检索结果-南通市图书馆

The optimal anticoagulation strategy for COVID-19,prophylactic or therapeutic?:a meta-analysis,trial sequential analysis,and meta-regression of more than 27,000 participants

引用

Emergency and Critical Care Medicine 2022年第3期2卷 148-166页

作者： Mingyue Guo Qi Han Jiaxuan Xing Feng Xu Jiali Wang Chuanbao Li Zechen Shan Yuan Bian Hao Wang Li Xue Qiuhuan Yuan Chang Pan Yanshan De Xingfang Wang Panpan Hao Shengchuan Cao Jiaojiao Pang Yuguo Chen Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityChest Pain CenterQilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineQilu Hospital of Shandong UniversityJinanShandongChina The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of EducationChinese Ministry of Health and Chinese Academy of Medical SciencesThe State and Shandong Province Joint Key Laboratory of Translational Cardiovascular MedicineQilu Hospital of Shandong UniversityJinanShandongChina.

Background:Anticoagulants are promising regimens for treating coronavirus disease 2019(COVID-19).However,whether prophylactic or intermediate-to-therapeutic dosage is optimal remains under active ***:We comprehensively searched PubMed,Embase,Scopus,Web of Science,Cochrane Library,ClinicalTrials,and MedRxiv databases on April 26,*** independent researchers conducted literature selection and data extraction separately according to predetermined ***,this is the first meta-analysis on COVID-19,taking serious consideration regarding the dosage overlap between the 2 comparison groups of prophylactic anticoagulation(PA)and intermediate-to-therapeutic anticoagulation(I-TA).Results:We included 11 randomized controlled trials(RCTs)and 36 cohort studies with 27,051 COVID-19 *** analyzing all the RCTs,there was no significant difference in mortality between the PA and I-TA groups,which was further confirmed by trial sequential analysis(TSA)(odds ratio[OR]:0.93;95%confidence interval[CI]:0.71–1.22;P=0.61;TSA adjusted CI:0.71–1.26).The rate of major bleeding was remarkably higher in the I-TA group than in the PA group,despite adjusting for TSA(OR:1.73;95%CI:1.15–2.60;P=0.009;TSA adjusted CI:1.09–2.58).RCTs have supported the beneficial effect of I-TA in reducing thrombotic *** including all studies,mortality in the I-TA group was significantly higher than in the PA group(OR:1.38;95%CI:1.15–1.66;P=0.0005).The rate of major bleeding was similar to the analysis from RCTs(OR:2.24;95%CI:1.86–2.69;P<0.00001).There was no distinct difference in the rate of thrombotic events between the 2 regimen *** addition,in both critical and noncritical subgroups,I-TA failed to reduce mortality but increased major bleeding rate compared with PA,as shown in meta-analysis of all studies,as well as RCTs ***-regression of all studies suggested that there was no relationship between the treatment effect and the overall risk of mortality or maj

关键词： Anticoagulation COVID-19 Major bleeding Mortality Prophylactic Therapeutic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Magnesium cationic cue enriched interfacial tissue microenvironment nurtures the osseointegration of gamma-irradiated allograft bone

引用

Bioactive Materials 2022年第4期7卷 32-47页

作者： Wenhao Wang Jie Shen Yuan Meng Miaoman Ye Shaozhang Lin Qi Zhao Le Wang Kenneth M.C.Cheung Shuilin Wu Yufeng Zheng Xuanyong Liu Paul K.Chu Kelvin W.K.Yeung Zhi-Yong Zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Department of Orthopaedics and Traumatology The University of Hong KongHong Kong999077PR China Shenzhen Key Laboratory for Innovative Technology in Orthopaedic Trauma The University of Hong Kong Shenzhen HospitalShenzhen518053PR China Department of Orthopaedic Surgery The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150PR China Shenzhen Key Laboratory of Spine Surgery Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen518036PR China Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials&EngineeringHubei UniversityWuhan430062PR China Ministry of Education Key Laboratory for Advanced Ceramics and Machining Technology School of Materials Science&EngineeringTianjin UniversityTianjin300352PR China State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollage of EngineeringPeking UniversityBeijing100871PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Materials Science and Engineering City University of Hong KongHong Kong999077PR China

