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Chinese Medical Journal 2023年第10期136卷 1243-1245页

作者： Yiyang Zhao Dongyuan Chang Liang Wu Xiaojuan Yu Suxia Wang Minghui Zhao Min Chen Department of Renal Medicine Peking University First HospitalBeijing 100034China research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases Chinese Academy of Medical SciencesBeijing 100034China

To the Editor:Diabetic kidney disease(DKD)has become the leading cause of end-stage kidney disease(ESKD).According to the Kidney Disease Improving Global Outcomes(KDIGO)guidelines,rapid kidney function decline in DKD is defined as an estimated glomerular filtration rate(eGFR)slope≤−5 mL∙min^(−1)∙1.73 m^(−2)·year^(−1).The prognoses of patients who experience rapid eGFR decline are usually *** a multicenter retrospective study,230 of 377(61%)biopsy-proven DKD patients were rapid decliners.[1]It was reported that 32%and 42%of 195 type 2 diabetes(T2D)Pima Indians with normoalbuminuria and microalbuminuria,respectively,had a rapid eGFR decline,indicating that proteinuria alone has difficulty in fully predicting rapid kidney function decline in DKD patients with T2D.[2]Therefore,it is of interest to identify more useful clinicopathological predictors of a rapid kidney function decline in T2D patients.

关键词： kidney patients biopsy

μ-opioid receptor agonist facilitates circulating tumor cell formation in bladder cancer via the MOR/AKT/Slug pathway:a comprehensive study including randomized controlled trial

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Cancer Communications 2023年第3期43卷 365-386页

作者： Xiaoqiang Wang Song Zhang Di Jin Jiamei Luo Yumiao Shi Yiqi Zhang Lingling Wu Yanling Song Diansan Su Zhiying Pan Haige Chen Ming Cao Chaoyong Yang Weifeng Yu Jie Tian Department of Anesthesiology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Department of Urology Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China Institute of Molecular Medicine Renji HospitalShanghai Jiaotong University School of MedicineShanghaiP.R.China The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation State Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamenFujianP.R.China

Background:μ-opioid receptor agonists(MORAs)are indispensable for analgesia in bladder cancer(BC)patients,both during surgery and for chronic pain *** MORAs affect BC progression and metastasis remains largely *** study focused on the effects of MORAs on the formation of circulating tumor cells(CTCs)in BC and aimed to provide potential therapeutic targets,which would retain the pain-relieving effects of MORAs in BC patients without sacrificing their long-term ***:Different preclinical models were used to identify the effects of MORAs on the progression of BC.A novel immunocapture microfluidic chip was utilized to analyze whether MORAs affected the number of CTCs in mouse models and clinical BC *** analyses,total transcriptome sequencing,and molecular biology methods were then used to investigate the underlying mechanisms in these models and in BC cell ***:Mouse models of hematogenous metastasis and in situ BC demonstrated that tumor metastasis was significantly increased after MORA treatment.A significant increase in the number of mesenchymal and/or epithelial CTCs was detected after MORA treatment in both the mouse models and clinical trial ***,MORAs facilitated the formation of CTCs by activating the MOR/PI3K/AKT/Slug signaling pathway,hereby promoting the epithelialmesenchymal transition(EMT)of BC cells,as knockdown of MOR,Slug or blockade of PI3K inhibited the EMT process and CTC ***:MORAs promoted BC metastasis by facilitating CTC *** EMT-CTC axis could be targeted for preventive measures during MORA treatment to inhibit the associated tumormetastasis or recurrence in BC patients.

关键词： μ-opioid receptor agonist AKT bladder cancer circulating tumor cell epithelial-mesenchymal transition microfluidic chip MOR PI3K Slug

“病理影像化”:基于组织学特征的磁共振成像在体识别心肌纤维化（英文）

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Science Bulletin 2023年第9期 864-867页

作者：陆敏杰朱乐怡 Sanjay K.Prasad 赵世华 Department of Magnetic Resonance Imaging Fuwai Hospital State Key Laboratory of Cardiovascular Disease Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Cardiovascular Imaging (Cultivation) Chinese Academy of Medical Sciences Cardiovascular Magnetic Resonance Unit Royal Brompton Hospital National Heart & Lung Institute Imperial College

Myocardial fibrosis, characterized by the excessive deposition of extracellular matrix proteins, is an important underlying mechanism for adverse outcomes in many cardiovascular diseases [1].Multiple modalities have been developed to identify and quantify myocardial fibrosis non-invasively. Cardiac magnetic resonance(CMR) imaging provides the gold standard for the assessment of cardiac structure and function.

