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Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1562-1576页

作者： Jiajun Chen Tian Li Dehua Huang Wenxia Gong Junsheng Tian Xiaoxia Gao Xuemei Qin Guanhua Du Yuzhi Zhou Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan030006China The key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi UniversityTaiyuan030006China The key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi province Taiyuan030006China Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China

Chaigui granules(CG)are a compound composed of six herbal medicines with significant antidepressant ***,the antidepressant mechanism of CG remains *** the present study,we attempted to elucidate the antidepressant mechanism of CG by regulating purine metabolism and purinergic ***,the regulatory effect of CG on purine metabolites in the prefrontal cortex(PFC)of chronic unpredictable mild stress(CUMS)rats was analyzed by ultra high-performance liquid chromatography tandem mass spectrometry(UHPLC-MS/MS)targeted quantitative ***,purinergic receptors(P2X7 receptor(P2X7R),A1 receptor(A1R)and A2A receptor(A2AR))and signaling pathways(nod-like receptor protein 3(NLRP3)inflammasome pathway and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)pathway)associated with purine metabolism were analyzed by western blotting and enzyme-linked immunosorbent assay(ELISA).Besides,antidepressant mechanism of CG by modulating purine metabolites to activate purinergic receptors and related signaling pathways was dissected by exogenous supplementation of purine metabolites and antagonism of purinergic receptors in *** in vivo study showed that the decrease in xanthine and the increase in four purine nucleosides were closely related to the antidepressant effects of ***,purinergic receptors(P2X7R,A1R and A2AR)and related signaling pathways(NLRP3 inflammasome pathway and cAMP-PKA pathway)were also significantly regulated by *** results of exogenous supplementation of purine metabolites and antagonism of purinergic receptors showed that excessive accumulation of xanthine led to activation of the P2X7R-NLRP3 inflammasome pathway,and the reduction of adenosine and inosine inhibited the A1R-cAMP-PKA pathway,which was significantly ameliorated by ***,CG could promote neuroprotection and ultimately play an antidepressant role by inhibiting the xanthine-P2X7R-NLRP3 inflammasome pathway and activating the adenosine/inosi

关键词： Chaigui granules Traditional Chinese medicine Antidepressant mechanism Purine metabolism Purinergic signaling

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Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19

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Protein & Cell 2022年第1期13卷 72-77页

作者： Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Liuqin Yu Wenjia Chen Wenshan Hong Jia Wang Yao Chen Kun Wu Wangheng Hou Yali Zhang Shengxiang Ge Yixin Chen Quan Yuan Qiyi Tang Tong Cheng Yi Guan Ningshao Xia State key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious DiseasesSchool of Life SciencesSchool of Public HealthXiamen UniversityXiamen 361000China State key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Joint Institute of Virology(Shantou University and The University of Hong Kong) Guangdong-Hongkong Joint Laboratory of Emerging Infectious DiseasesShantou UniversityShantou 515063China Department of Microbiology Howard University College of MedicineWashingtonDC 20059USA Research Unit of Frontier technology of Structural Vaccinology Chinese Academy of Medical SciencesXiamen 361102China

Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 200 million people,causing coronavirus disease 2019(COVID-19)*** are the primary target organ of SARS-CoV-2 *** mild COVID-19 cases develop symptoms of fever,fatigue,muscle weakness,chest pain,headache and cough(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020),while severe COIVD-19 cases might have pneumonia,breathing difficulties,multiple organ failure and death(Chen et al.,2020;Wang et al.,2020;Zhu et al.,2020).Both the clinicians and researchers have largely focused on the acute phase of COVID-19,but the long-term health consequences of the COVID-19 patients after clinical recovery remain less *** clinical cohorts demonstrated that some patients discharged from hospital still experience symptoms including fatigue,muscle weakness,chest pain,cough and breathing difficulties(Carfi et al.,2020;Lim et al.,2020;Huang et al.,2021).Moreover,severely impaired pulmonary diffusion capacities and abnormal chest imaging manifestations were observed in some convalescent patients(Huang et al.,2021).Surprisingly,residual virus(An et al.,2020;Yao et al.,2020;Kim et al.,2021)were detected in some convalescent patients.

