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Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1849-1860页

作者： Yong-Xia Ye Liu Yang Zheng Kang Mei-Qin Wang Xiao-Dong Xie Ke-Xin Lou Jun Bao Mei Du Zhe-Xuan Li Department of Radiology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina1 Department of Pathology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Colorectal Center The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina

BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient *** radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a *** To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable *** In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI *** MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were *** radiomics models used 3D features from T1WI and T2WI ***,a nomogram model combining conventional MRI and radiomics features was *** model used univariate analysis and multivariable logistic *** employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic *** performance was assessed using calibration and decision curve *** The nomogram model outperformed conventional MRI and single radiomics models in evaluating *** the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,*** the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),*** The nomogram model showed the best performance in predicting metastasis of evaluable LNs.

关键词： Radiomics Lymph node metastasis Rectal cancer Magnetic resonance imaging

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Light-modulated graphene-based φ_(0) Josephson junction and -φ_(0) to φ_(0) transition

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Chinese Physics B 2024年第2期33卷 476-481页

作者：程任翔于苗汪洪曹德亮李兴鳌戚凤华周兴飞 New Energy Technology Engineering Laboratory of Jiangsu Province School of ScienceNanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic and Information Engineering Jinling Institute of TechnologyNanjing 211169China School of Electronic Engineering Nanjing Xiaozhuang UniversityNanjing 211171China

We investigate the chiral edge states-induced Josephson current–phase relation in a graphene-based Josephson junction modulated by the off-resonant circularly polarized light and the staggered sublattice *** solving the Bogoliubov–de Gennes equation,a φ_(0) Josephson junction is induced in the coaction of the off-resonant circularly polarized light and the staggered sublattice potential,which arises from the fact that the center of-mass wave vector of Cooper pair becomes finite and the opposite center of-mass wave vector to compensate is lacking in the nonsuperconducting ***,when the direction of polarization of light is changed,-φ_(0) to φ_(0) transition generates,which generalizes the concept of traditional 0–π*** findings provide a purely optical way to manipulate a phase-controllable Josephson device and guidelines for future experiments to confirm the presence of graphene-based φ_(0)Josephson junction.

关键词： graphene circularly polarized light staggered sublattice potential φ_(0)Josephson junction

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Gypenosides ameliorate morphine-induced immunosuppression with an increased proportion of thymic T lymphocyte subsets and are involved in the regulation of the cAMP-CREM/CREB-IL-2 pathway

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Genes & Diseases 2024年第3期11卷 120-123页

作者： Hui Wang Zhonghao Li Qisheng Wang Weixin Lin Ziting Zhou Xinru Mu Yongwei Jiang Shengfeng Lu Shaodong Chen Zhigang Lu Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor Nanjing University of Chinese MedicineNanjingJiangsu 210023China Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese MedicineNanjingJiangsu 210023China College of Pharmacy Nanjing University of Chinese MedicineNanjingJiangsu 210023China School of Medicine Xiamen UniversityXiamenFujian 361102China

Opioid abuse can suppress the lymphatic system function,and produce severe immunosuppression that poses a significant risk of opportunistic infections such as methicillinresistant Staphylococcus aureus(MRSA)pneumonia.^(1,2)Gypenosides(Gps)are the most important immunomodulator components in the Chinese herbal medicine Gynostemma pentaphyllum.

关键词： herbal Gypenosides immunosuppression

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Effective dynamics for a spin-1/2 particle constrained to a curved layer with inhomogeneous thickness

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Chinese Physics B 2024年第2期33卷 78-83页

作者：梁国华尹佩林 School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China

We derive an effective Hamiltonian for a spin-1/2 particle confined within a curved thin layer with non-uniform thickness using the confining potential *** analysis reveals the presence of a pseudo-magnetic field and effective spin–orbit interaction(SOI)arising from the curvature,as well as an effective scalar potential resulting from variations in ***,we demonstrate that the physical effect of additional SOI from thickness fluctuations vanishes in low-dimensional systems,thus guaranteeing the robustness of spin interference measurements to thickness ***,we establish the applicability of the effective Hamiltonian in both symmetric and asymmetric confinement scenarios,which is crucial for its utilization in one-side etching systems.

