检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

直击2型糖尿病至缓解

英国医学杂志中文版 2018年第9期21卷 488-492页

作者：胡永莲(译) 武晓泓(校) 南京医科大学第一附属医院内分泌科

2型糖尿病，通常被认为进展性、不可治愈，目前影响着英国5％-10％的人口，大约320万。糖尿病在出现并发症之前，大多数患者完全是通过初级保健进行管理，构成全科医疗活动的主要组成部分。英国国家健康体系（NHS）总开支中大约有10％... 详细信息

2型糖尿病，通常被认为进展性、不可治愈，目前影响着英国5％-10％的人口，大约320万。糖尿病在出现并发症之前，大多数患者完全是通过初级保健进行管理，构成全科医疗活动的主要组成部分。英国国家健康体系（NHS）总开支中大约有10％用于治疗糖尿病。国际数据显示，糖尿病患者的医疗费用是年龄和性别相同的非糖尿病患者平均水平的2到3倍。

关键词：糖尿病缓解方法治疗方法预防措施

Implementation and fidelity of a participatory learning and action cycle intervention to prevent and control type 2 diabetes in rural Bangladesh

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Health Research and Policy 2019年第1期4卷 197-211页

作者： Joanna Morrison Kohenour Akter Hannah Maria Jennings Abdul Kuddus Tasmin Nahar Carina King Sanjit Kumer Shaha Naveed Ahmed Hassan Haghparast-Bidgoli Anthony Costello A.K.Azad Khan Kishwar Azad Edward Fottrell University College London Institute for Global Health LondonUK Diabetic Association of Bangladesh DhakaBangladesh Department for Public Health Sciences Karolinska InstitutetStockholmSweden

Introduction:There is an urgent need to address the growing type 2 diabetes disease burden.20-30%of adults in rural areas of Bangladesh have intermediate hyperglycaemia and about 10%have *** report on the implementation and fidelity of a Participatory Learning and Action(PLA)intervention,evaluated through a threearm cluster randomised controlled trial which reduced the incidence of diabetes and intermediate hyperglycaemia in rural *** interventions have been effective in addressing population level health problems in low income country contexts,and therefore we sought to use this approach to engage communities to identify and address community barriers to prevention and control of type 2 ***:We used a mixed methods approach collecting quantitative data through field reports and qualitative data through observations and focus group *** descriptive analysis,we considered fidelity to the participatory approach and implementation ***:One hundred twenty-two groups per month were convened by 16 facilitators and supervised by two *** worked through a four phase PLA cycle of problem identification,planning together,implementation and evaluation to address the risk factors for diabetes-diet,physical activity,smoking and *** reported a lack of awareness about diabetes prevention and control,the prohibitive cost of care and healthy eating,and gender barriers to exercise for *** set targets to encourage physical activity,kitchen-gardening,cooking with less oil,and reduced tobacco ***-tobacco committees operated in 90 *** hundred twenty-two groups arranged blood glucose testing and 74 groups organized testing ***-one women’s groups established funds,and 61 communities committed not to ridicule women *** and committed supervisors enabled fidelity to a participatory methodology.A longer intervention period and capacity building could enable en

关键词： Process evaluation diabetes Non-communicable diseases Health promotion Randomised controlled trial

Cell adhesion in renal tubular epithelial cells:Biochemistry,biophysics or both

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第4期46卷 937-940页

作者： CLAIRE ELIZABETH HILLS ELEFTHERIOS SIAMANTOURAS PAUL EDWARD SQUIRES diabetes Metabolism&Inflammation GroupSchool of Life SciencesJoseph Banks LaboratoriesUniversity of LincolnLincolnLN67DLUK

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset and ***,these relationships depend on both the biochemical and molecular association between cells and between cells and their extracellular matrix,as well as the biophysical and mechanical properties orchestrated by cytoskeletal,membrane and matrix *** fully appreciate the role of cell adhesion when determining normal physiology and the impact of disease on cellular function,it is important to consider both biochemical and biophysical attributes of the system being *** this short viewpoint we reflect on our experiences assessing cell-cell and/or cell-matrix interactions in renal tubular epithelial cells.

