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ON NON-ISOTROPIC JACOBI PSEUDOSPECTRAL METHOD

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Journal of Computational Mathematics 2008年第4期26卷 511-535页

作者： Benyu Guo Keji Zhang Department of Mathematics,shanghai Normal University,shanghai 200234.china Scientific Computing Key Laboratory of shanghai {4. division of Computational Science of E-Institute of shanghai {4. Department of Mathematics Shanghai Normal University Shanghai 200234

In this paper, a non-isotropic Jacobi pseudospectral method is proposed and its appli- cations are considered. Some results on the multi-dimensional Jacobi-Gauss type interpolation and the related Bernstein-Jackson type inequalities are established, which play an important role in pseudospectral method. The pseudospectral method is applied to a twodimensional singular problem and a problem on axisymmetric domain. The convergence of proposed schemes is established. Numerical results demonstrate the efficiency of the proposed method.

关键词： Jacobi pseudospectral method in multiple dimensions Jacobi-Gauss type inter-polation Bernstein-Jackson type inequalities Singular problem Problem on axisymmetricdomain.

Homotopic mapping solving method for gain fluency of a laser pulse amplifier

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Science china(Physics,Mechanics & Astronomy) 2009年第7期52卷 1007-1010页

作者： MO JiaQi1,2 1 Anhui Normal University, Wuhu 24.000, china 2 division of Computational Science, E-institutes of shanghai {4., at SJTU, shanghai 20024., china Anhui Normal University Wuhu 241000 China division of Computational Science E-Institutes of Shanghai Universities at SJTU Shanghai 200240 China

The model for gain fluency of a laser pulse amplifier is studied. Using the homotopic mapping method, firstly, the system of the original model is packed up standardization; secondly, introducing a homotopic mapping, taking the property of the mapping, inducing a contrived parameter, the solving of a nonlinear problem translates into the solving of a linear problem. Then the approximate expressions of the solution for the corresponding model are obtained. And the precision for the approximate solution is compared. It illuminates that the obtained approximate solution using the homotopic mapping method possesses higher approximate degree. At one time, the expansion of solution through the homotopic mapping method can be kept in the analytic operation. Thus it also enables us through differential and integral operations to obtain other physics behavior for the gain fluency of laser pulse amplifier.

关键词： nonlinear homotopic mapping laser pulse amplifier

Biomarkers of neurodegenerative disorders: How good are they?

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Cell Research 2004年第5期14卷 347-358页

作者： Varun RACHAKONDA Department of Neurology Baylor College of Medicine Houston TX USA

Biomarkers are very important indicators of normal and abnormal biological processes. Specific changes in pathologies, biochemistries and genetics can give us comprehensive information regarding the nature of any particular disease. A good biomarker should be precise and reliable, distinguishable between normal and interested disease, and differential between different diseases. It is believed that biomarkers have great potential in predicting chances for diseases, aiding in early diagnosis, and setting standards for the development of new remedies to treat diseases. New technologies have enabled scientists to identify biomarkers of several different neurodegenerative diseases. The followings, for instance, are only a few of the many new biomarkers that have been recently identified: the phosphorylated tau protein and aggregated β-amyloid peptide for Alzheimer’s disease (AD), α-synuclein contained Lewy bodies and altered dopamine transporter (DAT) imaging for Parkinson’s disease (PD), SOD mutations for familial amyotrophic lateral sclerosis (ALS), and CAG repeats resulted from Huntington’s gene mutations in Huntington’s disease (HD). This article will focus on the most-recent findings of biomarkers belonging to the four mentioned neurodegenerative diseases.

关键词： Alzheimer’s disease Parkinson’s disease Amyotrophic Lateral Sclerosis Huntington’s disease biomarkers.

Current advances in the application of proteomics in apoptosis research

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Science china(Life Sciences) 2011年第3期54卷 209-219页

作者： WANG LiShun & CHEN GuoQiang Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of china E-institutes of shanghai Municipal Education Commission Chemical Biology division,shanghai Jiao Tong University School of Medicine,shanghai 200025.china 1. Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China E-institutes of shanghai Municipal Education Commission Chemical Biology division Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular *** of apoptosis has been implicated in a number of diseases,including cancer and autoimmune ***,the investigation of apoptotic regulation has evoked considerable *** apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic ***,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the *** review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.

关键词： apoptosis proteomics small compound oncogene tumor suppressor

IL-12p4. is not required for islet allograft rejection

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Acta Pharmacologica Sinica 2006年第8期27卷 1065-1070页

作者： En-guang BI~(2,5) Wei SHI~(3,5) Jia ZOU~2 Zhen-hua HAO~3 Zhen-hu LI~2 Duan CAI~3 Hua-qun ZHANG~3 Bing SUN~(2,4.6) ~2Laboratory of Molecular Cell Biology shanghai institutes for Biological Sciences,Chinese Academy of Sciences,Graduate School of the Chinese Academy of Sciences,shanghai 200031,china ~3the Huashan Hospital of Fudan University,shanghai 20004.,china ~4.-institutes of shanghai universities immunology division,shanghai 200025.china Laboratory of Molecular Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai 200031 China

Aim:To investigate whether IL-12p4. plays a crucial role in regulating islet al-lograft rejection in a streptozotocin(STZ)-induced diabetes mouse ***:C57BL/6 and IL-12p4. gene knockout mice were selected as recipient mice,towhich the diabetes was induced with a treatment of STZ(150-200 mg/kg)by asingle ip ***/c mice were selected as donor mice and islet cells wereisolated from the *** 500 islets were transplanted into recipient mice be-neath the capsule of the left *** the islet transplantation the glu-cose from the mice sera was monitored and the rejection rate of islets was ***:STZ could induce diabetes in the recipient mice within 1 *** of allograft islets,the increased glucose in wild-type(WT)micereturned to normal level and was maintained for 10 ***,the rejectionrate of islet allograft between IL-12p4.-deficient mice and WT mice was ***:The results suggested that,although islet allograft rejection is be-lieved to be Th1-cell predominant,the Th1 response inducer,IL-12 and IL-23 arenot essential to induce islet allograft rejection.

