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High temperature self-lubricating Ti-Mo-Ag composites with exceptional high mechanical strength and wear resistance

Journal of Materials Science & Technology 2024年第13期180卷 80-90页

作者： Yu Zhen Minghui Chen Chengtao Yu Zongbang Yang Yang Qi Fuhui Wang Shenyang National Laboratory for Materials Science Northeastern UniversityShenyang 110819China School of Mechanical Engineering Ningxia Institute of Science and TechnologyShizuishan 753000China Lingyun Science&Technology Group Co.Ltd Wuhan 430040China

Titanium alloys are of keen interest as lightweight structural materials for aerospace and automotive ***,a longstanding problem for these materials is their poor tribological ***,we designed and fabricated a multiphase Ti-Mo-Ag composite(TMA)with heterogeneous triple-phase precipitation(TPP)structure by spark plasma sintering.A lamellarα-phase(αL)precipitates from theβ-phase under furnace cooling conditions and maintains a Burgers orientation relationship(BOR)withβ-*** active eutectic transition also occurs in the titanium matrix,resulting in TiAg *** intersecting acicular TiAg and lamellarαL cutβgrains into fine blocks and the primary equiaxedαphase also provides many interfaces withβphase,which together effectively impede dislocation move-ment and increase *** with other titanium composites,TMA with TPP microstructure gets an excellent combination of strength(yield strength 1205 MPa)and toughness(fracture strain 27%).Furthermore,the TPP structure endows TMA with strong cracking resistance,which aids in reducing abra-sive debris at high temperatures during sliding and obtaining a low wear ***,Ag parti-cles distributed at grain boundaries will easily diffuse to the wear surface,in situ forming the necessary lubricating phase Ag_(2)MoO_(4) with Mo-rich matrix debris via *** possesses excellent tribologi-cal properties with especially low wear rate of 8.0 x 10^(-6)mm^(3)N^(-1)m^(-1) and friction coefficient(CoF)of merely 0.20 at 600℃.Unlike other self-lubricating composites with high volume fraction of soft ceramic lubricants,which inevitably sacrifice their mechanical strength and ductility,the composite TMA pos-sesses well-balanced strength,toughness and self-lubricating *** holds important implications to design other metal matrix self-lubricating composites(MMSCs)used for load-bearing moving parts.

关键词： Titanium High-temperature oxidation Self-lubricating Mechanical properties

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Constructing the wolfberry(Lycium spp.) genetic linkage map using AFLP and SSR markers

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Journal of Integrative Agriculture 2022年第1期21卷 131-138页

作者： YIN Yue AN Wei ZHAO Jian-hua LI Yan-long FAN Yun-fang CHEN Jin-huan CAO You-long ZHAN Xiang-qiang State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100P.R.China National Wolfberry Engineering Research Center Ningxia Academy of Agricultural and Forestry SciencesYinchuan 751002P.R.China College of Biological Sciences and Technology Beijing Forestry UniversityBeijing 100083P.R.China

Genetic linkage maps are important for quantitative trait locus(QTL) and marker-assisted selection breeding. The wolfberry(Lycium spp.) is an important food and traditional medicine in China. However, few construction genetic linkage maps have been reported because of the lack of genomic and genetic resources. In this study, a population of 89 F1 seedings was derived from a cross between two heterozygous parents, L. chinense var. potaninii ‘BF-01’(female)and L. barbarum var. auranticarpum ‘NH-01’(male), in order to construct a genetic linkage map using simple sequence repeat(SSR) and amplified fragment length polymorphism(AFLP) markers based on the double pseudo-test cross mapping strategy. The resulting genetic map consisted of 165 markers(74 AFLPs and 91 SSRs) distributed across 12 linkage groups and spanned a total length of 557.6 cM with an average distance of 3.38 cM between adjacent *** 12 linkage groups contained 3 to 21 markers and ranged in length from 8.6 to 58.3 cM. Twenty-nine segregated markers distributed in the map were mainly located on LG4 and LG9 linkage groups at P<0.05. This is the first linkage map of Lycium species using SSR and AFLP markers, which can serve as basis for improving genes and selective breeding of the genome assembly.

