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Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci,the whitefly vector

Insect Science 2024年第3期31卷 707-719页

作者： Yun-Yun Fan Yao Chi Na Chen Wilmer J.Cuellar Xiao-Wei Wang Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang ProvinceInstitute of Insect SciencesZhejiang UniversityHangzhouChina Zhejiang Tianmushan National Nature Reserve Administration HangzhouChina Institute of Plant Protection Liaoning Academy of Agricultural SciencesShenyangChina Virology Laboratory Cassava ProgramInternational Center for Tropical Agriculture(CIAT)PalmiraColombia

Sri Lankan cassava mosaic virus(SLCMV)is a prominent causative agent of cassava mosaic disease in Asia and relies on the whitefly Bemisia tabaci cryptic complex for its ***,the molecular mechanisms involved in SLCMV transmission by *** have yet to be *** this study,we identified an aminopeptidase N-like protein(BtAPN)in *** Asia II 1,an efficient vector of SLCMV,which is involved in the SLCMV transmission *** the use of glutathione S-transferase pull-down assay and LC-MS/MS analysis,we demonstrated the interaction between BtAPN and the coat protein(CP)of *** interaction was further confirmed in vitro,and we observed an induction of BtAPN gene expression following SLCMV *** interfering with the function of BtAPN,the quantities of SLCMV were significantly reduced in various parts of *** Asia II 1,including the whole body,midgut,hemolymph,and primary salivary ***,we discovered that BtAPN is conserved in *** Middle East-Asia Minor 1(MEAM1)and interacts with the CP of tomato yellow leaf curl virus(TYLCV),a begomovirus known to cause severe damage to tomato *** BtAPN with antibody led to a significant reduction in the quantities of TYLCV in whitefly whole body and organs/*** results demonstrate that BtAPN plays a generic role in interacting with the CP of begomoviruses and positively regulates their acquisition by the whitefly.

关键词： BtAPN coat protein SLCMV TYLCV virus acquisition whitefly

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The relationship between compartment models and their stochastic counterparts:A comparative study with examples of the COVID-19 epidemic modeling

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Journal of Biomedical Research 2024年第2期38卷 175-188,I0016-I0018页

作者： Ziyu Zhao Yi Zhou Jinxing Guan Yan Yan Jing Zhao Zhihang Peng Feng Chen Yang Zhao Fang Shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Nanjing Hanwei Public Health Research Institute Co. LtdNanjingJiangsu 210005China china International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic ***,the relationship between CMs and their corresponding stochastic models is not well *** present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling *** demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and *** on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter *** advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of ***,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time ***,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of *** model offered a balance between computational efficiency and *** results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic ***,the results had implications for the development of hybrid models that integrated the strengths of both ***,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.

关键词： compartment models agent-based models compartment-agent mixed models comparative study COVID-19

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Genome Analysis of Plasmodium falciparum:A Preliminary Observation-Sierra Leone,2022-2023

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china CDC weekly 2024年第17期6卷 368-373页

作者： Tianyu Wang Haimo Shen Bin Xu Wanxuan Yang Shenbo Chen Junhu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesNational Centre for International Research on Tropical DiseasesShanghaiChina School of Basic Medical Sciences and Forensic Medicine Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina School of Global Health Chinese Centre for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiChina Hainan Tropical Diseases Research Center(Hainan Sub-Center Chinese Center for Tropical Diseases Research)Haikou CityHainan ProvinceChina.

Summary What is already known about this topic?Sierra Leone,with a gross domestic product(GDP)per capita below$300 and significant poverty,ranks among the world’s least developed countries(LDCs).Despite its modest population of 8.6 million,the nation reports approximately 2.6 million malaria cases ***,there has been no reporting on the malaria genome data from this *** is added by this report?In this study,we present the first reported wholegenome sequence analysis of 19 high parasite-density Plasmodium falciparum isolates from Sierra Leone,providing insights into the genomic epidemiology of this high-prevalence *** found a high degree of relatedness among infections and substantial genetic diversity,consistent with the gradual reduction in overall case ***,our whole-genome analysis revealed that,beyond drug-resistance genes,gene families related to blood cell invasion,immune evasion,and others are undergoing directional *** suggests that the population in Sierra Leone has developed a relatively strong acquired *** are the implications for public health practice?The genomic data not only facilitate the creation of single nucleotide polymorphism barcodes for case tracking but also enable the analysis of evolving transmission dynamics and selection ***,the samples from Sierra Leone exhibited higher selective pressures on resistance genes compared to those from Asia,a trend not commonly observed in other African *** suggests that less stringent healthcare systems and inconsistent treatment strategies can subject parasites to increased drug pressure,thereby accelerating the development of resistant strains.

