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Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan Yi-Juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1

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Protein & Cell 2015年第12期6卷 881-889页

作者： Chuankai Zhang Yunda Zhang Weiji Ding Yancheng Lin Zhengjie Huang Qi Luo Department of Gastrointestinal Surgery First Affiliated Hospital of Xiamen University Xiamen 361003 China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Xiamen 361102 China Department of Gastrointestinal Surgery First Clinical Medical College of Fujian Medical University Fuzhou 350005 China

MicroRNAs （miRNAs） are small noncoding RNAs that have a pivotal role in the post-transcriptional regulation of gene expression by sequence-specifically targeting multiple mRNAs. Although miR-33a was recently repotted to play an important role in lipid homeostasis, atherosclerosis, and hepatic fibrosis, the functions of miR-33a in tumor progression and metastasis are lar- gely unknown. Here, we found that downregulated miR- 33a in breast cancer tissues correlates with lymph node metastasis. MiR-33a expression is significantly lower in the highly metastatic breast cancer cell lines than the noncancerous breast epithelial cells and non-metastatic breast cancer cells. Moreover, the overexpression of miR-33a in metastatic breast cancer cells remarkably decreases cell proliferation and invasion in vitro and significantly inhibits tumor growth and lung metastasis in vivo, whereas its knockdown in non-metastatic breast cancer cells significantly enhances cell proliferation and invasion in vitro and promotes tumor growth and lung metastasis in vivo. Combining bioinformatics prediction and biochemical analyses, we showed that ADAM9 and ROS1 are direct downstream targets of miR-33a. These findings identified miR-33a as a negative regulator of breast cancer cell proliferation and metastasis.

关键词： miR-33a breast cancer proliferation,metastasis

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Growth and Characterization of γ-Nd^(3+): LaSc_3(BO_3)_4 Crystal

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Chinese Journal of Structural Chemistry 2001年第4期20卷 256-258页

作者：林洲斌王国富等 fujian Inst. Res. Struct. of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China

A new laser crystal Nd0.05La0.95Sc3(BO3)4 up to 50mm(38mm(7 mm was grown by top-seeded solution growth method from a Li6B4O9 flux. The grown crystal was characterized by X-ray powder diffraction. Its crystal structure is monoclinic with space group Cc and the unit cell dimensions: a=12.066(5), b=9.864(2), c=7.740(3) ?,β= 105.48(5)(, V=887.8(6)?3, Z=4, Dc=3.81g/cm3, which belongs to low-temperature phase. The optical absorption of the crystal shows that NLSB has a strong absorption band at 807.7 nm, which is suitable for laser-diode pumping.

关键词： lanthanum scandium borate crystal flux method X-ray powder diffraction absorption spectrum

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Enhanced removal of antibiotic resistance genes during chicken manure composting after combined inoculation of Bacillus subtilis with biochar

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Journal of Environmental sciences 2024年第1期135卷 274-284页

作者： Zewen Wu Luan Zhang Hao Lin Shungui Zhou fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China School of Environmental science and Engineering Hubei Key Laboratory of Mine Environmental Pollution Control and RemediationHubei Polytechnic UniversityHuangshi 435003China fujian Provincial Key Laboratory of Eco-Industrial Green technology Wuyi UniversityWuyishan 354300China

This study explored the combined effects of Bacillus subtilis inoculation with biochar on the evolution of bacterial communities,antibiotic resistance genes(ARGs),and mobile genetic elements(MGEs)during the composting of chicken *** results showed that *** inoculation combined with biochar increased bacterial abundance and diversity as well as prolonged the compost thermophilic *** organic matter biodegradation and facilitated the organic waste compost humification process,reduced the proliferation of ARGs by altering the bacterial *** and Actinobacteriota were the main resistant bacteria related to ARGs and *** decrease in ARGs and MGEs was associated with the reduction in the abundance of related host *** inoculation with *** and the addition of biochar could promote nutrient transformation,reduce the increase in ARGs and MGEs,and increase the abundance of beneficial soil taxa.

