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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu ZHANG Zi Yu LI Xin Xin LU Yao ZHANG Lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan Jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU Meng Jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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Relationship between Phenotypic Changes of Dendritic Cell Subsets and the Onset of Plateau Phase during Intermittent Interferon Therapy in Patients with CHB

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Biomedical and Environmental Sciences 2024年第3期37卷 303-314页

作者： YANG Liu WANG Shi Yu JIANG Ting Ting DENG Wen CHANG Min WU Shu Ling CAO Wei Hua LU Yao SHEN Ge LIU Ru Yu GAO Yuan Jiao XU Meng Jiao HU Lei Ping ZHANG Lu XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center for Infectious Diseases Second Affiliated Hospital of Air Force Medical UniversityXi'an 710038ShaanxiChina Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China

Objective This study aimed to evaluate whether the onset of the plateau phase of slow hepatitis B surface antigen decline in patients with chronic hepatitis B treated with intermittent interferon therapy is related to the frequency of dendritic cell subsets and expression of the costimulatory molecules CD40,CD80,CD83,and *** This was a cross-sectional study in which patients were divided into a natural history group(namely NH group),a long-term oral nucleoside analogs treatment group(namely NA group),and a plateau-arriving group(namely P group).The percentage of plasmacytoid dendritic cell and myeloid dendritic cell subsets in peripheral blood lymphocytes and monocytes and the mean fluorescence intensity of their surface costimulatory molecules were detected using a flow *** In total,143 patients were enrolled(NH group,n=49;NA group,n=47;P group,n=47).The results demonstrated that CD141/CD1c double negative myeloid dendritic cell(DNmDC)/lymphocytes and monocytes(%)in P group(0.041[0.024,0.069])was significantly lower than that in NH group(0.270[0.135,0.407])and NA group(0.273[0.150,0.443]),and CD86 mean fluorescence intensity of DNmDCs in P group(1832.0[1484.0,2793.0])was significantly lower than that in NH group(4316.0[2958.0,5169.0])and NA group(3299.0[2534.0,4371.0]),Adjusted P all<*** Reduced DNmDCs and impaired maturation may be associated with the onset of the plateau phase during intermittent interferon therapy in patients with chronic hepatitis B.

关键词： CHB Dendritic Cells Intermittent Interferon Therapy Plateau Phase

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Impact of ursodeoxycholic acid therapy in autoimmune liver disease patients with COVID-19 and its clinical prognosis

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Biosafety and health 2024年第3期6卷 165-170页

作者： Minghui Li Weihua Cao Tingting Jiang Wen Deng Shiyu Wang Shuling Wu Lu Zhang Yao Lu Min Chang Ruyu Liu Xiaoyan Ding Ge Shen Yuanjiao Gao Hongxiao Hao Xiaoxue Chen Leiping Hu Mengjiao Xu Yuyong Jiang Wei Yi Yao Xie Rui Song Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Medical Oncology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

To explore the impact of ursodeoxycholic acid(UDCA)on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and clinical outcomes in patients with autoimmune liver disease(AILD).Patients diagnosed with AILD were enrolled and divided into a UDCA group and a non-UDCA group based on whether they received UDCA *** data were collected regarding AILD diagnosis,treatment,biochemical indicators,and imaging *** incidence of SARS-CoV-2 infection and the prognosis of AILD patients were observed.A total of 1,138 patients completed *** usage rate of hormone(P=0.003)and immunosuppressant(P=0.001)used for treating AILD in the non-UDCA group was markedly lower than in the UDCA *** UDCA usage rate was markedly lower in SARS-CoV-2 infected patients than in uninfected patients(P=0.003).The rate of SARS-CoV-2 infection in the non-UDCA group was significantly higher than in the UDCA group(P=0.018).Logistic regression analysis showed that UDCA use(P=0.003)was correlated to a lower incidence of SARS-CoV-2,while immunosuppressant use(P=0.017)increased the *** time from SARS-CoV-2 infection was markedly longer for those receiving UDCA treatment than those in the non-UDCA group(P=0.018).UDCA is associated with low SARS-CoV-2 incidence in AILD patients,while immunosuppressant increases its incidence *** receiving UDCA treatment have a longer recovery time after being infected.