Regardless of the advancement of synthetic bone substitutes,allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone ***,the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term ***,improving osseointegration and transplantation efficiency remains *** alteration of bone tissue microenvironment(TME)to facilitate osseointegration has been generally ***,the concept of exerting metal ionic cue in bone TME without compromising the mechanical properties of bone allograft is *** address this concern,an interfacial tissue microenvironment with magnesium cationc cue was tailored onto the gamma-irradiated allograft bone using a customized magnesium-plasma surface *** formation of the Mg cationic cue enriched interfacial tissue microenvironment on allograft bone was verified by the scanning ion-selective electrode *** cellular activities of human TERT-immortalized mesenchymal stem cells on the Mg-enriched grafts were notably *** the animal test,superior osseointegration between Mg-enriched graft and host bone was found,whereas poor integration was observed in the gamma-irradiated controls at 28 days ***,the bony in-growth appeared on magnesium-enriched allograft bone was significant *** mechanism possibly correlates to the up-regulation of integrin receptors in mesenchymal stem cells under modified bone TME that directly orchestrate the initial cell attachment and osteogenic differentiation of mesenchymal stem ***,our findings demonstrate the significance of magnesium cation modified bone allograft that can potentially translate to various orthopaedic procedures requiring bone augmentation.

关键词： Osseointegration Allograft bone Bone tissue microenvironment Bone-implant interface Magnesium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Co-varying temperatures at 200 hPa over the Earth’s three poles

引用

Science China Earth Sciences 2021年第2期64卷 340-350页

作者： Keyan FANG Peng ZHANG Jingming CHEN Deliang CHEN Key Laboratory of Humid Subtropical Eco-geographical Process(Ministry of Education) College of Geographical SciencesFujian Normal UniversityFuzhou 350007China Regional Climate Group Department of Earth SciencesUniversity of GothenburgBox 460S-40530 GothenburgSweden Department of Geography and Program in planning University of Toronto100 St.George St.TorontoOntarioCanada

The Earth’s three poles,the North Pole,South Pole,and Third Pole(i.e.,the Tibetan Plateau and its surroundings),hold the largest amount of fresh water on Earth as glaciers,sea ice,and *** are sensitive to climate ***,the linkages between climate variations of the three poles,particularly between the South Pole and Third Pole,remain largely *** temperatures at 200 hPa over the three poles are the highest in the summer and are less affected by surface conditions,which could reflect large-scale dynamic *** at 200 hPa peak the three poles during their respective hemispheric summer and exhibit in-phase variations on interdecadal timescales(10–100 years).The 200 hPa temperatures over the North Pole and South Pole were significantly correlated with the Brewer-Dobson circulation(BDC),which transports stratospheric ozone poleward,heating the air at 200 *** warming over the Third Pole was found to enhance the poleward BDC,particularly to the South Pole,linking the Third Pole’s climate to the other two ***,the Interdecadal Pacific Oscillation(IPO)also exhibits links with the 200 hPa temperatures of the three poles.

