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Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners:A metabolic and bacteriological investigation in Escherichia coli

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Frontiers of Environmental Science & Engineering 2022年第9期16卷 53-64页

作者： Shuqin Liu Rui Wu Xi Yang Shuting Fang Zhangmin Xiang Shenghong Yang Gangfeng Ouyang guangdong Provincial key Laboratory of Chemical Measurement and Emergency Test Technology Guangdong Provincial Engineering Research Center for Ambient Mass SpectrometryInstitute of AnalysisGuangdong Academy of Sciences(China National Analytical Center Guangzhou)Guangzhou 510070China Shandong Provincial key Laboratory of Molecular Engineering School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China KLGHEI of Environment and Energy Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China

Incomplete separation and recycling of nanoparticles are causing undesirable nanopollution and thus raising great concerns with regard to *** microorganisms are important regulator of physiological processes in many organisms,the interaction between nanopollution and microbial metabolomics and the resultant impact on the host’s health are important but *** investigate how typical nanopollution perturbs microbial growth and metabolism,Escherichia coli(***)in vitro was treated with six water-dispersible nanomaterials(nanoplastic,nanosilver,nano-TiO 2,nano-ZnO,semiconductor quantum dots(QDs),carbon dots(CDs))at human-/environment-relevant concentration *** nanomaterials exhibited type-specific toxic effects on *** *** metabolite profiling was used to characterize metabolic disruption patterns in the model microorganism exposed to different *** percentage of significant metabolites(p1)accounted for 6%–38%of the total 293 identified metabolites in each of the nanomaterial-contaminated bacterial *** results also exhibited significant differences between different nanopollutants and dose levels,revealing type-specific and untypical concentration-dependent metabolic *** metabolites responsive to nanopollution exposures were mainly involved in amino acid and purine metabolisms,where 5,4,and 7 significant metabolic features were included in arginine and proline metabolism,phenylalanine metabolism,and purine metabolism,*** conclusion,this study horizontally compared and demonstrated how typical nanopollution perturbs microbial growth and metabolomics in a type-specific manner,which broadens our understanding of the ecotoxicity of nanopollutants on microorganisms.

关键词： Nano-toxicity Nano-plastics Quantum dots Microbial metabolite Metabolic dysregulation

Structure and antibacterial activity of Ce3+ exchanged montmorillonites

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Journal of Rare Earths 2009年第5期27卷 858-863页

作者： OUYANG Yousheng XIE Yushan TAN Shaozao SHI Qingshan CHEN Yiben guangdong Institute of Microbiology Guangzhou 510070 China Department of Chemistry Jinan University Guang1zhou 510632 China Department of Chemistry Jinan University Guang1zhou 510632 China Guangdong Institute of Microbiology Guangzhou 510070 China Guangdong Institute of Microbiology Guangzhou 510070 China

Four kinds of Ce3+ exchanged montmorillonites (Ce/MMTs) were prepared by an ion-exchange reaction, and characterized with energy dispersive X-ray analysis (EDX), X-ray difference (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The surface properties and antibacterial activity of Ce/MMTs were also investigated. The chemical compositions of Ce/MMTs were determined, and the cerium of Ce/MMTs was confirmed to be present as trivalent cerium state. The d001 basal spacings of Ce/MMTs were enlarged with the enhancement of the cerium contents, and the particles were formed with irregular shape. On increasing the Ce contents of Ce/MMTs, the special surface areas were decreased, but the total pore volumes and the average pore sizes were increased. The antibacterial activity of Ce/MMTs is increased with increasing the cerium contents, and 1.5 g/L of Ce/MMT-3 containing 11.46wt.% of curium could remove all the Staphylococcus aureus and more than 99.9% of the Escherichia coli within 24.0 h of contact. Moreover, Ce/MMTs displayed bactericidal activity.

