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Metadherin promotes stem cell phenotypes and correlated with immune infiltration in hepatocellular carcinoma

World Journal of Gastroenterology 2024年第8期30卷 901-918页

作者： Yi-Ying Wang Mei-Mei Shen Jian Gao Department of Gastroenterology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China Department of Gastroenterology and Hepatology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400010China

BACKGROUND Metadherin(MTDH)is a key oncogene in most cancer types,including hepato-cellular carcinoma(HCC).Notably,MTDH does not affect the stemness pheno-type or immune infiltration of *** To explore the role of MTDH on stemness and immune infiltration in *** MTDH expression in HCC tissues was detected using TCGA and GEO *** was used to analyze the tissue *** was stably knocked down or overexpressed by lentiviral transfection in the two HCC cell *** invasion and migration abilities of HCC cells were evaluated using Matrigel invasion and wound healing ***,we obtained liver cancer stem cells from the spheroids by culturing them in a serum-free *** expression was determined by western blotting and quantitative reverse transcri-ption *** cytometry,immunofluorescence,and tumor sphere formation assays were used to characterize stem-like *** effects of MTDH inhibition on tumor growth were evaluated in *** correlation of MTDH with immune cells,immunomodulators,and chemokines was analyzed using ssGSEA and TISIDB *** HCC tissues expressed higher levels of MTDH than normal liver *** MTDH expression was associated with a poor *** cells overex-pressing MTDH exhibited stronger invasion and migration abilities,exhibited a stem cell-like phenotype,and formed spheres;however,MTDH inhibition attenuated these *** inhibition suppressed HCC progression and CD133 expression in *** was positively correlated with immature dendritic,T helper 2 cells,central memory CD8^(+)T,memory B,activated dendritic,natural killer(NK)T,NK,activated CD4^(+)T,and central memory CD4^(+)T *** was negatively correlated with activated CD8^(+)T cells,eosinophils,activated B cells,monocytes,macrophages,and mast cells.A positive correlation was observed between the MTDH level and CXCL2 expression,whereas a negative correlation was observed between the MTDH level and CX3CL1 a

关键词： Metadherin Hepatocellular carcinoma Cancer stem cells Immune infiltration

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A Hybrid Channel Stock Model for Stock Price Forecasting with Multifaceted Feature Fusion

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Data Intelligence 2024年第3期6卷 792-811页

作者： Zhiyu Xu Yong Wang Yisheng Li Lulu Zhang Bin Jiang School of Artificial Intelligence Chongqing University of TechnologyChongqing 401135China

Stock market is volatile and predicting stock prices is a challenging *** prices are influenced by multiple factors,and prediction using only numerical or image features is *** solve this problem,we propose a Hybrid Channel Stock model that incorporates multiple features of basic stock data,K-line charts and technical indicator factors for predicting the closing price of a stock on day n+*** model combines multiple aspects of data and uses a multi-channel structure including improved CNN-TW,bidirectional LSTM and Transformer ***,we construct the multi-channel branches of the multi-faceted feature fusion input network model;second,in this paper,we will use the concatenate method to stitch the output of each branch as the input of the rest of the network;the last layer in the network is the fully connected layer,which combines the linear activation function regression to output the predicted ***,we conducted extensive experiments on the Dow 30,SSH 50 and CSI100 *** experimental results show that the Hybrid Channel Stock method has the best performance with the smallest MSE,RMSE,MAE and MAPE compared with existing *** addition,the experiments on different trading days validate the stability and effectiveness of the model,providing an important reference for investors to make stock investment decisions.

