检索结果-南通市图书馆

阿魏酸通过Sirt1-NLRP3信号通路减轻辐射诱导的炎症损伤（英文）

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acupuncture and Herbal Medicine 2024年第3期 367-374页

作者：聂窈黄明月杨婷羽梅雨张慧婷魏雪高月马增春辐射医学研究所安徽智飞龙科马生物制药有限公司天津中医药大学广东药科大学

本研究旨在建立辐射诱导的炎症损伤模型，并探究阿魏酸（FA）是否能够通过Sirt1-NLRP3信号通路减轻炎症反应，为发现辐射防护药物和揭示辐射诱导炎症损伤的分子机制提供依据。通过建立小鼠辐射免疫炎症损伤模型，验证了FA的体内抗炎作... 详细信息

本研究旨在建立辐射诱导的炎症损伤模型，并探究阿魏酸（FA）是否能够通过Sirt1-NLRP3信号通路减轻炎症反应，为发现辐射防护药物和揭示辐射诱导炎症损伤的分子机制提供依据。通过建立小鼠辐射免疫炎症损伤模型，验证了FA的体内抗炎作用。实验中，C57BL/6J小鼠被随机分为六组，接受5Gy全身照射以建立模型。在辐照前，小鼠连续12天接受胃溶剂、氨磷汀或不同剂量（25、50、100 mg/kg）的FA处理。辐照24小时后，收集小鼠血清以测定炎症因子IL-1β、IL-18、IL-6和TNF-α的水平，并计算脾脏和胸腺组织的脏器指数，随后进行病理检查和免疫荧光检测。结果显示，FA能够减轻辐射引起的脾脏和胸腺指数下降，显著降低血清中炎症因子的分泌，并逆转辐射诱导的小鼠脾脏和胸腺组织淋巴细胞减少。此外，FA还能激活Sirt1，抑制NLRP3炎症小体的表达，从而减轻炎症反应。因此，FA在动物水平上显示出减轻辐射引起的炎症的潜力，这可能是通过激活Sirt1和降低NLRP3炎症小体的表达，减少炎症因子分泌实现的。

关键词：阿魏酸辐射炎症 NLRP3炎症小体 Sirt1

In memory of Prof. Yang Zhong

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

science Bulletin 2017年第24期62卷 1626-1627页

作者： Xiao-Ya Chen Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China

Arabidopsis thaliana serves as a model organism for the study of genetics, and is the first flowering plant to get its genome completely sequenced. It also has greatly advanced our understanding of intraspecific genome variations. The extreme and unforgiving environments in Xizang （Tibet）, mainly due to the high altitude, have prompted scientists to ask how wild populations of plants adapt to biotic and abiotic environments.

关键词： In memory Prof. Yang Zhong

维普期刊数据库

Fungal diversity notes 603–708: taxonomic and phylogenetic notes on genera and species

在线全文

学校读者我要写书评

暂无评论

Fungal Diversity 2017年第6期87卷 1-235页

作者： Kevin D.Hyde Chada Norphanphoun Vanessa P.Abreu Anna Bazzicalupo K.W.Thilini Chethana Marco Clericuzio Monika C.Dayarathne Asha J.Dissanayake Anusha H.Ekanayaka Mao-Qiang He Sinang Hongsanan Shi-Ke Huang Subashini C.Jayasiri Ruvishika S.Jayawardena Anuruddha Karunarathna Sirinapa Konta Ivana Kusan Hyun Lee Junfu Li Chuan-Gen Lin Ning-Guo Liu Yong-Zhong Lu Zong-Long Luo Ishara S.Manawasinghe Ausana Mapook Rekhani H.Perera Rungtiwa Phookamsak Chayanard Phukhamsakda Igor Siedlecki Adriene Mayra Soares Danushka S.Tennakoon Qing Tian Saowaluck Tibpromma Dhanushka N.Wanasinghe Yuan-Pin Xiao Jing Yang Xiang-Yu Zeng Faten A.Abdel-Aziz Wen-Jing Li Indunil C.Senanayake Qiu-Ju Shang Dinushani A.Daranagama Nimali Ide Silva Kasun M.Thambugala Mohamed A.Abdel-Wahab Ali H.Bahkali Mary L.Berbee Saranyaphat Boonmee D.Jayarama Bhat Timur S.Bulgakov Bart Buyck Erio Camporesi Rafael F.Castaneda-Ruiz Putarak Chomnunti Minkwan Doilom Francesco Dovana Tatiana B.Gibertoni Margita Jadan Rajesh Jeewon E.B.Gareth Jones Ji-Chuan Kang Samantha C.Karunarathna Young Woon Lim Jian-Kui Liu Zuo-Yi Liu Helio Longoni Plautz Jr Saisamorn Lumyong Sajeewa S.N.Maharachchikumbura Neven Matocec Eric H.C.McKenzie Armin Mesic Daniel Miller Julia Pawłowska Olinto L.Pereira Itthayakorn Promputtha Andrea I.Romero Leif Ryvarden Hong-Yan Su Satinee Suetrong Zdenko Tkalcec Alfredo Vizzini Ting-Chi Wen Komsit Wisitrassameewong Marta Wrzosek Jian-Chu Xu Qi Zhao Rui-Lin Zhao Peter E.Mortimer Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of science Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Research foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand A.M.B Circolo Micologico“Giovanni Carini”C.P.314BresciaItaly A.M.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18Forlı`Italy Centre of Mountain Ecosystem Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China College of Agriculture and Biological sciences Dali UniversityDali 671003YunnanPeople’s Republic of China College of Life sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Department of Botany University of British ColumbiaVancouverCanada Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box:2455Riyadh 1145Saudi Arabia Department of Botany and Microbiology Faculty of ScienceSohag UniversitySohag 82524Egypt Department of Crop sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityP.O.Box 34123 Al-KhodOman Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Health sciences Faculty of ScienceUniversity of MauritiusReduit 80837Mauritius Department of Molecular Phylogenetics and Evolution Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsaw_Zwirki i Wigury 10102-089 WarsawPoland Departamento de Micologia Centro de BiocienciasUniversidade Federal de PernambucoAv.da Engenharia s/nRecifePernambuco 50760-600Brazil Dipartimento