关键词： Cell-adhesion Cadherin Cytoskeleton AFM Kidney Epithelium

Unravelling the story of protein misfolding in diabetes mellitus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of diabetes 2011年第7期2卷 114-118页

作者： Sally E Thomas Lucy Dalton Elke Malzer Stefan J Marciniak Department of Medicine University of CambridgeCambridge Institute for Medical ResearchWellcome Trust/MRC BuildingHills RoadCambridge CB0 2XYUnited Kingdom

Both environmental and genetic factors contribute to the development of diabetes mellitus and although monogenic disorders are rare,they offer unique insights into the fundamental biology underlying the *** of the insulin gene or genes involved in the response to protein misfolding cause early onset *** have revealed an important role for endoplasmic reticulum stress in β-cell *** form of cellular stress occurs when secretory proteins fail to fold *** all the professional secretory cells we possess,β-cells are the most sensitive to endoplasmic reticulum stress because of the large fluctuations in protein synthesis they face *** of endoplasmic reticulum stress signaling therefore offer the potential to identify new drug targets to treat diabetes.

关键词： Endoplasmic reticulum stress diabetes Unfolded protein response PKR-like ER kinase

Regulation ofα-cell glucagon secretion:The role of second messengers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic Diseases and Translational Medicine 2022年第1期8卷 7-18页

作者： Samuel Acreman Quan Zhang Oxford Centre for diabetes Endocrinology and MetabolismRadcliffe Department of MedicineUniversity of OxfordOxfordOX37LEUK Institute of Neuroscience and Physiology Department of PhysiologyMetabolic Research UnitUniversity of GoteborgBox 430S-40530GoteborgSweden

Glucagon is a potent glucose-elevating hormone that is secreted by pancreaticα-*** well-controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia,it is increasingly apparent that defects in the regulation of glucagon secretion contribute to impaired counter-regulation and hyperglycaemia in *** has therefore been proposed that pharmacological interventions targeting glucagon secretion/signalling can have great potential in improving glycaemic control of patients with ***,despite decades of research,a consensus on the precise mechanisms of glucose regulation of glucagon secretion is yet to be *** messengers are a group of small intracellular molecules that relay extracellular signals to the intracellular signalling cascade,modulating cellular *** is a growing body of evidence that second messengers,such as cAMP and Ca^(2+),play critical roles inα-cell glucose-sensing and glucagon *** this review,we discuss the impact of second messengers onα-cell electrical activity,intracellular Ca^(2+)dynamics and cell *** highlight the possibility that the interaction between different second messengers may play a key role in the glucose-regulation of glucagon secretion.

关键词： glucagon pancreatic islet second messenger

Extracellular matrix remodelling in obesity and metabolic disorders

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Life Metabolism 2023年第4期2卷 7-21页

作者： Vishal Musale David H.Wasserman Li Kang Division of Systems Medicine School of MedicineUniversity of DundeeDundee DD19SYUnited Kingdom Department of Molecular Physiology and Biophysics Mouse Metabolic Phenotyping CenterVanderbilt UniversityNashvilleTN 37235United States

Obesity causes extracellular matrix (ECM) remodelling which can develop into serious pathology and fibrosis, having metabolic effects in insulin-sensitive tissues. The ECM components may be increased in response to overnutrition. This review will focus on specific obesity-associated molecular and pathophysiological mechanisms of ECM remodelling and the impact of specific interactions on tissue metabolism. In obesity, a complex network of signalling molecules such as cytokines and growth factors has been implicated in fibrosis. Increased ECM deposition contributes to the pathogenesis of insulin resistance at least in part through the activation of cell surface integrin receptors and CD44 signalling cascades. These cell surface receptors transmit signals to the cell adhesome which orchestrates an intracellular response that adapts to the extracellular environment. Matrix proteins, glycoproteins, and polysaccharides interact through ligand-specific cell surface receptors that interact with the cytosolic adhesion proteins to elicit specific actions. Cell adhesion proteins may have catalytic activity or serve as scaffolds. The vast number of cell surface receptors and the complexity of the cell adhesome have made study of their roles challenging in health and disease. Further complicating the role of ECM-cell receptor interactions is the variation between cell types. This review will focus on recent insights gained from studies of two highly conserved, ubiquitous axes and how they contribute to insulin resistance and metabolic dysfunction in obesity. These are the collagen-integrin receptor-IPP (ILK-PINCH-Parvin) axis and the hyaluronan-CD44 interaction. We speculate that targeting ECM components or their receptor-mediated cell signalling may provide novel insights into the treatment of obesity-associated cardiometabolic complications.

