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Beta-elemene inhibits the growth of KDM6A-null bladder cancer cells by suppressing the epithelial-mesenchymal transition

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Clinical Traditional Medicine and Pharmacology 2024年第2期5卷 15-24页

作者： Ruonan Zhang Jiao Feng Yintao Zheng Qianru Zhu Bo Xiang Qibiao Wu Xinbing Sui The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health Cancer Research Institute and School of Basic Medical SciencesCentral South UniversityChangsha 410008HunanChina School of Pharmacy Hangzhou Normal UniversityHangzhou 311121ZhejiangChina Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou 311121ZhejiangChina Department of Gastrointestinal and Pancreatic Surgery Key Laboratory of Gastroenterology of Zhejiang ProvinceZhejiang Provincial People’s HospitalHangzhou 310014ZhejiangChina School of Pharmaceutical sciences Zhejiang Chinese Medical UniversityHangzhou 311402ZhejiangChina State Key Laboratory of Quality Research in Chinese Medicines Faculty of Chinese MedicineMacao University of Science and TechnologyMacao 999078China

Background:Bladder cancer is a highly prevalent and lethal malignant tumor characterized by frequent mutations/deletions of lysine-specific demethylase 6A(KDM6A),which is suggested to be a key event in cancer progression and ***-elemene has been shown to inhibit metastasis and growth of various tumors,but its effect on KDM6A-null bladder cancer cells remains ***:This study aimed to investigate the potential and molecular mechanism ofβ-elemene in inhibiting the growth of KDM6A-null bladder ***:This study examined the migration ability and viability of RT-4(KDM6A wild-type)and KU19-19(KDM6A-null)cell lines using wound healing assay and CCK-8,*** inhibitory effect ofβ-elemene on KU19-19 cell migration was evaluated using transwell and immunofluorescence assays,and the expression of transfer-related proteins and genes was analyzed through western blot and qRT-PCR,*** docking was performed to predict the targeting ofβ-elemene,and the effects were confirmed in KDM6Aknockdown RT-4 ***,the therapeutic effect ofβ-elemene on bladder cancer was tested in animal ***:The study observed that loss of KDM6A increased bladder cancer cell migration,with KU19-19 exhibiting significantly stronger migration than *** investigation revealed thatβ-elemene effectively inhibited KU19-19 cell migration,likely through targeting EZH2 as determined by molecular *** of KDM6A inhibited KU19-19 metastasis,while knockdown of KDM6A in RT-4 cells enhanced cell migration,which was reversed byβ-elemene ***,in vivo testing revealed a significant suppression of KU19-19 cell growth withβ-elemene administered at a dosage of 100 mg/***:β-elemene has the potential to suppress the growth of KDM6A-null bladder cancer by inhibiting epithelial-mesenchymal transition(EMT),which could make it a promising therapeutic option for patients with KDM6A-null bladder cancer.

关键词： β-Elemene Lysine-specific demethylase 6A(KDM6A) Bladder cancer Metastasis Epithelial-mesenchymal transition(EMT)

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Liquid-liquid interface‐assisted growth of two‐dimensional organic semiconductor single crystals:Mechanisms,properties,and applications

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Information ＆ Functional Materials 2024年第2期1卷 220-241页

作者： Jinwen Wang Tingyi Yan Lingyun Li Zheng Ren Xiujuan Zhang Jiansheng Jie Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhouJiangsuChina Jiangsu Key Laboratory for Carbon‐Based Functional Materials&Devices Soochow UniversitySuzhouJiangsuChina Jiangsu Key Laboratory of Advanced Negative Carbon Technologies Soochow UniversitySuzhouJiangsuChina macao Institute of Materials science and Engineering MUST‐SUDA Joint Research Center for Advanced Functional MaterialsMacao University of Science and TechnologyTaipaMacaoChina

