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Glycogen metabolism-mediated intercellular communication in the tumor microenvironment influences liver cancer prognosis

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Oncology Research 2024年第3期32卷 563-576页

作者： YANG ZHANG NANNAN QIN XIJUN WANG RUI LIANG QUAN LIU RUOYI GENG TIANXIAO JIANG YUNFEI LIU JINWEI LI Graduate School Kunming Medical UniversityKunming650000China Depatment of Vascular Surgery Fuwai Yunnan Cardiovascular HospitalAfliated Cardiovascular Hospital of Kunming Medical UniversityKunming650000China Department of Neurosurgery West China HospitalSichuan UniversityChengdu610000China Department of Neurosurgery The Fourth Afiliated Hospital of Guangxi Medical UniversityLiuzhou545000China Depatment of Gynecology Oncology The Fourth Afliated Hospital of Guangxi Medical UniversityLiuzhou545000China School of Basic Medical sciences Xianning Medical CollegeHubei University of Science and TechnologyXianning437100China College of Bioengineering Chongqing UniversityChongqing400030China Department of General Visceraland Transplant SurgeryLudwig Maximilians University MunichMunich81377Germany

Glycogen metabolism plays a key role in the development of hepatoellular carcinoma(HCC),but the function of glycogen metabolism genes in the tumor microenvironment(TME)is still to be *** cell RNA-seq data were obtained from ten HCC tumor samples totaling 64,545 cells and 65 glycogen metabolism genes were analyzed bya nonnegative matrix factorization(NMF).The prognosis and immune response of new glycogen TME cell dusters were predicted by using HCC and immunotherapy cohorts from public *** single cell analysis was divided into fibroblasts,NT T cells,macrophages,endothelial clls,and B cells,which were separately divided into new cell clusters by glycogen metabolism gene *** temporal trajectory analysis demonstrated the temporal differentiation trajectory of different glycogen subtype cell *** communication analysis revealed extensive interactions between endothelial cells with glycogen metabolizing TME *** subtypes and diferent glycogen subtype cell *** analysis of transcription factors upstream of TME cell clusters with different glycogen *** addition,TME cell dusters of glycogen metabolism were found to be enriched in expression in CAF subtypes,CD8 depleted,M1,and M2 *** seq analysis showed the prognostic signifcance of glycogen *** TME cell dusters in HCC,while a significant immune response was found in the immunotherapy cohort in patients treated with immune checkpoint blockade(ICB),especially for CAFs,T cells,and macrophages In summary,our study reveals for the first time that glycogen metabolism mediates intercellular communication in the hepatocellular carcinoma microenvironment while elucidating the anti-tumor mechanisms and immune prognostic responses of different subtypes of cell dusters.

关键词： Glycogen metabolism Metabolic map Single cell Tumor microenvironment Liver cancer Prognosis Immunotherapy

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Advances in the application of hydrogel-based scaffolds for tendon repair

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Genes & Diseases 2024年第4期11卷 296-313页

作者： Renqiang Chen Fanglin Chen Kenian Chen Jian Xu Department of Orthopedics The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Orthopedics The Fourth Affiliated Hospital of Guangxi Medical UniversityLiuzhou Guangxi 545005China

Tendon injuries often lead to joint dysfunction due to the limited self-regeneration capacity of *** tendons is a major challenge for surgeons and imposes a signif-icant financial burden on ***,there is an urgent need to develop effective stra-tegies for repairing injured *** tissue engineering using hydrogels has emerged as a promising approach that has attracted considerable *** possess excellent biocompatibility and biodegradability,enabling them to create an extracellular matrix-like growth environment for *** can also serve as a carrier for cells or other substances to accelerate tendon *** the past decade,numerous studies have made significant prog-ress in the preparation of hydrogel scaffolds for tendon *** review aims to provide an overview of recent research on the materials of hydrogel-based scaffolds used for tendon tis-sue engineering and discusses the delivery systems based on them.