关键词： curved surface inhomogeneous thickness spin-1/2 particle effective Hamiltonian

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Effective strategies to promote Z(S)-scheme photocatalytic water splitting

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Chinese Chemical Letters 2024年第3期35卷 27-39页

作者： Ye Yuan Junan Pan Weinan Yin Haoxuan Yu Fengshun Wang Weifeng Hu Longlu Wang Dafeng Yan College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China College of Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Artificial Z(S)-scheme photocatalytic water splitting systems have attracted extensive attention due to their advantages such as wide light absorption range,high charge separation efficiency and strong carrier redox ***,it is still challenging to design and prepare Z(S)-scheme photocatalysts with low-cost and highly stability for efficiently photocatalytic overall water splitting using solar *** review mainly introduces various strategies to improve the photocatalytic water splitting performance of Z(S)-scheme *** strategies mainly focus on enhancing or extending the range of light absorption,promoting charge separation,and enhancing surface redox reaction in Z(S)-scheme ***,the main challenges of Z(S)-scheme photocatalytic water splitting systems and their future development directions are pointed *** review would be beneficial to understanding the challenges and opportunities faced by the research field of Z(S)-scheme photocatalytic systems,and has important guiding significance for the development and utilization of high-performance Z(S)-scheme photocatalytic reaction system in the future.

关键词： Z(S)-scheme Overall water splitting Light absorption Charge separation Loading co-catalyst

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CRISPR-based genetic screens advance cancer immunology

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Science China Life Sciences 2024年

作者： Yuanfang Cao Xueting Li Yumu Pan Huahe Wang Siyu Yang Lingjuan Hong Lupeng Ye Institute of Modern Biology Nanjing University

CRISPR technologies have revolutionized research areas ranging from fundamental science to translational medicine. CRISPR-based genetic screens offer a powerful platform for unbiased screening in various fields, such as cancer immunology. Immune checkpoint blockade(ICB)therapy has been shown to strongly affect cancer treatment. However, the currently available ICBs are limited and do not work in all cancer patients. Pooled CRISPR screens enable the identification of previously unknown immune regulators that can regulate T-cell activation,cytotoxicity, persistence, infiltration into tumors, cytokine secretion, memory formation, T-cell metabolism, and CD4+T-cell *** novel targets can be developed as new immunotherapies or used with the current ICBs as new combination therapies that may yield synergistic efficacy. Here, we review the progress made in the development of CRISPR technologies, particularly technological advances in CRISPR screens and their application in novel target identification for immunotherapy.

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Two birds with one stone:Functionalized wood composites for efficient photocatalytic hydrogen production and solar water evaporation

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Chinese Chemical Letters 2024年第9期35卷 392-397页

作者： Deqi Fan Yicheng Tang Yemei Liao Yan Mi Yi Lu Xiaofei Yang College of Chemical Engineering Nanjing Forestry UniversityNanjing 210037China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of ScienceNanjing Forestry UniversityNanjing 210037China Key Laboratory of Chemistry and Engineering of Forest Products State Ethnic Affairs CommissionGuangxi Key Laboratory of Chemistry and Engineering of Forest ProductsGuangxi Minzu UniversityNanning 530006China

Maximizing solar energy utilization is a persistent challenge in photo catalysis,which determines sustainable solar-driven photocatalytic *** thermal-coupled photo catalysis is considered as a promising solution to tackle the issues of sustainable energy scarcity and environmental pollution by harvesting the full-spectrum solar ***,a highly efficient photo thermal-accelerated photo catalysis system is elaborately established,in which the assembled carbonized stick/Nb_(2)C MXene evaporator can heat water into vapor and the integrated g-C_(3)N_(4)photocatalyst further enables high-efficiency photocatalytic hydrogen *** designed hyperboloid wood-based architecture possesses a multiphase interface of water steam/catalyst/hydrogen to reduce the transport resistance of hydrogen gas in liquid and ultimately maximize the output of hydrogen ***,this coupled photothermal-photocatalytic system achieves a stable solar evaporation rate of 2.16 kg m^(-1)h^(-1)under one sun irradiation and highly efficient hydrogen-evolving rate of 3096μmol g^(-1)h^(-1).This work paves a way to explore the improvement of photocatalytic hydrogen production by synergic photothermal effect for potential applications in renewable solar energy utilization and hydrogen production.

