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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg German Division of Metabolic Diseases Department of Medicine Technische Universität München 80333 Munich German german Center for Diabetes research (DZD) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany german Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany german Mouse Clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg German Institute of Pathology Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Division of Metabolic Diseases Department of Medicine Technische Universität München 80333 Munich Germany Calibrium LLC Carmel IN 46032 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich German Depar

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病

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A map of human genome variation from population-scale sequencing

A map of human genome variation from population-scale sequen...

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培育生物产业，发展绿色经济——第五届中国生物产业大会·2011基因科学与产业发展论坛

作者： The 1000 Genomes Project Consortium The 1000 Genomes Project Consortium

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and *** we present results of the pilot phase of the project,designed to develop and compare different strategies for genome-wide sequencing with high-throughput *** undertook three projects:low-coverage whole-genome sequencing of 179 individuals from four populations;high-coverage sequencing of two mother-father-child trios;and exon-targeted sequencing of 697 individuals from seven *** describe the location,allele frequency and local haplotype structure of approximately 15 million single nucleotide polymorphisms,1 million short insertions and deletions,and 20,000 structural variants,most of which were previously *** show that,because we have catalogued the vast majority of common variation,over 95%of the currently accessible variants found in any individual are present in this data *** average,each person is found to carry approximately 250 to 300 loss-of-function variants in annotated genes and 50 to 100 variants previously implicated in inherited *** demonstrate how these results can be used to inform association and functional *** the two trios,we directly estimate the rate of de novo germline base substitution mutations to be approximately 10 per base pair per *** explore the data with regard to signatures of natural selection,and identify a marked reduction of genetic variation in the neighbourhood of genes, due to selection at linked *** methods and public data will support the next phase of human genetic research.

关键词： A map of human genome variation from population-scale sequencing

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Congratulations on 80^(th)Birthday of Professor Dr.-***.E.h.Jürgen Zierep,Editorial AdvisoryBoard Member of Journal of Thermal Science

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Journal of Thermal Science 2009年第1期18卷 1-1页

作者： Professor Shen YUExecutive Chief Editor,Journal of Thermal Science

It is often observed that great scientists originate from distinguished teachers.Jü rgen Zierep is no exception to *** scientific background can be traced back to eminent scientists like ***,***,and *** Koschmieder n... 详细信息

关键词：工程热物理杂志期刊编辑出版

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