Two‐dimensional organic semiconductor single crystals(2D OSSCs)represent the promising candidates for the construction of high‐performance electronic and optoelectronic devices due to their ultrathin thicknesses,free of grain boundaries,and long‐range ordered molecular *** recent years,substantial efforts have been devoted to the fabrication of the large‐sized and layer‐controlled 2D OSSCs at the liquid‐liquid *** unique interface could act as the molecular flat and defect‐free substrate for regulating the nucleation and growth processes and enabling the formation of large‐sized ultrathin 2D ***,this review focuses on the liquid-liquid interface‐assisted growth methods for the controllable preparation of 2D OSSCs,with a particular emphasis on the advantages and limitations of the corresponding ***,the typical methods employed to control the crystal sizes,morphologies,structures,and orientations of 2D OSSCs at the liquid-liquid interface are discussed in ***,the recent progresses on the 2D OSSCs‐based optoelectronic devices,such as organic field‐effect transistors,ambipolar transistors,and phototransistors are ***,the key challenges and further outlook are proposed in order to promote the future development of the 2D OSSCs in the field of the next‐generation organic optoelectronic devices.

关键词： ambipolar transistors liquid‐liquid interface‐assisted growth organic field‐effect transistors organic phototransistors two‐dimensional organic semiconductor single crystal

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声波超材料中D类拓扑的观测

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science Bulletin 2024年第7期69卷 893-900页

作者：吴世巧程文婷刘啸宇吴柄权 Emil Prodan Camelia Prodan 蒋建华 School of Physical science and technology&Collaborative Innovation Center of Suzhou Nano science and technology Soochow UniversitySuzhou 215006China School of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Guangdong-Hong Kong-macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic technology Foshan UniversityFoshan 528000China Department of Physics University of MichiganAnn Arbor MI 48109USA Department of Physics Yeshiva UniversityNew York NY 10033USA Department of Physics and Engineering Physics Fordham UniversityNew York NY 10023USA Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215123China

Topological materials and metamaterials opened new paradigms to create and manipulate phases of matter with unconventional *** D-class phases(TDPs)are archetypes of the ten-fold classification of topological phases with particle-hole *** two dimensions,TDPs support propagating topological edge modes that simulate the elusive Majorana elementary ***,a piercing ofπ-flux Dirac-solenoids in TDPs stabilizes localized Majorana excitations that can be braided for the purpose of topological quantum *** two-dimensional(2D)TDPs have been a focus in the research frontier,but their experimental realizations are still under ***,with a novel design scheme,we realize 2D TDPs in an acoustic crystal by synthesizing both the particle-hole and fermion-like time reversal symmetries for a wide range of *** design scheme leverages an enriched unit cell structure with real-valued couplings that emulate the targeted Hamiltonian of TDPs with complex hoppings:A technique that could unlock the realization of all topological classes with passive *** our experiments,we realize a pair of TDPs with opposite Chern numbers in two independent sectors that are connected by an intrinsic fermion-like timereversal symmetry built in the *** measure the acoustic Majorana-like helical edge modes and visualize their robust topological transport,thus revealing the unprecedented D and DIII class topologies with direct *** study opens up a new pathway for the experimental realization of two fundamental classes of topological phases and may offer new insights in fundamental physics,materials science,and phononic information processing.

关键词： D-class topology Chiral symmetry Time-reversal symmetry Particle-hole symmetry Gapless edge states

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SARS-CoV-2 pathogenesis in the gastrointestinal tract mediated by Spike-induced intestinal inflammation

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Precision Clinical Medicine 2024年第1期7卷 84-86页

作者： Zhanyu Li Jianzhong He Yun Yin Lei Tang Ye Liu Olivia Monteiro Famin Zeng Department of Pathology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 5190ooChina City University of macao Macao 999078China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

Dear Editor,The pathogenesis of COVID-19 in the gastrointestinal(GI)tract is well-documented[1].However,due to a lack of simple animal models,the pathogenic mechanisms of SARS-CoV-2 in the GI tract is not well ***,com... 详细信息

关键词： pathogenesis gastrointestinal inflammation

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大n值准相纯二维卤化物钙钛矿:从材料到器件的工具箱（英文）

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science Bulletin 2024年第3期 382-418页

