structural and mechanical analyses of granite samples deformed under 1.5 GPa (confining pressure), at 25 ℃-650 ℃ temperatures and at 2×10-6s-1 strain rate show the brittle-ductile deformation microstructures and microstructural associations similar to those observed in naturally deformed crustal rocks and minerals. Brittle fracturing and crystalline plasticity co-exist and react with each other in the brittle-ductile transition domain of the continental lithosphere. The interaction between the different mechanisms in the transitional domain results in the variation of anomalous strength values, which may best explain the genesis of the continental seismogenic zone. A new fault zone model is proposed on the basis of detailed micromechanical and microstructural analyses.

关键词： granite experimental rock deformation continental seismogenic zone fault zone model.

Existence of nondecreasing and Continuous Solutions of an Integral Equation with Linear Modification of the Argument

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1719-1728页

作者： J.CABALLERO B.LóPEZ K.SADARAnGAnI departamento de Matemáticas Universidad de Las Palmas de Gran CanariaCampus de Tafira Baja35017 Las Palmas de Gran CanariaSpain

We use a technique associated with measures of noncompactness to prove the existence of nondecreasing solutions to an integral equation with linear modification of the argument in the space C[0, 1]. In the last thirty years there has been a great deal of work in the field of differential equations with a modified argument. A special class is represented by the differential equation with affine modification of the argument which can be delay differential equations or differential equations with linear modifications of the argument. In this case we study the following integral equation x（t） = a（t）＋（Tx）（t） ∫0^σ（t） u（t, s, x（s）, x（λs））ds 0 〈 λ 〈 1 which can be considered in connection with the following Cauchy problem x＇（t） = u（t, s, x（t）, x（λt））, t ∈ [0, 1], 0 〈 λ 〈 1 x（0） = u0.

关键词： measure of noncompactness fixed point theorem nondecreasing solutions

Suitability of Blends from Virgin and Reprocessed Polylactide: Performance and Energy Valorization Kinet

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Journal of Renewable Materials 2018年第4期6卷 370-382页

作者： O.Gil-Castell J.D.Badia A.Ribes-Greus Instituto de Tecnología de Materiales(ITM) Universitat Politècnica de ValènciaCamino de Vera s/n46022 ValènciaSpain departament d’Enginyeria Química Escola Tècnica Superior d’EnginyeriaUniversitat de ValènciaAv.de la Universitat s/n46100 BurjassotSpain

A blending strategy of virgin and reprocessed polylactide may be postulated as an alternative to reduce the material cost at industrial level,and as a valorization route to plastic waste management of production *** performance of blends prepared from virgin polylactide and polylactide mechanically reprocessed up to two cycles(PLA-V/R)was assessed in terms of thermo-oxidative stability,morphology,viscoelasticity and thermal kinetics for energetic ***-V/R blends showed appropriate thermo-oxidative *** amorphous nature of polylactide was preserved after *** viscoelastic properties showed an increment of the mechanical blend effectiveness,which suggested the feasibility of using PLA-V/R blends under similar mechanical conditions to those of virgin PLA ***,it was shown that the energetic valorization of PLA-V/R blends would result in a more feasible process,due to the lower required activation energy,thus highlighting the advantages of the energetic demand for the *** conclusion,PLA-V/R blends showed similar processability,service performance and valorization routes as virgin PLA and therefore could be relevant in the sustainable circular industry of bioplastics.

关键词： Polylactide (PLA) mechanical recycling reprocessing energetic valorisation thermal analysis

Long-term open circuit microbial electrosynthesis system promotes methanogenesis

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Journal of Energy Chemistry 2020年第2期29卷 3-6页

作者： Raúl Mateos Adrián Escapa María Isabel San-Martín Heleen de Wever Ana Sotres deepak Pant Chemical and Environmental Bioprocess Engineering Group Natural Resources Institute(IRENA)University of LeonLeon 24071Spain department of Electrical Engineering and Automatic Systems Universidad de LeonLeon 24071Spain Reparation and Conversion Technology Flemish Institute for Technological Research(VITO)Mol 2400Belgium