关键词： Photocatalysis Photothermal Nb_(2)C MXene g-C_(3)N_(4) Wood

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Dielectric anisotropy in liquid crystal mixtures with nematic and smectic phases

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Chinese Physics B 2024年第8期33卷 519-524页

作者：汤星舟叶家耀王子烨姜皓译尚小虎杨朝雁李炳祥 nanjing university of Posts and Telecommunications College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology)Nanjing 210023China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

The modulation of dielectric anisotropy(△ε)is pivotal for elucidating molecular interactions and directing the alignment of liquid *** this study,we combine liquid crystals with opposing dielectric anisotropies to explore the impact of varying concentrations on their *** report the sign-reversal of△εin both the nematic and smectic A phases of these mixed liquid crystals,alongside a dual-frequency behaviour across a broad temperature *** research further quantifies the influence of mixture ratios under various temperatures and electric field *** exploration may pave the way for the discovery of new physical phenomena.

关键词： mixed liquid crystal dielectric anisotropy tunable nematic smectic

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基于Multitask⁃YOLO网络的卫星帆板ISAR图像快速分割

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Transactions of nanjing university of Aeronautics and Astronautics 2024年第2期41卷 253-262页

作者：姚雨晴汪玲王莲子张弓吴斌朱岱寅南京航空航天大学电子信息工程学院雷达成像与微波光子技术教育部重点实验室中国南京211106 上海宇航系统工程研究所中国上海201109

随着空间技术的飞速发展,空间态势感知能力需求不断增加。与传统光学传感器相比,逆合成孔径雷达(Inverse synthetic aperture radar,ISAR)具有全天候、远距离高分辨率成像的能力,且成像不受光照条件的影响。此外,空间态势感知系统需要... 详细信息

随着空间技术的飞速发展,空间态势感知能力需求不断增加。与传统光学传感器相比,逆合成孔径雷达(Inverse synthetic aperture radar,ISAR)具有全天候、远距离高分辨率成像的能力,且成像不受光照条件的影响。此外,空间态势感知系统需要对周围航天器进行准确的评估,因此对空间目标部件识别能力的需求日益迫切。本文提出了一种基于YOLOv5结构的Multitask⁃YOLO网络,用于卫星ISAR图像中卫星帆板的识别和分割。首先,本文添加了分割解耦头来实现网络的分割功能。然后用空间金字塔池快速算法(Spatial pyramid pooling fast,SPPF)和距离交并比算法(Distance intersection over union,DIoU)代替原有结构,避免图像失真,加快收敛速度。通过在通道中引入注意机制,提高了分割和识别的准确性。最后使用模拟卫星的ISAR图像进行实验。结果表明,所提出的Multitask⁃YOLO网络高效、准确地实现了部件的识别和分割。与其他的识别和分割网络相比,该网络的平均精度(mean Average precision,mAP)和平均交并比(mean Intersection over union,mIoU)提高了约5%。此外,该网络的运行速度高达16.4 GFLOP,优于传统的多任务网络的性能。

关键词： Multitask⁃YOLO 空间目标逆合成孔径雷达图像目标识别与分割

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雌激素受体降解剂(S)-8-(4-(1-(3-氟丙基)吡咯烷-3-基)氧基)苯基)-7-(4-羟基苯基)-5,6-二氢萘-2-醇的汇聚合成（英文）

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有机化学 2024年

作者：陈盼盼冯晓伟陆智彭厉廷有南京医科大学药学院核药学系南京医科大学药学院药物化学系

本文报道了一种更为可行的选择性雌激素受体降解剂(S)-8-(4-(1-(3-氟丙基)吡咯烷-3-基)氧)苯基)-7-(4-羟基苯基)-5,6-二氢萘-2-醇的汇聚合成策略，其合成过程简洁，不存在区域选择性难题。

关键词：乳腺癌选择性雌激素受体降解剂 (S)-8-(4-(1-(3-氟丙基)吡咯烷-3-基)氧基)苯基)-7-(4-羟基苯基)-5,6-二氢萘-2-醇合成改进

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