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过敏性鼻炎患者血清il-1β、il-10表达与病情的相关性研究

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蛇志 2024年第1期36卷 96-99页

作者：罗祝麟刘云香黄敏刘晓娟李双江邓红宾南昌市人民医院/南昌市第三医院耳鼻咽喉科江西南昌330002

目的探讨过敏性鼻炎(AR)患者血清白介素il-1β、il-10表达与病情的关系。方法选取2022年2月至2023年7月我院收治的60例AR患者为研究组,并依据AR病情程度分为轻度组、中度组、重度组,每组20例;同时选择同期体检健康者60例为对照组。比较... 详细信息

目的探讨过敏性鼻炎(AR)患者血清白介素il-1β、il-10表达与病情的关系。方法选取2022年2月至2023年7月我院收治的60例AR患者为研究组,并依据AR病情程度分为轻度组、中度组、重度组,每组20例;同时选择同期体检健康者60例为对照组。比较研究组与对照组的血清il-1β、il-10水平以及不同病情程度的AR患者血清il-1β、il-10水平,分析血清il-1β、il-10与AR患者病情的相关性,采用Logistic回归分析AR患者病情的影响因素,采用受试者工作特征曲线(ROC)分析血清il-1β、il-10对AR患者病情的诊断价值。结果研究组的血清il-1β水平高于对照组、il-10水平低于对照组,差异均有统计学意义(均Pil-1β水平高于轻、中度组患者,血清il-10水平低于轻、中度组患者,差异均有统计学意义(均Pil-1β与病情严重程度呈正相关(r=0.730,Pil-10水平与病情严重程度呈负相关(r=-0.747,Pil-1β高表达是AR患者病情加重的危险因素(OR=2.270,Pil-10高表达是AR患者病情加重的保护因素(OR=0.320,Pil-1β、il-10及联合检测诊断AR患者病情曲线下面积(AUC)为0.876、0.888、0.940,联合检测的诊断价值较单一指标检测高。结论AR患者的血清il-1β、il-10表达与患者病情密切相关,临床可通过检测患者的血清il-1β、il-10表达来判断其病情程度。

关键词：过敏性鼻炎白介素-1β 白介素-10 病情

益肾降浊方治疗CKD3-4期脾肾气虚、湿浊夹瘀型肾性贫血的临床疗效及对il-1β、il-6的影响

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中文科技期刊数据库（引文版）医药卫生 2024年第10期 0009-0012页

作者：王晓典洪江淮福建中医药大学福建福州350122 福建中医药大学附属人民医院福建福州350004

本课题通过临床观察,评估益肾降浊方联合西药在改善脾肾气虚、湿浊夹瘀型肾性贫血患者的临床症状和贫血相关指标方面的疗效及对il-1β、il-6的影响。方法选取福建中医药大学附属人民医院住院的CKD3-4期非血透病人,随机分为对照组与实验... 详细信息

本课题通过临床观察,评估益肾降浊方联合西药在改善脾肾气虚、湿浊夹瘀型肾性贫血患者的临床症状和贫血相关指标方面的疗效及对il-1β、il-6的影响。方法选取福建中医药大学附属人民医院住院的CKD3-4期非血透病人,随机分为对照组与实验组,分别采用常规治疗方案及常规治疗的基础上加用益肾降浊方,疗程6周,并纳入来自本院体检中心的同期健康人群对照组20例。结果治疗前CKD两组之间SCr、eGFR 、il-1β、il-6比较差异均无统计学意义(P>0.05),治疗后试验组SCr、eGFR 、il-1β、il-6改善程度均优于对照组;DKD 组血il-1β、il-6水平均高于健康组,差异均有统计学意义(Pil-1β和il-6水平具有调控作用,为临床治疗提供了参考依据。

关键词：益肾降浊方脾肾气虚肾性贫血

炎症因子NLR、PLR、CRP、il-6、PCT、TNF-α对小儿CAP 预后的评估价值研究

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中国现代药物应用 2024年第14期18卷 70-73页

作者：吴敏马小娜杨晨安顺市人民医院 561000

目的探讨炎症因子外周血中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(il-6)、肿瘤坏死因子-α(TNF-α)对小儿社区获得性肺炎(CAP)预后的评估价值。方法选取130例CAP患儿作... 详细信息