Microbial electrosynthesis(MES) can potentially provide a mean for storing renewable energy surpluses as chemical energy. However, the fluctuating nature of these energy sources may represent a threat to MES, as the microbial communities that develop on the biocathode rely on the continuous existence of a polarized electrode. This work assesses how MES performance, product generation and microbial community evolution are affected by a long-period(6 weeks) power off(open circuit). Acetogenic and H2-producing bacteria activity recovered after reconnection. However, few days later syntrophic acetate oxidation bacteria and H2-consuming methanogens became dominant, producing CH4 as the main product, via electromethanogenesis and the syntrophic interaction between eubacterial and archaeal communities which consume both the acetic acid and the hydrogen present in the cathode environment. Thus,the system proved to be resilient to a long-term power interruption in terms of electroactivity. At the same time, these results demonstrated that the system could be extensively affected in both end product generation and microbial communities.

关键词： Biocathode Electromethanogenesis Microbial electrosynthesis Microbial community dynamics Methanogens Acetogens

Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DnA fragmentation

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Cancer Drug Resistance 2019年第2期2卷 335-350页

作者： Akimasa Seno Akifumi Mizutani Kazuki Aizawa Ryoma Onoue Junko Masuda naotaka Ochi Saki Taniguchi Tatsuyuki Sota yuki Hiramoto Taisuke Michiue neha nair Masaharu Seno Laboratory of nano-Biotechnology Graduate School of Interdisciplinary Science and Engineering in Health SystemsOkayama UniversityOkayama 700-8530Japan Division of Medical Bioengineering Graduate School of Natural Science and TechnologyOkayama UniversityOkayama 700-8530Japan.

Aim:To identify a drug that can effectively eliminate these cancer stem cells(CSCs)and determine its mode of ***:CSCs were obtained from mouse induced pluripotent stem cells(miPSCs)using cancer cell-conditioned *** screening was performed on these cells or after transplantation into *** was analyzed by flow cytometry and western ***:Drug screening studies showed that daunorubicin,a topoisomerase II inhibitor,is specifically cytotoxic to ***-induced apoptosis was found to be associated with p53 accumulation,activation of the caspase cascade,and oligonucleosomal DnA *** with the caspase inhibitor abolished daunorubicin-induced DnA fragmentation and was therefore considered to act downstream of caspase *** was also suppressed by treatment with a Ca2+-specific chelator,which suggested that CAD endonuclease does not ***,no obvious ICAD reduction/degradation was ***:Daunorubicin effectively eliminated CSCs,which are dependent on the p53/caspase signaling *** current findings provided the basis for further studies on CSC-targeted drugs for the development of cancer treatment strategies.

关键词： Daunorubicin cancer stem cell DnA fragmentation

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海外油田钢制储罐用牺牲阳极保护技术

钢铁 2015年第8期50卷 95-99页

作者：杨朝晖李健黄涛于鸿江王亮李向阳钢铁研究总院青岛海洋腐蚀研究所山东青岛266071 青岛钢研纳克检测防护技术有限公司山东青岛266071 中国钢研科技集团有限公司钢铁研究总院北京100081 中油国际(曼格什套)有限责任公司哈萨克斯坦阿克套130000

通过电化学测试、阳极溶解形貌观察和SEM检测,确定了铝合金牺牲阳极在海外高矿化度、高氯离子含量的油田污水中的最佳配方(质量分数)为Al-4.5%Zn-0.025%In-1.5%Mg-0.05%Ti-0.015%Ga,并通过极差分析确定了各合金元素对电流效率的影响程度... 详细信息

通过电化学测试、阳极溶解形貌观察和SEM检测,确定了铝合金牺牲阳极在海外高矿化度、高氯离子含量的油田污水中的最佳配方(质量分数)为Al-4.5%Zn-0.025%In-1.5%Mg-0.05%Ti-0.015%Ga,并通过极差分析确定了各合金元素对电流效率的影响程度,分析了各合金元素对电流效率的作用机制;模拟试验和现场试验结果表明,选定最佳成分的牺牲阳极在高矿化度、高氯离子含量条件下对油田钢制储罐保护效果良好。

关键词：牺牲阳极合金元素钢制储罐极差分析

降钙素对小鼠成骨细胞增殖及OPG/RAnKL表达的影响

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中华医学杂志 2007年第21期87卷 1501-1505页

