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Multiphase modeling of fluid dynamic in ladle steel operations under non-isothermal conditions

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Journal of Iron and Steel Research International 2017年第9期24卷 888-900页

作者： H.Gonzalez J.A.Ramos-Banderas E.Torres-Alonso G.Solorio-Diaz C.A.Hernández-Bocanegra Graduate Program in Metallurgy Morelia Technological Institute(ITM)Morelia Michoacdn 58120Mexico Graduate Program in Engineering Mechanical UMSNHMorelia Michoacdn 58140Mexico CATEDRAS CONACyT Benito JuarezCDMX 03940Mexico

A numerical simulation was performed to study the flow pattern,mixing time and open-eye slag produced by argon gas injection in an industrial scale steel ladle under non-isothermal *** liquid steel remains 5min before the injection,and thermal stratification and convective flows were *** different sequences in stages employing various argon-gas flow rates were *** the first case,a sequence with the highest flow rates of argon was applied,while in the second and the third sequences,the intermediate and the lowest flow rates of argon gas were used,*** determining the chemistry homogenization,the mixing time was computed and analyzed in all three *** was found that the cold steel is located near the walls while the steel with a high temperature is accumulated in the center of the ladle above the argon-gas *** higher and lower flows promote a faster chemistry homogenization owing to the secondary recirculations that are developed closer to the *** results from steel temperature drop show a good concordance with plant trial measurements.

关键词： Thermal stratification Mixing time Open-eye slag Ladle steelmaking Multiphase modeling

Development of a risk score to guide targeted hepatitis C testing among human immunodeficiency virus patients in Cambodia

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World Journal of Hepatology 2021年第9期13卷 1167-1180页

作者： Anja De Weggheleire Jozefien Buyze Sokkab An Sopheak Thai Johan van Griensven Sven Francque Lutgarde Lynen Department of Clinical Sciences Institute of Tropical Medicine AntwerpAntwerp 2000Belgium Infectious Diseases Department Sihanouk Hospital Center of HopePhnom Penh 12101Cambodia Department of Gastroenterology Hepatology Antwerp University HospitalAntwerp 2000Belgium Laboratory of Experimental Medicine and Paediatrics University of AntwerpAntwerp 2000Belgium

BACKGROUND The World Health Organization recommends testing all human immunodeficiency virus(HIV)patients for hepatitis C virus(HCV).In resource-constrained contexts with low-to-intermediate HCV prevalence among HIV patients,as in Cambodia,targeted testing is,in the short-term,potentially more feasible and *** To develop a clinical prediction score(CPS)to risk-stratify HIV patients for HCV coinfection(HCV RNA detected),and derive a decision rule to guide prioritization of HCV testing in settings where‘testing all’is not feasible or unaffordable in the short *** We used data of a cross-sectional HCV diagnostic study in the HIV cohort of Sihanouk Hospital Center of Hope in Phnom *** populations were very rare in this *** development relied on the Spiegelhalter and Knill-Jones *** with an adjusted likelihood ratio≥1.5 or≤0.67 were retained,transformed to natural logarithms,and rounded to integers as score *** performance was evaluated by the area-under-the-ROC curve(AUROC)with 95% confidence intervals(CI),and diagnostic accuracy at the different *** the decision rule,HCV coinfection probability≥1% was agreed as *** Among the 3045 enrolled HIV patients,106 had an HCV *** the 11 candidate predictors(from history-taking,laboratory testing),seven had an adjusted likelihood ratio≥1.5 or≤0.67:≥50 years(+1 point),diabetes mellitus(+1),partner/household member with liver disease(+1),generalized pruritus(+1),platelets<200×10^(9)/L(+1),aspartate transaminase(AST)<30 IU/L(-1),AST-to-platelet ratio index(APRI)≥0.45(+1),and APRI<0.45(-1).The AUROC was 0.84(95%CI:0.80-0.89),indicating good discrimination of HCV/HIV coinfection and HIV *** CPS result≥0 best fits the test-threshold(negative predictive value:99.2%,95%CI:98.8-99.6).Applying this threshold,30%(n=926)would be *** coinfections(15%)would have been missed,none with advanced *** The CPS pe

