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Schwannoma in the hepatoduodenal ligament: A case report and literature review

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World Journal of Gastroenterology 2016年第46期22卷 10260-10266页

作者： Shao-Yan Xu Ke sun Hai-Yang Xie Lin Zhou Shu-sen Zheng Wei-Lin Wang Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public Health Hangzhou 310003 Zhejiang Province China Key Laboratory of Organ Transplantation Zhejiang Province Hangzhou 310003 Zhejiang Province China Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province Hangzhou 310003 Zhejiang Province China department of pathology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China

Schwannomas are mesenchymal neoplasms with low malignant potential that arise from Schwann cells. They can occur almost anywhere, although the most common locations are the head, neck and extremities. Primary benign schwannoma of the hepatoduodenal ligament is rare. To date, only three cases have been reported in the English literature. In the present study, we report a case of hepatoduodenal ligament schwannoma in a 43-year-old male, who was admitted to our {2. because of a abdominal mass found by physical examination. It was hard to determine the definitive location and diagnosis of the mass using ultrasound, computed tomography and magnetic resonance cholangiopancreatography. During laparotomy, the mass was found in the hepatoduodenal ligament and close to the cholecystic duct, so we resected the gallbladder and cholecystic duct along with the mass. The gross specimen revealed an 8.5 cm × 5.5 cm × 3.0 cm localized tumor. Microscopic examination showed that the tumor was mainly composed of spindle-shaped cells. Immunohistochemical staining showed a strong positive S-100 protein reaction. Finally, the lesion was diagnosed as a benign schwannoma in the hepatoduodenal ligament. However, one month later, the patient was readmitted to our {2. because of skin and sclera jaundice caused by common bile duct stenosis without common bile duct stone or tumor. The patient recovered well after implantation of a common bile duct stent under endoscopic retrograde cholangiopancreatography. He was followed up for a period of 17 mo, during which he was well with no complications.

关键词： Schwannoma Hepatoduodenal ligament Endoscopic retrograde cholangiopancreatography Laparotomy Jaundice

表现为肾病综合征的IgA肾病病理特征及其与预后的关系

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中国实用内科杂志 2005年第8期25卷 722-724页

作者：杨念生武庆庆杜勇张锐李幼姬叶任高余学清中山大学附属第一医院肾内科教育部肾脏病临床研究重点实验室广东省肾脏病重点实验室广州510080

目的探讨表现为肾病综合征(肾综)的IgA肾病病理特性及其与预后关系.方法分析1987～2.02.中山大学附属第一医院肾内科确诊的IgA肾病72.例,表现为肾综的IgA肾病的临床、病理特征及疗效,与非肾综IgA肾病进行比较并长期随访.结果 7.1%(51/7... 详细信息

目的探讨表现为肾病综合征(肾综)的IgA肾病病理特性及其与预后关系.方法分析1987～2.02.中山大学附属第一医院肾内科确诊的IgA肾病72.例,表现为肾综的IgA肾病的临床、病理特征及疗效,与非肾综IgA肾病进行比较并长期随访.结果 7.1%(51/72.)IgA肾病表现为肾综.肾综组高血压和肾功能不全发生率显著高于非肾综组(35.3%对13.8%和47.1%对19.2.,P4.9%、68.6%和100.0%、95.9%、91.9%(P4%(7/11)Lee氏Ⅰ～Ⅱ级的肾综对激素敏感.结论呈肾综的IgA肾病病理损害较重,预后差,但有少数病理病变轻微,可能对激素敏感.

关键词： IgA肾病预后病理蛋白尿

Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation

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Journal of Molecular Cell Biology 2020年第1期12卷 17-31页

作者： sen Lin Wei Liu Chun-Lin Chen Dong sun Jin-Xia Hu Lei Li Jian Ye Lin Mei Wen-Cheng Xiong department of Neuroscience&Regenerative Medicine and department of Neurology Augusta UniversityAugustaGA 30912USA department of Ophthalmology Daping HospitalArmy Medical Center of PLAChongqingChina department of Neurosciences School of MedicineCase Western Reserve UniversityClevelandOH 44106USA

Neogenin is a transmembrane receptor critical for multiple cellular processes,including neurogenesis,astrogliogenesis,endochondral bone formation,and iron *** we present evidence that loss of neogenin contributes to pathogenesis of persistent hyperplastic primary vitreous(PHPV)formation,a genetic disorder accounting for^5% of blindness in the *** loss of neogenin in neural crest cells(as observed in Wntl-Cre;Neofff mice),but not neural stem cells(as observed in GFAP-Cre and Nestin-Cre;Neo^f/f mice),resulted in a dysregulation of neural crest cell migration or delamination,exhibiting features of PHPV-like pathology(*** retrolental mass),unclosed retinal fissure,and *** results demonstrate an unrecognized function of neogenin in preventing PHPV pathogenesis,implicating neogenin regulation of neural crest cell delamination/migration and retinal fissure formation as potential underlying mechanisms of PHPV.

