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CaP-coated Zn-Mn-Li alloys regulate osseointegration via influencing macrophage polarization in the osteogenic environment

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Regenerative Biomaterials 2023年第1期10卷 1096-1110页

作者： Huifen Qiang Caiyao Hou Yujue Zhang Xin Luo Jun Li Chunxiu Meng Kun Liu Zhaoyong Lv Ximeng Chen Fengzhen Liu Department of Materials Science and Engineering Liaocheng UniversityLiaochengChina Liaocheng People’s Hospital Liaocheng Dongchangfu People’s HospitalLiaocheng 252000China School of Materials Science and Engineering University of Science and TechnologyBeijing 100083China

Immune response is an important factor in determining the fate of bone replacement materials,in which macrophages play an important *** is a new idea to design biomaterials with immunomodulatory function to reduce inflammation and promote bone integration by regulating macrophages *** this work,the immunomodulatory properties of CaP Zn-Mn-Li alloys and the specific mechanism of action were *** found that the CaP Zn0.8Mn0.1Li alloy promoted the polarization of macrophages toward M2 and reduced inflammation,which could effectively upregulate osteogenesis-related factors and promote new bone formation,indicating the important role of macrophages polarization in biomaterial induction of *** vivo studies further demonstrated that CaP Zn0.8Mn0.1Li alloy could stimulate osteogenesis better than other Zn-Mn-Li alloys implantations by regulating macrophages polarization and reducing *** addition,transcriptome results showed that CaP Zn0.8Mn0.1Li played an important regulatory role in the life process of macrophages,activating Toll-like receptor signaling pathway,which participated in the activation and attenuation of inflammation,and accelerated bone ***,by preparing CaP coatings on the surface of Zn-Mn-Li alloys and combining the bioactive ingredient with controlled release,the biomaterial will be imbibed with beneficial immunomodulatory properties that promote bone integration.

关键词： Zn-Mn-Li alloys CaP coatings macrophages polarization osteointegration inflammation

Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1

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Regenerative Biomaterials 2024年第3期3卷 134-147页

作者： Caiyao Hou Yujue Zhang Zhaoyong Lv Yurun Luan Jun Li Chunxiu Meng Kun Liu Xin Luo Liyu Chen Fengzhen Liu Department of Materials Science and Engineering Liaocheng UniversityLiaocheng 252000China Liaocheng People's Hospital Liaocheng Hospital Affliated Shandong First Medical UniversityLiaocheng 252000China The Second Hospital Cheeloo College of MedicineShandong UniversityJinan 250023China

In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication *** play a central role in mediating immune osteogenesis,exosomes derived from them have osteogenic regulation and can be used as cariers in bone tissue ***,there are problems with exosomal therapy alone,such as poor targeting,and the content of loaded molecules cannot reach the therapeutic *** this study,macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone ***3T3-E1 cells were incubated with the culture supermatants of Mo,M1 and M2 macrophages,and it was found that the culture medium of M2 macrophages had the most significant effects in contributing to ***-throughput sequencing identified that miR-365-2-5p was significantly expressed in exosomes derived from M2 *** incubated MC3T3-E1 with exosomes overexpressing or kmocking down miR-365-2-5p to examine the biological function of exosome miR-365-2-5p on MC3T3-E1 *** findings suggested that miR-365-2-5p secreted by exosomes increased the osteogenesis of ***,miR-365-2-5p had a direct influence over osteogenesis for *** analysis combined with dual luciferase detection indicated that miR-365-2-5p binded to the 3'-UTR of *** summary,exosomes secreted by M2 macrophages targeted OLFML1 through miR-365-2-5p to facilitate osteogenesis.

关键词： macrophage exosomes osteogenesis osteoimmunology

Influence Analysis and Vibration Restraint Solutions research on the Underwater Acoustic Monitoring System

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China Ocean Engineering 2020年第5期34卷 718-729页

作者： WANG Zhen ZHENG Yi MAO Yu-feng HE Chuan-lin GONG Jin-long HAO Zong-rui Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China shandong Provincial key Laboratory of Ocean Environmental Monitoring Technology Qingdao 266061China National Engineering and Technological research Center of Marine Monitoring Equipment Qingdao 266061China

