检索结果-南通市图书馆

Collisionless shock acceleration of protons in a plasma slab produced in a gas jet by the collision of two laser-driven hydrodynamic shockwaves

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第2期9卷 12-25页

作者： J.-R.Marquès L.lancia P.Loiseau P.Forestier-Colleoni M.Tarisien E.Atukpor V.Bagnoud C.Brabetz F.Consoli J.Domange F.Hannachi P.Nicolaï M.Salvadori B.Zielbauer LULI CNRSÉcole PolytechniqueCEASorbonne UniversitéInstitut Polytechnique de Paris91128 Palaiseau CedexFrance CEA DAMDIF91297 Arpajon CedexFrance UniversitéParis-Saclay CEALMCE91680 Bruyères-le-ChatelFrance CENBG CNRS-IN2P3Universitéde Bordeaux33175 Gradignan CedexFrance GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany University of Darmstadt Schloßgartenstr.764289 DarmstadtGermany ENEA Fusion and Technologies for Nuclear Safety department C.R.FrascatiVia Enrico Fermi 45FrascatiRomeItaly CELIA Universitéde Bordeaux–CNRS–CEA33405 TalenceFrance UniversitéParis-Saclay CEALIDYL91191 Gif-sur-YvetteFrance

We have recently proposed a new technique of plasma tailoring by laser-driven hydrodynamic shockwaves generated on both sides of a gas jet[Marquès et al.,*** 28,023103(2021)].In a continuation of this numerical work,we study experimentally the influence of the tailoring on proton acceleration driven by a high-intensity picosecond laser in three cases:without tailoring,by tailoring only the entrance side of the picosecond laser,and by tailoring both sides of the gas *** tailoring,the acceleration is transverse to the laser axis,with a low-energy exponential spectrum,produced by Coulomb *** the front side of the gas jet is tailored,a forward acceleration appears,which is significantly enhanced when both the front and back sides of the plasma are *** forward acceleration produces higher-energy protons,with a peaked spectrum,and is in good agreement with the mechanism of collisionless shock acceleration(CSA).The spatiotemporal evolution of the plasma profile is characterized by optical shadowgraphy of a probe *** refraction and absorption of this beam are simulated by post-processing 3D hydrodynamic simulations of the plasma *** with the experimental results allows estimation of the thickness and near-critical density of the plasma slab produced by tailoring both sides of the gas *** parameters are in good agreement with those required for CSA.

关键词： acceleration hydrodynamic collision

Targeted therapy for capillary-venous malformations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul Duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet Michael Dussiot denise MAdams Tristan Mirault laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance Division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous

Improving the utility of locally differentially private protocols for longitudinal and multidimensional frequency estimates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第2期10卷 369-379页

作者： Héber H.Arcolezi Jean-François Couchot Bechara Al Bouna Xiaokui Xiao Inria andÉcole Polytechnique(IPP) PalaiseauFrance Femto-ST Institute Univ.Bourg.Franche-ComtéUBFCCNRSBelfortFrance TICKET lab. Antonine University Hadat-BaabdaBaabdaLebanon School of Computing National University of SingaporeSingaporeSingapore

This paper investigates the problem of collecting multidimensional data throughout time(i.e.,longitudinal studies)for the fundamental task of frequency estimation under Local Differential Privacy(LDP)*** to frequency estimation of a single attribute,the multidimensional aspect demands particular attention to the privacy ***,when collecting user statistics longitudinally,privacy progressively ***,the“multiple”settings in combination(i.e.,many attributes and several collections throughout time)impose several challenges,for which this paper proposes the first solution for frequency estimates under *** tackle these issues,we extend the analysis of three state-of-the-art LDP protocols(Generalized Randomized Response–GRR,Optimized Unary Encoding–OUE,and Symmetric Unary Encoding–SUE)for both longitudinal and multidimensional data *** the known literature uses OUE and SUE for two rounds of sanitization(***),i.e.,L-OUE and L-SUE,respectively,we analytically and experimentally show that starting with OUE and then with SUE provides higher data utility(i.e.,L-OSUE).Also,for attributes with small domain sizes,we propose Longitudinal GRR(L-GRR),which provides higher utility than the other protocols based on unary ***,we also propose a new solution named Adaptive LDP for LOngitudinal and Multidimensional FREquency Estimates(ALLOMFREE),which randomly samples a single attribute to be sent with the whole privacy budget and adaptively selects the optimal protocol,i.e.,either L-GRR or *** shown in the results,ALLOMFREE consistently and considerably outperforms the state-of-the-art L-SUE and L-OUE protocols in the quality of the frequency estimates.