关键词： neogenin PHPV ocular fissure neural crest cells

应用临床路径对腰椎间盘突出症手术患者实施健康教育

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实用全科医学 2007年第5期5卷 428-429页

作者：贺秧青李超群陈佩珊郑少梅中山大学附属江门医院脊柱外科广东省江门市529000

目的探讨应用临床路径对腰椎间盘突出症手术患者实施健康教育的效果。方法将我科自2.05年2.-2.06年8月135例经后路行腰椎间盘髓核摘除术患者随机分成2.,实验组(75例)应用临床路径(Clinical Pathway,CP)对患者实施健康教育,对照组(60例... 详细信息

目的探讨应用临床路径对腰椎间盘突出症手术患者实施健康教育的效果。方法将我科自2.05年2.-2.06年8月135例经后路行腰椎间盘髓核摘除术患者随机分成2.,实验组(75例)应用临床路径(Clinical Pathway,CP)对患者实施健康教育,对照组(60例)采用传统方法进行健康教育。结果实验组在疾病知识掌握率、疾病治疗信心、护理质量满意度均明显高于对照组,住院大数及住院费用明显低于对照组。结论应用CP实施健康教育可以增加患者对手术治疗的信心,减少并发症发生,有效地提高手术成功率。

关键词：临床路径腰椎间盘突出手术健康教育

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沈德潜的格调说与对唐诗的评价问题

湘潭大学社会科学学报 2002年第4期26卷 87-89页

作者：章继光五邑大学中文系广东江门529020

沈德潜的“格调”是一个融合着气格、风骨、才力、声调等多元素质的概念。格调说是沈氏评论唐诗的基石。据此 ,沈氏对盛唐诗予以高度评价 ,并展示了李白、杜甫作为盛唐巨擘格调的丰富内涵。沈氏在推崇格调的同时 ,对影响较大的神韵说并... 详细信息

沈德潜的“格调”是一个融合着气格、风骨、才力、声调等多元素质的概念。格调说是沈氏评论唐诗的基石。据此 ,沈氏对盛唐诗予以高度评价 ,并展示了李白、杜甫作为盛唐巨擘格调的丰富内涵。沈氏在推崇格调的同时 ,对影响较大的神韵说并未忽视且有所借鉴。

关键词：沈德潜格调说神韵诗歌唐代《唐诗别裁》

Central pancreatectomy for pancreatic schwannoma: A case report and literature review

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World Journal of Gastroenterology 2016年第37期22卷 8439-8446页

作者： Shao-Yan Xu Ke sun Kwabena Gyabaah Owusu-Ansah Hai-Yang Xie Lin Zhou Shu-sen Zheng Wei-Lin Wang Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital School of Medicine Zhejiang University Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public Health First Affiliated Hospital School of Medicine Zhejiang University Key Laboratory of Organ Transplantation First Affiliated Hospital School of Medicine Zhejiang University Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University department of pathology First Affiliated Hospital School of Medicine Zhejiang University

Schwannomas are mesenchymal tumors originating from Schwann cells in peripheral nerve sheaths. Although the tumor can be located in any part of the human body, the most common locations are the head, neck, trunk and extremities. Pancreaticschwannomas are rare. To our knowledge, only 64 cases of pancreatic schwannoma have been reported in the English literature over the past 40 years. In this paper, we present a pancreatic schwannoma in a 59-year-old female. Ultrasound, computed tomography and magnetic resonance imaging revealed the tumor located in the pancreatic body; however, accurate diagnosis was hard to obtain preoperatively and a pancreatic cystadenoma was preliminarily considered. During laparotomy, the mass was found in the body of the pancreas. An enlarged gallbladder with multiple stones was also observed. We performed central pancreatectomy, end-to-side pancreaticojejunostomy and cholecystectomy. Notably, central pancreatectomy has been reported in only one case prior to this report. The gross specimen showed a mass with a thin capsule, 1.6 cm × 1.1 cm × 1.1 cm in size. Microscopic examination showed that the tumor was mainly composed of spindle-shaped cells with palisading arrangement and no atypia, which is consistent with a benign tumor. Both hypercellular and hypocellular areas were visible. Immunohistochemical staining revealed strongly positive results for protein S-100. Finally, the tumor was diagnosed as a schwannoma of the pancreatic body. Postoperatively, the patient recovered well and left the {2. 6 d later. During the 53-mo follow-up period, the patient remained well and free of complications.