In order to reduce the hydrodynamic and structural influences on the detection accuracy especially in the very-lowfrequency range, some vibration restraint methods are raised, which are the wrapped fairing improvement, the floating body shape improvement and the cable vibration reduction treatment. Through the improvement analysis and experimental comparison, the final treatments are proposed, namely the multilayer wrapped fairing structure with composite materials, the floating body with NACA0024 airfoil section and X-shape tail spoiler, as well as the brush cable. The sea test is carried out to evaluate the vibration restraint effect. Through comparison of the responses to the ocean ambient noise and the direction of arrival(DOA) estimations with the same underwater transmitting transducer, the results indicate that the horizontal floating platform with vibration restraint treatment has obvious flow resisting effect especially in low frequency range and more accurate DOA estimation.

关键词： hydrodynamic interference vibration restraint fairing DOA estimation computational fluid dynamics

Catalytic oxidation of CO on mesoporous codoped ceria catalysts:Insights into correlation of physicochemical property and catalytic activity

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Journal of Rare Earths 2019年第9期37卷 961-969,I0003页

作者： Hongjian Zhu Yingying Chen Yibo Gao Wenxu Liu Zhongpeng Wang Chenchen Cui Wei Liu Liguo Wang key Laboratory of Water Resources and Environmental Engineering in Universities of shandong School o f Water Conservation and EnvironmentUniversity of Jinan. Jinan 250022China School of Environmental Science and Engineering Shandong UniversityQingdao 266237China

Codoping approach is an appealing strategy to further improve the catalytic activity of Ce-based *** the present study,Mn and/or Cu doped ceria solid solutions MnxCuyCe1-x-yO2,CuxCe1-xO2,MnxCe1-xO2 and pure CeO2 were prepared by CTAB-assisted hydrothermal method for CO ***,SEM,EDS,BET,Raman,H2-TPR,XPS and in situ DRIFTS techniques were carried out to study the physicochemical properties and to correlate them to the *** doped samples maintain the cubic fluorite structure of CeO2 with high crystallinity and small crystallite size,forming Ce-based solid *** obtained catalysts have large mesoporous structure with average pore size of 10-14 *** doped transition metal enhances the oxygen vacancies and improves reducibility of the *** synergistic interaction of Mn and Cu codoping induces mo re oxygen vacancies,pro moting the increase of surface adsorbed oxygen and the transfer of bulk oxygen of catalyst,thereby enhancing the catalytic activity for CO ***,the decomposition rate of the carbonate species which is derived from in situ DRIFTS for each catalyst can provide a measure to evaluate its catalytic activity of CO oxidation.

关键词： CeO2 Codoping Solid solution Mesoporous CO oxidation Rare earths

Hypervalent iodine mediated C-H amination of quinoxalinones with heteroaromatic amines under metal-free conditions

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Chinese Chemical Letters 2021年第8期32卷 2559-2561页

作者： Qing-Qing Han De-Mao Chen Zu-Li Wang Yuan-Yuan Sun Shao-Hui Yang Jing-Cheng Song Dao-Qing Dong College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China

An efficient and facile method for C-H amination of quinoxalinones with heteroaromatic amines under metal-free conditions has been *** the presence of hypervalent PIDA reagent,the desired products with various groups ... 详细信息

关键词： Hypervalent iodine Amination Quinoxalinones Metal-free Heteroaromatic amines

Persulfate promoted tandem radical cyclization of ortho-cyanoarylacrylamides with oxamic acids for construction of carbamoyl quinoline-2,4-diones under metal-free conditions

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Chinese Chemical Letters 2021年第11期32卷 3632-3635页

作者： Qing-Qing Han Yuan-Yuan Sun Shao-Hui Yang Jing-Cheng Song Zu-Li Wang College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China

An efficient and practical methods for the synthesis of carbamoyl quinoline-2,4-diones via the reaction of ortho-cyanoarylacrylamides with oxamic acids was *** cyclic reaction could be performed efficiently under meta... 详细信息

关键词： Ortho-cyanoarylacrylamides Oxamic acids Quinoline-2.4-diones Meta I-free Persulfates

Effect of Y_(2)O_(3) on microstructure and properties of CoCrFeNiTiNb high entropy alloy coating on Ti-6Al-4V surface by laser cladding

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Journal of Rare Earths 2024年第3期42卷 586-599,I0006页