关键词： epidemiology invasion Observation

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Infection with SARS-CoV-2 can cause pancreatic impairment

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2143-2160页

作者： Wei Deng Linlin Bao Zhiqi Song Ling Zhang Pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan Qin NHC Key Laboratory of Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing 100871China Beijing Key Laboratory of Cardiometabolic Molecular Medicine Peking UniversityBeijing 100871China State Key Laboratory of Biomembrane and Membrane Biotechnology Peking-Tsinghua Center for Life SciencesBeijing 100871China Chinese Academy of Engineering Eastern Hepatobiliary Surgery Hospital225 Changhai RoadYangpu DistrictShanghai 200438China International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438PR China National Laboratory for Oncogenes and Related Genes Cancer Institute of Shanghai Jiao Tong UniversityShanghai 200441PR China Changping National laboratory(CPNL) Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity National Health Commission of the People’s Republic of ChinaBeijingPR China

Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of ***,we retrospectively analyzed pancreatic lesions in autopsy tissues from 67 SARS-CoV-2 infected non-human primates(NHPs)models and 121 vaccinated and infected NHPs from 2020 to 2023 and COVID-19 ***-label immunofluorescence revealed direct infection of both exocrine and endocrine pancreatic cells by the virus in NHPs and *** and limited phenotypic and histopathological changes were observed in adult *** proteomics and metabolomics results indicated metabolic disorders,mainly enriched in insulin resistance pathways,in infected adult NHPs,along with elevated fasting C-peptide and C-peptide/glucose ratio ***,in elder COVID-19 NHPs,SARS-CoV-2 infection causes loss of beta(β)cells and lower expressed-insulin in situ characterized by islet amyloidosis and necrosis,activation ofα-SMA and aggravated fibrosis consisting of lower collagen in serum,an increase of pancreatic inflammation and stress markers,ICAM-1 and G3BP1,along with more severe glycometabolic *** contrast,vaccination maintained glucose homeostasis by activating insulin receptorαand insulin receptorβ.Overall,the cumulative risk of diabetes post-COVID-19 is closely tied to age,suggesting more attention should be paid to blood sugar management in elderly COVID-19 patients.

关键词： infected elevated homeostasis

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The Current Status and Challenges Regarding Tuberculosis Infection Control in Health Care Facilities in china

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Biomedical and Environmental Sciences 2015年第11期28卷 848-854页

作者： ZHAO Fei CHENG Jun CHENG Shi Ming ZHANG Hui ZHAO Yan Lin ZHANG Can You HU Dong Mei FAN Hai Ying HUANG Fei QU Yan HE Guang Xue WANG Li Xia National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and Prevention Science and Technology Department Chinese Center for Disease Control and Prevention

Health care facilities are a high-risk environment for generating and spreading respiratory infectious diseases such as tuberculosis （TB）. The TB prevention and treatment staff in health care facilities are responsi... 详细信息

关键词： TB The Current Status and Challenges Regarding Tuberculosis Infection Control in Health Care Facilities in china

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Asymmetric synthesis of bedaquiline based on bimetallic activation and non-covalent interaction promotion strategies

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Science china Chemistry 2022年第10期65卷 1968-1977页

作者： Feng Gao Jing Li Tanveer Ahmad Yicong Luo Zhenfeng Zhang Qianjia Yuan Xiaohong Huo Tao Song Wanbin Zhang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Frontiers Science Center for Transformative MoleculesSchool of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China

Bedaquiline(BDQ),approved by Food and Drug Administration(FDA)in 2012 as the first anti-tuberculosis-specific drug in the last 40 years,is viewed as one of the world’s most promising treatments for tuberculosis(TB).Due to the stereoselective construction of the Csp^(3)–Csp^(3)bond with vicinal stereocenters of BDQ and its analogues being an unsolved challenge,there have not been any reports concerning its asymmetric synthesis for the current industrial production process until ***,we have successfully developed a cooperative bimetallic system for the asymmetric synthesis of BDQ under the guidance of density functional theory(DFT)*** on the optimized conditions,BDQ could be synthesized with excellent enantioselectivity(>99%ee)and diastereoselectivity(16:1 dr).A 5-g scale reaction was also conducted with comparably excellent results,showing its potential for industrial application.