关键词： Ursodeoxycholic acid(UDCA) Autoimmune liver disease(AILD) Coronavirus disease 2019(COVID-19) Primary biliary cholangitis(PBC) Autoimmune hepatitis(AIH)

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Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics

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World Journal of Stem Cells 2024年第1期16卷 1-6页

作者： Hang-Qi Hu Xi-Yan Xin Yu-Tian Zhu Rui-Wen Fan Hao-Lin Zhang Yang Ye Dong Li Department of Traditional Chinese Medicine Peking University Third HospitalBeijing 100191China

The incidence of premature ovarian insufficiency(POI)is increasing worldwide,particularly among younger women,posing a significant challenge to *** addition to menopausal symptoms,POI leads to several complications that profoundly affect female reproductive function and overall ***,current clinical treatment strategies for this condition are limited and often yield unsatisfactory *** approaches typically involve hormone repla-cement therapy combined with psychological ***,mesenchymal stem cell(MSC)therapies for POI have garnered considerable attention in global *** can restore ovarian reproductive and endocrine functions through diverse mechanisms,including controlling differentiation,promoting angiogenesis,regulating ovarian fibrosis,inhibiting apoptosis,enhancing autocrine and paracrine effects,suppressing inflammation,modulating the immune system,and genetic *** editorial offers a succinct summary of the application of MSC therapy in the context of POI,providing evidence for groundbreaking medical approaches that have potential to enhance reproductive health and overall well-being for women.

关键词： Mesenchymal stem cell therapy Mechanism Premature ovarian insufficiency Therapeutic Women

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Epidemiological research,burden,and clinical advances of inflammatory bowel disease in China

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Chinese Medical Journal 2024年第9期137卷 1009-1011页

作者： Hong Yang Jiaming Qian Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Inammatory bowel disease(IBD),which includes Crohn’s disease(CD)and ulcerative colitis(UC),is a chronic,progressive illness thatuctuates in severity and involves recurring periods of relapse and *** has emerged as a global public health ***,IBD has been predominantly found in Western countries,with North America and Europe exhibiting the highest rates of prevalence and ***cally,the prevalence and incidence rates for UC were 505/100,000 and 249/100,000,respectively,while for CD they were 322/100,000 and 319/100,000,respectively.[1]However,there has been a recent stabilization of IBD incidence in countries with high prevalence rates.

关键词： prevalence bowel stabilization

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PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes

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World Journal of Pediatrics 2024年第1期20卷 82-91页

作者： Han Zhang Kai Gao Shuang Wang Yue-Hua Zhang Zhi-Xian Yang Ye Wu Yu-Wu Jiang Department of Pediatrics Peking University First Hospital.No.1 Xi'an Men StreetWest DistrictBeijing 100034China Bejing Key Laboratory of Molecular Diagnosis and Study on Pediatric Genetic Diseases BeijingChina Children Epilepsy Center Peking University First HospitalBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health and Family Planning CommissionPeking UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijingChina

Background The PACS gene family has been demonstrated to be related to intracellular vesicular *** phenotypic manifestations caused by the pathogenic variants of PACS include epilepsy,intellectual disability/developmental delay,and malformations,such as facial *** We identified seven new cases with pathogenic or likely pathogenic PACS variants using next-generation *** information obtained from these patients was analyzed along with that obtained from previously reported *** With the inclusion of the newly diagnosed cases in this study,103 cases with PACS gene family-related neurological diseases were reported,of which 43 were PACS2-related cases and the remaining were PACSI-related *** patients had seizures,which have been reported to be effectively controlled by several types of anti-seizure medications(ASMs).The most efficacious and frequently prescribed ASMs included sodium valproate(43.3%,13/30),oxcarbazepine/carbamazepine(26.7%,8/30),and levetiracetam(20%,6/30).Almost all patients had intellectual disability/developmental *** most common pathogenic missense variants were PACSI ***203Trp and PACS2 *** addition,we report a patient carrying a likely pathogenic copy number variation(CNV)(de novo heterozygous deletion of chr14:105821380-106107443,286 kilobase,destroyed part of the furin-binding region domain and the protein structure after it)with more severe and refractory late-onset *** The clinical phenotypes of the different PACS heterozygous missense variants were *** pathogenic variant sites of PACSI and PACS2 were quite limited but located in different regions.A CNV destroying part of the PACS2 gene might also be *** findings may provide an important clue for further functional studies on the pathogenic mechanism of neurological disorders related to the PACS gene family.