关键词： Hepatitis C virus Hepatitis C/human immunodeficiency virus coinfection Clinical prediction rule Targeted screening Cambodia Development prediction model

Preprocessing of 2-Dimensional Gel Electrophoresis Images Applied to Proteomic Analysis： A Review

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 63-72页

作者： Manuel Mauricio Goez Maria Constanza Torres-Madronero Sarah Rothlisberger Edilson Delgado-Trejos Automatics Electronics and Computer Science Research Group Faculty of Engineering Instituto Tecnologico Metropolitano Medellin 050012 Colombia Biomedical Innovation and Research Group Faculty of Applied and Exact Sciences lnstituto Tecnologico Metropolitano Medellin 050012 Colombia Quality Metrology and Production Research Group Faculty of Economic and Management Sciences Instituto Tecnologico Metropolitano Medellin 050012 Colombia

Various methods and specialized software programs are available for processing two- dimensional gel electrophoresis （2-DGE） images. However, due to the anomalies present in these images, a reliable, automated, and highly reproducible system for 2-DGE image analysis has still not been achieved. The most common anomalies found in 2-DGE images include vertical and hor- izontal streaking, fuzzy spots, and background noise, which greatly complicate computational anal- ysis. In this paper, we review the preprocessing techniques applied to 2-DGE images for noise reduction, intensity normalization, and background correction. We also present a quantitative comparison of non-linear filtering techniques applied to synthetic gel images, through analyzing the performance of the filters under specific conditions. Synthetic proteins were modeled into a two-dimensional Gaussian distribution with adjustable parameters for changing the size, intensity, and degradation. Three types of noise were added to the images： Gaussian, Rayleigh, and exponen- tial, with signal-to-noise ratios （SNRs） ranging 8-20 decibels （dB）. We compared the performanceof wavelet, contourlet, total variation （TV）, and wavelet-total variation （WTTV） techniques using parameters SNR and spot efficiency. In terms of spot efficiency, contourlet and TV were more sen- sitive to noise than wavelet and WTTV. Wavelet worked the best for images with SNR ranging 10- 20 dB, whereas WTTV performed better with high noise levels. Wavelet also presented the best per- formance with any level of Gaussian noise and low levels （20-14 dB） of Rayleigh and exponential noise in terms of SNR. Finally, the performance of the non-linear filtering techniques was evaluated using a real 2-DGE image with previously identified proteins marked. Wavelet achieved the best detection rate for the real image.

关键词： Background correction Filtering Noise reduction Preprocessing 2D gel electrophoresis

One in four patients with gastrointestinal bleeding develops shock or hemodynamic instability:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第28期29卷 4466-4480页

作者： Mahmoud Obeidat Brigitta Teutsch Anett Rancz Edina Tari Katalin Márta Dániel Sándor Veres Nóra Hosszúfalusi Emese Mihály Péter Hegyi Bálint Erőss Centre for Translational Medicine Semmelweis UniversityBudapest 1085Hungary Institute for Translational Medicine Medical SchoolUniversity of PécsPécs 7623Hungary Department of Internal Medicine and Hematology Semmelweis UniversityFaculty of MedicineBudapest 1085Hungary Institute of Pancreatic Diseases Semmelweis UniversityBudapest 1083Hungary Department of Biophysics and Radiation Biology Semmelweis UniversityBudapest 1085Hungary

BACKGROUND Hemodynamic instability and shock are associated with untoward outcomes in gastrointestinal ***,there are no studies in the existing literature on the proportion of patients who developed these outcomes after gastrointestinal *** To determine the pooled event rates in the available literature and specify them based on the bleeding *** The protocol was registered on PROSPERO in advance(CRD42021283258).A systematic search was performed in three databases(PubMed,EMBASE,and CENTRAL)on 14^(th) October *** proportions with 95%CI were calculated with a random-effects model.A subgroup analysis was carried out based on the time of assessment(on admission or during hospital stay).Heterogeneity was assessed by Higgins and Thompson’s I^(2) *** Joanna Briggs Institute Prevalence Critical Appraisal Tool was used for the risk of bias *** Reference Citation Analysis(https://***/)tool was applied to obtain the latest highlight *** We identified 11589 records,of which 220 studies were eligible for data *** overall proportion of shock and hemodynamic instability in general gastrointestinal bleeding patients was 0.25(95%CI:0.17-0.36,I^(2)=100%).In non-variceal bleeding,the proportion was 0.22(95%CI:0.14-0.31,I^(2)=100%),whereas it was 0.25(95%CI:0.19-0.32,I^(2)=100%)in variceal *** proportion of patients with colonic diverticular bleeding who developed shock or hemodynamic instability was 0.12(95%CI:0.06-0.22,I^(2)=90%).The risk of bias was low,and heterogeneity was high in all *** One in five,one in four,and one in eight patients develops shock or hemodynamic instability on admission or during hospitalization in the case of non-variceal,variceal,and colonic diverticular bleeding,respectively.