关键词： Application Hydrogel-based Repairscaffolds Review Tendon injury Tissue engineering

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High-stability double-layer polymer-inorganic composite electrolyte fabricated through ultraviolet curing process for solid-state lithium metal batteries

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Frontiers of Materials science 2024年第2期18卷 117-128页

作者： Xinghua Liang Pengcheng Shen Lingxiao Lan Yunmei Qin Ge Yan Meihong Huang Xuanan Lu Qiankun Hun Yujiang Wang Jixuan Wang Guangxi Key Laboratory of Automobile Components and Vehicle technology Guangxi University of Science&TechnologyLiuzhou 545006China Guangxi Automobile Group Co. Ltd.Liuzhou 545006China School of Automotive Engineering Guangdong Polytechnic of Industry and CommerceGuangzhou 510510China

Electrolyte interface resistance and low ionic conductivity are essential issues for commercializing solid-state lithium metal batteries(SSLMBs).This work details the fabrication of a double-layer solid composite electrolyte(DLSCE)for *** composite comprises poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)and poly(methyl methacrylate)(PMMA)combined with 10 wt.%of Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),synthesized through an ultraviolet curing *** ionic conductivity of the DLSCE(2.6×10^(-4) S·cm^(-1))at room temperature is the high lithium-ion transference number(0.57),and the tensile strength is 17.8 *** this DLSCE was assembled,the resulted LFP/DLSCE/Li battery exhibited excellent rate performance,with the discharge specific capacities of 162.4,146.9,93.6,and 64.0 mA·h·g^(-1) at 0.1,0.2,0.5,and 1 C,***,the DLScE demonstrates remarkable stability with lithium metal batteries,facilitating the stable operation of a Li/Li symmetric battery for over 200 h at both 0.1 and 0.2 mA-cm^(-2).Notably,the formation of lithium dendrites is also effectively inhibited during *** work provides a novel design strategy and preparation method for solid composite electrolytes.

关键词： electrochemicalreliability lithium metal battery lithium-ion transference number double-layer solid composite electrolyte

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Efficacy and prognostic analysis of carbon nanotracers combined with the da Vinci robot in the treatment of esophageal cancer

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World Journal of Clinical Cases 2024年第22期12卷 4924-4931页

作者： Fen-Qiang Qi Yan Sun Cardiothoracic Surgery The fourth affiliated hospital of Guangxi medical university/Liuzhou workers hospitalLiuzhou 545005Guangxi Zhuang Autonomous RegionChina

BACKGROUND Traditional methods cannot clearly visualize esophageal cancer(EC)tumor contours and metastases,which limits the clinical application of da Vinci robotassisted *** To investigate the efficacy of the da Vinci robot in combination with nanocarbon lymph node tracers in radical surgery of *** In total,104 patients with early-stage EC who were admitted to liuzhou worker's Hospital from January 2020 to June 2023 were *** patients were assigned to an observation group(n=52),which underwent da Vinci robot-assisted minimally invasive esophagectomy(RAMIE)with the intraoperative use of nanocarbon tracers,and a control group(n=52),which underwent traditional surgery *** operation time,intraoperative blood loss,postoperative drainage tube indwelling time,hospital stay,number of lymph nodes dissected,incidence of complications,and long-term curative effects were comparatively *** postoperative stress response C-reactive protein(CRP),cortisol,epinephrine(E)and inflammatory response interleukin(IL)-6,IL-8,IL-10,and tumor necrosis factor-alpha(TNF-α)were *** Compared with the control group,the observation group had significantly lower postoperative CRP,cortisol,and E levels(P<0.05)with a milder inflammatory response,as indicated by lower IL-6,IL-10,and TNF-αlevels(P<0.05).Patients who underwent RAMIE had less intraoperative blood loss and shorter operation times and hospital stays than those who underwent traditional *** average number of dissected lymph nodes,time of lymph node dissection,and mean smallest lymph node diameter were all significantly lower in the observation group(P<0.05).The rate of postoperative complications was 5.77%in the observation group,significantly lower than the 15.38%observed in the control ***,the lymphatic metastasis rate,reoperation rate,and 12-and 24-month cumulative mortality in the observation group were 1.92%,0%,0%,and 0%,respectively,all of which were signifi