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Building a modern six-dimensional biobank fosters the future of precision medicine

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Science Bulletin 2022年第24期67卷 2490-2493页

作者： Tian-Yu Lian Yi Yan Dong Ding Yue-Jiao Ma Xue Zhang Zhi-Cheng Jing The Medical Science research Center Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China Heart Center and Shanghai Institute of Pediatric Congenital Heart Disease Shanghai Children’s Medical CenterNational Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China The Department of Cardiology Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

In 2001, Dr. Zhi-Cheng Jing encountered a pulmonary arterial hypertension (PAH) patient from a large pedigree. Dr. Jing collected the clinical information and blood samples from this pedigree and was the first to report the pedigree of familial PAH in China [1]. In2004, this pedigree was confirmed to carry a mutation in BMPR2(Arg491Trp), which was the first evidence of pathogenicity of BMPR2 mutation in the Chinese population [2].

关键词：罕见病新药研发生物样本 arterial hypertension

Single cell atlas of developing mouse dental germs reveals populations of CD24^(+)and Plac8^(+)odontogenic cells

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Science Bulletin 2022年第11期67卷 1154-1169页

作者： Yaofeng Wang Yifan Zhao Shubin Chen Xiaoming Chen Yanmei Zhang Hong Chen Yuansong Liao Jiashu Zhang Di Wu Hongxing Chu Hongying Huang Caixia Wu Shijuan Huang Huichao Xu Bei Jia Jie Liu Bo Feng Zhonghan Li Dajiang Qin Duanqing Pei Jinglei Cai Innovation Centre for Advanced Interdisciplinary Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510799China CAS Key Laboratory of Regenerative Biology GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Centre for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong KongChina Bioland Laboratory Guangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China Guangdong Provincial People’s hospital Ganzhou hospital Ganzhou Municipal HospitalGanzhou 341099China State Key Laboratory of Oral Disease West China Hospital of StomatologyCenter of Growth Metabolism and AgingKey Laboratory of Bio-Resource and Eco-Environment of Ministry of EducationCollege of Life SciencesSichuan UniversityChengdu 610041China Department of Regeneration Medicine School of Pharmaceutical ScienceJilin UniversityChangchun 130012China Department of Periodontics and Implantology Stomatological HospitalSouthern Medical University(Guangdong Provincial Stomatological Hospital)Guangzhou 510515China Animal Center Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China The Center for Prenatal and Hereditary Disease Diagnosis Department of Obstetrics and GynecologyNanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Obstetrics and Gynecology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Laboratory of Cell Fate Control School of Life SciencesWestlake UniversityHangzhou 310024China

The spatiotemporal relationships in high-resolution during odontogenesis remain poorly *** report a cell lineage and atlas of developing mouse *** performed a large-scale(92,688 cells)single cell RNA sequencing,tracing the cell trajectories during odontogenesis from embryonic days 10.5 to *** with an assay for transposase-accessible chromatin with high-throughput sequencing,our results suggest that mesenchymal cells show the specific transcriptome profiles to distinguish the tooth ***,we identified key gene regulatory networks in teeth and bone formation and uncovered spatiotemporal patterns of odontogenic mesenchymal ***24^(+)and Plac8^(+)cells from the mesenchyme at the bell stage were distributed in the upper half and preodontoblast layer of the dental papilla,respectively,which could individually induce nonodontogenic epithelia to form tooth-like ***,the Plac8^(+)tissue we discovered is the smallest piece with the most homogenous cells that could induce tooth regeneration to *** work reveals previously unknown heterogeneity and spatiotemporal patterns of tooth germs that may lead to tooth regeneration for regenerative dentistry.