This is the sixth in a series of papers where we bring collaborating mycologists together to produce a set of notes of several taxa of *** this study we introduce a new family Fuscostagonosporaceae in *** also introduce the new ascomycete genera Acericola,Castellaniomyces,Dictyosporina and Longitudinalis and new species Acericola italica,Alternariaster trigonosporus,Amarenomyces dactylidis,Angustimassarina coryli,Astrocystis bambusicola,Castellaniomyces rosae,Chaetothyrina artocarpi,Chlamydotubeufia krabiensis,Colletotrichum lauri,Collodiscula chiangraiensis,Curvularia palmicola,Cytospora mali-sylvestris,Dictyocheirospora cheirospora,Dictyosporina ferruginea,Dothiora coronillae,Dothiora spartii,Dyfrolomyces phetchaburiensis,Epicoccum cedri,Epicoccum pruni,Fasciatispora calami,Fuscostagonospora cytisi,Grandibotrys hyalinus,Hermatomyces nabanheensis,Hongkongmyces thailandica,Hysterium rhizophorae,Jahnula guttulaspora,Kirschsteiniothelia rostrata,Koorchalomella salmonispora,Longitudinalis nabanheensis,Lophium zalerioides,Magnibotryascoma mali,Meliola clerodendri-infortunati,Microthyrium chinense,Neodidymelliopsis moricola,Neophaeocryptopus spartii,Nigrograna thymi,Ophiocordyceps cossidarum,Ophiocordyceps issidarum,Ophiosimulans plantaginis,Otidea pruinosa,Otidea stipitata,Paucispora kunmingense,Phaeoisaria microspora,Pleurothecium floriforme,Poaceascoma halophila,Periconia aquatica,Periconia submersa,Phaeosphaeria acaciae,Phaeopoacea muriformis,Pseudopithomyces kunmingnensis,Ramgea ozimecii,Sardiniella celtidis,Seimatosporium italicum,Setoseptoria scirpi,Torula gaodangensis and Vamsapriya *** also provide an amended account of Rhytidhysteron to include apothecial ascomata and a J?*** type species of Ascotrichella hawksworthii(Xylariales genera incertae sedis),Biciliopsis leptogiicola(Sordariomycetes genera incertae sedis),Brooksia tropicalis(Micropeltidaceae),Bryochiton monascus(Teratosphaeriaceae),Bryomyces scapaniae(Pseud

关键词： Ascomycota Basidiomycota Mucoromycota Phylogeny Taxonomy

黄土高原典型流域淤地坝系泥沙拦截动态模拟（英文）

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2023年第8期 209-221页

作者： Pengcheng Sun Yiping Wu Key Laboratory of Degraded and Unused Land Consolidation Engineering the Ministry of Natural Resources Shaanxi Provincial Land Engineering Construction Group Co.Ltd. Key Laboratory of Soil and Water Conservation on the Loess Plateau of Ministry of Water Resources Yellow River Institute of Hydraulic Research Technology Innovation Center for Land Engineering and Human Settlement Shaanxi Provincial Land Engineering Construction Group Co.Ltd.& Xi'an Jiaotong University