关键词： Nanocarbon tracer Da Vinci robot Minimally invasive esophagectomy Esophageal cancer Clinical efficacy Prognostic

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Global, regional, and national burden of gallbladder and biliary diseases from 1990 to 2019

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2564-2578页

作者： Zhong-Zhuan Li Lin-Jing Guan Rong Ouyang Zhi-Xin Chen Guo-Qing Ouyang Hai-Xing Jiang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Liuzhou Workers’Hospital(The Fourth Affiliated Hospital of Guangxi Medical University)Liuzhou 545007Guangxi Zhuang Autonomous RegionChina Department of Abdomen Ultrasound Nanning Sixth People’s HospitalNanning 530002Guangxi Zhuang Autonomous RegionChina Department of General Surgery Liuzhou People’s Hospital Affiliated to Guangxi Medical UniversityLiuzhou 545006Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gallbladder and biliary diseases(GABDs)are a major public health *** To analysis the cause-specific incidence,prevalence,and years lived with disability(YLDs)and its temporal trends of GABDs at the global,regional,and national *** on GABD were available from the Global Burden of Disease study *** The estimated annual percentage change(EAPC)was used to quantify temporal trend in GABD age-standardized incidence rates(ASIRs),age-standardized prevalence rate(ASPR),and age-standardized YLD rate(ASYR)by region,*** analyzed the relationship between the GABD burden and country development level using the human development index(HDI).RESULTS In 2019,the incident cases of GABD were 52003772,with an ASIR of 63432/100000 ***,the number of incident cases and ASIR of GABD increased 97%and 58.9%between 1990 and ***,the ASPR and ASYR decreased from 1990 to 2019,the number of prevalent and YLDs cases *** highest ASIR was observed in Italy,and the highest ASPR and ASYR was observed in United *** highest burden of GABD was found in low-SDI region,and the burden in female was significantly higher than males.A generally negative correlation(ρ=-0.24,P<0.05)of GABD with the EAPC and human development index(HDI)(in 2021)were observed for ***’s more,no correlation in ASPR(ρ=-0.06,P=0.39)and ASYR(ρ=-0.07,P=0.36)of GABD with the EAPC and HDI(in 2021)were observed,*** GABD remain a major global public health challenge;however,the burden of GABD varies ***,the number of incident cases and ASIR of GABD increased between 1990 and *** results of our study provide insight into the global disease burden of GABD and may assist policymakers in formulating effective policies to mitigate modifiable risk factors.

关键词： Gallbladder and biliary diseases,incidence,prevalence,years lived with disability The Global Burden of Diseases study Estimated annual percentage changes

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A Shifting Strategy for Electric Commercial Vehicles Considering Mass and Gradient Estimation

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Computer Modeling in Engineering & sciences 2023年第10期137卷 489-508页

作者： Weiguang Zheng Junzhu Zhang Shanchao Wang Gaoshan Feng Xiaohong Xu Qiuxiang Ma School of Mechanical and Electrical Engineering Guilin University of Electronic TechnologyGuilin541004China Commercial Vehicle technology Center Dongfeng Liuzhou Automobile Co.Ltd.Liuzhou545005China School of Mechanical and Automotive Engineering Guangxi University of Science and TechnologyLiuzhou545005China

The extended Kalman filter (EKF) algorithm and acceleration sensor measurements were used to identify vehiclemass and road gradient in the work. Four different states of fixed mass, variable mass, fixed slope and variableslope were set to simulate real-time working conditions, respectively. A comprehensive electric commercial vehicleshifting strategy was formulated according to the identification results. The co-simulation results showed that,compared with the recursive least square (RLS) algorithm, the proposed algorithm could identify the real-timevehicle mass and road gradient quickly and accurately. The comprehensive shifting strategy formulated had thefollowing advantages, e.g., avoiding frequent shifting of vehicles up the hill, making full use ofmotor braking downthe hill, and improving the overall performance of vehicles.

