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Performance evaluation of new epoxy resin-based composite phase change materials and their asphalt mixture

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 507-522页

作者： Yuchao Gao Jiao Jin Shuai Liu Yinfei Du Guoping Qian Jie Mao Yongqiang Zhu School of Traffic and Transportation Engineering Changsha University of Science and TechnologyChangsha 410114China School of Civil Engineering Central South UniversityChangsha 410075China Guangdong Guanyue Highway and Bridge Co. Ltd.Guangzhou 511452China

In recent years,the temperature-adjusted asphalt pavement has been an extensive concern by scholars in various countries,and this pavement can reduce temperaturerelated *** this study,the shaped composite phase change materials(CPCMs)were successfully synthesized by two processes,which are vacuum impregnation and epoxy ***,the applicability of CPCMs in asphalt mixtures was evaluated by microscopic characterization,chemical compatibility,thermal properties,durability,and leakage ***,CPCMs were applied to the asphalt mixture to evaluate its temperatureadjusted characteristics and pavement ***,the performance of the temperature-adjusted asphalt mixture was analyzed by integrating all *** research shows that the prepared CPCMs have excellent thermal properties and durability,the phase transition temperature is 48.93℃,and the phase transition enthalpy is 106.5 J/g,which fully meets the requirements for use in *** temperature-adjusted asphalt mixture could alleviate the occurrence of extreme temperature,which was 4.9℃lower than the conventional *** pavement performance of the temperatureadjusted asphalt mixture can meet the specified standards for humid *** the factors,the recommended amount of CPCMs is 1.5%.The research results provide a basis for the promotion of temperature-adjusted asphalt pavement and effectively support the development of pavement engineering technology.

关键词： Pavement engineering Temperature-adjusted asphalt mixture Phase change materials Thermal performance

Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-Yun Wang Wen-Jing Xu Bo-Nan Li Tian-Song Sun Wen Sheng Department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

Quick Weighing of Passing Vehicles Using the Transfer-Learning-Enhanced Convolutional Neural Network

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2507-2524页

作者： Wangchen Yan Jinbao Yang Xin Luo College of Civil Engineering Xiangtan UniversityXiangtan411105China Energy&Environmental Engineering Department China CEC Engineering CorporationChangsha410114China

Transfer learning could reduce the time and resources required by the training of new models and be therefore important for generalized applications of the trainedmachine learning *** this study,a transfer learningenhanced convolutional neural network(CNN)was proposed to identify the gross weight and the axle weight of moving vehicles on the *** proposed transfer learning-enhanced CNN model was expected to weigh different bridges based on a small amount of training datasets and provide high identification *** of all,a CNN algorithm for bridge weigh-in-motion(B-WIM)technology was proposed to identify the axle weight and the gross weight of the typical two-axle,three-axle,and five-axle vehicles as they crossed the bridge with different loading routes and ***,the pre-trained CNN model was transferred by fine-tuning to weigh themoving vehicle on another ***,the identification accuracy and the amount of training data required were compared between the two CNN *** showed that the pre-trained CNN model using transfer learning for B-WIM technology could be successfully used for the identification of the axle weight and the gross weight for moving vehicles on another bridge while reducing the training data by 63%.Moreover,the recognition accuracy of the pre-trained CNN model using transfer learning was comparable to that of the original model,showing its promising potentials in the actual applications.

关键词： Bridge weigh-in-motion transfer learning convolutional neural network

CONVERGENCE ANALYSIS OF SOME FINITE ELEMENT PARALLEL ALGORITHMS FOR THE STATIONARY INCOMPRESSIBLE MHD EQUATIONS

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Journal of Computational Mathematics 2024年第1期42卷 49-70页

作者： Xiaojing Dong Yinnian He hunan Key Laboratory for Computation and Simulation in Science and Engineering Key Laboratory of Intelligent Computing&Information Processing of Ministry of EducationSchool of Mathematics and Computational ScienceXiangtan UniversityXiangtan 411105China Institute of Applied Physics and Computational Mathematics Beijing 100088China School of Mathematics and Statistics Xi'an Jiaotong UniversityXi'an 710049China

By combination of iteration methods with the partition of unity method(PUM),some finite element parallel algorithms for the stationary incompressible magnetohydrodynamics(MHD)with different physical parameters are presented and *** algorithms are highly *** first,a global solution is obtained on a coarse grid for all approaches by one of the iteration *** parallelized residual schemes,local corrected solutions are calculated on finer meshes with overlapping *** subdomains can be achieved flexibly by a class of *** proposed algorithm is proved to be uniformly stable and ***,one numerical example is presented to confirm the theoretical findings.