关键词： Ce3+ exchanged montmorillonite chemical composition microstructure antibacterial activity rare earths

Structure and synergetic antibacterial effect of zinc and cerium carried sodium zirconium phosphates

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Journal of Rare Earths 2011年第4期29卷 308-312页

作者：阳运华代光剑谭绍早刘应亮施庆珊欧阳友生 Department of Chemistry Jinan University guangdong Institute of Microbiology

Zinc and cerium carried zirconium phosphates （Zn-Ce/ZrPs） were prepared by exchanging zinc and cerium cations into sodium zirconium phosphate （NaZrP） through the ion-exchange method and characterized by X-ray diffraction（XRD）, energy dispersive X-ray spectroscopy （EDX） and scanning electron microscopy （SEM）. Furthermore, the specific surface area, zeta potential and antibacterial activity were tested. The results showed that Zn-Ce/ZrPs were with hexagonal crystal system, and the surface area of Zn-Ce/ZrPs increased much more than that of NaZrP. Zn-Ce/ZrPs showed obvious synergetic antibacterial effect, and have the potential to be used as antibacterial agents in environmental control.

关键词： zinc ion cerium ion sodium zirconium phosphates structure synergetic antibacterial effect rare earths

Hierarchically 3D structured milled lamellar MoS2/nano-silicon@carbon hybrid with medium capacity and long cycling sustainability as anodes for lithium-ion batteries

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Journal of Materials Science & Technology 2019年第9期35卷 1840-1850页

作者： Peng Zhang Qiang Rua Honglin Yan Xianhua Hou Fuming Chen Shejun Hu Lingzhi Zhao guangdong Engineering Technology Research Center o f Efficient Green Energy and Environmental Protection Materials South China Normal University Guangzhou 510006China guangdong Provincial key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China Engineering Research Center of Materials and Technology for Electrochemical Energy Storage (Ministry of Education) Guangzhou 510006China Institute of Optoelectronic Materials and Technology South China Normal UniversityGuangzhou 510631China

A hierarchically 3D structured milled lamellar MoS2/nano-siIicon@carbon hybrid with medium capacity and long-term lifespan is designed by a green and scalable approach using ball milling process and spraydrying/ pyrolysis routes. The microspheres consist of low-content nano-silicon (20 wt%), milled lamellar M0S2 sheets and porous carbon skeletons. A mixture of silicon nanoparticles and M0S2 flakes serves as an inner core, while porous carbon pyrolyzed from petroleum pitch acts as a protective shell. The particular architecture affords robust mechanical support, abundant buffering space and enhanced electrical conductivity, thus effectively accommodating drastic volume variation during repetitive Li+ intercalation/ extraction. The Si/MoS2@C hybrid delivers a high initial discharge specific capacity of 1257.8 mA hg^-1 and exhibits a reversible capacity of 767.52 m A hg^-1 at a current density 100 mA g'1 after 250 cycles. Most impressively, the electrode depicts a superior long-cycling durability with a discharge capacity of 537.6 mA hg^-1 even after 1200 cycles at a current density of 500 m A g^-1. Meanwhile, the hybrid also shows excellent rate performance such as 388.1 mA h g^-1 even at a large current density of 3000 mA g^-1.

关键词： Si MoS2 Medium capacity Long-term lifespan Lithium ion batteries

microRNA-21a-5p/PDCD4 axis regulates mesenchymal stem cell-induced neuroprotection in acute glaucoma

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Journal of Molecular Cell Biology 2017年第4期9卷 289-301页

作者： Wenru Su Zuohong Li Yu Jia Yingting Zhu Wenjia Cai Peixing Wan Yingying Zhang Song Guo Zheng Yehong Zhuo State key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China Department of Clinic Immunology The Third Affiliated Hospital at Sun Yat-sen University Guangzhou 510630 China Division of Rheumatology Department of Medicine Penn State Milton S. Hershey Medical Center Hershey PA 17033 USA