关键词： Single cell RNA-seq Dental germ development Spatiotemporal pattern Odontogenesis CD24^(+)odontogenic cells Plac8^(+)odontogenic cells

恒河猴自发性盆腔器官脱垂作为研究人盆腔器官脱垂理想模型的综合评价（英文）

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Science Bulletin 2023年第20期 2434-2447页

作者：李雅倩刘健张也毛萌王宏马懿迪陈志刚张又月廖成敏常晓青高倩倩郭建宾叶扬艾方方刘旭东赵晓悦田维杰杨华季维智谭韬朱兰 Medical Science research Center the State Key Laboratory for Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College State Key Laboratory of Primate Biomedical research Institute of Primate Translational Medicine Kunming University of Science and Technology Department of Obstetrics and Gynecology National Clinical Research Center for Obstetric & Gynecologic Diseases the State Key Laboratory for Complex Severe and Rare Diseases the State Key Laboratory of Common Mechanism Research for Major Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou University Department of Obstetrics and Gynecology Beijing Chao-Yang Hospital Capital Medical University Department of Obstetrics and Gynecology Xuanwu Hospital Capital Medical University Department of Gynecology Guizhou Provincial People's Hospital Medical College of Guizhou University

盆腔器官脱垂严重影响女性的生活质量且其治疗的并发症严重.开发新疗法须在临床前研究中对其免疫反应和安全性进行评估.但多数四足动物的解剖结构和病理变化与人相差较大,目前缺乏合适的动物模型.本研究对72只老年恒河猴进行了体格检查...

盆腔器官脱垂严重影响女性的生活质量且其治疗的并发症严重.开发新疗法须在临床前研究中对其免疫反应和安全性进行评估.但多数四足动物的解剖结构和病理变化与人相差较大,目前缺乏合适的动物模型.本研究对72只老年恒河猴进行了体格检查,发现恒河猴自发性盆腔器官脱垂的发生率与人相似.作者选取了5只正常恒河猴和4只脱垂恒河猴的阴道组织进行进一步分析.Verhoeff-van Gieson染色表明,与正常恒河猴相比,恒河猴脱垂阴道的弹力纤维含量明显降低.免疫组化结果表明,恒河猴脱垂阴道的平滑肌束紊乱,大平滑肌束的数量明显低于正常恒河猴.天狼星红染色提示恒河猴脱垂阴道中Ⅰ型和Ⅲ型?原蛋白的比值明显降低.恒河猴脱垂阴道的组织学形态和生化改变与人脱垂相似.作者进一步构建了恒河猴脱垂后阴道的单细胞转录组图谱,对比分析显示人和恒河猴的阴道具有相似的细胞组成.差异基因分析提示细胞外基质失调和免疫紊乱是保守的分子机制.成纤维细胞和巨噬细胞的相互作用可能在人和恒河猴脱垂中都起到重要作用.综上,该研究对恒河猴自发性脱垂进行了综合评估并表明其是盆腔器官脱垂研究的合适动物模型.

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Fruit and vegetable intake and the risk of arterial hypertension in China:A prospective cohort study

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Chronic Diseases and Translational Medicine 2023年第4期9卷 309-319页

作者： Zhi He Yanhui Jia Jianxin Li IJie Cao Fangchao Liu Hongfan Li Jichun Chen Dongsheng Hu Chong Shen Yingxin Zhao Xiaoqing Liu Ling Yu Jianfeng Huang Xiangfeng Lu Dongfeng Gu Shufeng Chen Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical College/National Center for Cardiovascular DiseasesBeijingChina Department of Epidemiology and Health Statistics Cllege of Public HealthZhengzhou UniversityZhengzhouHenanChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen UniversityShenzhenGuangdongChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina Cardio-Cerebrovascular Control and research Center Institute of Basic MedicineShandong First Medical University(Shandong Academy of Medicine Sciences)JinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital and Cardiovascular InstituteGuangzhouGuangdongChina Department of Cardiology Fujian Provincial HospitalFuzhouFujianChina