关键词： Local differential privacy Discrete distribution estimation Frequency estimation Multidimensional data Longitudinal studies

Experimental measurements of gamma-photon production and estimation of electron/positron production on the PETAL laser facility

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Matter and Radiation at Extremes 2024年第5期9卷 32-47页

作者： F.Brun L.Ribotte G.Boutoux X.Davoine P.E.Masson-laborde Y.Sentoku N.Iwata N.Blanchot D.Batani I.lantuéjoul L.Lecherbourg B.Rosse C.Rousseaux B.Vauzour D.Raffestin E.D’Humières X.Ribeyre Centre lasers Intenses et Applications UMR 5107Universitéde Bordeaux-CNRS-CEA33405 TalenceFrance CEA DAMCESTAF-33116 Le BarpFrance CEA DAMDIFF-91297 ArpajonFrance CEA LMCEUniversitéParis-Saclay91680 Bruyères-le-ChâtelFrance Institute of laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan

This article reports the first measurements of high-energy photons produced with the high-intensity PETawatt Aquitaine laser(PETAL)*** experiments were performed during the commissioning of the *** laser had an energy of about 400 J,an intensity of 8×10^(18)W cm^(−2),and a pulse duration of 660 fs(FWHM).It was shot at a 2 mm-thick solid tungsten *** high-energy photons were produced mainly from the bremsstrahlung process for relativistic electrons accelerated inside a plasma generated on the front side of the *** paper reports measurements of electrons,protons and *** electrons up to35 MeV with a few-MeV temperature were recorded by a spectrometer,called SESAME(SpectreÉlectronS Angulaire MoyenneÉnergie).K-and L-shells were clearly detected by a photon spectrometer called SPECTIX(Spectromètre PetalàCristal en TransmIssion pour le rayonnnement X).High-energy photons were diagnosed by CRACC-X(Cassette de RAdiographie Centre Chambre-rayonnement X),a bremsstrahlung *** cannon analysis is strongly dependent on the hypothesis adopted for the spectral *** shapes can exhibit similar reproductions of the experimental *** eliminate dependence on the shape hypothesis and to facilitate analysis of the data,simulations of the interaction were *** model the mechanisms involved,a simulation chain including hydrodynamic,particle-in-cell,and Monte Carlo simulations was *** simulations model the preplasma generated at the front of the target by the PETAL laser prepulse,the acceleration of electrons inside the plasma,the generation of MeV-range photons from these electrons,and the response of the detector impacted by the energetic photon *** this work enabled reproduction of the experimental *** high-energy photons produced have a large emission angle and an exponential distribution *** addition to the analysis of the photon spectra,positron production was also ***,if high

关键词： process. positron hypothesis

Structural Elucidation of the Polymeric Condensed Tannins of Acacia nilotica Subspecies by ^(13)C NMR, MALDI-TOF and TMA as Sources of Bioadhesives

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2024年第7期12卷 1291-1310页

作者： Zeinab Osman Antonio Pizzi Bertrand Charrier Institute of Engineering Research and Materials Technology National Center for ResearchP.O.Box 2404KhartoumSudan ENSTIB-LERMAB University of Lorraine27 rue Philippe SeguinEpinal88000France department of Materials Science and Engineering Institute of Analytical Sciences and Physico-Chemistry for the Environment and Materials-Xylomat(IPREM-UMR5254)University of Pau and the Adour RegionE2S UPPACNRSMont de Marsan40004France

Tannin was extracted from different subspecies of Acacia nilotica,Acacia nilotica nilotica(Ann),Acacia nilotica tomentosa(Ant)and Acacia nilotica adansonii(Ana).The aim was to elucidate their structure and evaluate their reactivity as bioadhesives in the wood *** extracts were prepared by hot water extraction(90°C tem-perature).Their gel time with paraformaldehyde was used atﬁrst to compare their *** tannin contents and the percentage of total polyphenolic materials in different solutions of the extracts spray dried powder were determined by the hide powder *** solutions(47%)were tested by both MALDI ToF,*** thermomechanical analysis(TMA)was performed to evaluate their modulus of elasticity(MOE)at different *** gel times of all the three tannin extracts showed that their reactivity and it was com-parable to other known procyanidin/prodelphinidin tannin extract ***,Ann and Ant showed highest per-cent of total polyphenolic materials at 70%,64%,and 57%,*** 13CNMR spectra showed that the three subspecies of condensed tannins were mainly constituted of procyanidins(PC)and prodelphinidins(PD)in slightly different ***(56.5%PC and 43.4%PD),Ant(57%PC and 43%PD)and Ana(58%PC and 42%PD).MALDI–TOF spectra showed the presence ofﬂavonoid monomers,and oligomers some of which linked to short carbohydrates monomers or *** revealed that the three types of tannins had high MOE at their initial pH(5).

