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Recent advances in promising drugs for primary prevention of gastroesophageal variceal bleeding with cirrhotic portal hypertension

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 4-13页

作者： Ji-Yao Sheng Zi-Fan Meng Qiao Li Yong-Sheng Yang Department of Hepatobiliary and Pancreatic Surgery the Second Hospital of Jilin UniversityChangchun 130041China jilin Engineering Laboratory for Translational Medicine of Hepatobiliary and Pancreatic Diseases the Second Hospital of Jilin UniversityChangchun 130041China

Background:Gastroesophageal variceal bleeding is one of the most severe complications of patients with *** primary prevention drugs,including non-selectiveβ-blockers,have effectively reduced the incidence of bleeding,their efficacy is limited due to side effects and related *** recent advances in precision medicine,precise drug treatment provides better treatment *** sources:Literature search was conducted in PubMed,MEDLINE and Web of Science for relevant articles published up to May *** on clinical trials was obtained from https://***/and http://***/.Results:The in-depth understanding of the pathogenesis and advances of portal hypertension has enabled the discovery of multiple molecular targets for promising *** to the site of action,these drugs could be classified into four classes:intrahepatic,extrahepatic,both intrahepatic and extrahepatic targets and *** these classes of drugs offer advantages over traditional treatments in prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal ***:This review classified and summarized the promising drugs,which prevent gastroesophageal variceal bleeding by targeting specific markers of pathogenesis of portal hypertension,demonstrating the significance of using the precision medicine strategy to discover and develop promising drugs for the primary prevention of gastroesophageal variceal bleeding in patients with cirrhotic portal hypertension.

关键词： Cirrhotic portal hypertension Target drug Primary prevention Bleeding

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Double-hit lymphoma (rearrangements of MYC, BCL-2) during pregnancy: A case report

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World Journal of Clinical Cases 2021年第2期9卷 482-488页

作者： Fan Xie Li-Hui Zhang Ya-Qing Yue Lu-Lu Gu Fei Wu Department of Obstetrics and Gynecology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND Double-hit lymphoma is a highly aggressive B-cell lymphoma that is genetically characterized by rearrangements of MYC and BCL2 and/or *** is often accompanied by atypical systemic symptoms similar to physiological changes during pregnancy and is often ***,we describe a gravid patient with high-grade B-cell lymphoma with a MYC and BCL-2 gene rearrangement involving multiple parts of the *** SUMMARY A 32-year-old female,gestational age 22+5 wk,complained of abdominal distension,chest tightness and limb weakness lasting approximately 4 wk,and ovarian tumors were found 14 d *** examinations and a trimanual gynecologic examination suggested malignant ovarian tumor and frozen *** with rapid progression,severe compression symptoms of hydrothorax,ascites and moderate anemia,labor was ***,biopsy and imaging examinations showed high-grade B-cell lymphoma with a MYC and BCL-2 gene rearrangement involving multiple parts of the *** was referred to the Department of Oncology and Hematology for *** of multiple recurrences after complete remission,chemotherapy plans were continuously *** present,the patient remains in treatment and *** The early detection and accurate diagnosis of lymphoma during pregnancy can help expedite proper multidisciplinary treatment to delay disease progression and decrease the mortality rate.

关键词： Ovarian neoplasms Double-hit lymphoma Lymphoma,non-Hodgkin Pregnancy Case report Multidisciplinary treatment

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Isoforsythiaside confers neuroprotection against Alzheimer's disease by attenuating ferroptosis and neuroinflammation in vivo and in vitro

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Food Science and Human Wellness 2023年第5期12卷 1730-1742页

作者： Chunyue Wang Hongbo Jiang Honghan Liu Shanshan Chen Hangyu Guo Shuoshuo Ma Weiwei Han Yu Li Di Wang School of Life Sciences Jilin UniversityChangchun 130012China Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi Jilin Agricultural UniversityChangchun 130118China

Ferroptosis and neuroinflammation contribute to the development of Alzheimer's disease(AD). Isoforsythiaside(IFY)is a phenylethanoid glycoside isolated from the dried fruit of Forsythia suspensa(Thunb.)Vahl that has been confirmed to improve the memory and cognitive abilities of APP/PS1 mice in our previous study. The purpose of this study was to explore the anti-ferroptosis and anti-neuroinflammatory properties of IFY-mediated neuroprotection. In APP/PS1 mice, erastin-damaged HT22 cells, and LPS-exposed BV2 cells, the neuroprotective effects against ferroptosis and neuroinflammation were investigated using immunohistochemistry, label-free proteomics, western blot, ELISA, MTT, fluorescence, and TEM. IFY alleviated the expression levels of NO, IL-6, and IL-1β in LPS-exposed BV2 cells and improved the morphology of mitochondria in erastin-damaged HT22 cells. Additionally, IFY upregulated the expression levels of GPX4, FTH, FTL, p-GSK-3β, Nrf2, and NQO1, and downregulated the expression of TFR1, DMT1, p-Fyn, GFAP, p-IKKα+β, p-IκBα, p-NF-κB, and pro-inflammatory factors in the brains of APP/PS1 mice and erastin-damaged HT22 cells. In conclusion, IFY inhibits ferroptosis and neuroinflammation in erastin-damaged HT22 cells and APP/PS1 mice, at least partially by regulating the activation of Nrf2 and NF-κB signaling. IFY may prevent ferroptosis and neuroinflammation in AD and provide a new treatment strategy for AD.

关键词： Ferroptosis Neuroinflammation Isoforsythiaside Alzheimer's disease

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Strategies of Response to Public Concerns during Public Emergencies in the Context of Modern Governance:Taking COVID-19 Pandemic as an Example

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学术界 2020年第4期 203-212页

作者： Kong Zeming Wang Junqiu College of the Humanities jilin University Changchun Jilin 130012

Public emergencies are generally sudden with huge real or potential danger to the whole *** COVID-19 pandemic is a typical public emergency with a long duration involving a wide range of people,and has extremely bad social *** pandemic can be classified into four stages:initial stage,outbreak stage,durative stage and post-pandemic *** focus of mass media varied according to the characteristics of different *** on different stages,mass media should change their roles timely and always be aware of the mainstream ideological construction in public opinions to firmly control the direction of public opinion by using the theory and method of communication.

关键词： public emergencies response to public concerns COVID-19 pandemic

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