关键词： EKF algorithm electric commercial vehicle vehicle mass road gradient comprehensive shifting strategy

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A defect recognition model for cross-section profile of hot-rolled strip based on deep learning

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Journal of Iron and Steel Research(International) 2023年第12期30卷 2436-2447页

作者： Tian-lun Li Wen-quan Sun An-rui He Jian Shao Chao Liu Ai-bin Zhang Yi Qiang Xiang-hong Ma National Engineering Research Center for Advanced Rolling and Intelligent Manufacturing University of Science and Technology BeijingBeijing100083China Academy of Machinery science and technology Beijing100044China School of Engineering and Applied science Aston UniversityBirminghamB47ETUK

The cross-section profile is a key signal for evaluating hot-rolled strip quality,and ignoring its defects can easily lead to a final *** characteristics of complex curve,significant irregular fluctuation and imperfect sample data make it a challenge of recognizing cross-section defects,and current industrial judgment methods rely excessively on human decision making.A novel stacked denoising autoencoders(SDAE)model optimized with support vector machine(SVM)theory was proposed for the recognition of cross-section ***,interpolation filtering and principal component analysis were employed to linearly reduce the data dimensionality of the profile ***,the deep learning algorithm SDAE was used layer by layer for greedy unsupervised feature learning,and its final layer of back-propagation neural network was replaced by SVM for supervised learning of the final features,and the final model SDAE_SVM was obtained by further optimizing the entire network parameters via error ***,the curve mirroring and combination stitching methods were used as data augmentation for the training set,which dealt with the problem of sample imbalance in the original data set,and the accuracy of cross-section defect prediction was further *** approach was applied in a 1780-mm hot rolling line of a steel mill to achieve the automatic diagnosis and classification of defects in cross-section profile of hot-rolled strip,which helps to reduce flatness quality concerns in downstream processes.

关键词： Hot-rolled strip cross section:Curve recognition Deep learning-Stacked denoising autoencoder Support vector machine Imperfect data

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Mobile Robot Combination Autonomous Behavior Strategy to Inspect Hazardous Gases in Relatively Narrow Man–Machine Environment

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Chinese Journal of Mechanical Engineering 2022年第6期35卷 110-122页

作者： Xueshan Gao Qingfang Zhang Mingkang Li Bingqing Lan Xiaolong Fu Jingye Li School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China School of Mechanical and Automotive Engineering Guangxi University of Science and TechnologyLiuzhou 545006China Xi’an Modern Chemistry Research Institute Xi’an 710065China.

Selecting the optimal speed for dynamic obstacle avoidance in complex man–machine environments is a challenging problem for mobile robots inspecting hazardous *** of personal space is important,especially in a relatively narrow man–machine dynamic environments such as warehouses and *** this study,human and robot behaviors in man–machine environments are analyzed,and a man–machine social force model is established to study the robot obstacle avoidance *** typical man–machine behavior patterns are investigated to design the robot behavior *** on the social force model and man–machine behavior patterns,the fuzzy-PID trajectory tracking control method and the autonomous obstacle avoidance behavior strategy of the mobile robot in inspecting hazardous gases in a relatively narrow man–machine dynamic environment are proposed to determine the optimal robot speed for obstacle *** simulation analysis results show that compared with the traditional PID control method,the proposed controller has a position error of less than 0.098 m,an angle error of less than 0.088 rad,a smaller steady-state error,and a shorter convergence *** crossing and encountering pattern experiment results show that the proposed behavior strategy ensures that the robot maintains a safe distance from humans while performing trajectory *** research proposes a combination autonomous behavior strategy for mobile robots inspecting hazardous gases,ensuring that the robot maintains the optimal speed to achieve dynamic obstacle avoidance,reducing human anxiety and increasing comfort in a relatively narrow man–machine environment.