关键词： Th1 cells Th2 cells islets of Langerhans transplantation homologous transplantation IL-12p4.-deficient mice

Opportunity and challenge of target-based therapy for leukemia:lessons from APL and CML

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中国病理生理杂志 2010年第A10期26卷 1946-1947页

作者： CHEN Guo-qiang(Department of Pathophysiology,Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education & Chemical Biology division of shanghai universities E-institutes,shanghai Jiaotong University School of Medicine,shanghai 200025.china)

In the past two decades,target-based therapies achieve the great success in adult *** typical examples are the applications of all-trans retinoic acid(ATRA)/arsenic trioxide(ATO)and specific tyrosine kinase inhibitor imatinib respectively in acute promyelocytic leukemia(APL)and chronic myeloid leukemia(CML).These successful clinical practices originated from our understanding on

关键词： trioxide myeloid ATRA arsenic originated challenge granulocyte alterations targeting lymphoid

Predominant expression of β-chain variable region genes of T-cell receptor in TILs from human renal cell carcinoma

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Chinese Science Bulletin 1997年第8期42卷 693-697页

作者： LI Xueyi, WANG Ying, ZHENG Zhongcheng, ZHANG Dongqing, FUSaili, LING Jianyu and ZHOU Guangyan (CHOU Kuangyen)1. shanghai Institute of immunology, shanghai Second Medical University, shanghai {4., china 2. shanghai Institute of Biochemistry, Chinese Academy of Sciences, shanghai 200031, china 3. shanghai Ruijin Hospital, shanghai {4., china shanghai Institute of immunology Shanghai Second Medical University Shanghai China shanghai Institute of Biochemistry Chinese Academy of Sciences Shanghai China shanghai Ruijin Hospital Shanghai China

THE repertoire of T-cell antigen receptor(TcR)can be effectively analysed by an approachwith quantitative polymerase chain reaction(qPCR),which allows to characterize the ex-panding T-cell clones by the patterns of re... 详细信息

关键词： renal cell carcinoma tumor-infiltrating lymphocyte T-cell receptor Vβ gene quantitative polymerase chain reaction.

Residues Met76 and Gln79 in HLA-G α1 domain involved in KIR2DL4.recognition

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Cell Research 2005年第3期15卷 176-182页

作者： Wei Hua YAN1,2,*,Li An FAN1,2,** 1Laboratory of Immunogenetics,shanghai Second Medical University,280 South Chongqing Road,shanghai 200025.china 2Laboratory of Immunogenetics,shanghai Institute of immunology,280 South Chongqing Road,shanghai 200025.china Laboratory of Immunogenetics Shanghai Second Medical University 280 South Chongqing Road Shanghai 200025 China Laboratory of Immunogenetics Shanghai Institute of Immunology 280 South Chongqing Road Shanghai 200025 China

Human leukocyte antigen-G (HLA-G) has long been speculated as a beneficial factor for a successful pregnancy for its restricted expression on fetal-maternal extravillous cytotrophoblasts and its capability of modulating uterine natural killer cell (uNK) function such as cytotoxicity and cytokine production through NK cell receptors. HLA class I α1 domain is an important killer cell Ig-like receptor (KIR) recognition site and the Met76 and Gln79 are unique to HLA-G in this region. NK cell receptor KIR2DL4.is a specific receptor for HLA-G, yet the recognition site on HLA-G remains unknown. In this study, retroviral transduction was applied to express the wild type HLA-G (HLA-wtG), mutant HLA-G (HLA-mG) on the chronic myelogenous leukemia cell line K562 cells and KIR2DL4.molecule on NK-92 cells, respectively. KIR2DL4.IgG Fc fusion protein was generated to determine the binding specificity between KIR2DL4.and HLA-G. Our results showed that residue Met76, Gln79 mutated to Ala76,79 in the α1 domain of HLA-G protein could affect the binding affinity between KIR2DL4.and HLA-G, meanwhile, the KIR2DL4.transfected NK-92 cells (NK-92- 2DL4. showed a considerably different cytolysis ability against the HLA-wtG and HLA-mG transfected K562 targets. Taken together, our data indicated that residue Met76 and Gln79 in HLA-G α1 domain plays a critical role in the recogni- tion of KIR2DL4. which could be an explanation for the isoforms of HLA-G, all containing the α1 domain, with the potential to regulate NK functions.

关键词： NK cell KIR2DL4 HLA-G receptor.

A CLASS OF NONLINEAR SINGULARLY PERTURBED INITIAL BOUNDARY VALUE PROBLEMS FOR REACTION DIFFUSION EQUATIONS WITH BOUNDARY PERTURBATION

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Applied Mathematics(A Journal of Chinese universities) 2007年第2期22卷 201-206页

作者： Mo Jiaqi Department of Mathematics, Anhui Normal University, Wuhu 24.000, china Department of Mathematics, Huzhou Teachers College, Huzhou 313000, china division of Computational Science, E-institutes of {4. universities at SJTU, {4. 20024., china. Department of Mathematics Anhui Normal University Wuhu 241000 China

A class of nonlinear initial boundary value problems for reaction diffusion equations with boundary perturbation is considered. Under suitable conditions and using the theory of differential inequalities the asymptoti... 详细信息

关键词： nonlinear reaction diffusion singular perturbation boundary perturbation