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Seismic performance of steel MRF building with nonlinear viscous dampers

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Frontiers of Structural and Civil Engineering 2016年第3期10卷 254-271页

作者： Baiping DONG James M. RICLES Richard SAUSE ATLSS Engineering Research Center Department of Civil and Environmental Engineering Lehigh University Bethlehem PA 18015 USA

This paper presents an experimental study of the seismic response of a 0.6-scale three-story seismicresistant building structure consisting of a moment resisting frame （MRF） with reduced beam sections （RBS）, and a frame with nonlinear viscous dampers and associated bracing （called the DBF）. The emphasis is on assessing the seismic performance for the design basis earthquake （DBE） and maximum considered earthquake （MCE）. Three MRF designs were studied, with the MRF designed for 100%, 75%, and 60%, respectively, of the required base shear design strength determined according to ASCE 7-10. The DBF with nonlinear viscous dampers was designed to control the lateral drift demands. Earthquake simulations using ensembles of DBE and MCE ground motions were conducted using the real-time hybrid simulation method. The results show the drift demand and damage that occurs in the MRF under seismic loading. Overall, the results show that a high level of seismic performance can be achieved under DBE and MCE ground motions, even for a building structure designed for as little as 60% of the base shear design strength required by ASCE 7-10 for a structure without dampers.

关键词： seismic response steel MRF nonlinear viscous damper design basis earthquake real-time hybrid simulation

Light People:*** May Lau,newly elected US NAE member in Hong Kong,talks about future of photonics and women in science

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Light(Science & Applications) 2024年第4期13卷 602-608页

作者： Yating Wan Chenzi Guo Electrical and Computer Engineering the ComputerElectrical and Mathematical Sciences and Engineering DivisionKing Abdullah University of Science and Technology23955-6900 ThuwalSaudi Arabia Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchunChina

Editorial Photonics technology remains a driving force in today’s scientific landscape,marked by continuous innovation and crossdisciplinary *** an enlighting conversation with Light:Science&Applications,*** May Lau,a pioneer in photonics research,shares her deep insights on the evolution of technologies of LEDs,lasers,challenges of hetero-epitaxy,and the future of micro-LEDs and quantum dot *** honored as a member of the US National Academy of Engineering(NAE)for her significant contributions to photonics and electronics using III-V semiconductors on silicon,*** stands out as the sole Hong Kong scholar inducted into the NAE this year,joining 114 new and 21 international *** this exclusive Light People interview,*** shares her journey as a pioneering woman in engineering,her commitment to mentorship and academia,and her perspective on advancing female representation in *** summary provided is distilled from ***’s thoughtful responses during the *** a deeper exploration of ***’s experiences and advice,the full interview is available in the Supplementary material.

关键词： interview lighting driving

The neurobiology of sensing respiratory gases for the control of animal behavior

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Frontiers in Biology 2012年第3期7卷 246-253页

作者： Dengke K. MA Niels RINGSTAD Department of Biology McGovern Institute for Brain Research MIT Cambridge MA 02139 USA. Department of Cell Biology and the Helen L. and Martin S. Kimmel Center for Biology and Medicine at the Slarball Institute of Biomolecular Medicine New York University Langone Medical Center New York NY 10016 USA

Aerobic metabolism is fundamental for almost all animal life. Cellular consumption of oxygen （O2） and production of carbon dioxide （CO2） signal metabolic states and physiologic stresses. These respiratory gases are also detected as environmental cues that can signal external food quality and the presence of prey, predators and mates. In both contexts, animal nervous systems are endowed with mechanisms for sensing O2/CO2 to trigger appropriate behaviors and maintain homeostasis of internal O2/CO2. Although different animal species show different behavioral responses to O2/CO2, some underlying molecular mechanisms and pathways that function in the detection of respiratory gases are fundamentally similar and evolutionarily conserved. Studies of Caenorhabditis elegans and Drosophila melanogaster have identified roles for cyclic nucleotide signaling and the hypoxia inducible factor （HIF） transcriptional pathway in mediating behavioral responses to respiratory gases. Understanding how simple invertebrate nervous systems detect respiratory gases to control behavior might reveal general principles common to nematodes, insects and vertebrates that function in the molecular sensing of respiratory gases and the neural control of animal behaviors.