关键词： asymmetric synthesis bedaquiline bimetallic system industrial synthetic process DFT computation

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Implementing a “free” tuberculosis (TB) care policy under the integrated model in Jiangsu, china: practices and costs in the real world

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Infectious Diseases of Poverty 2016年第1期5卷 1-8页

作者： Xinxin Jia Jiaying Chen Siyuan Zhang Bing Dai Qian Long Shenglan Tang Center for Health Policy Studies Nanjing Medical UniversityHanzhong Road 140210029 NanjingChina The Second Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina Zhenjiang Center for Disease Control and Prevention ZhenjiangJiangsu ProvinceChina Duke Global Health Institute Duke UniversityDurhamNCUSA Global Health Research Center Duke Kunshan UniversityKunshanChina

Background:In the 1990s,china introduced a“free”tuberculosis(TB)care policy under the national TB control ***,as a part of a new TB diagnosis and treatment model,it has been recommended that the integrated model scale *** paper examines whether or not TB designated hospitals in the selected project sites have provided TB care according to the national and local guidelines,and analyzes the actual practices and expenditures involved in completing TB *** also explores the reasons why“free”TB care in china cannot be effectively implemented under the integrated ***:This study was conducted in three counties of Zhenjiang city,Jiangsu *** methods were used,which comprised reviewing the national and local TB control guidelines,conducting TB patient surveys,collecting TB inpatient and outpatient hospital records,and conducting qualitative interviews with *** statistics were used for quantitative data analysis across counties and in order to compare patients who received only outpatient care and those who received both outpatient and inpatient *** chi-square test and analysis of variance were performed where *** data were analyzed using the framework ***:Although the national TB care guidelines recommend outpatient care as a basis for TB treatment in china,we found high hospital admission rates for TB patients ranging from 39%in Yangzhong county to 83%in Dantu *** all outpatient TB patients paid for lab tests and over 80%paid for liver protection drugs and around 70%paid for image *** three components accounted for three-quarters of the total outpatient *** patients who received only outpatient care,the total expenditure upon completion of TB treatment was on average 1,135 Chinese *** patients who received outpatient and inpatient care,the total expenditure upon completion of TB treatment was 11,117 Chinese ***:The“free”

关键词： Tuberculosis Anti-TB treatment practice guidelines Free Expenditure Jiangsu province china

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Use of anti-tuberculosis drugs among newly diagnosed pulmonary tuberculosis inpatients in china: a retrospective study

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Infectious Diseases of Poverty 2016年第1期5卷 9-14页

作者： Fei Huang Hui Zhang Qing Lv Kaori DSato Yan Qu Shitong Huan Jun Cheng Fei Zhao Lixia Wang National Center for TB control and prevention No 155 Changbai RoadChangping DistrictBeijing 102206China Duke Global Health Institute DurhamNCUSA Bill&Melinda gates foundation Beijing officeBeijingChina

Background:china’s national tuberculosis control program(NTP)provides free,first-line anti-tuberculosis(TB)drugs to pulmonary TB *** treatment regimen follows the World Health Organization’s(WHO)*** objective of this paper is to evaluate the current status of anti-TB drug use for newly diagnosed pulmonary TB inpatients treated in prefecture-and county-level designated ***:Three prefecture-level hospitals and nine county-level hospitals were selected for the *** newly diagnosed pulmonary TB inpatient medical records from 2012 were reviewed and doubly examined by two national senior *** rational use of anti-TB drugs was evaluated based on criteria in line with WHO’s ***:Of the 2,060 total treatment regimens for TB,53.1%were found to be rational(1093/2060).The percentages in prefecture-level and county-level hospitals were 50.3%(761/1513)and 60.7%(332/547),*** difference between the two levels of hospitals was statistically significant(Chi-square value=17.44,P<0.01).The percentages of rational treatment regimens for first-time hospitalizations and for two or more hospitalizations were 59.5%(983/1653)and 27.0%(110/407),respectively,with a statistically significant difference(Chi-square value=138.00,P<0.01).The overall use of second-line drugs(SLD)was 54.9%(1131/2060).The percentages for prefecture-level and county-level hospitals were 50.6%(766/1513)and 66.7%(365/547),respectively.A statistically significant difference was found(Chi-square value=42.06,P<0.01).The use of SLD for inpatients hospitalized once and inpatients hospitalized twice or more was 58.4%(966/1653)and 40.5%(165/407),respectively,with a statistically significant difference(Chi-square value=42.26,P<0.01).Conclusions:Half of inpatients might be treated with irrational regimens,and the use of SLD was more appropriately dispensed in city-level hospitals than in county-level *** and guidelines for health personnel,