作者：李子佳林越辛顾浩张楠王斌蔡海蕊廖金凤于德见陈义旺方国家梁超杨生春邢贵川 MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of Physics National Innovation Platform (Center) for Industry-Education Integration of Energy Storage Technology Xi'an Jiaotong University Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials Engineering University of Macau National Engineering Research Center for Carbohydrate Synthesis Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal University Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education School of Physics and Technology Wuhan University

Despite their excellent environmental stability, low defect density, and high carrier mobility, large-n quasi-two-dimensional halide perovskites(quasi-2DHPs) feature a limited application scope because of the formation of self-assembled multiple quantum wells(QWs) due to the similar thermal stabilities of large-n phases. However, large-n quasi-phase-pure 2DHPs(quasi-PP-2DHPs) can solve this problem perfectly. This review discusses the structures, formation mechanisms, and photoelectronic and physical properties of quasi-PP-2DHPs, summarises the corresponding single crystals, thin films, and heterojunction preparation methods, and presents the related advances. Moreover, we focus on applications of large-n quasi-PP-2DHPs in solar cells, photodetectors, lasers, light-emitting diodes, and field-effect transistors, discuss the challenges and prospects of these emerging photoelectronic materials, and review the potential technological developments in this area.

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Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhipeng Zhang Binyan Wang Yu Wang Xiangyi Kong Yong Sun Aimin Li Yimin Cui Yan Zhang Jianping Li Yong Huo Hui Huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

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Strong Anisotropic Order Parameters at All-Nitride Ferromagnet/Superconductor Interfaces

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Chinese Physics Letters 2024年第2期41卷 102-111页

作者： Qiao Jin Meng Yang Guozhu Song Nan Zhao Shengru Chen Haitao Hong Ting Cui Dongke Rong Qianying Wang Yiyan Fan Chen Ge Can Wang Jiachang Bi Yanwei Cao Liusuo Wu Shanmin Wang Kui-Juan Jin Zhi-Gang Cheng Er-Jia Guo Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China Department of Physics&Center of Materials science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Department of Physics Southern University of Science and TechnologyShenzhen 518055China Songshan Lake Materials Laboratory Dongguan 523808China Ningbo Institute of Materials technology&Engineering Chinese Academy of SciencesNingbo 315201China

Proximity effects between superconductors and ferromagnets(SC/FM)hold paramount importance in comprehending the spin competition transpiring at their *** competition arises from the interplay between Cooper pairs and ferromagnetic exchange *** proximity effects between transition metal nitrides(TMNs)are scarcely investigated due to the formidable challenges of fabricating high-quality SC/FM *** fabricated heterostructures comprising SC titanium nitride(TiN)and FM iron nitride(Fe_(3)N)with precise chemical compositions and atomically well-defined *** magnetoresistance of Fe_(3)N/TiN heterostructures shows a distinct magnetic anisotropy and strongly depends on the external ***,the superconducting transition temperatureT_(C) and critical field of TiN experience notable suppression when proximity to Fe_(3)*** observe the intriguing competition of interfacial spin orientations near𝑇T_(C)(∼1.25 K).These findings not only add a new materials system for investigating the interplay between superconductor and ferromagnets,but also potentially provide a building block for future research endeavors and applications in the realms of superconducting spintronic devices.

关键词： proximity Superconductor titanium

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Distributed learning particle swarm optimizer for global optimization of multimodal problems

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Frontiers of Computer science 2018年第1期12卷 122-134页

作者： Geng ZHANG Yangmin LI Yuhui SHI Department of Electromechanical Engineering Faculty of Science and Technology University of Macao Macao China Industrial and Systems Engineering Faculty of Engineering The Hong Kong Polytechnic University Hong Kong China Department of Computer science and Engineering Southern University of Science and Technology Shenzhen 518055 China

Particle swarm optimizer （PSO） is an effective tool for solving many optimization problems. However, it may easily get trapped into local optimum when solving com- plex multimodal nonseparable problems. This paper presents a novel algorithm called distributed learning particle swarm optimizer （DLPSO） to solve multimodal nonseparable prob- lems. The strategy for DLPSO is to extract good vector infor- mation from local vectors which are distributed around the search space and then to form a new vector which can jump out of local optima and will be optimized further. Experimen- tal studies on a set of test functions show that DLPSO ex- hibits better performance in solving optimization problems with few interactions between variables than several other peer algorithms.