关键词： acute impaired pathogenesis

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Effects of Salinity and Temperature on Growth and Survival of Juvenile Iwagaki Oyster Crassostrea nippona

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Journal of Ocean University of China 2018年第4期17卷 941-946页

作者： WANG Tao LI Qi key Laboratory of Mariculture Ministry of Education Ocean University of China Laboratory for Marine Fisheries science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology

Iwagaki oyster Crassostrea nippona occurs naturally along the coasts of Japan and Korea. Because of its unique flavor, delicious taste, edibility during the summer and high commercial value, it has been identified as a potential aquaculture species. To determine the optimum aquaculture conditions and provide necessary information for mass production of the juvenile, the effects of six salinities(15, 20, 25, 30, 35 and 40) and five temperatures(16, 20, 24, 28 and 32℃) on growth and survival of juvenile C. nippona were examined in this study. In the salinity experiment, the largest values of mean shell height and growth rate were observed at salinity 25(20.96 ± 0.36 mm and 172.0 μm d^(-1), respectively), which were significantly different(P 0.05). The maximum survival rate 84.44% was always observed at salinity 20, and there was no significant difference(P > 0.05) in survival rate among salinities varying between 15 and 35. In the temperature-related experiments, the highest growth and survival rates of juvenile were observed at 24℃(180.8 μm d^(-1) and 84.4%) and 28℃(190.7 μm d^(-1) and 83.3%), respectively, on day 20, and showed significantly(P < 0.05) larger size and higher survival rate than any other groups. Both juvenile survival and growth were significantly depressed at extreme salinities(15, 40) and temperatures(16℃, 32℃). Based on the results of the present study, a salinity range from 25 to 30 and a temperature range from 24℃ to 28℃ are considered optimal conditions for survival and growth of juvenile C. nippona.

关键词： Crassostrea nippona juvenile salinity temperature survival growth

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Yield Increasing and Quality Improving Effects of Smash-ridging Method("4453" Effects) and Its Potential in Benefiting the Nation and the People

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Agricultural science & technology 2014年第10期15卷 1767-1769页

作者：韦本辉广西农业科学院经济作物研究所广西南宁530007

Yuan Longping proposed that smash-ridging technology could be extend-ed widely nationwide. ln the research, smash-ridging technology reconstruct cultiva-tion layers with loose soils in agricultural fields, creating ＂4453＂ effects, as fol ows：＂Four increases＂ include to increase loosen soil quantity in cultivation layers, soil nutri-ents use, ＂water pool＂ in soils, and ＂oxygen pool＂ in soils. Four reductions are to reduce soil erosion, carbon emission, salt content and heavy metal in soils. Five resistances refer to improve crop resistance capacity in terms of drought, high tem-perature, lower temperature, disease and lodging. Three improvements indicate to enhance photosynthetic efficiency over 10%, yield in 10%-30% and quality over 5%. lt is researched that without additional chemical fertilizer, yield could increase by 10% by labor force, animal, tractor or smash-ridging machine. What’s more, by smash-ridging cultivation, the depth can be 20 times or higher compared with tractor cultivation, with looser soils. lt is estimated that if smash-ridging cultivation is applied once in agricultural lands in China, present soil layers can be twice as deep as present. Specifical y, the thickness of loose soil-layers could be extended from 10-18 cm at present to 25-35 cm, and natural rainfal would increase by 40 bil ion cm3. After vitalization of soil nutrients, chemical fertilizer would decrease by 7 bil ion kg, and the increased c rops would feed more than 300 mil ion population as per yield at 7 50 kg/hm2.

关键词： Smash-ridging technology Extension nationwide lncrease range in 10%-30% Supporting more 300 mil ion population"4453" effects Development potential

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钛/铝爆炸焊接界面扩散行为分子动力学模拟

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稀有金属材料与工程 2023年第6期52卷 2017-2023页

作者：李岩刘琪李聚才刘翠荣吴志生太原科技大学材料科学与工程学院山西太原030024 山西师范大学现代文理学院转设筹备处山西临汾041000

为揭示钛/铝爆炸焊接界面原子的扩散行为,采用分子动力学模拟从原子尺度分析了钛/铝爆炸焊接界面原子的微观扩散机理。利用Materials Studio建立了钛/铝爆炸焊接焊点处的分子动力学模型,结合爆炸焊接的物理过程,将爆炸焊接过程分为加载... 详细信息

为揭示钛/铝爆炸焊接界面原子的扩散行为,采用分子动力学模拟从原子尺度分析了钛/铝爆炸焊接界面原子的微观扩散机理。利用Materials Studio建立了钛/铝爆炸焊接焊点处的分子动力学模型,结合爆炸焊接的物理过程,将爆炸焊接过程分为加载和卸载2个阶段,通过LAMMPS程序计算了爆炸焊接钛、铝原子的均方位移、径向分布函数、扩散层厚度等,利用OVITO软件再现了不同阶段界面原子的扩散行为。在爆炸焊接加载阶段,钛、铝原子不发生扩散,只在平衡位置做振动,铝原子振动要比钛原子振动强。爆炸焊接卸载开始时,钛、铝原子发生互扩散。钛/钛原子键能高,不易破坏,铝/铝原子键能低,容易破坏产生空位、间隙等缺陷,有利于钛原子深入扩散到铝晶格内部,但铝原子难以进入钛的晶格内部。采用扫描电镜和EDS能谱表征了钛/铝爆炸焊接复合材料界面元素分布,与模拟结果有很好的一致性。