关键词： Tuberculosis Inpatient Drug Regimen Rationality

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Drug-resistant tuberculosis control in china: progress and challenges

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Infectious Diseases of Poverty 2016年第1期5卷 75-81页

作者： Qian Long Yan Qu Henry Lucas Global Health Research Center Duke Kunshan UniversityKunshanChina Duke Global Health Institute Duke UniversityDurhamNCUSA china Center for Disease Control and Prevention BeijingChina Institute of Development Studies Sussex UniversityBrightonUK

Background:china has the second highest caseload of multidrug-resistant tuberculosis(MDR-TB)in the *** 2009,the Chinese government agreed to draw up a plan for MDR-TB prevention and control in the context of a comprehensive health system reform launched in the same ***:china is facing high prevalence rates of drug-resistant TB and ***-TB disproportionally affects the poor rural population and the highest rates are in less developed regions largely due to interrupted and/or inappropriate TB *** households with an affected member suffer a heavy financial burden because of a combination of treatment and other related *** influential Global Fund programme for MDR-TB control in china provides technical and financial support for MDR-TB diagnosis and ***,this programme has a fixed timeline and cannot provide a long term *** 2009,the Bill and Melinda gates foundation,in cooperation with the National Health and Family Planning Commission of china,started to develop innovative approaches to TB/MDR-TB management and case-based payment mechanisms for treatment,alongside increased health insurance benefits for patients,in order to contain medical costs and reduce financial barriers to *** these efforts appear to be in the right direction,they may not be sufficient unless(a)domestic sources are mobilized to raise funding for TB/MDR-TB prevention and control and(b)appropriate incentives are given to both health facilities and their care ***:Along with the on-going Chinese health system reform,sustained government financing and social health protection schemes will be critical to ensure universal access to appropriate TB treatment in order to reduce risk of developing MDR-TB and systematic MDR-TB treatment and management.

关键词： Multidrug-resistant tuberculosis Health financing Health system strengthening china

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Assessing food security performance from the One Health concept:an evaluation tool based on the Global One Health Index

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Infectious Diseases of Poverty 2023年第5期12卷 98-99页

作者： Si-Yu Gu Fu-Min Chen Chen-Sheng Zhang Yi-Bin Zhou Tian-Yun Li Ne Qiang Xiao-Xi Zhang Jing-Shu Liu Shu-Xun Wang Xue-Chen Yang Xiao-Kui Guo Qin-Qin Hu Xiao-Bei Deng Le-Fei Han School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai China One Health Center Shanghai Jiao Tong University-The University of Edinburgh Shanghai China National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research) Shanghai China Minhang District Center for Disease Control and Prevention Shanghai China School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China

Background Food systems instantiate the complex interdependencies across humans,physical environments,and other *** One Health approaches for agri-food system transformation,which adopts integrated and unifying approaches to optimize the overall health of humans,animals,plants,and environments,is crucial to enhance the sustainability of food *** study develops a potential assessment tool,named the global One Health index-Food Security(GOHI-FS),aiming to evaluate food security performance across countries/territories from One Health perspective and identify relevant gaps that need to be improved for sustainable food *** We comprehensively reviewed existing frameworks and elements of food *** indicator framework of GOHI-FS was conceptualized following the structure-process-outcome model and confirmed by expert *** available data in 2020 was collected for each *** weighting strategy was determined by the Fuzzy Analytical Hierarchy *** data for each indicator was normalized and aggregated by weighted arithmetic *** regressions were performed to evaluate the associations of GOHI-FS with health and social-economic *** The GOHI-FS includes 5 first-level indicators,19 second-level indicators and 45 third-level *** were 146 countries/territories enrolled for *** highest average score of first-level indicators was Nutrition(69.8)and the lowest was Government Support and Response(31.3).There was regional heterogeneity of GOHI-FS *** median scores with interquartile range(IQR)were shown in North America(median:76.1,IQR:75.5-76.7),followed by Europe and Central Asia(median:66.9,IQR:60.1-74.3),East Asia and the Pacific(median:60.6,IQR:55.5-68.7),Latin America and the Caribbean(median:60.2,IQR:57.8-65.0),Middle East and North Africa(median:56.6,IQR:52.0-62.8),South Asia(median:51.1,IQR:46.7-53.8),and sub-Saharan Africa(median:41.4,IQR:37.2-46.5).We

关键词： Food security One Health Index Indicator framework Assessment

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