关键词： Lycium genetic linkage map AFLP SSR

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Warming moxibustion attenuates inflammation and cartilage degradation in experimental rabbit knee osteoarthritis

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Journal of Traditional Chinese Medicine 2021年第6期41卷 959-967页

作者： LIU Di WU Yongli LI Chun WANG Minglei MA Xiaoxiu LIU Junwei ZHANG Yanling YANG Lei Traditional Chinese Medicine and Traumatology General Hospital of Ningxia Medical UniversityYinchuan 750004China Radiology Department General Hospital of Ningxia Medical UniversityYinchuan 750004China Department of Acu-moxibustion and Tuina Ningxia Medical UniversityYinchuan 750004China

OBJECTIVE:To explore the molecular mechanism of warming moxibustion(WM)in knee osteoarthritis(KOA).METHODS:The knee joints of 40 New Zealand rabbits were placed in a plaster cast in an extended position to establish a KOA *** animals were randomly divided into four groups:the control group,model group,WM group,and diclofenac(DF)***-eosin staining and the modified Mankin score were applied to evaluate the histopathological *** apoptosis was determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)*** blotting and real-time quantitative polymerase chain reaction were performed to measure the expression of interleukin-1β(IL-1β),prostaglandin E receptor 3(PTGER3),a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-5(ADAMTS-5),matrix metalloproteinase-13(MMP-13),and C-terminal telopeptides of collagen typeⅡ(CTX-Ⅱ)in cartilage tissues of the different *** concentrations of IL-1β,PTGER3,and CTX-Ⅱin serum were detected by the enzyme-linked immunosorbent ***:Rabbits with KOA in the WM and DF groups showed significantly reduced cartilage erosion and Mankin scores,compared with the untreated *** number of TUNEL-positive cells observed in the WM group was much fewer than that in the model *** expression of PTGER3,MMP-13,CTX-Ⅱ,IL-1β,and ADAMTS-5 in cartilage tissues was remarkably downregulated following therapy with WM and ***,a marked reduction was observed in the serum levels of IL-1β,PTGER3,and CTX-Ⅱin the WM and DF ***:WM exerts favorable therapeutic effects on articular injuries of KOA by regulating the expression of inflammatory and cartilage degradation-related cytokines.

关键词： warming moxibustion osteoarthritis,knee inflammation cartilage degradation

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Optimization of cerebral organoids:a more qualified model for Alzheimer’s disease research

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Translational Neurodegeneration 2021年第3期10卷 346-358页

作者： Feng-Chen Bi Xin-He Yang Xiao-Yu Cheng Wen-Bin Deng Xiao-Li Guo Hui Yang Yin Wang Juan Li Yao Yao School of Basic Medical Sciences Ningxia Medical UniversityYinchuan 750004China Key Laboratory of Traditional Chinese Medicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004China School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease The Second Affiliated HospitalSoochow UniversitySuzhou 215004China School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityGuangzhou 510275China Research Center of Medical Science and Technology Ningxia Medical UniversityYinchuan 750004China

Alzheimer’s disease(AD)is a neurodegenerative disease that currently cannot be cured by any drug or intervention,due to its complicated *** animal and cellular models of AD are unable to meet research needs for ***,recent three-dimensional(3D)cerebral organoid models derived from human stem cells have provided a new tool to study molecular mechanisms and pharmaceutical developments of *** this review,we discuss the advantages and key limitations of the AD cerebral organoid system in comparison to the commonly used AD models,and propose possible solutions,in order to improve their application in AD *** concerns associated with human cerebral organoids are also *** also summarize future directions of studies that will improve the cerebral organoid system to better model the pathological events observed in AD brains.

关键词： Cerebral organoids Alzheimer’s disease Pluripotent stem cells

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