关键词： particle swarm optimizer (PSO) orthogonal ex-perimental design (OED) swarm intelligence

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Continuous-Time Prediction of Industrial Paste Thickener System With Differential ODE-Net

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 686-698页

作者： Zhaolin Yuan Xiaorui Li Di Wu Xiaojuan Ban Nai-Qi Wu Hong-Ning Dai Hao Wang the Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Artificial IntelligenceBeijing Key Laboratory of Knowledge Engineering for Materials ScienceSchool of Computer and Communication EngineeringUniversity of Science and Technology Beijing the Department of ICT and Natural science Norwegian University of Science and Technology IEEE the Institute of Systems Engineering and Collaborative Laboratory for Intelligent Science and SystemsMacao University of Science and Technology the Department of Computing and Decision sciences Lingnan University the Department of Computer science Norwegian University of Science and Technology

It is crucial to predict the outputs of a thickening system,including the underflow concentration(UC)and mud pressure,for optimal control of the *** proliferation of industrial sensors and the availability of thickening-system data make this ***,the unique properties of thickening systems,such as the non-linearities,long-time delays,partially observed data,and continuous time evolution pose challenges on building data-driven predictive *** address the above challenges,we establish an integrated,deep-learning,continuous time network structure that consists of a sequential encoder,a state decoder,and a derivative module to learn the deterministic state space model from thickening *** a case study,we examine our methods with a tailing thickener manufactured by the FLSmidth installed with massive sensors and obtain extensive experimental *** results demonstrate that the proposed continuous-time model with the sequential encoder achieves better prediction performances than the existing discrete-time models and reduces the negative effects from long time delays by extracting features from historical system *** proposed method also demonstrates outstanding performances for both short and long term prediction tasks with the two proposed derivative types.

关键词： Industrial 24 paste thickener ordinary differential equation(ODE)-net recurrent neural network time series prediction

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Study of the Modified Gaussian Model on olivine diagnostic spectral features and its applications in space weathering experiments

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Research in Astronomy and Astrophysics 2020年第8期20卷 261-279页

作者： Hui-Jie Han Xiao-Ping Lu Ya-Zhou Yang Hao Zhang Admire Muchimamui Mutelo State Key Laboratory of Lunar and Planetary sciences Macao University of Science and TechnologyTaipa 999078MacaoChina State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190China Planetary science Institute School of Earth SciencesChina University of GeosciencesWuhan 430074China CAS Center for Excellence in Comparative Planetology Hefei 230026China School of Earth science and Resources China University of GeosciencesBeijing 100083China

The absorption features of olivine in visible and near-infrared(VNIR)reflectance spectra are the key spectral parameters in its mineralogical ***,these spectral parameters can be obtained by exploiting the Modified Gaussian Model(MGM)with a proper continuum ***,different continua may change the deconvolution results of these *** paper investigates the diagnostic spectral features of olivine with diverse chemical *** different continuum removal methods with MGM for getting the deconvolution results are presented and the regression equations for predicting the Mg-number(Fo#)are *** results show that different continua superimposed on the mineral absorption features will make the absorption center shift,as well as the obvious alterations in shape,width and strength of the absorption ***,it is also found that the logarithm of a second-order polynomial continuum can match the overall shape of the spectrum in logarithmic space,and the improved regression equations applied to estimate the chemical composition of olivine-dominated spectra also have a better *** an application example,the improved approach is applied to pulse laser irradiated olivine grains to simulate and study the space weathering effects on olivine diagnostic spectral *** experiments confirm that space weathering can make the absorption band center shift toward longer ***,the Fo#estimated from remote sensing spectra may be less than its actual chemical *** results may provide valuable information for revealing the difference between the spectra of olivine grains and olivine-dominated asteroids.

关键词： techniques:spectroscopic instrumentation:spectrographs methods:statistical minor planets asteroids:general

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