关键词： extracellular matrix fibrosis insulin resistance obesity metabolism

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

全球肥胖危机和体重管理的进展

英国医学杂志中文版 2021年第3期24卷 158-164页

作者： Michael E J Lean Arne Astrup Susan B Roberts 巴天皓(译) 任倩(校) Human Nutrition School of MedicineDentistry and NursingUniversity of GlasgowGlasgowUK Department of Nutrition Exercise and SportsUniversity of CopenhagenDenmark Tufts University BostonMAUSA 北京大学人民医院

毫无疑问,食物和肥胖相关,但关系复杂。Michael Lean和他的同事探讨了有关体重管理我们已知和未知的领域。肥胖是一个未解决的危机,在全球范围内造成了长期的困扰和行动障碍,导致人力资本减少,疾病负担和医疗费用增加。肥胖的病因学很复... 详细信息

毫无疑问,食物和肥胖相关,但关系复杂。Michael Lean和他的同事探讨了有关体重管理我们已知和未知的领域。肥胖是一个未解决的危机,在全球范围内造成了长期的困扰和行动障碍,导致人力资本减少,疾病负担和医疗费用增加。肥胖的病因学很复杂,在科学界和传媒界都引发了广泛争议1.

关键词：疾病负担体重管理病因学传媒界肥胖全球范围行动障碍人力资本

Journal of Hepatology|与肝脂肪相关的不同遗传变异及其与心血管疾病和癌症的对比关系

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床肝胆病杂志 2024年第9期40卷 1872-1872页

作者：刘坤禹季慧范吉林大学第一医院感染病中心肝病科

关于脂肪变性肝病与心血管疾病和癌症预后之间联系的潜在机制尚有待研究。来自英国林肯大学健康与科学学院约瑟夫·班克斯实验室的Ahmed等对37358名英国生物库参与者进行了全基因组关联研究,以确定与MRI扫描测得的肝脂肪相关的遗传变异。

关键词：脂肪变性 MRI扫描心血管疾病全基因组关联研究肝脂肪对比关系生物库班克斯

Genome-wide Studies Reveal Genetic Risk Factors for Hepatic Fat Content

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2024年第2期22卷 57-68页

作者： Yanni Li Eline H.van den Berg Alexander Kurilshikov Dasha V.Zhernakova Ranko Gacesa Shixian Hu Esteban A.Lopera-Maya Alexandra Zhernakova Lifelines Cohort Study Vincent E.de Meijer Serena Sanna Robin P.F.Dullaart Hans Blokzijl Eleonora A.M.Festen Jingyuan Fu Rinse K.Weersma Department of Gastroenterology and Hepatology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Genetics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Laboratory of Genomic Diversity Center for Computer TechnologiesITMO UniversitySaint Petersburg 199034Russia Institute of Precision Medicine the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Surgery Section of Hepatobiliary Surgery and Liver TransplantationUniversity of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Endocrinology University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands Department of Pediatrics University of GroningenUniversity Medical Center GroningenGroningen 9713 GZThe Netherlands 不详

Genetic susceptibility to metabolic associated fatty liver disease(MAFLD)is complex and poorly *** characterization of the genetic background of hepatic fat content would provide insights into disease etiology and causality of risk *** performed genome-wide association study(GWAS)on two noninvasive definitions of hepatic fat content:magnetic resonance imaging proton density fat fraction(MRI-PDFF)in 16,050 participants and fatty liver index(FLI)in 388,701 participants from the United Kingdom(uk)Biobank(ukBB).Heritability,genetic overlap,and similarity between hepatic fat content phenotypes were analyzed,and replicated in 10,398 participants from the University Medical Center Groningen(UMCG)Genetics Lifelines Initiative(UGLI).Meta-analysis of GWASs of MRI-PDFF in ukBB revealed five statistically significant loci,including two novel genomic loci harboring CREB3L1(rs72910057-T,P=5.40E−09)and GCM1(rs1491489378-T,P=3.16E−09),respectively,as well as three previously reported loci:PNPLA3,TM6SF2,and *** of FLI in ukBB identified 196 genome-wide significant loci,of which 49 were replicated in UGLI,with top signals in ZPR1(P=3.35E−13)and FTO(P=2.11E−09).Statistically significant genetic correlation(rg)between MRI-PDFF(ukBB)and FLI(UGLI)GWAS results was found(rg=0.5276,P=1.45E−03).Novel MRI-PDFF genetic signals(CREB3L1 and GCM1)were replicated in the FLI *** identified two novel genes for MRI-PDFF and 49 replicable loci for *** a difference in hepatic fat content assessment between MRI-PDFF and FLI,a substantial similar genetic architecture was *** is identified as an easy and reliable approach to study hepatic fat content at the population level.

关键词： Hepatic fat content MAFLD Genome-wide association study Fatty liver index Magnetic resonance imaging proton density fat fraction