Background:Population-based epidemiological evidence regarding the association between fruit and vegetable intake and the incidence of hypertension is *** prospective cohort study aimed to investigate the association between fruit and vegetable intake and the risk of new-onset ***:Based on the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR),58,981 Chinese adults without hypertension at baseline were *** on fruit and vegetable intake was collected using a food-frequency *** proportional hazards models were performed to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)of incident ***:During 640,795 person-years of follow-up,21,008 new cases of hypertension were *** with participants in the lowest quintile(Q1)of total fruit and vegetable(TFV)intake,the HRs(95%CIs)of incident hypertension were 0.90(0.86-0.95),0.85(0.81-0.90),0.82(0.78-0.86),and 0.83(0.78-0.88)for the Q2 to Q5 group(ptrendlevel(500 g/day),we found that increasing the intake of TFV,even though it was still insufficient for the recommendation,also had a protective effect against the incident *** considering the intake of fruit or vegetable separately,we found similar trends as the TFV ***:These results suggest that a higher intake of fruit and vegetable is beneficial for preventing hypertension in Chinese adults.

关键词： fruit and vegetable hypertension prospective study

Prevalence of familial hypercholesterolemia and its association with coronary artery disease:A Chinese cohort study

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Chronic Diseases and Translational Medicine 2023年第2期9卷 134-142页

作者： Xiapikatijiang Aihaiti Shufeng Chen Jianxin Li Zhennan Lin Qingmei Cui Xue Xia Fangchao Liu Chong Shen Dongsheng Hu Keyong Huang Yingxin Zhao Fanghong Lu Xiaoqing Liu Jie Cao Ling Yu Ying Li Huan Zhang Zhenyan Fu Liancheng Zhao Jianfeng Huang Dongfeng Gu Xiangfeng Lu Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina China National clinical research Center for Neurological Diseases Beijing Tiantan hospital Capital Medical UniversityBejingChina Department of Epidemiology and Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsuChina School of Public Health Zhengzhou UniversityZhengzhouHenanChina School of Public Health Shenzhen UniversityShenzhenGuangdongChina Cardio-Cerebrovascular Control and research Center Institute of Basic MedicineShandong Academy of Medical SciencesJinanShandongChina Division of Epidemiology Guangdong Provincial People's Hospital Guangdong Cardiovascular InstituteGuangzhouGuangdongChina Department of Cardiology Fujian Provincial People's HospitalFuzhouFujianChina Center for Genetic Epidemiology and Genomics School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesSoochow University Medical CollegeSuzhouJiangsuChina Department of Cardiology First Affiliated Hospital of Xinjiang Medical UniversityUrumqiXinjiangChina School of Medicine Southern University of Science and TechnologyShenzhenGuangdongChina

Background:Familial hypercholesterolemia(FH)is underrecognized,and its association with coronary artery disease(CAD)remains limited,especially in *** aimed to investigate the prevalence of FH and its relationship with CAD in a large Chinese ***:FH was defined using the Make Early Diagnosis to Prevent Early Death(MEDPED)*** crude and age-sex standardized prevalence of FH were calculated based on surveys of the Prediction for Atherosclerotic Cardiovascular Disease Risk in China(China-PAR)project during 2007−*** associations of FH with incident CAD and its major subtypes were estimated with the cohort-stratified multivariate Cox proportional hazard models based on the data from the baseline to the last follow-up(2018−2020).Results:Among 98,885 included participants,190 participants were defined as *** and age−sex standardized prevalence and 95%confidence interval(CI)of FH were 0.19%(0.17%-0.22%)and 0.13%(0.10%-0.16%),*** prevalence varied across age groups and peaked in the group of 60-<70 years(0.28%),and the peak prevalence(0.18%)in males was earlier,yet lower than the peak crude prevalence in females(0.41%).During a mean follow-up of 10.7 years,2493 cases of incident CAD were *** multivariate adjustment,FH patients had a 2.03-fold greater risk of developing CAD compared to non-FH ***:The prevalence of FH was estimated to be 0.19%in the participants,and it was associated with an elevated risk of incident *** study suggests that early screening of FH has certain public health significance for the prevention of CAD.