关键词： oxygen carbon dioxide C. elegans Drosophila respiratory gases animal behaviors

nflammasomes in cancer： a double-edgecl sword

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Protein & Cell 2014年第1期5卷 12-20页

作者： Ryan Kolb Guang-Hui Liu Ann M. Janowski Fayyaz S. Sutterwala Weizhou Zhang Department of Pathology Carver College of Medicine University of Iowa Iowa City IA 52242 USA National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Graduate Program in Immunology Carver College Of Medicine University of Iowa iowa City IA 52242 USA Department of Internal Medicine Carver College of Medicine University of Iowa Iowa City IA 52242 USA Veterans Affairs Medical Center Iowa City IA 52241 USA

Chronic inflammatory responses have long been observed to be associated with various types of cancer and play decisive roles at different stages of cancer development. Inflammasomes, which are potent induc- ers of interleukin （IL）-I~ and IL-18 during infammation, are large protein complexes typically consisting of a Nod-like receptor （NLR）, the adapter protein ASC, and Caspase-1. During malignant transformation or cancer therapy, the inflammasomes are postulated to become activated in response to danger signals arising from the tumors or from therapy-induced damage to the tumor or healthy tissue. The activation of inflammasomes plays diverse and sometimes contrasting roles in cancer promotion and therapy depending on the specific con- text. Here we summarize the role of different inflamma- some complexes in cancer progression and therapy. Inflammasome components and pathways may provide novel targets to treat certain types of cancer; however, using such agents should be cautiously evaluated due to the complex roles that inflammasomes and pro- inflammatory cytokines play in immunity.

关键词： inflammasome cancer inflammation

Varicocele and testicular function

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Asian Journal of Andrology 2015年第4期17卷 659-667页

作者： Alexander W Pastuszak Center for Reproductive Medicine Baylor College of Medicine Houston TX USA Scott Department of Urology Bay or Co ege of Medicine Houston TX USA Divisionof Urology University of Texas Med ca School at Houston Houston TX USA Department of Urology University of Texas MD Anderson Cancer Center HoustonTX USA

Testicular varicocele, a dilation of the veins of the pampiniform plexus thought to increase testicular temperature via venous congestion, is commonly associated with male infertility. Significant study has clarified the negative impact of varicocele on semen parameters and more recent work has shed light on its detrimental effects on the molecular and ultrastructural features of sperm and the testicular microenvironment, as well as more clearly defined the positive impacts of treatment on couples＇ fertility. The relationship between varicocele and testicular endocrine function, while known for some time based on histologic evaluation, has become more apparent in the clinical setting with a growing link between varicocele and hypogonadism. Finally, in the pediatric setting, while future study will clarify the impact of varicocele on fertility and testicular function, recent work supports a parallel effect of varicocele in adolescents and adults, suggesting a re-evaluation of current treatment approaches in light of the progressive nature of the condition and potential increased risk of future disease.

关键词： hypogonadism Leydig cell male fertility oxidative stress Sertoli cell ultramorphology varicocele

Aptamer-based molecular imaging

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Protein & Cell 2012年第10期3卷 739-754页

作者： Tianjiao Wang Judhajeet Ray Department of Biochemistry Biophysics and Molecular BiologyIowa State UniversityAmesIA 50011USA

Molecular imaging has greatly advanced basic biology and translational medicine through visualization and quantification of single/multiple molecular events temporally and spatially in a cellular context and in living ***,short single-stranded nucleic acids selected in vitro to bind a broad range of target molecules avidly and specifically,are ideal molecular recognition elements for probe development in molecular *** review summarizes the current state of aptamer-based biosensor development(probe design and imaging modalities)and their application in imaging small molecules,nucleic acids and proteins mostly in a cellular context with some animal *** article is concluded with a brief discussion on the perspective of aptamer-based molecular imaging.

关键词： aptamer imaging small molecule nucleic acid protein biosensor

Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs

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Science China(Life Sciences) 2022年第2期65卷 309-327页

作者： Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin Department of Orthopaedic Surgery University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Orthopedic Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Pathology University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Bioengineering University of Pittsburgh Swanson School of EngineeringPittsburgh PA 15219USA Department of Bioinformatics University of Pittsburgh School of MedicinePittsburgh PA 15219USA McGowan Institute for Regenerative Medicine University of Pittsburgh School of MedicinePittsburgh PA 15219USA Department of Biology University of Pittsburgh Dietrich School of Arts and SciencePittsburgh PA 15219USA Department of Research B2B Life Length SLMadrid 28010Spain Xiangya Third Hospital Central South UniversityChangsha 410013China

Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic *** from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-***,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis ***,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and *** results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in *** P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans.