关键词： Three poles Tibetan Plateau Brewer-Dobson circulation Interdecadal Pacific Oscillation Climate teleconnection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antidiabetic effect of an engineered bacterium Lactobacillus plantarum-pMG36e-GLP-1 in monkey model

引用

Synthetic and Systems Biotechnology 2021年第4期6卷 272-282页

作者： Jie Luo Hongfei Zhang Jiachen Lu ChaoLin Ma Tingtao Chen School of Public Health and Key Laboratory of Preventive Medicine Nanchang UniversityNanchang330031China Institute of Life Sciences Nanchang UniversityNanchang330031China School of Queen Mary Nanchang UniversityNanchang330031China National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineThe First Affiliated HospitalNanchang University1299 Xuefu RoadHonggu DistrictNanchang330031PR China

Glucagon-like peptide-1(GLP-1)reduces postprandial hyperglycaemia,but its short half-life inhibits clinical *** aim of the current study was to evaluate the treatment efforts of an engineered strain,Lactobacillus plantarum-pMG36e-GLP-1(***-pMG36e-GLP-1),that continuously expresses GLP-1 in spontaneous type 2 diabetes mellitus(T2DM)*** 7 weeks of oral supplementation with ***-pMG36e-GLP-1,the fasting blood glucose(FPG)of monkeys was significantly(p<0.05)reduced to a normal level and only a small amount of weight was *** results of metagenomic sequencing showed that ***-pMG36e-GLP-1 caused a substantial(p<0.05)reduction in the intestinal pathogen Prevotella and marked enhancement of butyrate-producing Alistipes *** to the functional analysis using Kyoto Encyclopaedia of Genes and Genomes(KEGG)pathways,19 metabolism-related pathways were significantly enriched in T2DM monkeys after treatment with ***-MS faecal metabolomics analysis found 41 significant differential metabolites(11 higher and 30 lower)in monkeys after treatment pathways linked to the metabolism of cofactors and vitamins were the most *** present study suggests that ***-pMG36e-GLP-1 had an impact on the gut microbial composition and faecal metabolomic profile in spontaneous T2DM monkeys and may be a novel candidate for diabetes treatment.

关键词： L.plantarum-pMG36e-GLP-1 T2DM Gut microbiome Faecal metabolomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-loading Co-doped NiO nanosheets on carbon-welded carbon nanotube framework enabling rapid charge kinetic for enhanced supercapacitor performance

引用

Journal of Energy Chemistry 2020年第11期29卷 240-247页

作者： Hao Xu Yufang Cao Yong Li Pei Cao Dandan Liu Yongyi Zhang Qing wen Li School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026AnhuiChina Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina Division of Nanomaterials and Jiangxi Key Lab of Carbonene Materials Suzhou Institute of Nano-Tech and Nano-BionicsNanchangChinese Academy of SciencesNanchang 330200JiangxiChina School of Materials Science and Engineering Nanchang UniversityNanchang 330031JiangxiChina

Developing high power and energy supercapacitors(SCs)is a long-pursued goal for the application in transportation and energy storage ***,a rationally-designed Co-doped nickel oxide nanosheets@carbon-welded carbon nanotube foam(Co-doped NiO@WCNTF)as freestanding electrode is successfully prepared for high power and energy *** WCNTF framework with high specific surface area provides three dimensional highly conductive network for fast charge transport and ensures high loading of active materials(9.2 mg/cm2).Moreover,porous Co-doped NiO nanosheets uniformly anchored on the WCNTF framework enable rapid charge kinetics due to the high intrinsic conductivity of Co-doped Ni O nanosheets and their good contact with conductive WCNTF *** a result,the unique integrated electrode with 3D architecture exhibits an ultrahigh specific capacitance of 11.45 F/cm2 at 5 mA/cm2,outstanding rate capability(11.45 F/cm2 at 5 mA/cm2 and a capacitance retention of 86.2%at 30 mA/cm2)and good cycling stability,suggesting great potential for high performance supercapacitor.