作者： Zhen Li Wei Zhao Kedong Yu Ning Guo Guangchun Xiao Zhiming Wang Hui Zhang College of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan250353China shandong Institute of Mechanical Design and research Jinan250031China

The effects of Y_(2)O_(3) on the microstructure, microhardness, wear resistance, high-temperature oxidation resistance, hot corrosion resistance, and electrochemical corrosion behaviour of CoCrFeNiTiNb high entropy alloy coatings formed on Ti-6Al-4V alloy surfaces were studied. The results show that the addition of Y_(2)O_(3) changes the proportion of the phase but does not change its type. The average grain size is only 1/4.7 of that of the high entropy alloy(HEA) coating, and the fine-grained strengthening leads to increases in the microhardness and wear resistance of 21.8% and 26.9%, respectively. The addition of Y_(2)O_(3) enhances the denseness and bonding properties of the oxide and corrosion product layers, reducing the oxidation and hot corrosion rates by 60.3% and 40.3%, respectively. The addition of Y_(2)O_(3) doubles the corrosion resistance which is attributed to the refinement of the grains, the increased proportion of HCP and TiN, and the weakening of galvanic coupling corrosion.

关键词： Laser cladding High entropy alloy coatings Rare earths Wear properties High temperature properties Electrochemical corrosion

Biomineralized CO gas-releasing nanoprodrug for endoplasmic reticulum stress mediated cancer therapy

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Nano research 2023年第5期16卷 7373-7382页

作者： Rui Gu Wanlan Yang Lifei Han Chao Liu Yatao Xu Yunlong Liu Weili Si Wenjun Wang Xiaochen Dong key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Breast Disease Center.Zhongda Hospital School of MedicineSoutheast UniversityNanjing 210009China School of Chemistry&Materials Science Jiangsu Normal UniversityXuzhou 221116China

The anti-tumor effect of therapeutic carbon monoxide(CO)has been considered concerning the electron transport chain on the inner mitochondrial ***,a tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles(NPs)were constructed through biomineralizing acryloyl-modified flavonol,which could release CO both in normoxia and hypoxia conditions upon irradiation at tumor *** in vitro experiments demonstrated that the endoplasmic reticulum stress-related signal pathways could be activated through oxidative stress caused by CO mediated mitochondrial biogenesis and calcium ion turbulence induced by Ca_(3)(PO_(4))_(2)acidolysis,resulting in mitochondrial dysfunction and cell *** addition,the Ca-Flav NPs exhibited excellent biocompatibility and tumor inhibition effect in *** work provides new insight into the potential characteristics of CO,paving a new way to engineer more efficient treatment based on CO.

关键词： carbon monoxide gas therapy mitochondrial endoplasmic reticulum

Flexible servo riveting system control strategy based on the RBF network and self-pierce riveting process

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Advances in Manufacturing 2023年第1期11卷 39-55页

作者： Yan Liu Qiu Tang Xin-Cheng Tian Long Cui Center for Robotics School of Control Science and EngineeringShandong UniversityJinan250061People’s Republic of China Engineering research Center of Intelligent Unmanned System Ministry of EducationJinan250061People’s Republic of China

As more and more composite materials are used in lightweight vehicle white bodies,self-pierce riveting(SPR)technology has attracted great ***,the existing riveting tools still have the disadvantages of low efficiency and *** improve these disadvantages and the riveting qualification rate,this paper improves the control scheme of the existing riveting tools,and proposes a novel controller design approach of the flexible servo riveting system based on the RBF network and SPR ***,this paper briefly introduces the working principle and SPR procedure of the servo riveting *** a moving component force analysis is performed,which lays the foundation for the motion ***,the riveting quality inspection rules of traditional riveting tools are used for reference to plan the force-displacement curve *** control this process,the riveting force is fed back into the closed-loop control of the riveting tool and the riveting speed is computed based on the admittance control ***,this paper adopts the permanent magnet synchronous motor(PMSM)as the power of riveting tool,and proposes an integral sliding mode control approach based on the improved reaching law and the radial basis function(RBF)network friction compensation for the PMSM speed ***,the proposed control approach is simulated by Matlab,and is applied to the servo riveting system designed by our *** simulation and riveting results show the feasibility of the designed controller.

关键词： Lightweight vehicle body connection Self-pierce riveting(SPR)process Flexible servo riveting tool Riveting force planning and control