Mesenchymal stem ceils （MSCs） have been demonstrated to have promising therapeutic benefits for a variety of neurological dis- eases; however, the underlying mechanisms are poorly understood. Here, we showed that intravitreal infusion of MSCs promoted retinal ganglion cell （RGC） survival in a mouse model of acute glaucoma, with significant inhibition of microglial activation, production of TNF-α, IL-1β, and reactive oxygen species, as well as caspase-8 and caspase-3 activation. In vitro, MSCs inhibited both caspase-8-mediated RGC apoptosis and microgUal activation, partly via the action of stanniocalcin 1 （STCl）. Furthermore, we found that microRNA-21a-Sp （miR-21） and its target, PDCD4, were essential for STC1 production and the neuroprotective property of MSCs in vitro and in vivo. Importantly, miR-21 overexpression or PDCD4 knockdown augmented MSC-mediated neuroprotective effects on acute glaucoma. These data highlight a previously unrecognized neuroprotective mechanism by which the miR-21/ PDCD4 axis induces MSCs to secrete STC1 and other factors that exert neuroprotective effects. Therefore, modulating the miR- 21/PDCD4 axis might be a promising strategy for clinical treatment of acute glaucoma and other neurological diseases.

关键词： mesenchymal stem ceils microRNA neuroprotection glaucoma neurological diseases

Influence of high-temperature oxidation of SiC powders on curing properties of SiC slurry for digital light processing

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Journal of Advanced Ceramics 2023年第1期12卷 169-181页

作者： Zhang-Ao SHI Jia-Min WU Zhi-Qiang FANG Yu-Sheng SHI State key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministry of EducationWuhan 430074China

Fabrication of silicon carbide(SiC)ceramics by digital light processing(DLP)technology is difficult owing to high refractive index and high ultraviolet(UV)absorptivity of SiC *** surface of the SiC powders can be coated with silicon oxide(SiO_(2))with low refractive index and low UV absorptivity via high-temperature oxidation,reducing the loss of UV energy in the DLP process and realizing the DLP preparation of the SiC ***,it is necessary to explore a high-temperature modification process to obtain a better modification effect of the SiC ***,the high-temperature modification behavior of the SiC powders is thoroughly investigated in this *** results show that nano-scale oxide film is formed on the surface of the SiC powders by short-time high-temperature oxidation,effectively reducing the UV absorptivity and the surface refractive index(nʹ)of the SiC *** the oxidation temperature is 1300℃,compared with that of unoxidized SiC powders,the UV absorptivity of oxidized SiC powders decreases from 0.5065 to 0.4654,and a curing depth of SiC slurry increases from 22±4 to 59±4μ***,SiC green bodies are successfully prepared by the DLP with the the oxidized powders,and flexural strength of SiC sintered parts reaches 47.9±2.3 MPa after 3 h of atmospheric sintering at 2000℃without any sintering aid.

关键词： silicon carbide(SiC)powders oxidation modification digital light processing(DLP) ultraviolet(UV)absorptivity curing depth

Decreased b-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes

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Neuroscience Bulletin 2019年第1期35卷 25-33页

作者： Xubin Yang Wen Xu Yanhua Zhu Hongrong Deng Ying Tan Longyi Zeng Jianping Weng Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThird Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