关键词： Partition of unity method Local and parallel algorithm Finite element method Iteration methods Magnetohydrodynamics

Ride-hailing origin-destination demand prediction with spatiotemporal information fusion

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Transportation Safety and Environment 2024年第2期6卷 63-74页

作者： Ning Wang Liang Zheng Huitao Shen Shukai Li School of Traffic and Transportation Engineering Central South UniversityChangsha 410075China State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China

Accurate demand forecasting for online ride-hailing contributes to balancing traffic supply and demand,and improving the service level of ride-hailing *** contrast to previous studies,which have primarily focused on the inflow or outflow demands of each zone,this study proposes a conditional generative adversarial network with a Wasserstein divergence objective(CWGAN-div)to predict ride-hailing origin-destination(OD)demand *** blocks and refined loss functions help to enhance the stability of model *** conditional information is employed to capture external spatiotemporal dependencies and guide the model towards generating more precise *** analysis using ride-hailing data from Manhattan,New York City,demon-strates that our proposed CWGAN-div model can effectively predict the network-wide OD matrix and exhibits strong convergence *** experiments also show that the CWGAN-div outperforms other benchmarking ***,the proposed model displays potential for network-wide ride-hailing OD demand prediction.

关键词： intelligent transport system ride-hailing generative adversarial networks spatiotemporal dependencies origin-destination(OD)demand prediction

Debris Flow Susceptibility Evaluation in Meizoseismal Region:A Case Study in Jiuzhaigou,China

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Journal of Earth Science 2024年第1期35卷 263-279页

作者： Yongwei Li Linrong Xu Yonghui Shang Shuyang Chen School of Civil Engineering Central South UniversityChangsha 410075China National Engineering Research Center of High-Speed Railway Construction Technology Central South UniversityChangsha 410075China School of Civil Engineering Central South University of Forestry and TechnologyChangsha 410004China

Jiuzhaigou is situated on a mountain-canyon region and is famous for frequent tectonic *** abundance of loose co-seismic landslides and collapses were produced on gullies after the Jiuzhaigou Earthquake on August 8,2017,which was served as material source for debris flow in later *** flow appears frequently which are seriously endangering the safety of people's lives and *** the earliest debris flow appeared in areas where no case ever reported *** debris flow susceptibility evaluation(DFSE)is used for predicting the areas prone to debris flow,which is urgently required to avoid hazards and help to guide the strategy of preventive ***,this work employs debris flow in Jiuzhaigou to reveal the characteristics of disaster-pregnant environment and to explore the application of machine learning in *** new viewpoints are suggested:(i)Material density factor of debris flow is first adopted in this work,and it is proved to be a critical factor for triggering debris flows by sensitivity analysis method.(ii)Deep neural network and convolutional neural network(CNN)achieve relatively good area under the curve(AUC)values and are 0.021-0.024 higher than traditional machine learning methods.(iii)Watershed units combined with CNNbased model can achieve more accurate,reliable and practical susceptibility *** work provides an idea for prevention of debris flow in mountainous lands.

关键词： machine learning earthquakes debris flow susceptibility convolutional neural network deep neural network watershed unit

Procyanidin Aand its digestive products inhibit acrylamide-induced IPEC-J2 cell damage: apoptosis and cell cycle arrest

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Food Science and Human Wellness 2024年

作者： Fangfang Yan Si Qin Chengming Wang Wolfram Weckwerth Qun Lu Rui Liu Lab of Food Function and Nutrigenomics， College of Food Science and Technology， hunan Agricultural University College of Food Science and Technology， Huazhong Agricultural University Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University)， Ministry of Education Molecular Systems Biology， Department of Functional and Evolutionary Ecology， University of Vienna