目的探讨炎症因子外周血中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(il-6)、肿瘤坏死因子-α(TNF-α)对小儿社区获得性肺炎(CAP)预后的评估价值。方法选取130例CAP患儿作为观察组,依据CAP类型分为轻型组(95例)和重型组(35例);同时选取同期体检儿童80例作为对照组。观察组患儿采用注射用头孢噻肟钠治疗。比较对照组和观察组治疗前NLR、PLR、CRP、il-6、PCT、TNF-α水平,轻型组和重型组治疗前后NLR、PLR、CRP、il-6、PCT、TNF-α水平。结果观察组治疗前NLR、PLR、CRP、il-6、PCT、TNF-α分别为(6.95±1.42)、(196.15±31.52)、(8.62±2.05)mg/L、(55.07±16.81)pg/ml、(3.00±0.58)ng/ml、(399.75±36.74)pg/ml,均高于对照组的(3.18±0.98)、(135.78±20.46)、(2.81±0.82)mg/L、(6.48±1.53)pg/ml、(0.47±0.19)ng/ml、(35.84±9.68)pg/ml,差异有统计学意义(Pil-6、PCT、TNF-α分别为(7.18±1.59)、(208.94±45.20)、(9.58±4.08)mg/L、(61.19±29.28)pg/ml、(3.17±0.67)ng/ml、(410.71±42.53)pg/ml,均高于轻型组的(6.87±1.15)、(191.44±45.31)、(8.27±3.13)mg/L、(52.82±23.91)pg/ml、(2.94±0.94)ng/ml、(395.71±40.19)pg/ml,但差异无统计学意义(P>0.05);治疗后,重型组NLR、PLR、CRP、il-6、PCT、TNF-α分别为(5.09±0.84)、(160.74±16.58)、(6.02±1.01)mg/L、(30.14±9.21)pg/ml、(1.67±0.63)ng/ml、(284.75±40.29)pg/ml,均高于轻型组的(4.38±1.05)、(150.18±11.47)、(4.02±0.58)mg/L、(12.47±2.08)pg/ml、(1.06±0.22)ng/ml、(100.47±12.91)pg/ml,差异有统计学意义(Pil-6、PCT、TNF-α水平均低于同组治疗前,差异有统计学意义(Pil-6、PCT、TNF-α对小儿CAP预后评估具有一定的临床价值。

关键词：小儿社区获得性肺炎外周血中性粒细胞/淋巴细胞比值血小板/淋巴细胞比值 C反应蛋白降钙素原白细胞介素-6 肿瘤坏死因子-α

氨氧基乙酸腹腔注射在il-10^(-/-)老年鼠自发性结肠炎治疗中的作用

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老年医学研究 2024年第2期5卷 34-37页

作者：李文阳吴许军河西学院医学院甘肃张掖734000 甘肃医学院附属医院甘肃平凉744000

目的探讨氨氧基乙酸(AOAA)对il-10^(-/-)老年鼠自发性结肠炎的作用。方法将雄性6~8周龄il-10^(-/-)小鼠饲养至15周制作小鼠自发性结肠炎模型,将其随机分为CTRL组、AOAA组,每组5只。AOAA组小鼠腹腔注射AOAA(5 mg/kg,1次/天),CTRL组给予... 详细信息

目的探讨氨氧基乙酸(AOAA)对il-10^(-/-)老年鼠自发性结肠炎的作用。方法将雄性6~8周龄il-10^(-/-)小鼠饲养至15周制作小鼠自发性结肠炎模型,将其随机分为CTRL组、AOAA组,每组5只。AOAA组小鼠腹腔注射AOAA(5 mg/kg,1次/天),CTRL组给予同等体积的无菌PBS,连续40 d。每天观察小鼠的粪便特征及肛门血;测算小鼠结肠长度及脾脏指数;采用ELISA法测定小鼠结肠组织中il-6、il-13的水平;取出结肠分离固有层单个核细胞进行流式细胞分析。结果与CTRL组相比,AOAA组小鼠大便稀疏及便血明显缓解,肛周未见肿胀包块。与CTRL组相比,AOAA组小鼠结肠长度长,脾脏指数高,结肠组织中il-6、il-13水平减少,结肠黏膜固有层中巨噬细胞、单核细胞的百分比降低,固有层中的CD80+细胞(M1巨噬细胞标志物)的百分比降低,固有层中的CD206+细胞(M2巨噬细胞标志物)的百分比升高,两组相比P均il-10缺陷诱发的老年结肠炎小鼠具有保护作用,其机制可能与平衡巨噬细胞极化和调节炎性细胞因子的分泌有关。

关键词：自发性结肠炎氨氧基乙酸炎症免疫巨噬细胞

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Surface morphology and cell viability of samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide/polycaprolactone targeting wound dressing

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Journal of Rare Earths 2024年第3期42卷 555-561,I0005页