关键词：爆炸焊接分子动力学模拟钛/铝界面扩散

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Optical and scintillation properties of Bi_4Si_3O_(12):RE(RE=Eu^(3+), Sm^(3+),Ho^(3+), Tb^(3+))single crystals

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Journal of Rare Earths 2019年第3期37卷 260-264页

作者： Xuefeng Xiao Jiayue Xu Haicheng Wei Yaoqing Chu Bobo Yang Xuefeng Zhang key Laboratory of Physics and Photoelectric Information Functional Materials sciences and technology North Minzu University College of Electric and Information Engineering North Minzu University School of Materials science and Engineering Tongji University School of Materials science and Engineering Shanghai Institute of Technology Ningxia Ju Jing Yuan Crystal technology Company Limited

Bi_4 Si_3 O_(12):RE(BSO:RE, RE = Eu^(3+), Sm^(3+), Ho^(3+), Tb^(3+)) crystals were grown by the modified vertical Bridgeman method, and doping effects on scintillation properties were investigated. Under γ-ray irradiation, the light yield of BSO doped with small doses of Eu^(3+) increases slightly, and the energy resolution improves significantly compared to pure BSO, therefore the ability of distinguishing between particles will be improved for BSO crystals with a small amount of Eu^(3+) dopant. The results show that a small amount of Eu^(3+) doping can sensitize the Bi^(3+) ions. The sensitization effect enables the reduction of intrinsic defects, and thus improves the scintillation properties. However, the relative light yield of BSO:Tb(1.0 mol%) crystal is 4.3%, which is smaller than 5.0% of pure BSO. The improved light yield and energy resolution in the BSO:Eu and BSO:Sm crystals are considered an impressive achievement in the optimization of this scintillator which is already suitable for applications such as dual-readout calorimeters and homogeneous hadron calorimeters.

关键词： BSO crystal Vertical Bridgeman method Scintillation characteristics Relative light yield Rare earths

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Hybridized Mechanical and Solar Energy-Driven Self-Powered Hydrogen Production

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Nano-Micro Letters 2020年第7期12卷 135-144页

作者： Xuelian Wei Zhen Wen Yina Liu Ningning Zhai Aimin Wei Kun Feng Guotao Yuan Jun Zhong Yinghuai Qiang Xuhui Sun Jiangsu province Engineering Laboratory of High Efficient Energy Storage technology and Equipments School of Materials Science and EngineeringChina University of Mining and TechnologyXuzhou 221116People’s Republic of China Jiangsu key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123People’s Republic of China Department of Mathematical sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123People’s Republic of China

Photoelectrochemical hydrogen generation is a promising approach to address the environmental pollution and energy *** this work,we present a hybridized mechanical and solar energy-driven selfpowered hydrogen production system.A rotatory disc-shaped triboelectric nanogenerator was employed to harvest mechanical energy from water and functions as a su cient external power ***3/BiVO4 heterojunction photoanode was synthesized in a PEC water-splitting cell to produce *** transformation and rectification,the peak current reaches 0.1 m A at the rotation speed of 60 *** this case,the H2 evolution process only occurs with sunlight *** the rotation speed is over 130 rpm,the peak photocurrent and peak dark current have nearly equal *** electrolysis of water is almost simultaneous with photoelectrocatalysis of *** is worth noting that the hydrogen production rate increases to 5.45 and 7.27μL min-1 without or with light illumination at 160 *** corresponding energy conversion e ciency is calculated to be 2.43%and 2.59%,*** the results demonstrate such a self-powered system can successfully achieve the PEC hydrogen generation,exhibiting promising possibility of energy conversion.

关键词： WO3/BiVO4 heterojunction Photoelectrochemical hydrogen generation Triboelectric nanogenerator Mechanical energy Solar energy

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Partial Anomalous Pulmonary Venous Connection and the Nature of Associated Sinus Venosus Defect

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Congenital Heart Disease 2022年第2期17卷 201-214页

作者： Ling Sun Chengcheng Pang Xiaoyan Wang Mingguo Xu Zhiwei Zhang Shushui Wang Department of Pediatric Cardiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhouChina Department of Pediatric Cardiology Chengdu Women’s and Children’s Central HospitalThe Affiliated Women’s and Children’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina Department of Pediatric Cardiology Shenzhen Children’s HospitalShenzhenChina