Check-dam construction is an effective and widely used method for sediment trapping in the Yellow River Basin and other places over the world that are prone to severe soil erosion. Quantitative estimations of the dynamic sediment trapped by check dams are necessary for evaluating the effects of check dams and planning the construction of new ones. In this study, we propose a new framework, named soil and water assessment tool(SWAT)–dynamic check dam(DCDam), for modeling the sediment trapped by check dams dynamically, by integrating the widely utilized SWAT model and a newly developed module called DCDam. We then applied this framework to a typical loess watershed, the Yan River Basin, to assess the time-varying effects of check-dam networks over the past 60 years(1957–2016). The DCDam module generated a specific check-dam network to conceptualize the complex connections at each time step(monthly). In addition, the streamflow and sediment load simulated by using the SWAT model were employed to force the sediment routing in the check-dam network. The evaluation results revealed that the SWAT-DCDam framework performed satisfactorily, with an overestimation of 11.50%,in simulating sediment trapped by check dams, when compared with a field survey of the accumulated sediment deposition. For the Yan River Basin, our results indicated that the designed structural parameters of check dams have evolved over the past 60 years, with higher dams(37.14% and 9.22% increase for large dams and medium dams, respectively) but smaller controlled areas(46.03% and 10.56% decrease for large dams and medium dams, respectively) in recent years. Sediment retained by check dams contributed to approximately 15.00% of the total sediment load reduction in the Yan River during 1970–2016. Thus, our developed framework can be a promising tool for evaluating check-dam effects,and this study can provide valuable information and support to decision-making for soil and water conservation and check-dam

关键词：

Fungal diversity notes 1151-1276:taxonomic and phylogenetic contributions on genera and species of fungal taxa

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2020年第1期100卷 5-277页

作者： Kevin DHyde Yang Dong Rungtiwa Phookamsak Rajesh Jeewon DJayarama Bhat EBGareth Jones Ning‑Guo Liu Pranami DAbeywickrama Ausana Mapook Deping Wei Rekhani HPerera Ishara SManawasinghe Dhandevi Pem Digvijayini Bundhun Anuruddha Karunarathna Anusha HEkanayaka Dan‑Feng Bao Junfu Li Milan CSamarakoon Napalai Chaiwan Chuan‑Gen Lin Kunthida Phutthacharoen Sheng‑Nan Zhang Indunil CSenanayake Ishani DGoonasekara Kasun MThambugala Chayanard Phukhamsakda Danushka STennakoon Hong‑Bo Jiang Jing Yang Ming Zeng Naruemon Huanraluek Jian‑Kui(Jack)Liu Subodini NWijesinghe Qing Tian Saowaluck Tibpromma Rashika SBrahmanage Saranyaphat Boonmee Shi‑Ke Huang Vinodhini Thiyagaraja Yong‑Zhong Lu Ruvishika SJayawardena Wei Dong Er‑Fu Yang Sanjay KSingh Shiv Mohan Singh Shiwali Rana Sneha SLad Garima Anand Bandarupalli Devadatha MNiranjan VVenkateswara Sarma Kare Liimatainen 馻‑ Tuula Niskanen Andy Overall Renato Lúcio Mendes Alvarenga Tatiana Baptista Gibertoni Walter PPfliegler EnikőHorváth Alexandra Imre Amanda Lucia Alves Ana Carla da Silva Santos Patricia Vieira Tiago Timur SBulgakov Dhanushaka NWanasinghe Ali HBahkali Mingkwan Doilom Abdallah MElgorban Sajeewa SNMaharachchikumbura Kunhiraman CRajeshkumar Danny Haelewaters Peter EMortimer Qi Zhao Saisamorn Lumyong Jianchu Xu Jun Sheng Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina State Key Laboratory for Conservation and Utilization of Bio‑Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China Yunnan Research Institute for Local Plateau Agriculture and Industry Kunming 650201China Key Laboratory for Agro‑biodiversity and Pest Control of Ministry of Education Yunnan Agricultural UniversityKunming 650201China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanChina Centre for Mountain Futures(CMF) Kunming Institute of BotanyKunming 650201YunnanChina Mushroom Research foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Health sciences Faculty of ScienceUniversity of MauritiusReduitMauritius No.128/1‑J Azad Co‑Op Housing SocietyCurcaGoa Velha 403108India Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Department of Botany and Microbiology College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Kingdom of Saudi Arabia School of science Mae Fah Luang UniversityChiang Rai 57100Thailand Faculty of Agriculture National Resources and EnvironmentNaresuan UniversityPhitsanulok 65000Thailand Beijing Key Laboratory of Environment Friendly Management on Fruit Diseases and Pests in North China Institute of Plant and Environment ProtectionBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China Department of Soil Ecology UFZ-Helmholtz Centre for Environmental ResearchHalleGermany Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyang 550006GuizhouChina Shenzhen Key Laboratory of Microbial Genetic Engineering College of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Department of Plant M