关键词： developmental delay Epilepsy Intellectual disability PACSI PACS2

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Hepatology research|急性失代偿期酒精性肝硬化患者90天生存预后模型的建立和验证

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临床肝胆病杂志 2024年第3期40卷 520-520页

作者：全卉于浩江宇泳首都医科大学北京地坛医院中西医结合中心

酒精性肝硬化是临床发病率不断升高的慢性肝病之一,首次进展至急性失代偿期作为患者生活质量、住院概率的转折点,表现出更严重的全身炎症及并发症的进展,以及显著升高的短期死亡风险。目前与急性失代偿期酒精性肝硬化生存相关的危险因... 详细信息

酒精性肝硬化是临床发病率不断升高的慢性肝病之一,首次进展至急性失代偿期作为患者生活质量、住院概率的转折点,表现出更严重的全身炎症及并发症的进展,以及显著升高的短期死亡风险。目前与急性失代偿期酒精性肝硬化生存相关的危险因素尚未清晰,且患者在这一阶段病程进展迅速,预后不良。因此,对其早期预警因素的探讨十分必要。

关键词：酒精性肝硬化慢性肝病临床发病率死亡风险全身炎症急性失代偿期预后不良早期预警

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Long-term follow-up of auditory performance and speech perception and effects of age on cochlear implantation in children with pre-lingual deafness

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Chinese Medical Journal 2019年第16期132卷 1925-1934页

作者： Jing Lyu Ying Kong Tian-Qiu Xu Rui-Juan Dong Bei-Er Qi Shuo Wang Yong-Xin Li Hai-Hong Liu Xue-Qing Chen Department of Otolaryngology Head and Neck SurgeryBeijing Tongren HospitalCapital Medical UniversityBeijing Institute of OtolaryngologyBeijing 100005China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryDepartment of OtolaryngologyHead and Neck SurgeryBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China.

Background: The development of auditory and speech perception ability of children with hearing loss is affected by many factors after they undergo cochlear implantation (CI). Age at CI (CI age) appears to play an important role among these factors. This study aimed to evaluate the development of auditory and speech perception ability and explore the impact of CI age on children with pre-lingual deafness present before 3 years of age. Methods: Two hundred and seventy-eight children with pre-lingual deafness (176 boys and 102 girls) were included in this study, and the CI age ranged from 6 to 36 months (mean age, 19 months). Categorical auditory performance (CAP) was assessed to evaluate auditory ability, and the speech intelligibility rating was used to evaluate speech intelligibility. The evaluations were performed before CI and 1, 3, 6, 12, 18, 24, 36, 48, and 60 months after CI. Results: The auditory ability of the pre-lingually hearing-impaired children showed the fastest development within 6 months after CI (k = 0.524, t = 30.992, P 0.05). The optimal cutoff age for CI was 15 months. Conclusions: Within 5 years after CI, the auditory and speech ability of young hearing-impaired children continuously improved, although speech development lagged behind that of hearing. An earlier CI age is recommended;the optimal cutoff age for CI is at 15 months.

