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Single-incision laparoscopic transabdominal preperitoneal repair in the treatment of adult female patients with inguinal hernia

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World Journal of Gastrointestinal surgery 2024年第1期16卷 49-58页

作者： Xiao-Jun Zhu Jing-Yi Jiao Hui-Min Xue Peng Chen Chang-Fu Qin Peng Wang Department of general surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Hernia and Abdominal Wall surgery Peking University People's HospitalBeijing 100044China

BACKGROUND Women have a 3%lifetime chance of developing an inguinal hernia,which is not as common in *** to its cosmetic benefits,single-incision laparoscopic transabdominal preperitoneal(SIL-TAPP)inguinal hernia repair is becoming in-creasingly popular in the management of inguinal hernia in ***,there are no studies comparing the safety and applicability of SIL-TAPP repair with conventional laparoscopic transabdominal preperitoneal(CL-TAPP)inguinal hernia repair for the treatment of inguinal hernia in *** To compare the outcomes of SIL-TAPP and CL-TAPP repair in adult female patients with inguinal hernia and to estimate the safety and applicability of SIL-TAPP repair in adult female inguinal hernia *** We retrospectively compared the clinical information and follow-up data of fe-male inguinal hernia patients who underwent SIL-TAPP inguinal hernia repair and those who underwent CL-TAPP inguinal hernia repair at the Affiliated Hos-pital of Nantong University from February 2018 to December 2020 and assessed the long-term and short-term outcomes of both *** This study included 123 patients,with 71 undergoing SIL-TAPP repair and 52 un-dergoing CL-TAPP *** two cohorts of patients and inguinal hernia charac-teristics were similar,with no statistically meaningful *** rate of intraoperative inferior epigastric vessel injury was lower in patients in the SIL-TAPP cohort(0,0%)than in patients in the CL-TAPP cohort(4,7.7%)and was significantly different(P<0.05).In addition,the median[interquartile range(IQR)]total hospitalization costs were significantly lower in patients in the SIL-TAPP cohort[$3287(3218-3325)]than in patients in the CL-TAPP cohort[$3511(3491-3599)].Postoperatively,the occurrence rate of trocar site hernia was lower in the SIL-TAPP cohort(0,0%)than in the CL-TAPP cohort(4,7.7%),and the median(IQR)cosmetic score was significantly higher in the SIL-TAPP cohort[10(10-10)]than in the CL-TAPP cohort[9(9

关键词： Single-incision Groin hernia Female Inguinal hernia Laparoscopic transabdominal preperitoneal inguinal hernia repair

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Robot-assisted partial splenectomy for benign splenic tumors:Four case reports

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World Journal of Clinical Oncology 2024年第10期15卷 1366-1375页

作者： Hui-Min Xue Peng Chen Xiao-Jun Zhu Jing-Yi Jiao Peng Wang Department of general surgery The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina

BACKGROUND Robotic-assisted partial splenectomy(RAPS)is a superior approach for treating splenic cysts and splenic hemangiomas,as it preserves the immune function of the spleen and reduces the risk of overwhelming post splenectomy ***-tly,there are no standardized guidelines for performing a partial *** SUMMARY Four patients with splenic cysts or splenic hemangiomas were treated by *** aspects with RAPS include carefully dissecting the splenic pedicle,accurately identifying and ligating the supplying vessels of the targeted segment,and ensuring precise hemostasis during splenic parenchymal *** successful RAPS cases are presented,where the tumors were removed by pret-reating the splenic artery,dissecting and ligating the corresponding segmental vessels of the splenic pedicle,transecting the ischemic segment of the spleen,and using electrocautery for optimal *** patients underwent successful surgeries with minimal bleeding during the procedure,and there were no signs of bleeding or recurrence *** Four cases confirm the feasibility and superiority of RAPS for the treatment of benign splenic tumors.

关键词： Partial splenectomy Robotic-assisted partial splenectomy Splenic cyst Splenic hemangiomas Case report

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Research progress on the immune microenvironment of the gallbladder in patients with cholesterol gallstones

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World Journal of Gastrointestinal surgery 2022年第9期14卷 887-895页

作者： Jing-Yi Jiao Xiao-Jun Zhu Chun Zhou Peng Wang Department of Hepatobiliary and Pancreatic surgery Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina medical School Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Hepatobiliary surgery Nantong First People's HospitalNantong 226001Jiangsu ProvinceChina Department of general Practitioner Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

Cholesterol gallstones are very common in hepatobiliary surgery and have been studied to a certain extent by doctors worldwide for ***,the mechanism of cholesterol gallstone formation is not fully understood,so there is currently no completely effective drug for the treatment and prevention of cholesterol *** formation and development of cholesterol gallstones are caused by a variety of genetic and environmental factors,among which genetic susceptibility,intestinal microflora disorders,impaired gallbladder motility,and immune disorders are important in the pathogenesis of cholesterol *** review focuses on recent advances in these *** also discuss some new targets that may be effective in the treatment and prevention of cholesterol gallstones,which may be hot areas in the future.

关键词： Microflora Cholesterol gallstones Gallbladder Pathogenesis Immune disorders

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Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality

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Cancer Communications 2023年第1期43卷 123-149页

作者： Lu Zhang Qingya Li Jing Yang Penghui Xu Zhe Xuan Jianghao Xu Zekuan Xu Department of general surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029P.R.China Jiangsu key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166P.R.China

Background:Previous studies have revealed the critical role of transglutaminase 2(TGM2)as a potential therapeutic target in cancers,but the oncogenic roles and underlying mechanisms of TGM2 in gastric cancer(GC)are not fully *** this study,we examined the role and potential mechanism of TGM2 in ***:Western blotting,immunohistochemistry,CCK8,colony formation and transwell assays were used to measure TGM2 expression in the GC cells and tissues and to examine the in vitro role of TGM2 in *** and in vivo metastasis experiments were performed to examine the in vivo role of TGM2 in *** set enrichment analysis,quantitative PCR and western blotting were conducted to screen for potential TGM2 targets involved in ***/loss-offunction and rescue experiments were conducted to detect the biological roles of STAT1 in GC cells in the context of ***-immunoprecipitation,mass spectrometry,quantitative PCR and western blotting were conducted to identify STAT1-interacting proteins and elucidate their regulatory *** in TGM2 and two molecules(ZM39923 and A23187)were used to identify the enzymatic activity of TGM2 involved in the malignant progression of GC and elucidate the underlying ***:In this study,we demonstrated elevated TGM2 expression in the GC tissues,which closely related to pathological grade,and predicted poor survival in patients with ***2 overexpression or knockdown promoted(and inhibited)cell proliferation,migration,and invasion,which were reversed by STAT1 knockdown or *** studies showed that TGM2 promoted GC progression by inhibiting STAT1 ubiquitination/***,tripartite motif-containing protein 21(TRIM21)was identified as a ubiquitin E3 ligase of STAT1 in ***2 maintained STAT1 stability by facilitating the dissociation of TRIM21 and STAT1 with GTP-binding enzymatic activity.A23187 abolished the role of TGM2 in STAT1 and reversed the pro-tumor role of TGM2 in vitro and

关键词： TGM2 STAT1 TRIM21 ubiquitination degradation gastric cancer

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