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CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai Fengyang Jing Xuefen Li Jianyun Zhang Heyu Zhang Tiejun Li Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central Laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

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Comparative study on the hydrogen storage performance of as-milled MgRENi rapid quenched alloy catalyzed by metal sulfides

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Journal of Magnesium and Alloys 2024年第5期12卷 2010-2023页

作者： Xiaoping Dong Zhaoqing Zhang Liying Yang Shenghai Xin Dandan Su Zhiyuan Li Department of Mechanical Design and Manufacture and Automation Hebei UniversityBaoding 071000PR China Baoding New Energy Vehicle Power Engineering technology Research Center Hebei UniversityBaoding 071002PR China hebei technology Innovation Center for Lightweight of New Energy Vehicle Power System(Preparation) Hebei UniversityBaoding 071002PR China

The composites of Mg_(20)Pr_(1)Sm_(3)Y_(1)Ni_(10)as-quenched alloy and 3 wt.%M(M=CoS,CoS_(2),MoS_(2))catalyst were prepared by high-speed vibration ball *** effects of metal sulfides on the hydrogenation and dehydrogenation dynamics of alloys were *** results show that the as-milled composites contain a large number of amorphous embedded by a small amount of nanocrystals,and there are many point *** ball milling,the crystal grain size in the composites containing CoS is relatively larger,followed by CoS_(2)and MoS_(2)*** hydrogenation,the amorphous phase is crystallized to form Mg_(2)NiH_(4),YH_(3),Pr_(8)H_(18.96),Sm_(3)H_7,Mg,Co or Mo phases,however,Mg_(2)Ni,YH_(2),PrH_(2)and Ni_(3)Y phases appeared after *** maximum hydrogenation capacity of the composites containing CoS,CoS_(2)and MoS_(2)are 3.939,4.265 and 4.507 wt.%,*** hydrogenation saturation ratio of composite containing MoS_(2)is higher than that of the composites containing CoS and CoS_(2).The dehydrogenation activation energy of the composites containing CoS,CoS_(2)and MoS_(2)is 107.76,68.43 and 63.28 ***^(-1).H_(2).On the improvement of hydrogen storage performance of Mg_(20)Pr_(1)Sm_(3)Y_(1)Ni_(10)alloy,the catalytic effect of MoS_(2)sulfide is better than that of CoS_(2)sulfide,and which is better than CoS sulfide.

关键词： Mg_(20)Pr_(1)Sm_(3)Y_(1)Ni_(10)as-quenched alloy CoS CoS_(2)and MoS_(2)sulfide Milling Activation energy Hydrogen storage dynamics

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Surface vitrification of carbon by laser treatment: Insights of glass formation from molecular dynamics

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Journal of Advanced Ceramics 2024年第6期13卷 729-735页

作者： Yanhui Zhang Haifeng Yu Yongying Jia Zhisheng Zhao Li-Min Wang Riping Liu Center for Advanced Structural Materials State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China

Microstructural modification of carbon materials,such as carbon fibers(Cf)and pyrolytically deposited carbon,is important for engineering ***,the regulation of these materials is not an effortless *** understand the impacts of thermal spikes from pulsed laser processing on the structural adaptation of amorphous carbon(a-C),we performed melt quenching by molecular dynamics(MD)*** results confirm that the vitrification behavior of carbon can be tuned by adjusting the cooling rate(R),which is controlled by the thermal spikes of laser ***,we set up a two-step way to locate the critical cooling rate(R_(c))of monoatomic carbon,which is refined by the sharp change in the environmental similarity *** this novel technique,we demonstrate that the ordering degree and the local atomic motif can be largely modified by going across a bar of 100 K/ps,which is extracted as the critical cooling rate to ensure the complete amorphization of *** approach provides a criterion for both experimentally processing and theoretically simulating a-C ***,this work provides guidelines on how to tune the amorphous carbon structures of engineering materials and provides an outlook for the wonderland of amorphous carbon materials.