关键词： Social force model Man–machine behavior pattern Dynamic obstacle avoidance

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Model of Surface Texture for Honed Gear Considering Motion Path and Geometrical Shape of Abrasive Particle

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Chinese Journal of Mechanical Engineering 2023年第4期36卷 311-325页

作者： Yuhu Liu Xiaohui Huang Huajun Cao Jiacheng Wang Huapan Xiao College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

Gear power-honing is mainly applied to finish small and medium-sized automotive gears,especially in new energy *** distinctive curved surface texture greatly improves the noise emission and service life of honed *** surface texture for honed gear considering the motion path and geometrical shape of abrasive particles has not been *** this paper,the kinematics of the gear honing process is analyzed,and the machining marks produced by the abrasive particles of honing wheel scratching abrasive particles against the workpiece gear are *** tooth surface roughness is modeled considering abrasive particle shapes and material plastic *** results in a mathematical model that characterizes the structure of the tooth surface and the orientation of the machining *** were used to verify the model,with a maximum relative error of less than 10%when abrasive particles are *** on this model,the effects of process parameters on the speeds of discrete points on the tooth flank,orientations of machining marks and roughness are *** results show that the shaft angle between the workpiece gear and the honing wheel and the speed of the honing wheel is the main process parameters affecting the surface *** research proposes a surface texture model for honed gear,which can provide a theoretical basis for optimizing process parameters for gear power-honing.

关键词： Hardened gear Gear power-honing Surface texture Roughness

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Correlation between preoperative systemic immune inflammation index, nutritional risk index, and prognosis of radical resection of liver cancer

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2445-2455页

作者： Jing Li Hai-Yan Shi Min Zhou Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Radiology Liuzhou Hospital of Traditional Chinese MedicineLiuzhou 545001Guangxi Zhuang Autonomous RegionChina Department of Integrated Chinese and Western Medicine Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Institute of Cancer ResearchNanjing 210009Jiangsu ProvinceChina

BACKGROUND Radical surgery is the most commonly used treatment for hepatocellular carcinoma(HCC).However,the surgical effect remains not ideal,and prognostic evaluation is ***,clinical intervention is rife with uncertainty and not conducive to prolonging patient *** To explore correlations between the systemic immune inflammatory index(SII)and geriatric nutritional risk index(GNRI)and HCC operation *** This retrospective study included and collected follow up data from 100 ***–Meier survival curves were used to analyze the correlation between SII and GNRI scores and *** and GNRI were calculated as follows:SII=neutrophil count×platelet count/lymphocyte count;GNRI=[1.489×albumin(g/L)+41.7×actual weight/ideal weight].We analyzed the predictive efficacy of the SII and GNRI in HCC patients using receiver operating characteristic(ROC)curves,and the relationships between the SII,GNRI,and survival rate using Kaplan–Meier survival *** regression analysis was utilized to analyze independent risk factors influencing *** After 1 year of follow-up,24 patients died and 76 *** area under the curve(AUC),sensitivity,specificity,and the optimal cutoff value of SII were 0.728(95%confidence interval:0.600-0.856),79.2%,63.2%,and 309.14,*** to ROC curve analysis results for predicting postoperative death in HCC patients,the AUC of SII and GNRI combination was higher than that of SII or GNRI alone,and SII was higher than that of GNRI(P10 cm),lymph node metastasis,and TNM stage III-IV in patients with SII>309.14 was higher than that in patients with SII≤309.14(P70 years was higher in patients with GNRI≤98 than that in patients with GNRI>98(P309.14 group(compared with the SII≤309.14 group)and GNRI≤98 group(compared w

关键词： Systemic immune inflammation index Nutritional risk index Radical resection Liver cancer Prognosis Correlation

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