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Nano research 2023年第12期16卷 13042-13055页

作者： Fenfen Li Ying Zhao Guangjun Nie School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 101408China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China GBA National Institute for Nanotechnology Innovation Guangzhou 510530China

Liver fibrosis and hepatic carcinoma(HCC)pose a huge challenge worldwide due to the lack of effective treatment options for end-stage liver *** to their functions and roles,hepatic myofibroblasts mainly include nontumoral fibroblasts(mainly activated hepatic stellate cells(HSCs)),which are involved in the wound-healing process of liver fibrosis,and cancer-associated fibroblasts(CAFs)in hepatic *** play a significant role in regulating extracellular matrix(ECM)deposition in progressive liver *** can be derived from activated HSCs and differentiate into ECM-producing ***,growing evidence shows that CAFs are the primary regulators of the HCC microenvironment,releasing growth factors and cytokines and suppressing the antitumor immune *** therapeutic strategies show reduced drug resistance and side ***-based combined strategies aim to improve the delivery efficiency of various therapeutic agents with reduced toxicity via multiple *** this review,we will discuss recent developments in combinational strategies based on nanotechnology that regulate myofibroblasts and the diseased microenvironment for liver fibrosis and HCC *** will also identify the major challenges that the field is facing and offer some insights for future drug discovery.

关键词： fibroblasts liver fibrosis hepatic carcinoma nanotechnology

recent Progress in Non-motor Features of Parkinson’s disease with a Focus on Circadian rhythm dysregulation

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Neuroscience Bulletin 2021年第7期37卷 1010-1024页

作者： Yufei Liu Long Niu Xinyao Liu Cheng Cheng Weidong Le Liaoning Provincial key Laboratory for research on the Pathogenic Mechanisms of Neurological diseases the First Affiliated HospitalDalian Medical UniversityDalian 116021China Liaoning Provincial Center for Clinical research on Neurological diseases the First Affiliated HospitalDalian Medical UniversityDalian 116021China Institute of Neurology Sichuan Academy of Medical Science-Sichuan Provincial HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Parkinson’s disease(Pd)is the second most common neurodegenerative disease,which manifests with both motor and non-motor *** rhythm dysregulation,as one of the most challenging non-motor features of Pd,usually appears long before obvious motor ***,the dysregulated circadian rhythm has recently been reported to play pivotal roles in Pd pathogenesis,and it has emerged as a hot topic in Pd *** this review,we briefly introduce the circadian rhythm and circadian rhythm-related genes,and then summarize recent research progress on the altered circadian rhythm in Pd,ranging from clinical features to the possible causes of Pd-related circadian *** believe that future comprehensive studies on the topic may not only help us to explore the mechanisms of Pd,but also shed light on the better management of Pd.

关键词： Circadian rhythm dysregulation Circadian rhythm gene Parkinson’s disease rEM sleep behavior disorder dopamine

Electrically detaching Behavior and Mechanism of Ionic Conductive Adhesives

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Chinese Journal of Polymer Science 2023年第7期41卷 1142-1154页

作者： Yong Wei Yang Mei Min Wu Song Chen Lan Liu School of Materials Science and Engineering Engineering Research Center of Biomass MaterialsMinistry of EducationSouthwest University of Science and TechnologyMianyang621010China College of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Macromolecular MaterialsSouth China University of TechnologyGuangzhou 510641China

design of rapidly detachable adhesives with high initial bonding strength is of great significance but it is full of great challenge. Here, we report the fast electrically detaching behavior (100% detaching efficiency in just 1 min under dozens of dC voltage) and high initial bonding strength (>12 MPa) of epoxy-based ionic conductive adhesives (ICAs). The epoxy-based ICAs are fabricated by introducing polyethylene glycol dimethyl ether (PEGdE) and 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([EMIM]OTF) into epoxy. The combination of PEGdE and [EMIM]OTF enables the free ions to migrate directively in electric field, and the anchoring of PEG chains onto epoxy chains ensures the long-term reliability of ICAs. The investigation on the electrically detaching mechanism suggests that the enrichment and following rapid interfacial electrochemical reactions of [EMIM]OTF lead to formation of metal hydroxide (Me(OH)n) nanoparticles at the bonding interfaces, thus the strong interactions containing interlocked forces, van de Waals’ forces and hydrogen bonding interactions between ICAs and bonding substrates are destroyed. This work provides a promising direction for detachable adhesives with both high initial bonding strength and high detaching efficiency in short time.