关键词： Acacia nilotica condensed tannins procyanidins prodelphinidins 13C NMR MALDI-ToF

The inhomogeneous incompressible Hall-MHD system with only bounded density

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Mathematics 2024年

作者： Jin Tan lan Zhang laboratoire de Math′ematiques AGM UMR CNRS 8088 Cergy Paris Universit′e Center for Mathematical Sciences and department of Mathematics Wuhan University of Technology

This paper is dedicated to the global-in-time existence and uniqueness issues of solutions for the inhomogeneous incompressible Hall-magnetohydrodynamics(MHD) system with merely bounded density. In a three-dimensional case, assuming that the initial density is a small perturbation of a positive constant in the L∞norm, we prove global well-posedness for small initial velocity and magnetic fields in critical Besov spaces. Next, we consider the so-called 21/2D flows for the inhomogeneous Hall-MHD system(that is 3D flows independent of the vertical variable) and establish the global existence of strong solutions by only assuming that the initial magnetic field is small in critical spaces and the initial density is bounded and bounded away from zero. In particular, those solutions allow piecewise constant density with jumps so that a mixture of fluids can be considered. Compared with inhomogeneous incompressible Navier-Stokes equations, the new difficulties of proving these results come from the additional so-called Hall term, which endows the magnetic equation with a quasi-linear character. In order to overcome them, we reformulate the system by taking advantage of the curl form of the magnetic equation and develop some new maximal regularity estimates for the Stokes system with just bounded coefficients.

关键词：

Purity-dependent Lorenz number,electron hydrodynamics and electron-phonon coupling in WTe_(2)

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 153-158页

作者： Wei Xie Feng Yang Liangcai Xu Xiaokang Li Zengwei Zhu Kamran Behnia Wuhan National High Magnetic Field Center and School of Physics Huazhong University of Science and TechnologyWuhan 430074China laboratoire de Physique et d’Etude des Matériaux(ESPCI-CNRS-Sorbonne Université)PSL University Paris 75005France

We present a study of electrical and thermal transport in Weyl semimetal WTe_(2)down to 0.3 *** Wiedemann-Franz law holds below 2 K and a downward deviation starts *** deviation is more pronounced in cleaner samples,as expected in the hydrodynamic picture of electronic transport,where a fraction of electron-electron collisions conserve *** are the dominant heat carriers and their mean-free-path does not display a Knudsen *** is presumably a consequence of weak anharmonicity,as indicated by the temperature dependence of the specific *** momentum exchange between phonons and electrons leads to quantum oscillations of the phononic thermal ***-Grüneisen picture of electron-phonon scattering breaks down at low temperature when Umklapp ph-ph collisions cease to be a sink for electronic flow of *** with semi-metallic Sb shows that normal ph-ph collisions are amplified by *** both semimetals,at cryogenic temperature,e-ph collisions degrade the phononic flow of energy but not the electronic flow of momentum.

关键词： thermal conductivity Wiedemann-Franz law electron hydrodynamics electron-phonon coupling

Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie Haushalterlaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

Protein-Repairing Methionine Sulfoxide Reductases in Photosynthetic Organisms： Gene Organization, Reduction Mechanisms, and Physiological Roles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2009年第2期2卷 202-217页

作者： Lionel Tarrago Edith laugier Pascal Rey CEA DSV IBEB Laboratoire d'Ecophysiologie Moleculaire des Plantes B~timent 161 SBVME CEA-Cadarache 13108 Saint-Paul-lez-Durance Cedex France

Methionine oxidation to methionine sulfoxide （MetSO） is reversed by two types of methionine sulfoxide reducrases （MSRs）, A and B, specific to the S- and R-diastereomers of MetSO, respectively. MSR genes are found in most organisms from bacteria to human. In the current review, we first compare the organization of the MSR gene families in photosynthetic organisms from cyanobacteria to higher plants. The analysis reveals that MSRs constitute complex families in higher plants, bryophytes, and algae compared to cyanobacteria and all non-photosynthetic organisms. We also perform a classification, based on gene number and structure, position of redox-active cysteines and predicted sub-cellular localization. The various catalytic mechanisms and potential physiological electron donors involved in the regeneration of MSR activity are then de- scribed. Data available from higher plants reveal that MSRs fulfill an essential physiological function during environmental constraints through a role in protein repair and in protection against oxidative damage. Taking into consideration the ex- pression patterns of MSR genes in plants and the known roles of these genes in non-photosynthetic cells, other functions of MSRs are discussed during specific developmental stages and ageing in photosynthetic organisms.

关键词： Genome methionine methionine sulfoxide reductase oxidation photosynthetic organisms protein repair.