关键词： Gastrointestinal bleeding Hemodynamic instability Shock Meta-analysis Statistics Review

Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment

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Microsystems & Nanoengineering 2022年第2期8卷 135-147页

作者： Muhammad R.Haque Caitlin R.Wessel Daniel D.Leary Chengyao Wang Abhinav Bhushan Faraz Bishehsari Division of Digestive Diseases Rush Center for Integrated Microbiome&Chronobiology ResearchRush University Medical CenterChicagoIL 60612USA University of Louisville School of Medicine LouisvilleKT 40202USA Department of Biomedical Engineering Illinois Institute of TechnologyChicagoIL 60616USA

The patient population suffering from pancreatic ductal adenocarcinoma(PDAC)presents,as a whole,with a high degree of molecular tumor *** heterogeneity of PDAC tumor composition has complicated treatment and stalled success in clinical *** in vitro techniques insufficiently replicate the intricate stromal components of PDAC tumor microenvironments(TMEs)and fail to model a given tumor's unique genetic *** development of patient-derived organoids(PDOs)has opened the door for improved personalized medicine since PDOs are derived directly from patient tumors,thus preserving the tumors'unique behaviors and genetic *** study developed a tumor-chip device engineered to mimic the PDAC TME by incorporating PDOs and stromal cells,specifically pancreatic stellate cells and *** PDOs in a multicellular microfluidic chip device prolongs cellular function and longevity and successfully establishes a complex organotypic tumor environment that incorporates desmoplastic stroma and immune *** primary cancer cells in monoculture were subjected to stroma-depleting agents,there was no effect on cancer cell ***,targeting stroma in our tumor-chip model resulted in a significant increase in the chemotherapy effect on cancer cells,thus validating the use of this tumor-chip device for drug testing.

关键词： cancer chemotherapy adenocarcinoma

Implication of gut microbiome in age-related macular degeneration

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Neural Regeneration Research 2023年第12期18卷 2699-2700页

作者： Wendy Luo Dimitra Skondra Pritzker School of Medicine University of ChicagoChicagoILUSA Department of Ophthalmology and Visual Science University of ChicagoChicagoILUSA

Age-related macular degeneration(AMD) is the most common cause of blindness in the United States in adults over 55 years of age and is one of the leading global causes of blindness: at least 196 million of the worldwide population have AMD, and prevalence is projected to rise to 288 million by 2040(Lin et al., 2021). As cases and disease burden increase, improvements in the characterization of AMD pathobiology and exploration of potential therapeutic solutions are necessary first steps in addressing this global health concern.

关键词： degeneration AMD steps

The archaeogenomic validation of Saint Ladislaus'relic provides insights into theárpád dynasty's genealogy

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Journal of Genetics and Genomics 2023年第1期50卷 58-61页

作者： Gergely I.B.Varga Lilla Alida Kristóf Kitti Maár Luca Kis Oszkár Schütz Orsolya Váradi Bence Kovács Alexandra Gînguță Balázs Tihanyi Péter L.Nagy Zoltán Maróti Emil Nyerki Tibor Török Endre Neparáczki Department of Archaeogenetics Institute of Hungarian ResearchH-1014 BudapestHungary Doctoral School of History University of SzegedSzegedHungary Department of Genetics University of SzegedH-6726 SzegedHungary Department of Biological Anthropology University of SzegedH-6726 SzegedHungary Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabes-Bolyai University400006 Cluj-NapocaRomania Praxis Genomics LLC AtlantaUSA Department of Pediatrics and Pediatric Health Center University of SzegedH-6725 SzegedHungary