Our previous study has demonstrated that procyanidin A1(A1) and its simulated digestive product (D-A1) can prevent acrylamide （ACR）-induced cytotoxicity in small intestine cells. However， the potential mechanism remains poorly understood. In this study， ACR treatment was found to increase the levels of 8-hydroxy-deoxyguanine （8-OHdG） and phosphorated histone H2AX (γH2AX)， two DNA damage markers， thereby resulting in cell cycle arrest in the G2/M phase; whereas both A1and D-A1could prevent the phosphorylation of ataxia telangiectasia mutated （ATM） and checkpoint kinase 2 （Chk2）， and then regulate the expression of G2/M phase-related proteins， finally maintaining normal cell cycle progression. Moreover， A1and D-A1could increase the B cell lymphoma 2 （Bcl-2）/Bcl2-associated X （Bax） ratio and decrease the expression of cleaved caspase-3 and cleaved caspase-9 proteins to alleviate ACR-induced cell apoptosis， which might be related to the inhibition of the mitogen-activated protein kinase （MAPK） pathway. More importantly， A1showed no remarkable variation in inhibitory effect before and after digestion， indicating that it can endure gastrointestinal digestion and may be a promising phytochemical to alleviate ACR-induced intestinal cell damage.

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气体流量和喷嘴直径对鼓泡塔内气泡大小和形状分布的影响

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1710-1720页

作者：闫红杰张河杨刘柳 Thomas ZIEGENHEIN 周萍中南大学能源科学与工程学院长沙410083 TIV Consultancy 7th Pl Road 131285281 TempeArizonaUnited States

通过高速摄影结合图像处理算法,研究气体流量和喷嘴直径对气泡尺寸和纵横比分布的影响。结果表明,在所有喷嘴直径下,气泡当量直径的概率密度呈现双峰分布,其中第一个峰值接近直径为1.5~2 mm的小气泡区域,另一个峰值位于较大的气泡区域... 详细信息

通过高速摄影结合图像处理算法,研究气体流量和喷嘴直径对气泡尺寸和纵横比分布的影响。结果表明,在所有喷嘴直径下,气泡当量直径的概率密度呈现双峰分布,其中第一个峰值接近直径为1.5~2 mm的小气泡区域,另一个峰值位于较大的气泡区域。将气体流量从0.1 L/min增加到0.2 L/min会导致大气泡的概率密度更高,表明气泡聚并现象普遍存在。当气体流量增加至1.2L/min时,峰值对应的气泡直径变小,并且气泡破裂占主导地位。对于直径为1~2 mm的气泡,形状受气体流量的影响较小,而3~9 mm的气泡在所有气体流量下气泡纵横比概率密度分布的峰值均位于纵横比E=0.5处。Iguchi和Chihara提出的模型能更好地预测气泡脱离直径随气体流量的增大的变化。

关键词：气泡尺寸分布气泡直径气泡纵横比气体流量喷嘴直径鼓泡塔

线粒体动力学调控机制及其在肾脏病理生理学中的作用

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生理学报 2024年第1期76卷 148-160页

作者：谭子璇朱武政湖南师范大学生命科学学院动物营养与人体健康实验室长沙410081

线粒体是一种动态变化的细胞器,它通过不断的融合、分裂来维持线粒体的形态、数量和功能稳定,这一过程称为线粒体动力学,是线粒体质量控制的重要机制。线粒体的过度融合与分裂都会导致线粒体动力学的稳态失衡,引起线粒体功能障碍,导致... 详细信息

线粒体是一种动态变化的细胞器,它通过不断的融合、分裂来维持线粒体的形态、数量和功能稳定,这一过程称为线粒体动力学,是线粒体质量控制的重要机制。线粒体的过度融合与分裂都会导致线粒体动力学的稳态失衡,引起线粒体功能障碍,导致细胞损伤甚至死亡。肾脏的生理活动主要由线粒体供能,线粒体动力学稳态失衡影响着线粒体功能,与急性肾损伤、糖尿病肾病等肾脏疾病密切相关。本文对线粒体动力学的调节、线粒体动力学稳态失衡如何导致线粒体损伤以及线粒体损伤对肾脏病理生理学的影响进行综述,以加深对肾脏疾病中线粒体作用的理解与认识。

关键词：线粒体融合线粒体分裂肾脏疾病