关键词： Carbon nanotube foam Pseudocapacitors Co-doped NiO nanosheets Freestanding electrode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hollow MnO_2/GNPs serving as a multiresponsive nanocarrier for controlled drug release

引用

Chinese Journal of Chemical Engineering 2020年第5期28卷 1405-1414页

作者： Zheng Zhang Yuanhui Ji Wei Chen Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Department of Pharmaceutical Engineering School of EngineeringChina Pharmaceutical UniversityNanjing 210009China

In this work,hollow manganese dioxide/gold nanoparticle(MnO2/GNPs)hybrid drug nanocarriers were prepared by coupling the gold nanoparticles(GNPs)with hollow structure manganese dioxide(MnO2).Among them,GNPs have been used as near-infrared(NIR)-responsive element for photothermal effect under NIR laser *** glutathione(GSH)-responsive and p H-responsive performances of drug release were derived from hollow ***,Doxorubicin hydrochloride(DOX)can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%.Moreover,the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were *** hollow MnO2/GNPs possessed satisfactory drug release efficiency(ca.87.4%of loaded drug released in 12 h)and have high photothermal conversion efficiency,multiresponsive properties,and ***,the kinetics of drug release was discussed in ***,our finding highlights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.

关键词： Hollow manganese dioxide Gold nanoparticles Photothermal effect GSH-/pH-responsive properties Drug release

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism investigation on coal and gas outburst: An overview

引用

International Journal of Minerals,Metallurgy and Materials 2020年第7期27卷 872-887页

作者： Yan-kun Ma Bai-sheng Nie Xue-qiu He Xiang-chun Li Jun-qing Meng Da-zhao Song State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology(Beijing)Beijing 100083China Beijing Key Laboratory for Precise Mining of Intergrown Energy and Resources China University of Mining and Technology(Beijing)Beijing 100083China Xinjiang Institute of Engineering Urumqi 830023China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 10083China

Coal and gas outburst is a frequent dynamic disaster during underground coal mining *** about 150 years of exploration,the mechanisms of outbursts remain unclear to *** on outburst mechanisms worldwide focused on the physicochemical and mechanical properties of outburst-prone coal,laboratory-scale outburst experiments and numerical modeling,mine-site investigations,and doctrines of outburst *** mechanisms are divided into two categories:single-factor and multi-factor *** multi-factor mechanism is widely accepted,but all statistical phenomena during a single outburst cannot be explained using present *** topics about outburst mechanisms are proposed by summarizing the phenomena that need precise *** most appealing research is the microscopic process of the interaction between coal and *** physical-chemical methods can help characterize the natural properties of outburst-prone *** experiments can compensate for the deficiency of first-hand observation at the *** the original outburst scene by constructing a geomechanical model or numerical model and reproducing the entire outburst process based on mining environment conditions,including stratigraphic distribution,gas occurrence,and geological structure,are *** studies can explore outburst mechanisms at the microscale.

关键词： coal and gas outburst outburst mechanism outburst model outburst simulation microscopic pore structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Natural killer cells are activated and play a protective role against ZIKA virus infection in mice

引用

Science Bulletin 2017年第14期62卷 982-984页

作者： Xuefeng Duan Shihua Li Gary Wong Dongfang Wang Haoyu Wang Jiao Lu Yuhai Bi Xuancheng Lu Yi Shi Jinghua Yan Min Fang George Fu Gao CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences University of Chinese Academy of Sciences Institute of Health Sciences Anhui University Laboratory Animal Center Chinese Center for Disease Control and Prevention (China CDC) International College University of Chinese Academy of Sciences National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention (China CDC) Savaid Medical School University of Chinese Academy of Sciences Research Network of Immunity and Health (RNIH) Beijing Institutes of Life Science Chinese Academy of Sciences

Zika virus(ZIKV)is a mosquito-borne Flavivirus that was responsible for an epidemic in the Americas during 2015–2016[1].ZIKV infections in adults have been linked to Guillain-Barrésyndrome[2,3],as well as abnormalities such as abortion,stillbirth,and microcephaly in some cases[4].In addition,we have reported that ZIKV infect testicular stem-like peritubular

关键词：病毒感染细胞活性保护作用杀伤自然小鼠对齐

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure of SARS-CoV-2 main protease in the apo state