作者： Muteb H.Alshammari Ahmed Onayzan Alshammari Mohamed Tharwat Elabbasy Rafat Zreiq Faris Mohammed Albati M.A.El-Morsy A.A.Menazea Department of Health Informatics College of Public Health and Health InformaticsUniversity of Ha'ilHa'ilSaudi Arabia Department of Surgery College of MedicineUniversity of Ha'ilHa'ilSaudi Arabia Department of Public Health College of Public Health and HealthInformaticsHalUniversityHa'il2440Saudi Arabi Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Applied Science Research Center Applied Science Private UniversityAmman541350Jordan College of Shariah and Law Ha'il UniversityHa'il2440Saudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamittaNew Damietta34517.Egyp Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt

Combinations of metal and lanthanide oxides have been done through casted films for potential medical applications. In this regard, samarium(Ⅲ) oxide/chromium(Ⅲ) oxide/graphene oxide(GO)/polycaprolactone(PCL) based films nano-composites(NCs) were fabricated, pointing their utilization as a biological scaffold for wound dressing purposes. Also, samarium(Ⅲ) oxide and chromium(Ⅲ) oxide have been merged as promising optical constituents due to their unique optical behavior. The structural and compositional examination of the studied NCs was executed by X-ray diffraction(XRD), Raman, and field emission scanning electron microscopy(FESEM). The Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL NC exhibits a surface with a lower roughness degree owing to the presence of GO. Cr_(2)O_(3)shows size reduction upon GO insertion to reach 1.2 μm as the average grain size, whilst Sm_(2)O_(3)records an average grain size of less than 1 μm. As well, the polymeric nano-compositions exhibit variation in contact angle values that hit 29.76°± 3.52°for Sm_(2)O_(3)/PCL, and 48.62°± 1.37°for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL as the second lowest contact angle. The optical behavior contributes to absorption edge relocation along the x-axis from 1.7 eV for pure PCL, to 2.65 eV for Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL. Regarding biological responses, the cell exposed to 2.5 μg/m L of Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL shows cell viability of 119.31%, while 5 μg/m L hits 99.6%. Additionally, the resulting cell attachment micrographs show layers of fibroblast tissue, besides the proliferation and growth of cultivated cells. Thus, the Sm_(2)O_(3)/Cr_(2)O_(3)/GO/PCL scaffold provides 3D proliferation of fibroblast cells endorsing the wound healing process.

关键词： Wound healing Wound dressing Polycaprolactone Sm_(2)O_(3) Cr_(2)O_(3) Rare earths

分析咳嗽变异性哮喘患儿血清25-(OH)D3与il-4的表达水平及相关性

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中文科技期刊数据库（引文版）医药卫生 2024年第8期 0089-0092页

作者：朱燕文杜正强邵轶佘艳佘艳宜兴市第二人民医院儿科江苏无锡214000 宜兴市第二人民医院检验江苏无锡214000

对咳嗽变异性哮喘患儿的血清25-羧基维生素D3[25-(OH)D3]水平及白细胞介素-4(il-4)水平进行检测并对两种指标之间的相关性进行分析。方法选取60例在宜兴市第二人民医院进行治疗的CVA患儿归入至CVA组,起始治疗时间为2021年10月,截止时... 详细信息

对咳嗽变异性哮喘患儿的血清25-羧基维生素D3[25-(OH)D3]水平及白细胞介素-4(il-4)水平进行检测并对两种指标之间的相关性进行分析。方法选取60例在宜兴市第二人民医院进行治疗的CVA患儿归入至CVA组,起始治疗时间为2021年10月,截止时间为至2022年3月,将30例同期参与研究的健康志愿儿童受试者归入至对照组,比较CVA组与对照组、轻度与重度CVA患儿以及预后良好组和预后不良组CVA患儿血清25-(OH)D3及il-4水平,针对两者相关性进行分析。结果相比于对照组,CVA组25-(OH)D3水平更低,il-4更高(Pil-4水平(Pil-4水平(Pil-4水平具有相关性且呈现为负相关(Pil-4水平具有相关性,检测25-(OH)D3水平及il-4水平有助于临床对咳嗽变异性哮喘患儿病情严重程度进行判断,还可对预后进行评估。

关键词：咳嗽变异性哮喘血清25-(OH)D3 il-4 相关性

Dysprosium oxide,alumina,and graphene oxide reinforced polycaprolactone thin films:Thermal stability,morphology,and cell viability

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Journal of Rare Earths 2024年第7期42卷 1337-1343,I0005页