The house of Arp ad ruled Hungary for more than four centuries,establishing dynastical relationships with numerous European nobleand ruling houses,and giving many Catholic saints and blesseds to the Catholic *** were one of the significant dynasties of Medieval Europe(Krist o and Makk,1996).The knight-king Saint Ladislaus I(c.1040-1095,reign:1077-1095)is one of the most outstanding kings of this *** addition to the hand relic(the Holy Right)of King Saint Stephanus I(c.975-1038,reign:1000/1001-1038),the skull relic in the Saint Ladislaus’Herma(Fig.1A-1C)preserved in the Cathedral of Gy or,is one of the most important relics for Hungarians(Klaniczai,2000).

关键词： relic provides insights into the The archaeogenomic validation of Saint Ladislaus d dynasty’s genealogy

Doubled Haploid Production Using an Improved Anther Culture Protocol for Sorghum[Sorghum bicolor(L.)Moench]

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Phyton-International Journal of Experimental Botany 2021年第2期90卷 475-487页

作者： Paul Chege Erzsébet Kiss Csaba Lantos Andrea Palágyi János Pauk Cereal Research Non-profit Ltd. Alsókikötősor 9Szeged6726Hungary Doctoral School of Plant Science Szent István UniversityGödöllőH2103Hungary

Sorghum[Sorghum bicolor(L.)Moench]can benefit from accelerated breeding and release of improved varieties through doubled haploid *** technology has been used in speeding up the breeding of other major cereals such as wheat,maize and rice,for which generally widely applied optimised protocols exist.A reproducible protocol for the crop,that can overcome genotype dependency and other species-specific challenges such as phenolic exudation is however *** study aimed at sorghum doubled haploids production thereby contributing to the development of an improved *** the 28 hybrid genotypes,both F1 registered-and experimental hybrids involved,this study successfully produced haploids from five genotypes and subsequently,four confirmed doubled-haploid lines on W14mf medium or its modification with 1.0 gl^(-1)L-proline,1.0 gl^(-1)L-asparagine and 1.0 gl^(-1)KH_(2)PO_(4).Medium 190-2Cu was used for regeneration and rooting,which occurred successfully,if the calli were transferred on to it less than 7 days after induction,and temperature was maintained at 25°C under light *** dependency was not wholly overcome;however,sorghum’s high tillering ability and abiotic stress tolerance were observed to contribute to attainment of haploid *** diploids producing seeds at rates of upto 80.5%were obtained,therefore eliminating the need for colchicine duplication.

关键词： In vitro androgenesis doubled-haploid sorghum anther-culture breeding

Negative weights in network time model

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Frontiers of Engineering Management 2022年第2期9卷 268-280页

作者： Zoltan A.VATTAI Levente MALYUSZ Faculty of Architecture Budapest University of Technology and EconomicsMuegyetem rkp.3H-llll BudapestHungary

Time does not go backward.A negative duration,such as“time period”at first sight is difficult to *** network techniques(CPM/PERT/PDM)did not support negative parameters and/or loops(potentially necessitating recursive calculations)in the model because of the limited computing and data storage capabilities of early *** Roy and John Fondahl implicitly introduced negative weights into network techniques to represent activities with fixed or estimated durations(MPM/PDM).Subsequently,the introduction of negative lead and/or lag times by software developers(IBM)apparently overcome the limitation of not allowing negative time parameters in time *** to general digraph(Event on Node)representation where activities are represented by pairs of nodes and pairwise relative time restrictions are represented by weighted arrows,we can release most restraints in constructing the graph structure(incorporating the dynamic model of the inner logic of time plan),and a surprisingly flexible and handy network model can be developed that provides all the advantages of the above-mentioned *** paper aims to review the theoretical possibilities and technical interpretations(and use)of negative weights in network time models and discuss approximately 20 types of time-based restrictions among the activities of construction *** focus on pure relative time models,without considering other restrictions(such as calendar data,time-cost trade-off,resource allocation or other constraints).

关键词： graph technique network technique construction management scheduling