检索结果-南通市图书馆

Immune response in COVID-19:addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

Signal Transduction and Targeted Therapy 2020年第1期5卷 1759-1768页

作者： Michele Catanzaro Francesca Fagiani Marco Racchi Emanuela Corsini Stefano Govoni Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Scuola Universitaria Superiore IUSS Pavia P.zza Vittoria1527100 PaviaItaly Laboratory of Toxicology Department of Environmental and Political SciencesUniversitàDegli Studi di MilanoVia Balzaretti 920133 MilanoItaly

To date,no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive ***,based on the fast and global spread of the virus,urgent investigations are warranted in order to develop preventive and therapeutic *** this regard,treatments addressing the immunopathology of SARS-CoV-2 infection have become a major ***,while a rapid and well-coordinated immune response represents the first line of defense against viral infection,excessive inflammatory innate response and impaired adaptive host immune defense may lead to tissue damage both at the site of virus entry and at systemic *** studies highlight relevant changes occurring both in innate and adaptive immune system in COVID-19 *** particular,the massive cytokine and chemokine release,the so-called“cytokine storm”,clearly reflects a widespread uncontrolled dysregulation of the host immune *** the prospective of counteracting cytokine storm is compelling,a major limitation relies on the limited understanding of the immune signaling pathways triggered by SARS-CoV-2 *** identification of signaling pathways altered during viral infections may help to unravel the most relevant molecular cascades implicated in biological processes mediating viral infections and to unveil key molecular players that may be ***,given the key role of the immune system in COVID-19,a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages.

关键词： drugs impaired storm

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2

引用

Signal Transduction and Targeted Therapy 2020年第1期5卷 1040-1042页

作者： Francesca Fagiani Michele Catanzaro Cristina Lanni Department of Drug Sciences(Pharmacology Section) University of PaviaV.le Taramelli 1427100 PaviaItaly Scuola Universitaria Superiore IUSS Pavia P.zza Vittoria1527100 PaviaItaly

An elegant paper by Yuan et al.,recently published in Science,provides novel insights into the molecular features of neutralizing antibody responses to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).

关键词： al acute respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：