作者： Mohamed Tharwat Elabbasy Mohamed R.Atteya Mai A.Samak Mousa Abdelrahman Tahani AlMahmoud M.A.El-Morsy A.A.Menazea M.F.H.Abd El-Kader Department of Public Health College of Public Health and Health InformaticsUniversity of Ha'ilHa'il2440Saudi Arabia Food Control Department Faculty of Veterinary MedicineZagazig UniversityZagazig44519Egypt Department of Physical Therapy College of Applied Medical SciencesUniversity of Ha'ilHa'ilSaudi Arabia Department of Histology and Cell Biology Faculty of MedicineZagazig UniversityZagazig44519Egypt College of Nursing University of Ha'ilHa'ilSaudi Arabia College of Science and Humanities in Al-Kharj Physics DepartmentPlasma Technology and Material Science UnitPrince Sattam Bin Abdulaziz UniversityAl-kharj11942Saudi Arabia Physics Department Faculty of ScienceUniversity of DamiettaNew Damietta34517Egypt Spectroscopy Department Physics Research InstituteNational Research CentreDokki12622GizaEgypt Biophysics Department Faculty of ScienceCairo UniversityGizaEgypt

Developing a biomaterial for wound healing applications is still a ***,dysprosium oxide(Dy_(2)O_(3)),aluminum oxide(Al_(2)O_(3)),and graphene oxide(GO)were embedded in cast films based on polycaprolactone(PCL)to be examined for wound dressing *** techniques were used to characterize the fabricated films including X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),Raman,and scanning electron microscopy(SEM),besides their biological *** thermogravimetric analysis(TGA)exhibits high thermal stability as the scaffold weight decreases slightly to 98.6%after raising the temperature from room temperature to 280℃.The cell viability was investigated and it is shown that the viable cells grow up to approximately 93%at 75μg/***,the cell attachment shows excellent behavior as the cells attach on most of the surface of the modified PCL which shows high biocompatibility.

关键词： Wound healing Polycaprolactone Dy_(2)O_(3) Al_(2)O_(3) Biocompatible Rare earths

Remediation of amide pesticide-polluted soils by combined solarization and ozonation treatment

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Pedosphere 2024年第3期34卷 641-651页

作者： Isabel GARRIDO Carmen MMARTINEZ Pilar FLORES Pilar HELLIN Fulgencio CONTRERAS Jose FENOLL Department of Sustainability and Quality Group of Fruit and Vegetable Products Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

Agriculture has a close relationship with nature,but it can also be the source of negative and permanent environmental *** use of pesticides in modern agriculture is a common practice,but their side effects on the environment cannot be *** this study,we evaluated a combination of solarization and ozonation techniques for the elimination of six amide pesticides(boscalid,chlorantraniliprole,cyflufenamid,fluopyram,napropamide,and propyzamide)in *** experiments were performed with four different soils to assess the efficiency of this methodology at different soil temperatures and ozone dosages under laboratory conditions,and then a greenhouse pot experiment was conducted under controlled conditions during *** days after the onset of the experiments,higher degradation percentages of amide pesticides were observed in ozonized soils than in other treated soils,particularly when ozone was applied at 10 cm soil *** results show that the utilization of ozonation,along with solarization,represents a valid method for degrading residues of the studied pesticides and suggest that this combined technology may be a promising tool for remediating pesticide-polluted soils.

关键词： intermediate ozone pesticide degradation pesticide residue polyethylene film remediation technique

解热醒神注射液对内生致热原性发热家兔下丘脑cAMP及il-1_β含量的影响

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北京中医药大学学报 2001年第4期24卷 28-30页

作者：张丹卉蒋玉凤黄启福贾旭严京路雪雅北京中医药大学基础医学院北京100029

建立家兔内生致热原性发热模型 ,观察解热醒神注射液对发热动物的体温及下丘脑cAMP、il 1β 含量的影响。结果显示 :解热醒神注射液组的体温变化曲线、最大体温上升高度 (ΔT)、体温反应指数 (TRI3)与生理盐水组无明显差别 (P >0 0 5 ... 详细信息

建立家兔内生致热原性发热模型 ,观察解热醒神注射液对发热动物的体温及下丘脑cAMP、il 1β 含量的影响。结果显示 :解热醒神注射液组的体温变化曲线、最大体温上升高度 (ΔT)、体温反应指数 (TRI3)与生理盐水组无明显差别 (P >0 0 5 ) ,表明解热醒神注射液对正常体温影响不大。而解热醒神注射液 +内生致热原组的ΔT、TRI3及下丘脑cAMP、il 1β 含量明显低于内生致热原组 (P il 1β 含量变化呈正相关。说明解热醒神注射液不但抑制内生致热原引起的发热反应而且抑制内生致热原引起的下丘脑cAMP及il 1β 含量的增多。

关键词：解热醒神注射液发热内生致热原白细胞介素-1β 环-磷酸腺苷下丘脑