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surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells

Nano Research 2017年第10期10卷 3269-3284页

作者： Indrajit srivastava santosh K. Misra Fatemeh Ostadhossein Enrique Daza Jasleena singh Dipanjan Pan Department of Bioengineering University of Illinois Urbana-Champaign Urbana Illinois 61801 USA Biomedical Research Center Carle Foundation Hospital Urbana Illinois 61801 USA Department of Materials science and Beckman institute University of illinois Urbana-Champaign Urbana Illinois 61801 USA

Relationship of the surface physicochemical characteristics of nanoparticles with their interactions with biological entities may provide critical information for nanomedicinal application. Here, we report the systematic synthesis of sub-50 nm carbon nanoparticles （CNP） presenting neutral, anionic, and cationic surface functionalities. A subset of CNPs with -10, 20, and 40 nm hydrodynamic sizes were synthesized with neutral surface headgroups. For the first time, the cellular internalization of these CNPs was systematically quantified in various stages of breast cancer cells （early, late, and metastatic）, thereby providing a parametric assessment of charge and size effects. Distinct activities were observed when these systems interacted with cancer cells in various stages. Our results indicated that metastatic breast cancer could be targeted by a nanosystem presenting anionic phosphate groups. On the contrary, for patients in late stage of cancer, drugs could be delivered with sulfonate functionalized carbon nano- particles, which have higher probability of intracellular transport. This study will facilitate the better understanding of nanoparticle-biological entity interaction, and the integration of this knowledge with pathophysiology would promote the engineering of nanomedicine with superior likelihoods of crossing the endocytic ＂barrier＂ for drug delivery inside cancerous cells.

关键词： personalized medicine endocytosis surface charge size carbon nanoparticles

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Buckling analysis of shear deformable composite conical shells reinforced by CNTs subjected to combined loading on the two-parameter elastic foundation

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Defence Technology（防务技术） 2022年第2期18卷 205-218页

作者： A.H.sofiyev N.Kuruoglu Department of Civil Engineering of Engineering Faculty Suleyman Demirel University32260IspartaTurkey Information Technology Research and Application Center Member of Consultancy Board of ITRAC Center Istanbul Commerce UniversityBeyoglu34445IstanbulTurkey scientific Research Centers for Composition Materials of UNEC-Azerbaijan state Economic University 1001/BakuAzerbaijan Department of Civil Engineering of Faculty of Engineering and Architecture of Istanbul Gelisim University IstanbulTurkey

The main objective of this study is to investigate the buckling analysis of CCss reinforced by CNTs subjected to combined loading of hydrostatic pressure and axial compression resting on the twoparameter elastic foundation(T-P-EF).It is one of the first attempts to derive the governing equations of the CCss reinforced with CNTs,based on a generalized first-order shear deformation shell theory(FsDsT)which includes shell-foundation *** adopting the extended mixing rule,the effective material properties of CCss reinforced by CNTs with linear distributions are approximated by introducing some efficiency *** carbon nanotube distribution in the matrix,*** distribution(U)and V and X-types linear distribution are taken into *** stability equations are solved by using the Galerkin procedure to determine the combined buckling loads(CBLs)of the structure selected *** numerical illustrations cover CBLs characteristics of CCss reinforced by CNTs in the presence of the ***,a parametric study is carried out to study the influences of the foundation parameters,the volume fraction of carbon nanotubes and the types of reinforcement on the CBLs.

关键词： Nanocomposites CNTs Composite conical shells Two-parameter elastic foundations Combined buckling loads shear deformation shell theories

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肝豆状核变性病人血清和尿中铜的测定及其临床意义

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光谱学与光谱分析 2003年第3期23卷 576-578页

作者：邓世林李新凤郭小林中南大学现代分析测试中心湖南长沙410078

本文为拓宽分析仪器在临床医学中的应用 ,建立了肝豆状核变性病人血清和尿中铜的火焰原子吸收光谱测定方法。方法的相对标准偏差小于 1.4 % ,检出限为 7 3× 10 - 3μg·mL- 1 ,加标回收率在 94 %～10 4 %之间。讨论了肝豆状核变性病人... 详细信息

本文为拓宽分析仪器在临床医学中的应用 ,建立了肝豆状核变性病人血清和尿中铜的火焰原子吸收光谱测定方法。方法的相对标准偏差小于 1.4 % ,检出限为 7 3× 10 - 3μg·mL- 1 ,加标回收率在 94 %～10 4 %之间。讨论了肝豆状核变性病人血铜和尿铜水平对临床诊断及治疗的意义。实验结果表明 ,血清铜和尿铜水平对于WD虽不具单独诊断意义 ,必须结合临床症状和其他生化指标综合诊断 ,但它们却是诊断本病的重要参考指标 ,尤其在治疗方面 ,及时监控血铜水平和尿铜排出量具有指导意义。本法已广泛应用于临床实际样品的分析 ,获得良好效果。

关键词：肝豆状核变性血清尿铜测定临床意义原子吸收光谱法

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