关键词： Ionic conductive adhesives Electrically detaching behavior Epoxy Ionic liquids

Preparation and properties of graphene nanoplatelets reinforced aluminum composites

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Transactions of Nonferrous Metals Society of China 2021年第4期31卷 878-886页

作者： Zhong ZHENG Xiao-xia YANG Jian-chao LI Xue-xi ZHANG Imran MUHAMMAd Lin GENG School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China College of Materials Science and Engineering Shandong UniversityJinan 250014China Mechanical Engineering department University of Engineering&Technology TaxilaTaxila 47050Pakistan

5.0 vol.% graphene nanoplatelets(GNPs) and aluminum powders were mixed to prepare GNPs/Al composites via high-energy ball milling(HEBM). The mixed powders were subjected to spark plasma sintering(SPS) and subsequent hot extrusion. The microstructure and mechanical properties of extruded composites were investigated by X-ray photoelectron spectroscopy(XPS), transmission electron microscopy(TEM) and tensile tests. In the extruded composites, 5.0 vol.% GNPs were dispersed homogeneously and no serious GNP-Al interfacial reaction occurred. As a result, the yield strength and ultimate tensile strength of the extruded GNPs/Al composites reached 462 and 479 MPa, which were 62% and 60% higher than those of the extruded Al matrix, respectively. The enhanced mechanical properties were attributed to the effective load transfer capacity of dispersed GNPs. This demonstrated that it may be promising to introduce dispersed high-content GNPs via HEBM, SPS and hot extrusion techniques and GNP-Al interfacial reaction can be controlled.

关键词： aluminum matrix composites graphene nano-platelets powder metallurgy interface microstructure mechanical properties

Genome-wide analysis of nuclear factor Y genes and functional investigation of watermelon ClNF-YB9 during seed development

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作物学报:英文版 2023年第5期11卷 1469-1479页

作者： Qin Feng Ling Xiao Jiafa Wang Jie Wang Chenyang Chen Jianyang Sun Xixi Wu Man Liu Xian Zhang Shujuan Tian Li Yuan State key Laboratory of Crop Stress Biology for Arid areas College of HorticultureNorthwest A&F UniversityYangling 712100ShaanxiChina Shenzhen research Institute Northwest A&F UniversityShenzhen 518000GuangdongChina

The nuclear factor Y(NF-Y) gene family is a class of transcription factors that are widely distributed in eukaryotes and are involved in various biological processes. However, the NF-Y gene family members in watermelon, a valued and nutritious fruit, remain largely unknown and their functions have not been characterized. In the present study, 22 ClNF-Y genes in watermelon, 29 CsNF-Y genes in cucumber, and 24CmNF-Y genes in melon were identified based on the whole-genome investigation and their protein properties, gene location, gene structure, motif composition, conserved domain, and evolutionary relationship were investigated. ClNF-YB9 from watermelon and its homologs in cucumber and melon were expressed specifically in seeds. Its expression remained low in the early stages of watermelon seed development,increased at 20 days after pollination(dAP), and peaked at 45–50 dAP. Moreover, the knockout mutant Clnf-yb9 exhibited abnormal leafy cotyledon phenotype, implying its critical role during seed ***, protein interaction assays showed that ClNF-YB9 interacts with all ClNF-YCs and the ClNF-YB9-YC4 heterodimer was able to recruit a ClNF-YA7 subunit to assemble a complete NF-Y complex, which may function in seed development. This study revealed the structure and evolutionary relationships of the NF-Y gene family in Cucurbitaceae and the novel function of ClNF-YB9 in regulating seed development in watermelon.