关键词： cohort study coronary artery disease familial hypercholesterolemia prevalence

PD-L1 Expression and Tumor Infiltrating Lymphocytes in Neurofibromatosis Type 1-Related Benign Tumors and Malignant Peripheral Nerve Sheath Tumors:An Implication for Immune Checkpoint Inhibition Therapy

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第2期3卷 63-67,75页

作者： Jin LIU Haibo LI Chengjiang WEI Qingfeng LI Zhichao WANG Shanghai Jiao Tong University School of Medicine Shanghai 200011China Xiangya Medical College of Central South University ChangshaHunan 410013China Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Background Neurofibromatosis type 1(NF1)is an autosomal dominant inherited *** can affect multiple systems of the body and cause severe disfigurement and discomfort in these *** are two types of neurofibromas,named cutaneous and plexiform *** latter type may transform into malignant peripheral nerve sheath tumors(MPNSTs).Surgical resection is difficult to perform owing to the complex tissue structure of neurofibromas;therefore,it is necessary to develop novel and effective therapies for the treatment of these *** cell death protein 1(PD-1)/programmed cell death-ligand 1(PD-L1)-related immune checkpoint inhibitors have been proven effective for various cancers,and the positive expression of PD-L1 and tumor-infiltrating lymphocytes(TILs)has been recognized as a biomarker for the response to immune checkpoint *** We conducted immunohistochemistry(IHC)staining to detect PD-L1 expression in plexiform neurofibroma and MPNST tissue *** transcription-polymerase chain reaction(RT-PCR)and western blotting were performed to detect PD-L1 and PD-1 expression in MPNST cell *** staining was used to show immune cell infiltration in NF1 and MPNST *** IHC staining showed PD-L1 positive expression in neurofibromas and MPNST tumor *** addition,qPCR and western blotting showed high expression of PD-L1 in MPNST tumor *** staining revealed that aberrant T lymphocytes infiltrated the plexiform neurofibroma and MPNST tumor *** These results indicate that immune checkpoint mechanisms may play a pivotal role in the development of NF1-related tumors,and immune checkpoint inhibitors may be effective for managing neurofibromas and *** therapy with other molecular agents may be explored in the future.

关键词： Neurofibromatosis type 1 Malignant peripheral nerve sheath tumor PD-L1 Tumor-infiltrating lymphocytes Immune checkpoint inhibition

肌肉超声束颤定量分析有助于肌萎缩侧索硬化的鉴别诊断（英文）

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Chinese Medical Sciences Journal 2023年第4期 265-272页

作者：樊静李亦牛静雯胡南管宇宙崔丽英刘明生中国医学科学院北京协和医学院北京协和医院神经内科浙江大学医学院附属第一医院神经内科

目的研究超声束颤对肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)的鉴别诊断价值。方法前瞻性收集2017年至2020年在北京协和医院就诊的ALS患者，同时招募神经根神经病患者及健康者分别作为病例对照组和健康对照组。采用医学研... 详细信息

目的研究超声束颤对肌萎缩侧索硬化(amyotrophic lateral sclerosis,ALS)的鉴别诊断价值。方法前瞻性收集2017年至2020年在北京协和医院就诊的ALS患者，同时招募神经根神经病患者及健康者分别作为病例对照组和健康对照组。采用医学研究会(Medical research Council,MRC)量表评估肌力。采用肌肉超声评估ALS及病例对照组患者双侧上下肢16组肌群的最大束颤级别、束颤总分及束颤级别。采用受试者工作特征(receiver operating characteristic,ROC)分析评估最大束颤级别、束颤总分及束颤级别诊断ALS的特异度和敏感度。结果束颤最大级别大于2级的ALS患者和神经根神经病患者的比例分别为84.9%的和9.8%，两者比较具有统计学意义(χ2=101.3,P <0.001)。ALS和神经根神经病患者的束颤总分分别为29(15,41)和3(0,8)[中位数(四分位数间距)]。ALS患者中，MRC评分为2和4分患者的肌肉束颤最明显，MRC评分为5分患者的肌肉束颤次之，MRC评分为0和1患者的肌肉束颤最不明显。束颤总分诊断ALS的敏感性和特异性分别为80.6%和93.4%(截断值为14)。对于ALS患者，MRC评分为4和5的肌肉中，肌肉束颤级别≥3的比例分别为42.3%和24.1%；对于神经根神经病患者，MRC评分为4和5的肌肉中，肌肉束颤级别≥3的比例仅为1.7%和0。结论肌肉束颤级别联合肌肉MRC评分有助于ALS的鉴别诊断。

关键词：肌萎缩侧索硬化神经根神经病肌肉超声束颤肌力