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Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng Li Zhuoran Yang Ziming Yan Huibin Shi Zhanli Liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

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Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： Jie CHEN Xinyue ZHANG Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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Multi-layer multi-pass friction rolling additive manufacturing of Al alloy:Toward complex large-scale high-performance components

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 425-438页

作者： Haibin Liu Run Hou Chenghao Wu Ruishan Xie Shujun Chen College of Mechanical&Energy Engineering Beijing University of TechnologyBeijing 100124China Chongqing Research Institute of beijing University of Technology Chongqing 401121China

At present,the emerging solid-phase friction-based additive manufacturing technology,including friction rolling additive man-ufacturing(FRAM),can only manufacture simple single-pass *** this study,multi-layer multi-pass FRAM-deposited alumin-um alloy samples were successfully prepared using a non-shoulder tool *** material flow behavior and microstructure of the over-lapped zone between adjacent layers and passes during multi-layer multi-pass FRAM deposition were studied using the hybrid 6061 and 5052 aluminum *** results showed that a mechanical interlocking structure was formed between the adjacent layers and the adja-cent passes in the overlapped center *** friction and rolling of the tool head led to different degrees of lateral flow and plastic deformation of the materials in the overlapped zone,which made the recrystallization degree in the left and right edge zones of the over-lapped zone the highest,followed by the overlapped center zone and the non-overlapped *** tensile strength of the overlapped zone exceeded 90%of that of the single-pass deposition *** is proved that although there are uneven grooves on the surface of the over-lapping area during multi-layer and multi-pass deposition,they can be filled by the flow of materials during the deposition of the next lay-er,thus ensuring the dense microstructure and excellent mechanical properties of the overlapping *** multi-layer multi-pass FRAM deposition overcomes the limitation of deposition width and lays the foundation for the future deposition of large-scale high-performance components.

关键词： aluminum alloy additive manufacturing solid-state friction stir welding multi-layer multi-pass

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Bo’s abdominal acupuncture treatment for adult-onset Still's disease:A case report

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World Journal of Clinical Cases 2025年第8期13卷 41-48页

作者： Jia-Min Yang Yu Wang Yu-Qing Zhang Hong-Lin Zhang Zhi-Yun Bo College for People's Livelihood and Well-being Beijing Vocational College of Labor and Social SecurityBeijing 100029China College of Acupuncture and Moxibustion Beijing University of Chinese MedicineBeijing 100029China Guang'Anmen Hospital China Academy of Traditional Chinese MedicineBeijing 100053China beijing Zhiyuntang Traditional Chinese Medicine Clinic Beijing Bo’s Abdominal Acupuncture Research InstituteBeijing 100122China

BACKGROUND Adult-onset Still's disease(AOSD)is a rare autoinflammatory disease charac-terized by nonspecific symptoms such as fever,rash,sore throat and *** paper reports a clinical case of AOSD successfully treated with Bo’s abdo-minal acupuncture(BAA).CASE SUMMARY We report a 20-year-old man who suffered from cold exposure,presenting with high fever,rash,sore throat,arthralgia,and elevated erythrocyte sedimentation rate,leukocytosis with neutrophilic predominance,elevated ferritin,elevated C-reactive protein,and negative rheumatoid *** was diagnosed with AOSD based on the Yamaguchi *** treatment with traditional Chinese medi-cine(TCM)decoction and prednisone acetate tablets,there was some alleviation of sore throat,joint and muscle pain,and fever,but he still had persistent low-grade fever,rash,sore throat and *** went to the TCM acupuncture outpatient department to receive *** acupoints Zhongwan(CV12),Xiawan(CV10),0.5 cm below Xiawan(CV10),Qihai(CV6),Guanyuan(CV4),bilateral Qixue(KI13),bilateral Huaroumen(ST24),bilateral Shangfengshidian(AB1)and bilateral Daheng(SP15)were *** 3 months treatment,all symptoms disappeared,and the laboratory examination returned to normal *** did not take glucocorticoids or nonsteroidal anti-inflammatory drugs afterwards,and no relapse was observed during the 3-year follow-up *** BAA can be used as a complementary medical approach for treatment of AOSD.

关键词： Adult-onset Still’s disease Bo’s abdominal acupuncture Traditional Chinese medicine Complementary medicine Case report

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Adaptive Synchronization of an Array of Time-Varying Coupled Delayed Neural Networks

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Chinese Physics Letters 2010年第3期27卷 60-63页

作者：王健安刘贺平 School of Information Engineering University of Science and Technology Beijing Beijing 100083

Synchronization in an array of time-varying coupled delayed neural networks is investigated. We assume that the entries of time-varying coupling configuration matrix and inner-coupling matrix of the model are all bounded. By combining linear feedback with an adaptive control approach, some simple controllers are proposed to ensure the states of such coupled networks globally asymptotically synchronize to a desired synchronous solution. Simulation results are provided to demonstrate the effectiveness of the proposed approach.