关键词： Watermelon NF-Y gene family Evolution relationship ClNF-YB9 gene function Seed development

Effects of N Management on Yield and N Uptake of rice in Central China

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Journal of Integrative Agriculture 2012年第12期11卷 1993-2000页

作者： PAN Sheng-gang HUANG Sheng-qi ZHAI Jing WANG Jing-ping CAO Cou-gui CAI Ming-li ZHAN Ming TANG Xiang-ru key Laboratory of Huazhong Crop Physiology Ecology and Production Ministry of Agriculture/College of Plant Science & Technology Huazhong Agricultural University College of Agriculture South China Agricultural University

Efficient N fertilizer management is critical for the economic production of rice and the long-term protection of environmental quality. A field experiment was designed to study the effects of N fertilizer management practices on grain yield and N uptake office. The experiment was laid out in the randomized complete block design with four replications in Central China during 2008 and 2009. Five N treatments denoted as No, NIsoA, N15oB, N24OA, and N24oB, respectively, were studied. NO represented no N application and served as a control, N15OA and N15oB indicated the total N application of 150 kg N ha-I but with two different application schedules （A and B） across the early stage of rice growth. Schedule A was applied as follows： 40% basal, 30% at 10 d after transplanting （dAT） and 30% at 36 dAT （nearly at the panicle initiation stage）, while schedule B was as follows： 30% at basal, 20% at 10 dAT, and 50% at 36 dAT. Similarly, N240A and N240B indicated the total N application of 240 kg N ha-1 with schedules A and B as described above. To quantify N uptake from fertilizer and soil, a 15N experiment was also conducted within the main experimental field, with micro-plots. Grain yields were significantly increased as N rates increased from 0 to 240 kg N ha-1. At the same rate, splitting N application as schedule B significantly increased the grain yield, spikelets per panicle, percentage of ripened grain, and 1 000-grain weight, compared with the N application according to schedule A. Mean rice recovery of N fertilizer by ~SN tracing method ranged from 25.39% at N24oA to 34.89% at NIsoB, however, N fertilizer residual rate in the soil ranged from 12.40% at N240A to 16.61% at N^s0w About 31.5 and 28.5% of total uptake of ~SN derived from basal fertilizer was absorbed at panicle initiation and heading stages, respectively. However, 65.6-92.5% of total uptake of 15N derived from topdressing fertilizer was absorbed at the heading stage. Based on yield and nitrogen recovery e

关键词： 15SN N fate N management recovery rice

Joint Communication and Computation Optimization for Wireless Powered Mobile Edge Computing with d2d Offloading

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Journal of Communications and Information Networks 2019年第4期4卷 72-86页

作者： dixiao Wu Feng Wang Xiaowen Cao Jie Xu School of Information Engineering Guangdong University of TechnologyGuangzhou 510006China

This paper studies a wireless powered mobile edge computing(MEC)system with device-to-device(d2d)-enabled task *** this system,a set of distributed multi-antenna energy transmitters(ETs)use collaborative energy beamforming to wirelessly charge multiple *** using the harvested energy,the actively computing user nodes can offload their computation tasks to nearby idle users(as helper nodes)via d2d communication links for self-sustainable remote *** consider the frequency division multiple access(FdMA)protocol,such that the d2d communications of different user-helper pairs are implemented over orthogonal frequency ***,we focus on a particular time block for task execution,which is divided into three slots for computation task offloading,remote computing,and result downloading,respectively,at different user-helper *** this setup,we jointly optimize the collaborative energy beamforming at ETs,the communication and computation resource allocation at users and helpers,and the user-helper pairing,so as to maximize the sum computation rate(i.e.,the number of task input-bits executed over this block)of the users,subject to individual energy neutrality constraints at both users and ***,we consider the computation rate maximization problem under any given user-helper pairs,for which an efficient solution is proposed by using the techniques of alternating optimization and convex ***,we develop the optimal user-helper pairing scheme based on exhaustive search and a low-complexity scheme based on greedy *** results show that the proposed design significantly improves the sum computation rate at users,as compared to benchmark schemes without such joint optimization.