作者：田庆显黄公怡周君琳刘清和杜心如北京首都医科大学附属北京朝阳医院 100020 卫生部北京医院骨科

目的探讨降钙素对小鼠成骨细胞增殖及骨保护素(OPG)/细胞核因子 KB 受体活化因子配体(RAnKL)表达的影响。方法取出生24 h 内的小鼠30只,无菌的条件下取出颅骨,应用酶消化法进行成骨细胞的培养,在培养成骨细胞的培养液中加入不同浓度的... 详细信息

目的探讨降钙素对小鼠成骨细胞增殖及骨保护素(OPG)/细胞核因子 KB 受体活化因子配体(RAnKL)表达的影响。方法取出生24 h 内的小鼠30只,无菌的条件下取出颅骨,应用酶消化法进行成骨细胞的培养,在培养成骨细胞的培养液中加入不同浓度的降钙素,首先应用 MTT 法检测这种药物对成骨细胞增殖的影响,然后应用 RT-PCR 法检测其对 OPG/RAnKL mRnA 的表达及ELISA 法检测 OPG 蛋白分泌的影响。结果降钙素能促进成骨细胞的增殖。降钙素能增强成骨细胞中 OPG mRnA 的表达同时抑制成骨细胞中 RAnKL mRnA 的表达,并能促进 OPG 蛋白的分泌。结论降钙素能促进成骨细胞的增殖及成骨细胞中 OPG mRnA 的表达,同时抑制 RAnKL 的 mRnA的表达。

关键词：降钙素成骨细胞 nF-KB

来源骨髓的树突状细胞培养方法特征及其合理时间

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中国临床康复 2005年第23期9卷 48-49,i001页

作者：吴舰宇宋春芳许评刘锐哈尔滨医科大学附属第一医院普外一科黑龙江省哈尔滨市150001

目的:观察从骨髓来源的免疫辅佐细胞树突状细胞的培养操作技术及合理的培养时间。方法:实验于2003-10/2004-12在卫生部细胞移植重点实验室进行。树突细胞来源为健康SD大鼠的骨髓细胞,分别加入4种细胞因子:重组大鼠粒细胞-巨噬细胞集落... 详细信息

目的:观察从骨髓来源的免疫辅佐细胞树突状细胞的培养操作技术及合理的培养时间。方法:实验于2003-10/2004-12在卫生部细胞移植重点实验室进行。树突细胞来源为健康SD大鼠的骨髓细胞,分别加入4种细胞因子:重组大鼠粒细胞-巨噬细胞集落刺激因子5μg/L,重组大鼠白细胞介素45μg/L,重组大鼠肿瘤坏死因子α10μg/L,重组大鼠γ干扰素20μg/L,共培养2周。每隔2d加细胞因子1次,保持各细胞因子的浓度不变,分离树突细胞采用“培养黏附法”。在培养的第3天吸去上清后重新加入培养液,在培养2周后收获悬浮的树突状细胞,分离树突细胞采用“培养黏附法”。在培养的第1,3,5,7,9,11,13,15天用光学倒置显微镜观察细胞的形态;取一部分细胞在培养的第7,11,13,15天行流式细胞仪检查,并用PE标记的抗大鼠CD86单克隆抗体检测它的成熟度(CD86单抗阳性为成熟)。结果:①树突状细胞的形态:从培养第7天开始细胞周围开始逐渐伸出突起,第13天以后突起五六支左右,且长度逐渐缩短,成熟的树突状细胞伸出长短不等的突起,类似神经细胞的树突。②培养所得的树突状细胞数量:1只大鼠平均得到(1.18±0.21)×107。③树突状细胞的成熟度:培养第7,11,13,15天CD86单抗的阳性率分别为30%,80%,92%,94%。结论:应用骨髓来源的树突状细胞,在两种常规的细胞因子粒细胞-巨噬细胞集落刺激因子和白细胞介素4基础上加入肿瘤坏死因子α和γ干扰素,培养2周,应用培养黏附法分离树突状细胞,可得到成熟的树突状细胞,且数量较多。

关键词：树突细胞粒细胞巨噬细胞集落刺激因子重组白细胞介素4 肿瘤坏死因子干扰素γ 重组