关键词： Antibiotic resistance gene Bacillus subtilis Bacterial community Biochar Composting

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Decolorization of azo dyes by a salt-tolerant Staphylococcus cohnii strain isolated from textile wastewater

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Frontiers of Environmental science & Engineering 2012年第6期6卷 806-814页

作者： Bin YAN Cuihong DU Meilan XU Wenchao LIAO Department of Environmental Engineering Xiamen University of TechnologyXiamen 361024China School of Biotechnology Engineering Jimei UniversityXiamen 361021China

The salt-tolerant Staphylococcus cohnii strain, isolated from textile wastewater, has been found effective on decolorizing several kinds of azo dyes with different structures. The optimal conditions for azo dye acid red B （ARB） decolorization by S. cohnii were determined to be pH= 7.0 and 30℃. The decolorization efficiency increased with the increase of the salinity concentration, and around 90% of ARB （100mg.L-1） could be decolorized in 24 h when the salinity concentration was up to 50 g-L 1. Moreover, the strain could still decolorize 19% of ARB in 24 h even when the NaC1 concentration was increased to 150 g. L1. Meanwhile, the dependence of the specific decolorization rate by S. cohnii on the ARB concentration could be described with Michaelis-Menten kinetics （Kin = 585.7mg·L-1, Vmax = t09.8mg-g cell ·h ^-1）. The addition of quinone redox mediator, named 2-hydroxy-l,4-naphthoquinone and anthraqui- none-2,6-disulfonate, significantly accelerated the deco- lorization performance ofS. cohnii. Furtherly, the activities of azoreductase （0.55 μ*** protein^-***-1） and Nicotineamide adenine dinucleotide-dichlorophenol indophenol （NADH-DCIP） reductase （8.9μ*** ***-1） have been observed in the crude cell extracts of S. cohnii. The decolorization products of ARB were analyzed by HPLC-MS, and the results indicated the reductive pathway was responsible for azo dye decoloriza- tion by S. cohnii.

关键词： Staphylococcus cohnii decolorization salt,azoreductase Nicotineamide adenine dinucleotide-dichlor-ophenol indophenol (NADH-DCIP) reductase

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Dynamic characteristics of charged droplets in an electrostatic spraying process with twin capillaries

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2403-2411页

作者： Jun Zhang Hongzhou He Guanxing Huang Cleaning Combustion and Energy Utilization Research Center of fujian Province School of Mechanical Engineering Jimei University Engineering training Centre Jimei University

The experimental and simulated investigations on electrostatic spraying with twin capillaries are carried out. The starting electric voltage required for the cone-jet and the deposition characteristics of the droplets are *** whole spraying process, which includes jet and droplet motions, is simulated and the simulated results on the motions of jet and droplet are basically consistent with the experiments. According to the simulated results,the contributions of various electric forces to droplet movement are quantitatively analyzed and the droplet dynamic characteristics, especially the interaction mechanism between two sprays, are revealed. The test results on the droplet deposition characteristics partially support the simulated results on the droplet motion. The present work is useful for a better understanding on the interaction between sprays in double or multi-capillary system.

关键词： Electrostatic spray Twin capillaries Simulation Interaction

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Robust 3D network architectures of MnO nanoparticles bridged by ultrathin graphitic carbon for high-performance lithium-ion battery anodes

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Nano Research 2018年第2期11卷 1135-1145页

作者： Jingchun Jia Xiang Hu Zhenhai Wen Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou China fujian Provincial Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou China

A strategy was developed to fabricate a set of MnO@C nanohybrids with MnO nanopartides （NPs） embedded in an ultrathin three-dimensional （3D） carbon framework for use as anode materials for lithium-ion batteries （LIBs）. The 3D carbon frameworks provide MnO NPs with electrical pathways and mechanical robustness, which efficiently improved the reaction kinetics, prevented the MnO from fracturing and agglomerating, and limited the formation of a solid electrolyte interface （SEI） at the MnO-electrolyte interface. Benefitting from the unique 3D framework structure, the MnO/C nanohybrids carbonized at 500 ℃ exhibited a highly reversible specific capacity of 1,420 mAh.g-1 at 0.2 A.g-1, excellent cycling stability with 98% capacity retention, and enhanced rate performance of 680 mAh-g-1 at 2 A.g-L The feasibility of the large-scale production of such MnO/C nanohybrids, associated with their outstanding Li-ion storage properties, opens a promising avenue for the development of high-performance anodes for next- generation LIBs.