关键词： Instrumentation and measurement

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ANTIMONY INDUCED CRYSTALLIZATION OF AMORPHOUS SILICON

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Acta Metallurgica Sinica(English Letters) 2007年第3期20卷 167-170页

作者： Y. Wang H.Z. Li C.N. Yu G.M. Wu I. Gordon P. Schattschneider O. Van Der Biest School of Science Beijing Institute of Petro-Chemical Technology Beijing 102617 China Center of Engineering education Beijing Institute of Petro-Chemical Technology Beijing 102617 China School of Materials Science and Engineering Beijing Institute of Pctro-Chcmical Technology Beijing 102617 China Development of Technique Interuniversity Micro Electronics Center B-3001 Leuven Belgium School of Materials Science and Engineering Technische Universitat Wien A-1040 Wien Austria School of Materials Science and Engineering Kathofieke Universiteit Leuven B-3001 Heverlee （Leuven） Belgium

Antimony induced crystallization of PVD （physics vapor deposition） amorphous silicon can be observed on sapphire substrates. Very large crystalline regions up to several tens of micrometers can be formed. The Si diffraction patterns of the area of crystaUization can be observed with TEM （transmission electron microscopy）. Only a few and much smaller crystals of the order of 1 μm were formed when the antimony layer was deposited by MBE （molecular beam epitaxy） compared with a layer formed by thermal evaporation. The use of high vacuum is essential in order to observe any Sb induced crystallization at all. In addition it is necessary to take measures to limit the evaporation of the antimony.

关键词： antimony polycrystalline silicon thin film

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Tumor-microenvironment activated programmable synergistic cancer therapy by bioresponsive rare-earth nanocomposite

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Journal of Rare Earths 2022年第9期40卷 1399-1406,I0003页

作者： Qi Jia Xin Han Yuxin Liu Xianquan Liao Jing Zhou Capital Normal University Beijing 100048China

Synergistic chemotherapy-photothermal therapy(CT-PTT)can improve the cancer treatment efficacy,but its treatment effect is still limited by factors such as targeting efficiency and treatment ***,a H_(2)S-responsive metal organic frameworks(MOFs)coated rare-earth nanocomposite(csEr@-MOF)was constructed and loaded with a chemotherapeutic drug(DOX)and a heat shock protein(HSP)inhibitor(Shepherdin).As the drug-loaded csEr@MOF reaches the H_(2)S-riched colorectal tumor region,based on the reaction between H_(2)S and MOF,Shepherdin is released for inhibiting the function of HSPs,the generated CuS is used for PTT and DOX is released for *** being monitored by ratiometric imaging of rare-earth nanocomposite,it is possible to perform the precise treatment timing for *** the help of Shepherdin,the treatment effect of PTT was ***,programmable CT-PTT synergistic cancer therapy activated by a single H_(2)S trigger is achieved in vitro and in *** work provides new ideas for designing tumor microenvironment-responsive therapeutic agents for programmable synergistic therapy with better targeting and therapeutic efficiency.

关键词： Rare-earth nanocomposite Tumor microenvironment Hydrogen sulfide Synergistic therapy Programmable therapy

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Defective layered Mn-based cathode materials with excellent performance via ion exchange for Li-ion batteries

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Journal of Energy Chemistry 2023年第7期82卷 537-546,I0012页

作者： Yongheng Si Kun Bai Yaxin Wang Han Lu Litong Liu Ziyan Long Yujuan Zhao beijing Key Laboratory for Green Catalysis and Separation Department of ChemistryThe Faculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

Defective layered Mn-based materials were synthesized by Li/Na ion exchange to improve their electrochemical activity and Coulombic *** annealing temperature of the Na precursors was important to control the P3-P2 phase transition,which directly affected the structure and electrochemical characteristics of the final products obtained by ion *** O3-Li_(0.78)[Li_(0.25)Fe_(0.075)Mn_(0.675)]O_(δ) cathode made from a P3-type precursor calcined at 700℃ was analyzed using X-ray photoelectron spectrometry and electron paramagnetic *** results showed that the presence of abundant trivalent manganese and defects resulted in a discharge capacity of 230 mAh/g with an initial Coulombic efficiency of about 109%.Afterward,galvanostatic intermittent titration was performed to examine the Li^(+) ion diffusion coefficients,which affected the reversible *** principles calculations suggested that the charge redistribution induced by oxygen vacancies(OV_(s))greatly affected the local Mn coordination environment and enhanced the structural ***,the Li-deficient cathode was a perfect match for the pre-lithiation anode,providing a novel approach to improve the initial Coulombic efficiency and activity of Mn-based materials in the commercial application.

关键词： Ion exchange Defective cathode materials Oxygen vacancies Initial coulombic efficiency DFT calculations

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Improvement in the Oxidation Resistance of Tungsten by Sol-Gel Derived Al_2O_3 Coating

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稀有金属材料与工程 2012年第S1期41卷 303-305页

作者： Fan Ailing1,Meng Lingsheng1,Huang Lang1,2,Ma Jie1 1 College of Materials Science and Engineering,beijing University of Technology,beijing 100124,China 2 Department of Safety and Environment,Xinyu Iron&Steel Group Co.Ltd,Xinyu 338001,China beijing Univ Technol Coll Mat Sci & Engn Beijing 100124 Peoples R China Xinyu Iron & Steel Grp Co Ltd Dept Safety & Environm Xinyu 338001 Peoples R China

An Al2O3 coating was prepared from aluminum isopropoxide as precursor on tungsten *** dependences of crystalline and phase in Al2O3 coating on temperature were *** results show the coatings being compact,uniform and crack-free can be obtained by suitable *** main phase of coating is α-*** to the uncoated specimens,the ones with coatings synthesized by sol-gel process provide excellent oxidation resistance at high temperature.

关键词： sol-gel process tungsten filament Al2O3 coating

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