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Association of chromosome 7 aneuploidy measured by fluorescence in situ hybridization assay with muscular invasion in bladder cancer

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Cancer Communications 2020年第4期40卷 167-180页

作者： Xiayao Diao Jinhua Cai Junjiong Zheng Jianqiu Kong Shaoxu Wu Hao Yu Hao Huang Weibin Xie Xiong Chen Chengran Huang Lifang Huang Haide Qin Jian Huang Tianxin Lin Department of Urology Sun Yat-sen Memorial HospitalSun Yat-senUniversityGuangzhouGuangdong510120P.R.China guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouGuangdong510120P.R.China Department of Neurology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong510120P.R.China State key Laboratory of Oncology in South China GuangzhouGuangdong510120P.R.China

background:The preoperative prediction of muscular invasion status is important for adequately treating bladder cancer(bC)but nevertheless,there are some existing dilemmas in the current preoperative diagnostic accuracy of bC with muscular ***,we investigated the potential association between the fluorescence in situ hybridization(FISH)assay and muscular invasion among patients with bC.A cytogenetic-clinical nomogram for the individualized preoperative differentiation of muscle-invasive bC(MIbC)from non-muscle-invasive bC(NMIbC)is also ***:All eligible bC patients were preoperatively tested using a FISH assay,which included 4 sites(chromosome-specific centromeric probe[CSP]3,7,and 17,and gene locus-specific probe[GLP]-p16 locus).The correlation between the FISH assay and bC muscular invasion was evaluated using the Chi-square *** the training set,univariate and multivariate logistic regression analyses were used to develop a cytogenetic-clinical nomogram for preoperative muscular invasion ***,we assessed the performance of the nomogram in the training set with respect to its discriminatory accuracy and calibration for predicting muscular invasion,and clinica usefulness,which were then validated in the validation ***,model comparison was set to evaluate the discrimination and clinical usefulness between the nomogram and the individual variables incorporated in the ***:Muscular invasion was more prevalent in bC patients with positive CSP3,CSP7 and CSP17 status(OR[95%CI],2.724[1.555 to 4.774],PbC muscular invasion by the multivariate regression analysis in the training ***,a cytogenetic-clinical nomogram incorporating these three independent risk factors was constructed and was observed

关键词： chromosome aneuploidy fluorescence in situ hybridization muscular invasion nomogram preoperative prediction urinary bladder neoplasms

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PD-1/L1 inhibitors can improve but not replace chemotherapy for advanced urothelial carcinoma:A systematic review and network meta-analysis

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Cancer Innovation 2023年第3期2卷 191-202页

作者： Longkun Mao Meihua Yang Xinxiang Fan Wenjie Li Xiaodong Huang Wang He Tianxin Lin Jian Huang guangdong Provincial key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen(Zhongshan)UniversityGuangzhouChina Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen(Zhongshan)UniversityGuangzhouChina guangdong Provincial Clinical research Center for Urological Diseases GuangzhouChina The First Affiliated Hospital of Nanchang University NanchangChina

background:programmed cell death-1/ligand 1 inhibitors are a new treatment strategy for advanced urothelial ***,a comparative evaluation of their efficacy and toxicity compared with chemotherapy is ***:We comprehensively searched PubMed,Web of Science,Embase,and Cochrane Library databases and performed a meta-analysis of randomized controlled trials up to July *** considered overall survival as the primary outcome,and progression-free survival,objective response rate,and treatment-related adverse events as secondary ***:Overall,3584 patients from five studies were *** with first-line chemotherapy,programmed cell death-1/ligand 1 inhibitors were significantly associated with worse progression-free survival(pbjective response rates(pprogrammed cell death-1/ligand 1 inhibitors significantly improved overall survival(pbjective response rate(p=0.34).Compared with chemotherapy,programmed cell death-1/ligand 1 inhibitors were well tolerated(first-line chemotherapy:pprogrammed cell death-1/ligand 1 inhibitors in patients with advanced urothelial carcinoma is not superior to that of first-line platinum-based chemotherapy but is better than second-line chemotherapy;however,programmed cell death-1/ligand 1 inhibitors are safer than first-and second-line chemotherapy and have a broader prospect for use in combination therapy.

关键词： chemotherapy efficacy immune checkpoint inhibitors safety urinary bladder neoplasms

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