关键词： molecular dynamics(MD) structural order carbon fibers(Cf) vitrification critical cooling rate(R_(c))

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Regulating electrochemical performances of lithium battery by external physical field

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Rare Metals 2024年第6期43卷 2391-2417页

作者： Shi-Kang Wang Shuai Wu Yi-Cheng Song Hassanien Gomaa Cui-Hua An Qi-Bo Deng Ning Hu School of Mechanical Engineering School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai 200444China Department of Chemistry Faculty of ScienceAl-Azhar UniversityAssiut 71524Egypt Tianjin Key Laboratory of Power Transmission and Safety technology for New Energy Vehicles Tianjin 300401China State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of EducationHebei University of TechnologyTianjin 300130China

Lithium batteries have always played a key role in the field of new energy ***,non-controllable lithium dendrites and volume dilatation of metallic lithium in batteries with lithium metal as anodes have limited their ***,a large number of studies have shown that the electrochemical performances of lithium batteries can be enhanced through the regulation of external physical ***,it significantly hinders the growth of lithium dendrites and promoting the reaction *** review summarizes recent innovations in the investigation of various physical fields of lithium *** application of magnetic field in the synthesis of lithium battery electrode materials is *** influence factors and regulation mechanism of various physical fields on the electrochemical performance of lithium batteries are reviewed *** addition,the current research status and existing challenges,along with future directions for the evolution of lithium batteries,are minutely discussed and *** strategies for the further evolution of lithium batteries have also been provided.

关键词： Lithium battery External field assist Reaction kinetics Lithium dendrite

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Ultra-broadband microwave absorber and high-performance pressure sensor based on aramid nanofiber,polypyrrole and nickel porous aerogel

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1912-1921页

作者： Leyi Zhang Hongyu Jin Hanxin Liao Rao Zhang Bochong Wang Jianyong Xiang Congpu Mu Kun Zhai Tianyu Xue Fusheng Wen State Key Laboratory of Metastable Materials science&technology Yanshan UniversityQinhuangdao 066004China Key Laboratory for Microstructural Material Physics of hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

Electronic devices have become ubiquitous in our daily lives,leading to a surge in the use of microwave absorbers and wearable sensor devices across various sectors.A prime example of this trend is the aramid nanofibers/polypyrrole/nickel(APN)aerogels,which serve dual roles as both microwave absorbers and pressure *** this work,we focused on the preparation of aramid nanofibers/polypyrrole(AP15)aerogels,where the mass ratio of aramid nanofibers to pyrrole was 1:*** employed the oxidative polymerization method for the preparation *** this,nickel was thermally evaporated onto the surface of the AP15 aerogels,resulting in the creation of an ultralight(9.35 mg·cm^(-3)).This aerogel exhibited a porous *** introduction of nickel into the aerogel aimed to enhance magnetic loss and adjust impedance matching,thereby improving electromagnetic wave absorption *** minimum reflection loss value achieved was-48.7 dB,and the maximum effective absorption bandwidth spanned 8.42 GHz with a thickness of 2.9 *** impressive metrics can be attributed to the three-dimensional network porous structure of the aerogel and perfect impedance ***,the use of aramid nanofibers and a three-dimensional hole structure endowed the APN aerogels with good insulation,flame-retardant properties,and compression *** under a compression strain of 50%,the aerogel maintained its resilience over 500 *** incorporation of polypyrrole and nickel particles further enhanced the conductivity of the ***,the final APN aerogel sensor demonstrated high sensitivity(10.78 kPa-1)and thermal *** conclusion,the APN aerogels hold significant promise as ultra-broadband microwave absorbers and pressure sensors.

关键词： porous aerogel aramid nanofibers microwave absorbers pressure sensor porous structure

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A high-speed true random number generator based on Ag/SiNx/n-Si memristor

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Frontiers of physics 2024年第1期19卷 241-250页

作者： Xiaobing Yan Zixuan Zhang Zhiyuan Guan Ziliang Fang Yinxing Zhang Jianhui Zhao Jiameng Sun Xu Han Jiangzhen Niu Lulu Wang Xiaotong Jia Yiduo Shao Zhen Zhao Zhenqiang Guo Bing Bai Institute of Life science and Green Development Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei ProvinceCollege of Electron and Information EngineeringHebei UniversityBaoding 071002China

The intrinsic variability of memristor switching behavior can be used as a natural source of randomness,this variability is valuable for safe applications in hardware,such as the true random number generator(TRNG).However,the speed of TRNG is still be further ***,we propose a reliable Ag/SiNx/n-Si volatile memristor,which exhibits a typical threshold switching device with stable repeat ability and fast switching *** volatile-memristor-based TRNG is combined with nonlinear feedback shift register(NFSR)to form a new type of high-speed dual output ***,the bit generation rate reaches a high speed of 112 kb/*** addition,this new TRNG passed all 15 National Institute of Standards and technology(NIST)randomness tests without post-processing steps,proving its performance as a hardware security *** work shows that the SiNx-based volatile memristor can realize TRNG and has great potential in hardware network security.

