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Pharmacodynamic evaluation for antiplasmodial activity of Holarrhena antidysentrica(Kutaja) and Azadirachta indica(Neemb) in Plasmodium berghei infected mice model

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 520-524页

作者： Jadhav Priyanka Lal Hingorani Kshirsagar Nilima university Department of Infectious Diseases and university Department of Interpathy Research and Technology.maharashtra university of health sciences.Mumbai India Pharmanza Herbals Pvt.Ltd. MumbaiIndia Office of National Chair(Clinical Pharmacology).Indian Council of Medical Research(ICMR).Government of India Dean ESI-PGIMSR MGM HospitalGovt.of India.MumbaiIndia

Objective:To investigate in-vivo anti-plasmodial activity of aqueous extracts of plants selected based on the symptomology mentioned in ***:The aqueous extracts of Holarrhena antidysentrica(***)(Kutaja) and Azadirachta indica(***)(Neemb) for their antiplasmodial potential in Plasmodium berghei(***) infected mice was assessed using Peters four day suppressive *** the extracts were administered at 2 dose levels,full dose(1 000 mg/d) and minimized dose(200 mg/d).10~6 *** infected RBCs were injected on day ’0’ and treated from day ’0’ till day ’3’ post-infection,Tail blood smears were collected, giemsa stained and *** mice were observed for survival and parasitemia was assessed till 50%of mice in control ***:It was observed that the percentage of parasitemia increased gradually in all the groups,with maximum in control group(Day 3-35,Day 9-46.98) and minimum in Chloroquine arm(Day *** 9-19.92).The percentage of parasitemia was compared using Mann-Whitney U test depicting that all test groups exhibited reduction in parasitemia as compared to control(P-value<0.002 for all groups).These groups showed similar percentage of survival as ***:The present investigation demonstrated the anti-plasmodial effects of *** and *** are two most commonly used medicinal plants in Ayurved for treatment of fever.

关键词： Holarrhena antidysentrica Azadirachta indica Plasmodium berghei Malaria Peter’s 4 day test Ayurved Parasitemia

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