关键词： Pancreaticojejunostomy Schwannoma Pancreas Central pancreatectomy S-100

Successful treatment of a pancreatic schwannoma by spleen-preserving distal pancreatectomy

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World Journal of Gastroenterology 2017年第20期23卷 3744-3751页

作者： Shao-Yan Xu Ying-Sheng Wu Jian-Hui Li Ke sun Zhen-Hua Hu Shu-sen Zheng Wei-Lin Wang Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang University Key Laboratory of Combined Multi-organ Transplantation Ministry of Public HealthFirst Affiliated HospitalSchool of MedicineZhejiang University Key Laboratory of Organ Transplantation Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang University Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province department of pathology First Affiliated HospitalSchool of MedicineZhejiang University

Schwannomas are neurogenic tumors that arise from the neural sheaths of peripheral nerves. These tumors can be located in any area of the human body; the most common locations are the head, neck, trunk and extremities. Pancreatic schwannomas are very rare. Over the past 40 years, only 67 cases of pancreatic schwannomas have been reported in the English literature. Here we present a case of pancreatic schwannoma in a 62.year-old male. The tumor was revealed by ultrasound and computed tomography in the neck and body of the pancreas. An accurate diagnosis was difficult to obtain preoperatively. The patient consented to the performance of a laparotomy, and the mass was found in the neck and body of the pancreas and successfully treated using a spleen-preserving distal pancreatectomy with splenic artery and vein preservation. The procedure has only been reported in one other case of pancreatic schwannoma; here we present the second reported case. Macroscopically, the tumor was well circumscribed, gray-white in color and 3.3 cm x 2.8 cm in size. Microscopically, the tumor cells were spindle-shaped and had a palisading arrangement with no atypia, which are results compatible with a benign tumor. Both hypercellular and hypocellular areas were visible. Immunohistochemically, the tumor cells were strongly positive for S-100 protein. The tumor was definitively diagnosed as a schwannoma of the pancreatic neck and body. The patient was followed for 72.mo and has been doing well without any complications.

关键词： Schwannoma Pancreas Spleen-preserving distal pancreatectomy S-100 Mesenchymal tumor

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气轨上单摆的混沌实验

物理实验 2001年第6期21卷 12-14页

作者：张才国关小泉吴森汤艳芬五邑大学数学物理系广东江门529020

设计并自制了一个气轨上单摆的混沌演示装置 ,建立了系统的动力学方程 ,直观地显示了混沌的一些基本特征 .

关键词：混沌单摆非线性气轨演示实验动力学方程课堂教学素质教育

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儿童耳鸣特点的初步分析

听力学及言语疾病杂志 2009年第6期17卷 554-556页

作者：曾祥丽王树芳岑锦添黎志成李鹏中山大学附属第三医院耳鼻咽喉头颈外科中山大学耳鼻咽喉科研究所广州510630

目的探讨儿童耳鸣的临床特点。方法分析33例儿童耳鸣患者的病因、年龄分布、就诊目的及烦恼程度。结果①病因:2.肌源性及1例血管源性客观性耳鸣;中耳病变:分泌性中耳炎6例,外伤性鼓膜穿孔1例;内耳病变:膜迷路积水2.,高频听力损失17例... 详细信息

目的探讨儿童耳鸣的临床特点。方法分析33例儿童耳鸣患者的病因、年龄分布、就诊目的及烦恼程度。结果①病因:2.肌源性及1例血管源性客观性耳鸣;中耳病变:分泌性中耳炎6例,外伤性鼓膜穿孔1例;内耳病变:膜迷路积水2.,高频听力损失17例,纯音听阈正常、耳声发射异常4例;②主动诉说耳鸣的儿童最小年龄4.5岁,6岁以下主要病因为分泌性中耳炎,8～14岁主要病因为内耳病变;③就诊的目的和动机:2.例为对耳内新出现的声音好奇,向家长反映"耳内有噪声",3例因耳鸣而难以集中注意力,3例对耳鸣有不同程度的担心而求助于家长;④烦恼程度:3例感觉耳鸣较响,轻度烦恼及担心,1例感觉耳鸣很响、很烦、非常担心,其余患儿无担心及烦恼感。结论儿童耳鸣的病因以中、内耳病变为主,是否主动就医与其主诉能力及家长的重视程度有关;儿童耳鸣很少有心理因素参与,预后较成人好。

关键词：儿童耳呜临床特点