关键词： network architectures ultrathin carbon MnO Li-ion batter anode

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Sensitizing effect of Nd^(3+) on Tb^(3+) activated ZrP_(2)O_(7) long persistent phosphor materials

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Journal of Rare Earths 2021年第7期39卷 757-764,I0001页

作者： Meihua Wu Wen Chen Siyuan Liu Yichao Sun Lingfeng Huang Guoliang Chen Zishan Zheng School of Chemistry Chemical Engineering&EnvironmentMinnan Normal UniversityZhangzhou 363000China

The long persistent phosphors of Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)with Nd^(3+)as sensitized ions and Tb^(3+)as emission centers were synthesized using high temperature solid state *** crystal structure and defects,excitation and emission spectra,decay curves and thermoluminescence(TL) curves of the phosphors were *** synthesized Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is essentially in line with the standard card PDF#*** emission band with main peak at 548 nm exhibits the characteristic transitions of ^(5)D_(3)-^(7)F_(j)(j=5,4) and ^(5)D_(3)-^(7)F_(j)(j=6,5,4,3) of Tb^(3+).The analysis of excitation and emission spectra shows that there exists the overlap between the emission peaks of Nd^(3+)at 466 and 485 nm and the excitation of Tb^(3+)at 443 and 485 nm,and the energy transfer from Nd^(3+)to Tb^(3+)plays an important role in the improvement of luminescence *** decay curves shows that Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)has longer afterglow time than ZrP_(2)O_(7) and Zr_(0.982)P_(2)O_(7):0.018 Tb^(3+).Additionally,the TL curves indicate that the trap depth at 0.72 eV in Zr_(0.97)P_(2)O_(7):0.018 Tb^(3+),0.012 Nd^(3+)is to the benefit of the afterglow *** possible luminescence mechanism of ZrP_(2)O_(7):Tb^(3+),Nd^(3+)is proposed on the basis of the XPS spectra,EPR spectra,excitation and emission spectra,decay curves,TL curves and the analysis of defect equations.

关键词： ZrP_(2)O_(7) Tb^(3+) Nd^(3+) Sensitizer Energy transfer Rare earths

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Improvement of mechanical properties, microscopic structures, and antibacterial activity by Ag/ZnO nanocomposite powder for glaze-decorated ceramic

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Journal of Advanced Ceramics 2017年第3期6卷 269-278页

作者： Qian ZHANG Lv Si XU Xiaoyan GUO College of Chemical Engineering Huaqiao University Xiamen China

With the increase in the international trade of ceramics, improvement in the physical and chemical properties of ceramics has become a market demand in recent years. The addition of nanomaterials in glaze can simultaneously improve the mechanical and corrosion resistance properties of ceramics. In this study, the effect of nano-sized Ag/ZnO in glazed ceramic was investigated considering the hardness, whiteness, and microscopic structures of the products. Results showed that the Ag/ZnO nanocomposite powder significantly affects the performance of glaze. Glaze hardness reached the highest value (96.6 HV) at the low sintering temperature of 1130 ℃ with the addition of 10% Ag/ZnO nanocomposite powder. Furthermore, the Ag/ZnO nanocomposite powder improved crack resistance and whiteness. Ag as AgO and Ag2O in the glaze was effective for antibacterial activity of ceramic. In addition, the Ag/ZnO nanocomposite powder could also promote the shrinkage of bubbles in the glaze layer and smooth the glaze. These results indicated that the nanoparticles could act as an active center for melting raw materials, which is crucial for ceramic properties.

关键词： Ag/ZnO nanocomposite powder sintering temperature performance microstructure antibacterial activity

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