The influence of b-cell function on cardiovascular autonomic neuropathy(CAN), an important diabetesrelated complication, is still unclear. In this study, we aimed to investigate the association between residual b-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. The patients were divided into a CAN? group(diabetic patients with CAN, n = 20) and a CAN-group(diabetic patients without CAN, n = 70) according to the standard Ewing battery of tests. Fasting and postprandial plasma glucose, insulin, and C-peptide were *** model assessment-beta cells(HOMA-B) and HOMA-insulin resistance(IR) were calculated. The prevalence of CAN in this population was 22.2%. Compared with the CAN-group, the CAN? group had significantly lower fasting plasma insulin(6.60 ± 4.39 vs 10.45 ± 7.82 l/L, P = 0.029), fasting C-peptide(0.51 ± 0.20 vs0.82 ± 0.51 nmol/L, P = 0.004), and HOMA-B(21.44 ± 17.06 vs 44.17 ± 38.49, P = 0.002). Fasting C-peptide was correlated with the Valsalva ratio(r = 0.24, P = 0.043) and the 30:15 test(r = 0.26,P = 0.023). Further analysis showed that fasting C-peptide(OR: 0.041, 95% CI 0.003–0.501, P = 0.012) and HOMAB(OR: 0.965, 95% CI 0.934–0.996, P = 0.028) were independently associated with cardiovascular autonomic nerve function in this population. The patients with fasting C-peptide values \ 0.67 nmol/L were more likely to have CAN than those with C-peptide levels C0.67 nmol/L(OR:6.00, 95% CI 1.815–19.830, P = 0.003). A high prevalence of CAN was found in patients with newly-diagnosed type 2 diabetes. Decreased b-cell function was closely associated with CAN in this population.

关键词： Cardiovascular autonomic neuropathy b-cell function Type 2 diabetes mellitus

Enhanced degradation of florfenicol by microscale SiC/Fe:Dechlorination via hydrogenolysis

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Chinese Chemical Letters 2024年第7期35卷 218-221页

作者： Yun-Fei Zhang Chun-Hui Zhang Jian-Hui Xu Lei Li Dan Li Jin-Hong Fan Jiale Gao Xin Quan Qi Wu Yue Zou Yan-Ling Liu Dongguan University of Technology School of Environment and Civil EngineeringDongguan 523830China State key Laboratory of Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Herein,the degradation of florfenicol(FLO)over zero-valent iron(ZVI)enhanced by SiC was systematically *** was found that 5 g/L of ZVI/SiC(1:3)at pH 3.0 could completely degrade 20 mg/L of FLO within 1 h,with a Kobsvalue of 0.0873 min^(-1),12.5 times greater than that of pure ZVI(0.0069 min^(-1)).Vibrating sample magnetometer(VSM)characterizations revealed that the use of SiC supporter reduces the magnetic intensity of ZVI,which mitigates iron particle agglomeration,increases Brunauer-Emmett-Teller(BET)surface area,and enhances FLO degradation ***,ZVI/SiC exhibits a much lower hydrogen evolution potential(HEP)and significantly higher corrosion currents compared to pure *** was proposed to undergo degradation via reductive dechlorination,involving a hydrogenolysis mechanism that entails the cleavage of theσ*** study provides new insights into the reduction hydrogenation mechanism of ZVI.

关键词： Zero-valent iron Silicon carbide Reductive dechlorination Hydrogenolysis Florfenicol

Mechanistic insight into the synergistic Cu/Pd-catalyzed carbonylation of aryl iodides using alcohols and dioxygen as the carbonyl source

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Science China Chemistry 2022年第1期65卷 68-74页

作者： Junxuan Li Jinlei Zhou Yumei Wang Yue Yu Qiang Liu Tilong Yang Huoji Chen Hua Cao School of Chemistry and Chemical Engineering and guangdong Cosmetics Engineering&Technology Research Center Guangdong Pharmaceutical UniversityZhongshan 528458China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515China The Hong Kong University of Science and Technology Clear Water BayKowloonHong KongChina

Pd-catalyzed carbonylation,as an efficient synthetic approach to the installation of carbonyl groups in organic compounds,has been one of the most important research fields in the past *** elegant reactions that allow highly selective carbonylations have been developed,straightforward routes with improved reaction activity and broader substrate scope remain long-term challenges for new practical ***,we show a new type of synergistic Cu/Pd-catalyzed carbonylation reaction using alcohols and dioxgen as the carbonyl sources.A broad range of aryl iodides and alcohols are compatible with this *** reaction is concise and practical due to the ready availability of the starting materials and the scalability of the *** addition,the reaction affords lactones and lactams in an intermolecular ***,DFT calculations have been performed to study the detailed mechanisms.

关键词： Cu/Pd-catalyzed carbonylations radical relay process alcohols dioxgen