Background:Partial anomalous pulmonary venous connection(PAPVC)is frequently associated with atrial septal defect(ASD),especially sinus venosus defect(SVD).Although Waggstaffe described the pathology of SVDs in 1868,the exact anatomic features and the nature of SVD remains *** with no posterior atrial rim were observed in recent ***,no studies suggested that absence of the residual posterior atrial septal tissue might be the key feature of *** aims of this study were to investigate if absence of posterior rim of atrial septum played a crucial role in patients with ***:From January 2011 to December 2019,256 children with PAPVC combined ASD and 878 children with isolated ASD who underwent corrective cardiac surgery were consecutively *** review of preoperative transthoracic echocardiography,computed-tomography images and surgical findings were performed by experienced pediatric *** subtypes of PAPVC,locations and types of ASD,and presence of posterior atrial rim of associated ASD were ***:PAPVC was right-sided in 244 children,left-sided in 6 children,and bilateral in 6 *** PAPVC cases,ASD without posterior atrial rim existed in 226 SVD *** without posterior atrial septum only existed in cases with one or more right pulmonary veins returning to right atrium(RA)or to RA-superior vena cava *** cases with isolated ASD,there were 3 SVD,and the other 875 cases were secundum ***:ASD without posterior atrial rims was associated with one or more right pulmonary veins returning to RA or RA-superior venous cava(SVC)*** SVD,the key feature is that the defect is in the posterior of the interatrial septum with no posterior septal rim,rather than adjacent to the SVC or to the inferior vena cava.

关键词： Partial anomalous pulmonary venous connection sinus venosus atrial septal defect echocardiography right atrium inferior vena cava

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Design and experiment of an upper-side-discharge straw-returning and bundle self-unloading integrated corn residual film recycling machine

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International Journal of Agricultural and Biological Engineering 2023年第5期16卷 61-70页

作者： Xiaolong Liu Wuyun Zhao Hua Zhang Guanping Wang Wei Sun Fei Dai Hui Li Shanglong Xin Mechanical and Electrical Engineering College Gansu Agricultural UniversityLanzhou 730070China

Due to the arid climate,flat terrain,certain irrigation sources and high popularization of mechanical harvest in Hexi Irrigation Area of Gansu province,the widely adopted half film-flat-mulching for corn cultivation faces serious adverse situations,such as high soil compactness,strong film-soil adhesion,significant straw stubble and thick covering accumulation on ***,a new kind of segmented combination upper-side-discharge straw-returning and bundle self-unloading integrated corn residual film recycling machine was *** scheme was characterized by small volume,low resistance,low complexity and film-impurities twice *** is constructed based on the concept of module subsection *** was composed of film surface straw cleaning device and the followed residual film recycling machine,in terms of function,any usage requirements of separate and joint operations can be *** film surface straw cleaning device is responsible for the removal of vertical corn straw and ground covering beyond the *** its stubble cutter roller obtuse-angle Lshaped blades paired single-helix arrangement is simple,it runs smoothly and the straw crushing effect is good *** layout that upper-side-discharge straw-returning cross-range screw conveyor auger is back and beyond the stubble cutter roller,eliminates the common connecting transportation mechanism between crushing and straw-returning section,so that,the system structure can be optimized and the efficiency has been significantly *** integrated residual film recycling machine is composed of triangular pyramid arc two-stage wing(TPATSW)type film lifting shovel,rod-tooth-belt type film-impurities separation device and semi-enclosed shaftless bundle film *** them,TPATSW type film lifting shovel has good corn root whisker cutting effect,low soil contact resistance and small soil congestion area,but its ability to lift film is strong,more importantly,the special seg

关键词： corn segmented combination film surface straw cleaning straw-returning TPATSW type film lifting shovel filmimpurities twice separation semi-enclosed shaftless bundle film collector self-unloading

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Preparation of entangled states of atomic qubits via atom-cavity-laser interaction

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Chinese Optics Letters 2010年第5期8卷 529-532页

作者：郭裕刘桂云 Department of Physics and Electronic science Changsha University of Science and Technology key Laboratory of Low-Dimensional Quantum Structures and Quantum Control(Hunan Normal University) Ministry of Education

We propose a scheme to prepare the Bell states for atomic qubits trapped in separate optical cavities via atom-cavity-laser *** quantum information of each qubit is encoded on the degenerate ground states of the atom,so the entanglement between them is relatively stable against spontaneous *** proposed scheme consists of a Mach-Zehnder interferometer（MZI） with two arms,and each arm contains a cavity with an N-type atom in *** requires two classical fields and a single-photon source. By controlling the sequence and time of atom-cavity-laser interaction,the deterministic production of the atomic Bell states is *** also introduce the generalization of the present scheme to generate the 2N-atom Greenberger-Horne-Zeilinger state.

关键词： Bells Laser tissue interaction Plasma interactions Quantum entanglement Quantum optics

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