Fungal diversity notes is one of the important journal series of fungal taxonomy that provide detailed descriptions and illustrations of new fungal taxa,as well as providing new information of fungal taxa *** article is the 11th contribution to the fungal diversity notes series,in which 126 taxa distributed in two phyla,six classes,24 orders and 55 families are described and *** in this study were mainly collected from Italy by Erio Camporesi and also collected from China,India and Thailand,as well as in some other European,North American and South American *** described in the present study include two new families,12 new genera,82 new species,five new combinations and 25 new records on new hosts and new geographical distributions as well as sexual-asexual *** two new families are Eriomycetaceae(Dothideomycetes,family incertae sedis)and Fasciatisporaceae(Xylariales,Sordariomycetes).The twelve new genera comprise Bhagirathimyces(Phaeosphaeriaceae),Camporesiomyces(Tubeufiaceae),Eriocamporesia(Cryphonectriaceae),Eriomyces(Eriomycetaceae),Neomonodictys(Pleurotheciaceae),Paraloratospora(Phaeosphaeriaceae),Paramonodictys(Parabambusicolaceae),Pseudoconlarium(Diaporthomycetidae,genus incertae sedis),Pseudomurilentithecium(Lentitheciaceae),Setoapiospora(Muyocopronaceae),Srinivasanomyces(Vibrisseaceae)and Xenoanthostomella(Xylariales,genera incertae sedis).The 82 new species comprise Acremonium chiangraiense,Adustochaete nivea,Angustimassarina camporesii,Bhagirathimyces himalayensis,Brunneoclavispora camporesii,Camarosporidiella camporesii,Camporesiomyces mali,Camposporium appendiculatum,Camposporium multiseptatum,Camposporium septatum,Canalisporium aquaticium,Clonostachys eriocamporesiana,Clonostachys eriocamporesii,Colletotrichum hederiicola,Coniochaeta vineae,Conioscypha verrucosa,Cortinarius ainsworthii,Cortinarius aurae,Cortinarius britannicus,Cortinarius heatherae,Cortinarius scoticus,Cortinarius subsaniosus,Cytospora fusispor

关键词： 96 new taxa Agaricomycetes Ascomycota Basidiomycota Dothideomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Saccharomycetes Taxonomy

消栓肠溶胶囊辅助治疗缺血性脑卒中的疗效及机制研究：一项随机临床试验（英文）

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional chinese Medical sciences 2024年第4期 405-414页

作者：温春丽苏志霞丁志斌马存根胡风云宋丽娟朱陵群北京中医药大学东直门医院山西省人民医院山西省白求恩医院山西中医药大学神经生物学研究中心

目的：观察消栓肠溶胶囊（XSECC）治疗脑梗死的临床疗效，探索其可能的作用机制。方法：急性缺血性脑卒中（AIS）气虚血瘀型患者被随机分配到对照组和观察组。在第0天、第14天、第30天和第90天，使用美国国立卫生研究院卒中量表（NIHSS... 详细信息

目的：观察消栓肠溶胶囊（XSECC）治疗脑梗死的临床疗效，探索其可能的作用机制。方法：急性缺血性脑卒中（AIS）气虚血瘀型患者被随机分配到对照组和观察组。在第0天、第14天、第30天和第90天，使用美国国立卫生研究院卒中量表（NIHSS）、日常生活活动量表（ADL）、Hachinski缺血量表（HIS）、Barthel指数（BI）、临床疗效评分和中医证候评分对患者进行评估。此外，在第30天和第90天测量了VEGF和BDNF水平。最后，分析两组中每个量表评分和血管神经因子的变化。结果：治疗14天后，观察组在NIHSS、ADL和BI的差异值上均高于对照组，并且中医证候和临床疗效评分也有所增加（P <0.05）。治疗30天后，NIHSS、ADL、HIS和中医证候评分与对照组相比有所下降，而BI和临床疗效评分则有所增加（P<0.05）。90天后，观察组在ADL的差异值上高于对照组，并且中医证候评分也有所增加（P=0.047,P=0.005）。在第14天、第30天和第90天，观察组的VEGF和BDNF水平高于对照组（P<0.05）。第0天的VEGF和BDNF水平与急性缺血性中风患者的预后相关；因此，它们对急性脑梗死的预后具有预测价值。结论：联合消栓肠溶胶囊治疗可以改善急性和复发性脑梗死患者的临床疗效。其作用机制可能与促进血管内皮生长因子（VEGF）和脑源性神经营养因子（BDNF）的分泌有关。

关键词：脑梗塞消栓肠溶胶囊气虚血瘀血管内皮生长因子脑源性神经营养因子