关键词： mobile edge computing(MEC) wireless power transfer(WPT) device-to-device(d2d)offloading cooperative computing collaborative energy beamforming optimization

recent advances in bifunctional catalysts for zinc-air batteries:Synthesis and potential mechanisms

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Science China(Technological Sciences) 2022年第10期65卷 2221-2245页

作者： ZHAO LinWei GU TengTeng LIANG ZiWei LIU Jun School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510641China

Zinc-air batteries(ZABs) are considered promising candidates for next-generation clean and sustainable energy storage devices because of their low cost, safety, environment-friendliness, and high specific energy density. However, owing to its poor chargedischarge capacity and low efficiency, its practical application remains challenging. The main obstacles are the intrinsic slow reaction kinetics on the air cathode, including the oxygen reduction reaction(Orr) during discharging and oxygen evolution reaction(OEr) during recharging. Therefore, a reasonable design of bifunctional Orr/OEr electrocatalysts with high activity and stability is the key to the development of ZABs. In this review, the recent advances in bifunctional Orr/OEr electrocatalysts as air cathodes in ZABs are discussed from three perspectives: metal-organic framework-based catalysts, metal-free carbon catalysts, and metal-based catalysts. In particular, the synthesis, electrocatalytic activity, and potential mechanism of bifunctional catalysts in ZABs are discussed. In recent years, research on bifunctional catalysts has intensified, and the performance of these catalysts has significantly improved. However, most of the experimental products have complex preparation processes and high costs;therefore, the industrialization of these experimental products remains difficult. This review offers prospects for the optimal design of high-activity rechargeable ZAB bifunctional air cathodes.

关键词： zinc-air batteries air cathode bifunctional electrocatalysts non-noble metal catalyst

A novel Ti cored wire developed for wire-feed arc deposition of TiB/Ti composite coating

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Journal of Materials Science & Technology 2021年第24期83卷 145-160页

作者： Yang Bao Lujun Huang Shan Jiang rui Zhang Qi An Caiwei Zhang Lin Geng Xinxin Ma State key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyP.O.Box 433Harbin150001PR China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin150001PR China

A novel Ti cored wire containing Ti B2,Al60 V40 and Ti6 Al4 V mixed powders was developed for wirefeed arc deposition of Ti B/Ti composite coating,to enhance the hardness and wear resistance of Ti *** showed that after experiencing several chemical reactions,the wire was melted in the arc zone and turned into nonuniform droplets composed of Ti-Al-V-B melt and undecomposed Ti B2 *** the increase of welding current,the detachment time of droplet shortened while the transfer frequency accelerated,accompanied by the improvement in coating surface *** spatial distribution of Ti B whiskers in coating was governed by welding current.A uniform distribution could be achieved as welding current was sufficient at the expense of elevated dilution ratio,while increasing wire feeding speed could compensate the dilution loss of Ti B whisker to some *** decomposition process of Ti B_(2)particles and the microstructure evolution mechanism of coating was discussed in *** optimum coating possessed uniform microstructure,relatively low dilution ratio,and high hardness(639.1 HV_(0.5))as compared with Ti6 Al4 V substrate(326 HV_(0.5)).Indentation morphology analysis verified the excellent performance was ascribed to the load-sharing strengthening of Ti B *** study provides a high-efficiency fabrication method for the ever-developing titanium matrix composites(TMCs)coating.

关键词： Ti flux cored wire TiB/Ti composite coating Wire-feed arc deposition Microstructure evolution Hardness

A direct measurement method of quantum relaxation time

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National Science review 2021年第4期8卷 91-99页

作者： Peng Zhang Haoqi Tang Chuanchuan Gu Hong Wang Guangfu Luo Yalin Lu X.-d.Xiang department of Materials Science and Engineering & department of Physics Southern University of Science and Technology Synergetic Innovation Center of Quantum Information and Quantum Physics & Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Materials Genome Initiative Center and School of Materials Science and Engineering Shanghai Jiao Tong University State key Laboratory of Green Building Materials China Building Materials Academy guangdong Provincial key Laboratory of Computational Science and Material design Southern University of Science and Technology

The quantum relaxation time of electrons in condensed matters is an important physical property, but its direct measurement has been elusive for a century. Here, we report a breakthrough that allows direct determination of quantum relaxation time at zero and non-zero frequencies using optical *** dielectric loss function, we connect bound electron effects to the physical parameters of plasma resonance and find an extra term of quantum relaxation time from inelastic scattering between bound electrons and conduction electrons at non-zero frequencies. We demonstrate here that the frequency-dependent inelastic polarization effect of bound electrons is the dominant contribution to quantum relaxation time of conduction electrons at optical frequencies, and the elastic polarization effect of bound electrons also dramatically changes the plasma resonance frequency through effective screening to charge carriers.

关键词： quantum relaxation time plasma resonance dielectric loss function