关键词： Categorical auditory performance Speech intelligibility rating Cochlear implantation Children Pre-lingual deafness Age at cochlear implantation

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Neuroendoscopic Evaluation and Treatment for Cerebral Ventricular Infection

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Chinese Medical Journal 2018年第17期131卷 2114-2116页

作者： Feng Guan Hui Huang Zu-Yuan Ren Zhen-Yu Wang Ji-Di Fu Ying-Bin Li Feng-Qi Cui Wei-Cheng Peng Bin Dai Guang-Tong Zhu Zhi-Yong Xiao Bei-Bei Mao Zhi-Qiang Hu Department of Neurosurgery Beijing Shijitan Hospital Capital Medical University Beijing 100038 China Department of Neurosurgery Peking Union Medical College Hospital Beijing 100032 China Department of Neurosurgery Peking University Third Hospital Peking University Beijing 100191 China Department of Neurosurgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Neurosurgery The Second Affiliated Hospital of Nanjing Medical University Nanjing 210000 China Department of Neurosurgery Beijing Liangxiang Hospital Beijing 102401 China

To the Editor： Cerebral ventricular infection （CVI）, also termed ependymitis, involves an inflammatory response in the cerebral ventricular system. CVI is characterized by leukocytosis in tile cerebrospinal fluid （CSF）, a positive culture result of pathogenic bacteria, and imaging changes in tile ventricles.

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Sleep Duration and Factors Related to Sleep Loss in 3-14-Year-Old Children in Beijing： A Cross-Sectional Survey

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Chinese Medical Journal 2018年第15期131卷 1799-1807页

作者： Xiao-Dan Li Jun Tai Zhi-Fei Xu Gui-Xiang Wang Yun-Xiao Wu Jiang-Nan Du Jie Zhang Xiao-Xia Peng Xin Ni Department of Otorhinolaryngology-Head and Neck Surgery Beijing Children's Hospital Capital Medical University Beijing 100045 China Department of Respiratory Beijing Children's Hospital Capital Medical University Beijing 100045 China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University Beijing 100045 China Center for Clinical Epidemiology and Evidence-based Medicine Beijing children's Hospital Capital Medical University Beijing 100045 China

Background： It is known that short sleep duration adversely affects children＇s behavior and physical development. This study aimed to investigate the status of sleep duration in 3-14-year-old children in Beijing and explore the related factors of sleep loss with them. Methods： In this study, a cross-sectional study of random stratified cluster sampling was conducted on 3-14-year-old children and adolescents in Beijing. According to the proportion of children in each district and school, the final cohort included a total of 11 kindergartens, 7 primary schools, and 8 junior high schools from 7 districts of Beijing. Children of sampled classes were included, and their parents were invited to fill a series of questionnaires including the simplified Chinese version of Pediatric Sleep Questionnaire, Sleep Questionnaire Scale, and Hong Kong-Children Sleep Questionnaire about the performance of the last 6 months. Results： Out of the total 11,420 questionnaires, 9198 questionnaires were valid and effective with the response rate of 80.54%. The age of the investigated children was 8.8 ± 3.8 years, including 4736 males and 4462 females. The daily sleep duration of children in Beijing was 9.7 ± 0.7 h. The prevalence of sleep loss （〈9 h/day） of children in Beijing was 11.8%. The daily sleep duration of children aged 〈6, 6 ≤ age 〈11, and ≥11 years was 9.7 ± 0.6 h, 9.6 ± 0.6 h, and 9.5 ± 0.8 h, respectively. The sleep duration reduced significantly in children aged ≥11 years as compared to younger children in Beijing which was mainly contributed by the variation tendency of sleep duration on weekdays. The multivariate logistic regression analysis identified factors associated with sleep loss （P 〈 0.05）： male （odds ratio [OR] = 1.32, 95% confidence interval [CI ]： 1.15-1.51 ）, age ≥11 years （OR = 2.37, 95% CI： 1.92-2.93）, overweight （OR = 1.34, 95% CI： 1.17-1.54）, family history of snoring （OR - 1.35, 95% CI： 1.13-1.61 ） and activities before bedtime with watching TV （OR = 1.24, 95

关键词： Child Cross-Sectional Survey Sleep Duration

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