关键词： Stock Price Forecast Hybrid Channel Stock model CNN-TW Multi-channel Multifaceted feature

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Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin,South China

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-Qing Liu Qiang Shi Dong-Ge Wang Ke-Ning Qi Yu-Chong Wang Da-Wei Qiao Xiao-Shuai Chen Li-Zhi Wu Meng Tian Long Chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-Qian Liu Xuan-Chun Liu An-Qing Chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of Coal Mine Disaster Dynamics and Control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the Cryogenian-Ediacaran(C-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the C-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the Cryogenian sediments in the studied *** Member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original Chengkou“Guanyinya Formation”),directly overlaid the Cryogenian sediments and displayed a 623±2.3 Ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the C-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional Member I cap dolomite:(i)Member II purple-red,gray-green sandstone strata,(ii)MemberⅢblack mudstone strata,and(iii)Member IV P-Mn bearing *** the C-E transition,the study area experienced(i)the global deglaciation stage in the terminal Marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： Marinoan glaciation Doushantuo formation Cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

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探索Bi_(2)SeO_(5)的高介电性能:从块体到双层和单层

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Science China Materials 2024年第3期67卷 906-913页

作者：董欣月何育彧管乐祝元昊吴金雄付会霞颜丙海 Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsSmart Sensor Interdisciplinary Science CenterSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China Center of Quantum Materials and Devices College of PhysicsChongqing UniversityChongqing 401331China chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China Department of Condensed Matter Physics Weizmann Institute of ScienceRehovot 7610001Israel

Bi_(2)SeO_(5)是一种具有优异电绝缘性能的范德华(vdW)层状介电材料,引起了极大关注.然而,目前关于Bi_(2)SeO_(5)的研究主要停留在实验层面,仍然缺乏对其原子级薄膜的介电性能的相关理论认识.本文通过第一性原理计算确定了Bi_(2)SeO_(5... 详细信息

Bi_(2)SeO_(5)是一种具有优异电绝缘性能的范德华(vdW)层状介电材料,引起了极大关注.然而,目前关于Bi_(2)SeO_(5)的研究主要停留在实验层面,仍然缺乏对其原子级薄膜的介电性能的相关理论认识.本文通过第一性原理计算确定了Bi_(2)SeO_(5)的介电性能,发现其块体、双层和单层均具有超高平均介电常数(εr>20).研究表明,单层Bi_(2)SeO_(5)与双层Bi_(2)O_(2)Se之间的导带和价带能量偏移量均大于1 eV,表明单层Bi_(2)SeO_(5)依然可作为原子薄Bi_(2)O_(2)Se的良好介电层.此外,不同于h-BN或其他2D vdW绝缘体,Bi_(2)SeO_(5)的εr由其离子部分主导,且随着厚度的减小几乎保持不变.计算发现,单层Bi_(2)SeO_(5)的等效氧化层厚度可薄至0.3 n m,且单层Bi_(2)SeO_(5)在拉伸或压缩应变达到6%时均能保持高介电常数,这极大地促进了它与各种二维半导体的集成.本工作证明单层Bi_(2)SeO_(5)可以作为高性能二维电子器件良好的封装和介电层.

关键词： Bi_(2)SeO_(5) high-κ equivalent oxide thickness dielectric constant van der Waals first-principles calculations

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石墨烯/钼基二硫族化合物范德华异质结光电探测器的研究进展

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新型炭材料（中英文） 2024年第3期39卷 439-457页

作者：张鑫华刘伟迪龚佑品刘庆丰陈志刚南京工业大学化工学院材料化学工程国家重点实验室江苏南京211816 School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Center for Materials ScienceQueensland University of TechnologyBrisbaneQLD 4000Australia 重庆大学物理学院前沿交叉学科研究院量子材料与器件研究中心重庆400044

石墨烯因其高载流子迁移率和宽光谱吸收范围而广泛应用于光电探测。然而,其低光吸收率导致的高暗电流严重限制了它的光电探测性能。钼基二硫族化合物(MoX_(2),X=S、Se和Te)具有高的吸收系数,能够弥补石墨烯基光电探测器中暗电流较高的劣... 详细信息