引用

Science China(Life Sciences) 2021年第4期64卷 656-659页

作者： Xuelan Zhou Fanglin Zhong Cheng Lin Xiaohui Hu Yan Zhang Bing Xiong Xiushan Yin Jinheng Fu Wei He Jingjing Duan Yang Fu Huan Zhou Peter J.Mc Cormick Qisheng Wang Jian Li Jin Zhang School of Basic Medical Sciences Nanchang UiniversinNanchang 330031China College of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000 China Laboratory of Prevention and Treatment of Cardovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversiyGanzhou 341000China Shenzhen Crystalo Biopharmacutical Co LtdShenzhen 518118China Jiangxi Jmerry Biopharmaceutical Co LtdGanzhou 341000China The Second Afiliaed Hospital of Nanchang Universiy Nanchang 330031China Department of Medicinal Chemisry Shanghai Instiute of Materia MedicalChinese Academy of SciencesShanghai 201203China Appled Blology Laboratory Shenyang Untversity of Chemical TechnologyShenyang 110142China Biotech&Biomedicine Science(Jiangxi)Co LtdGanzhou 341000China Jiangxi-OA1 Joint Research Isiution Nanchang UniversityNanchang 330047China Human Aging Research Instiute(HARI) School of Life SciencesNanchang UniversinNanchang 330031China School of Medicine Souhern Universiny of Science and Technologx Shenzhen 518055China Shanghai Synchroron Radiation Facilig Shanghai Advanced Research InstiueChinese Academy of SciencesShanghai 201204China Centre for Endocrinology William Harvey Research InstiuteBari's and the London School of Medicine and DentisrQneen MaryUniversity of LondonLondon ECIM 6BQUK

Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has been a global pandemic that severely threatens global health with concordant economic ***,there i... 详细信息

关键词： drugs al. acute

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Can the Grain-for-Green Program Really Ensure a Low Sediment Load on the Chinese Loess Plateau?

引用

Engineering 2019年第5期5卷 855-864页

作者： Pengcheng Sun Yiping Wu Zhifeng Yang Bellie Sivakumar Linjing Qiu Shuguang Liu Yanpeng Cai Department of Earth and Environmental Science School of Human Settlements and Civil EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China School of Civil and Environmental Engineering The University of New South WalesSydneyNSW 2052Australia Department of Land Air and Water ResourcesUniversity of CaliforniaDavisCA 95616USA Department of Civil Engineering Indian Institute of Technology BombayMumbai 400076India National Engineering Laboratory for Applied Technology of Forestry and Ecology in South China Central South University of Forestry and TechnologyChangsha 410004China

The Chinese Loess Plateau is the most seriously eroded area in the world and contributes the vast majority of the sediment that goes into the Yellow *** the 1950s,progressive soil and water conservation measures have been implemented—in particular,large-scale ecological restoration has been ongoing since 1999—resulting in a significant reduction of the sediment ***,the mechanism of the sediment transport dynamics is not fully understood due to multiple and complicated influencing factors including climate change and human activities(e.g.,ecological restoration).A challenging question,then,arises:Is the current low sediment level a“new normal”in this era and in the future?To address this question,we selected a typical loess hilly region where considerable ecological restoration has been implemented,and which is regarded as the site of the first and most representative Grainfor-Green program in the Loess *** investigated the evolution of discharge–sediment relationships in the past decades(1960–2010)and their association with the soil and water conservation measures in this *** results showed that there was a distinct change in the regression parameters of the commonly used annual discharge–sediment regression equation—a continuously increasing trend of parameter b and a decreasing trend of parameter a,accompanying the ecological *** increase in exponent b(i.e.,a steeper slope)implies a potential lower sediment load resulting from low discharge and a potential higher sediment load resulting from large *** finding may question the new normal of a low sediment level and implies the potential risk of a large sediment load during extremely wet years.

关键词： Discharge–sediment relationship Ecological restoration Loess hilly region Sediment load Sediment rating parameters

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：