关键词： volatile memristor true random number generator(TRNG) delay time threshold switching device

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Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

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Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-Hu Wang Ke-Wei Tong Chao-Qin Chen Jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak *** contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular *** this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence *** only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates Polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

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An Effective Power Optimization Approach Based on Whale Optimization Algorithm with Two-Populations and Mutation Strategies

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Chinese Journal of Electronics 2024年第2期33卷 423-435页

作者： Juncai HE Zhenxue HE Jia LIU Yan ZHANG Fan ZHANG Fangfang LIANG Tao WANG Limin XIAO Xiang WANG hebei Agricultural University Beijing Information science and technology University School of Computer science and Engineering Beihang University School of Electronic and Information Engineering Beihang University

Power is an issue that must be considered in the design of logic circuits. Power optimization is a combinatorial optimization problem, since it is necessary to search for a logical expression that consumes the least amount of power from a large number of Reed-Muller(RM) logical expressions. The existing approach for optimizing the power of multi-output mixed polarity RM(MPRM) logic circuits suffer from poor optimization results. To solve this problem, a whale optimization algorithm with two-populations strategy and mutation strategy(TMWOA) is proposed in this paper. The two-populations strategy speeds up the convergence of the algorithm by exchanging information about the two-populations. The mutation strategy enhances the ability of the algorithm to jump out of the local optimal solutions by using the information of the current optimal solution. Based on the TMWOA, we propose a multi-output MPRM logic circuits power optimization approach(TMMPOA). Experiments based on the benchmark circuits of the Microelectronics Center of North Carolina(MCNC) validate the effectiveness and superiority of the proposed TMMPOA.

关键词： Logic circuits Benchmark testing Search problems Whale optimization algorithms Microelectronics Optimization Convergence

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Recent advances in nickel-based catalysts in eCO_(2)RR for carbon neutrality

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Carbon Energy 2024年第2期6卷 61-91页

作者： Weikang Peng Fengfeng Li Shuyi Kong Chenxi Guo Haotian Wu Jiacheng Wang Yi Shen Xianguang Meng Mingxi Zhang hebei Key Laboratory of Inorganic Nonmetallic Materials School of Materials Science and EngineeringNorth China University of Science and TechnologyTangshanHebeiChina hebei Iron and Steel Laboratory North China University of Science and TechnologyTangshanChina State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghaiChina School of Materials science and Engineering Taizhou UniversityZhejiangChina

The excessive use of nonrenewable energy has brought about serious greenhouse *** CO_(2) into high-value-added chemicals is undoubtedly the best choice to solve energy *** to the excellent cost-effectiveness and dramatic catalytic performance,nickel-based catalysts have been considered as the most promising candidates for the electrocatalytic CO_(2) reduction reaction(eCO_(2)RR).In this work,the electrocatalytic reduction mechanism of CO_(2) over Ni-based materials is *** strategies to improve the eCO_(2)RR performance are ***,the research on Ni-based materials for syngas generation is briefly ***,the prospects of nickel-based materials in the eCO_(2)RR are provided with the hope of improving transition-metal-based electrocatalysts for eCO_(2)RR in the future.

关键词： carbon energy carbon neutrality CO_(2)reduction electrocatalysis nickel-based materials

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Chemical constituents,pharmacological activities and quality evaluation methods of genus Hippocampus:A comprehensive review

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Chinese Herbal Medicines 2024年第3期16卷 344-357页

作者： Zhiyong Zhang Xiaoyang Zhang Xi Wang Xuting Guo Xinhao Yan Zheng Li Wenlong Li College of Pharmaceutical Engineering of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

The genus Hippocampus is a multi-origin animal species with high medicinal and healthcare *** 57 species of Hippocampus spread worldwide,of which about 14 species can be used as medicine,showing anti-oxidation,anti-inflammation,anti-depressant,anti-hypertension,anti-prostatic hyperplasia,antivirus,anti-apoptotic,antifatigue,and so *** those pharmacological effects are mainly related to their active ingredients,including amino acids,abundant proteins(peptides and oligopeptides),fatty acids,nucleosides,steroids,and other small molecular *** main means of authentication of Hippocampus species are morphological identification,microscopic identification,thin layer chromatography method,fingerprint method and genomics *** review will provide useful insight for exploration,further study and precise medication of Hippocampus in the future.

关键词： chemical constituents Hippocampus pharmacological activities quality evaluation

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