石墨烯因其高载流子迁移率和宽光谱吸收范围而广泛应用于光电探测。然而,其低光吸收率导致的高暗电流严重限制了它的光电探测性能。钼基二硫族化合物(MoX_(2),X=S、Se和Te)具有高的吸收系数,能够弥补石墨烯基光电探测器中暗电流较高的劣势,因此基于石墨烯/MoX_(2)范德华异质结的光电探测器能够表现出优异的光电子特性。本综述首先回顾了光电探测器的工作原理、性能指标和结构。之后,从材料基础的角度突出了石墨烯/MoX_(2)范德华异质结光电探测器的重要性。接着,总结了石墨烯/MoX_(2)范德华异质结光电探测器的制备方法和性能增强策略。最后,强调了这类异质结光电探测器当前面临的挑战及未来的发展方向。本综述将为这类高性能范德华异质结光电探测器的设计提供一定的指导和参考。

关键词：石墨烯钼基二硫族化合物异质结光电探测器范德华

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Corrosion Resistance of Friction Stir Welded Al–Cu–Li Alloy AA2099-T8

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 127-134页

作者： Yan-Long Ma Hui-Bin Xu Zhao-Yuan Liang Lei Liu College of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China chongqing Municipal Engineering research Center of Institutions of Higher Education for Special Welding Materials and Technology Chongqing University of TechnologyChongqing 400054China

In order to study the eff ect of friction stir welding(FSW)on corrosion resistance of Al–Cu–Li alloy AA2099-T8,the microstructure and microhardness of FSW joints were characterized,and then,the corrosion behavior of the FSW joints was investigated by the immersion and potentiodynamic polarization tests in a 3.5%NaCl solution at room *** is indicated that the alloy was softened by FSW,with the lowest hardness appearing at the boundary between the nugget zone and the thermo-mechanically aff ected *** exposed to the NaCl solution,the FSW joint was characterized by shallow pits and was free of severe localized corrosion,probably due to dissolution of T 1(A 2 CuLi)phase in the FSW *** is suggested that further work should be carried out to evaluate the galvanic coupling eff ect between the FSW joint and the base metal,as well as the stress corrosion cracking resistance of the FSW joint.

关键词： Frictions stir welding(FSW) Al–Cu–Li alloy AA2099 Localized corrosion

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Identification and characterization of toxins in the venom gland of the Chinese bird spider, Haplopelma hainanum, by transcriptomic analysis

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Insect Science 2016年第3期23卷 487-499页

作者： Ting-Cai Cheng Ren-Wen Long Yu-Qian Wu You-Bing Guo Duo-Lian Liu Li Peng Dai-Qin Li Dai-Wen Yang Xin Xu Feng-Xiang Liu Qing-You Xia State Key Laboratory of Silkworm Genome Biology College of Biotechnology Southwest University Chongqing China Departmentof Biological Sciences National University of Singapore Singapore Singapore College of Life Sciences Hunan Normal UniversityChangsha China College of Life Sciences Hubei University Wuhan China

Tarantula venoms provide a model system for studying toxin selectivity, structure-activity relationships and molecular evolution ofpeptide toxins. Previous studies have identified a large number of peptide toxins in the venom of the Chinese bird spider Haplopelma hainanum, generally regarded as a highly venomous spider. However, the lack of available RNA-seq transcriptomic and genomic data is an obstacle to understanding its venom at the molecular level. In this study, we investigated the venom gland transcriptome of/-/, hainanum by RNA-seq, in the absence of an available genomic sequence. We identi- fied 201 potential toxins among 57 18 l de novo assembled transcripts, including knottins, Kunitz-type toxins, enzymes and other proteins. We systematically identified most of the knottins and Kunitz-type toxins, some of which showed strongly biased expression in the venom gland, including members of the huwentoxin-1, huwentoxin-2 and magi-1 families. We also discovered several novel potential toxins. These data demonstrate the high molec- ular and structural diversity in the venom toxins ofH. hainanum. This study offers a useful strategy for exploring the complex components of spider venoms.

