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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel

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World Journal of Gastroenterology 2018年第35期24卷 4036-4053页

作者： Keizo Hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori Koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue Department of Physiology Graduate School of Medical Sciences Fukuoka University Department of Pathology Faculty of Medicine Fukuoka University Department of Gastroenterological Surgery Faculty of Medicine Fukuoka University Department of Cell Biology University of Connecticut Health Center Department of Gastroenterology and Medicine Faculty of Medicine Fukuoka University College of Letters and Science University of CaliforniaDavis

AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting ***^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel *** factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting *** from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO *** active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,*** counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of ***,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen *** the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly *** The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis

关键词： Intestinal fibrosis Myofibroblast Transient receptor potential ankyrin 1 Crohn’s disease Collagen α-smooth muscle actin

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Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease

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Neural Regeneration research 2017年第5期12卷 747-748页

作者： Takashi Morishita Tooru Inoue Department of Neurosurgery Fukuoka University Faculty of Medicine Fukuoka Japan

Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric *** efforts to improve the clinical outcomes of the procedure have been prev... 详细信息

关键词： DBS Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson’s disease deep

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