关键词： osteoarthritis MSC senescence cartilage tissue engineering disease-modifying OA drug senolytic

The Paleoarchean Northern Mundo Novo Greenstone Belt,São Francisco Craton:Geochemistry,U-Pb-Hf-O in zircon and pyriteδ^(34)S-Δ^(33)S-Δ^(36)S signatures

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Geoscience Frontiers 2022年第5期13卷 190-206页

作者： Guilherme S.Teles Farid Chemale jr. Janaína N.Ávila Trevor R.Ireland Unidade Acadêmica de Mineração e Geologia Universidade Federal de Campina GrandeCampina GrandeBrazil Programa de Pós-Graduação em Geologia Universidade de BrasíliaBrasíliaBrazil Programa de Pós-Graduação em Geologia Universidade do Vale do Rio dos SinosSão LeopoldoBrazil Research School of Earth Sciences The Australian National UniversityCanberraACT 2601Australia Griffith Centre for Social and Cultural Research Griffith UniversityNathanQueensland 4111Australia

Greenstone belts contain several clues about the evolutionary history of primitive ***,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the Northern Mundo Novo Greenstone Belt(N-MNGB),and present data collected with different techniques,including U–Pb–Hf–O isotopes of zircon and multiple sulfur isotopes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrite from this supracrustal sequence.A pillowed metabasalt situated in the upper section of the N-MNGB is 3337±25 Ma old and has zircon with ε_(Hf)(t)=2.47 to1.40,Hf model ages between 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰to+7.3‰.These isotopic data,together with compiled whole-rock trace element data,suggest that the mafic metavolcanic rocks formed in a subduction-related setting,likely a back-arc basin juxtaposed to a continental *** this context,the magma interacted with older Eoarchean crustal components from the Gavião *** zircons from the overlying quartzites of the Jacobina Group are sourced from Paleoarchean rocks,in accordance with previous studies,yielding a maximum depositional age of 3353±22 *** detrital zircons have ε_(Hf)(t)=5.40 to0.84,Hf model ages between 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰to+6.4‰.The pyrite multiple sulfur isotope investigation of the 3.3 Ga supracrustal rocks from the N-MNGB enabled a further understanding of Paleoarchean sulfur *** samples have diverse isotopic compositions that indicate sulfur sourced from distinct ***,they preserve the signal of the anoxic Archean atmosphere,expressed by MIF-S signatures(Δ^(33)S between1.3‰to+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 that is indistinguishable from the so-called Archean array.A BIF sample has a magmatic origin of sulfur,as indicated by the limited Δ^(34)S range(0 to+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist shows positive Δ^(34)S(2.1‰–3.5‰)and elevated Δ^(33)S(1.2‰–1.4‰)values,with corresponding negative Δ^(36)S

关键词： Northern Mundo Novo Greenstone Belt Multiple sulfur isotopes Geochronology Paleoarchean Gavião Block São Francisco Craton

Wave tectono-sedimentary processes in Tarim basin

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Science China Earth Sciences 2005年第11期48卷 1949-1959页

作者： JIN Zhijun1,2, ZHANG Yiwei1 & CHEN Shuping1 1. Key Laboratory for Hydrocarbon Accumulation, Ministry of Education, China University of Petroleum, Beijing 102249, China 2. Exploration and Production Research Institute, China Petroleum & Chemical Corporation, Beijing 100083, China Key Laboratory for Hydrocarbon Accumulation Ministry of Education China University of Petroleum Beijing China Exploration and Production Research Institute China Petroleum & Chemical Corporation Beijing China

Based on the unconformities, the formation times of structures, and geological wave filtering applied to basin fills of typical wells around the Manjiaer area in the Tarim basin, the wave tectono-sedimentary processes in the Tarim Basin are discussed. The results of geological wave filtering of basin fills of typical wells show that, in time domain, the evolution of the Tarim basin was controlled by various wave processes with the periods of 740±Ma, 200±Ma, 100±Ma and 30±Ma. The analyses of basin fills, basin subsidence and unconformities show that the trends of the sedimentary facies belts, depocenters, and centers of subsidence migrated and interchanged periodically with periods of 200±Ma. These show the propagation of wave movements in space domain. The wave evolution of the Tarim basin is of significance to understanding the formation of the oil and gas reservoirs in the basin.

关键词： Tarim basin, tectonics, sedimentation, crustal undation, wave evolution