关键词： diversity Haplopelma hainanum tarantula venom toxin transcriptome

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Genome editing in Bombyx mori: New opportunities for silkworm functional genomics and the sericulture industry

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Insect Science 2019年第6期26卷 964-972页

作者： San-Yuan Ma Guy Smagghe Qing-You Xia State Key Laboratory of Silkworm Genome Biology Southwest University ChongqingChina chongqing Engineering and Technology research Center for Novel Silk Materials Southwest University Chongqing China Department of Crop Protection Faculty of Bioscience Engineering Ghent University Ghent Belgium

In recent years, research in life sciences has been remarkably revolutionized owing to the establishment, development and application of genome editing technologies. Genome editing has not only accelerated fundamental research but has also shown promising applications in agricultural breeding and therapy. In particular, the clustered, regularly interspaced, short palindromic repeat (CRISPR) technology has become an indispensable tool in molecular biology owing to its high efficacy and simplicity. Genome editing tools have also been established in silkworm (Bombyx mori), a model organism of Lepidoptera insects with high economic importance. This has remarkably improved the level and scope of silkworm research and could reveal new mechanisms or targets in basic entomology and pest management studies. In this review, we summarize the progress and potential of genome editing in silkworm and its applications in functional genomic studies for generating novel genetic materials.

关键词： CRISPR genome editing silkworm TALEN ZFN

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Design of 5H-pyrrolo[2,3-b]pyrazine-2-phenyl Ether Derivatives as Potential JAK3 Inhibitor Based on Surflex Docking,3D-QSAR Modeling and Reverse Docking

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Chinese Journal of Structural Chemistry 2017年第12期36卷 1975-1986页

作者：刘蒙蒙王必武汪斌李静舒茂张娅林治华 College of Pharmacy and Bioengineering Chongqing University of Technology College of Chemistry and Chemical Engineering Chongqing University

Tyrosine protein kinase JAK3 has a very important significance on organ transplantation and the treatment of autoimmune diseases, which has been a potential therapeutic target. In recent years, a large number of JAK3 inhibitors have been reported. However, the poor selectivity and side effects have limited their widespread use in clinical practice. In order to solve this problem, 52 potential small-molecule inhibitors were combined with JAK1, JAK2 and JAK3 respectively to obtain the optimal conformation of small molecules. On the basis of that we established 3D quantitative structure-activity relationships（3D-QSAR） model. Comparative molecular field analysis（Co MFA） and molecular similarity analysis（Co MSIA） were used to evaluate the model. We took advantage of reverse docking to explore the underlying toxicity and side effects. Combining 3D quantitative structure-activity relationships, surflex-dock and reverse docking results, ten 5 H-pyrrolo[2,3-b]pyrazine-2-phenyl ether derivatives based on the most optimal selectivity and activity compound 39 were designed. It can be seen from Co MFA and Co MSIA predicted active values of designed molecules that the selectivity of designed small molecules was improved obviously. Among them, compounds 61 and 62 could become the potential small molecule compounds.

关键词： JAK3 inhibitors 3D-QSAR surflex-doek reverse docking selectivity

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Experimental investigation and correlations for proppant distribution in narrow fractures of deep shale gas reservoirs

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Petroleum Science 2022年第2期19卷 619-628页

作者： Hao Zeng Yan Jin Hai Qu Yun-Hu Lu College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China College of Petroleum Engineering Chongqing University of Science and TechnologyChongqing401331China

Hydraulic fracturing is a crucial stimulation for the development of deep shale gas reservoirs.A key challenge to the effectiveness of hydraulic fracturing is to place small proppants in complex narrow fractures *** experiments with varied particle and fluid parameters are carried out in a narrow planar channel to understand particle transport and *** four dimensionless parameters,including the Reynold number,Shields number,density ratio,and particle volume fraction,are introduced to describe the particle transport in narrow *** results indicate that the narrow channel probably induces fluid fingers and small particle aggregation in a highly viscous fluid,leading to particle settlement near the *** low viscous fluid is beneficial to disperse particles further into the fracture,especially in the high-speed fluid *** linear and natural logarithmic laws have relationships with dimensionless parameters *** multiple linear regression method developed two correlation models with four dimensionless parameters to predict the bed equilibrium height and covered area of small particles in narrow *** study provides fundamental insight into understanding small size proppant distribution in deep reservoirs.

关键词： Proppant transport Multiphase flow Hydraulic fracturing Deep reservoir Narrow fractures

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