检索结果-南通市图书馆

Molecular Determinants of Antibiotic Resistance in the Costa Rican Pseudomonas aeruginosa AG1 by a Multi-omics Approach:A Review of 10 Years of Study

引用

Phenomics 2021年第3期1卷 129-142页

作者： Jose Arturo Molina-Mora Fernando García Centro de Investigación en Enfermedades Tropicales(CIET)&Facultad de Microbiología Universidad de Costa RicaSan JoséCosta Rica

Pseudomonas aeruginosa AG1(PaeAG1)is a Costa Rican strain that was isolated in 2010 in a major *** strain has resistance to multiple antibiotics such asβ-lactams(including carbapenems),aminoglycosides,and ***1 is considered critical(Priority 1)due to its resistance to carbapenems,and it was the first report of a *** isolate carrying both VIM-2 and IMP-18 genes encoding for metallo-β-lactamases(MbL)enzymes(both with carbapenemase activity).Owing to these traits,we have studied this model for 10 years using diverse approaches including *** this review,we summarize the main points of the different steps that we have studied in PaeAG1:preliminary analyses of this strain at the genomic and phenomic levels revealed that this microorganism has particular features of antibiotic *** the multi-omics approach,the genome assembly was the initial step to identify the genomic determinants of this strain,includ-ing virulence factors,antibiotic resistance genes,as well as a complex accessory ***,a comparative genomic approach was implemented to define and update the phylogenetic relationship among complete *** genomes,the genomic island content in other strains,and the architecture of the two MbL-carrying ***,the proteomic profile of PaeAG1 was studied after exposure to antibiotics using 2-dimensional gel electrophoresis(2D-GE).Fourth,to study the central response to multiple perturbations in ***,i.e.,the core perturbome,a machine learning approach was *** analysis revealed biological functions and determinants that are shared by different ***,to evaluate the effects of ciprofloxacin(CIP)on PaeAG1,a growth curve comparison,differential expression analysis(RNA-Seq),and network analysis were *** the results of the core perturbome(pathways that also were found in this perturbation with CIP),it was possible to identify the“exclusive”response and determina

关键词： Pseudomonas aeruginosa PaeAG1 Antibiotic resistance Multi-omics High risk

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：