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Treatment of colonic varices with a superior mesenteric venous stent:a case report describing a unique approach

Gastroenterology Report 2021年第6期9卷 597-599页

作者： Sandra Naffouj Mustafa Al-Shammari Reena Salgia Department of Internal Medicine Henry Ford HospitalDetroitMIUSA Division of Gastroenterology and Hepatology Department of MedicineHenry Ford HospitalDetroitMIUSA

Introduction Ectopic varices are a rare cause of gastrointestinal(GI)bleeding that may occur in the GI tract outside the esophageal and gastric distribution[1].The majority of these cases are rectal varices in cirrhotic patients with portal *** varices(CV)are less common than rectal,duodenal,and smallbowel varices[2].There are no clear guidelines for managing CV given the rarity of this finding[3].We report a case of massive lower-GI bleeding due to CV in a patient with non-alcoholic steatohepatitis(NASH)without cirrhosis or portal hypertension secondary to porto-mesenteric venous thrombosis that was successfully treated with superior mesenteric venous(SMV)*** the extent of the mesenteric thrombosis,treatment modalities like transjugular intrahepatic portosystemic shunt(TIPS)and balloon-occluded retrograde transvenous obliteration(BRTO)were not possible.

关键词： venous varices balloon

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MRI and glymphatic system

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Stroke & Vascular Neurology 2019年第2期4卷 75-77页

作者： Quan Jiang Departments of Neurology Henry Ford HospitalDetroitMichiganUSA

Glymphatic system is newly discovered pseudolymphatic system in brain and it plays an important role in the removal of interstitial metabolic waste products. We discuss and review the role of glymphatic system in neurological diseases, especially focus on the potential of MRI modelling and its associated challenges to obtain useful new information related to understand the glymphatic system dynamics, pathways, and provide quantitative maps for diagnosis, monitoring and prognosis of the disease. The non-invasive nature of MRI might more readily help with translation of glymphatic measurements from the laboratory to the clinic.

关键词： lymphatic diagnosis diseases

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Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

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World Journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth E Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks Jennifer J Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAID-Division of AIDS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PEG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. METHODSA prospective, multicenter, phase 3, open-label, single-arm study of PEG-IFN alfa, weight-based RBV, and boceprevir, with a PEG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (TE) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PEG-IFN plus RBV) rates in sustained viral response (SVR). RESULTSA total of 257 enrolled participants were analyzed (135 TN and 122 TE). In the TN group, 81.5% were male and 54.1% were black. In the TE group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

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