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A clinical analysis of seven cases of pancreatic carcinoid

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A clinical analysis of seven cases of pancreatic carcinoid

第九届国际治疗内镜和消化疾病学术会议

作者： LIN Jing-hua~1 YANG Li~2.LIU Si-chun~1 CUI Yi~2.(1.department of Gastroenterology,Huangpu Branch,The First Affiliated hospital,{2. Ynt-sen university,Guangzhou,Guangdong 510700,P.R.china 2.department of Gastroenterology,The First Affiliated hospital,{2. Yat-sen university,Guangzhou,Guangdong 510080,P.R.china)

＜正＞Objective To investigate the clinical characteristics and diagnosis of pancreatic *** Clinical data of seven eases of pancreatic carcinoid seen in our hospital were analyzed *** Of them,abdominal discomfort, distention or pain was in four cases,lumbar and dorsal pain,weight loss and weakness in one,carcinoid syndrome in *** patient had no *** patients were combined with hepatic *** patients had lymph nodes *** positive was in five,Syn positive in five,CgA positive in *** （5/7）,endoscopic ultrasonography （3/4） could locate the lesion accurately. Conclusions The clinical presentations of pancreatic carcinoid were not *** main symptom was abdominal discomfort. Typical carcinoid syndrome was *** diagnosis should be based on {2. and *** ultrasonography and CT were important imaging examinations in the detection of the lesion.

关键词： Pancreatic carcinoid Clinical medicine

Structure comparisons of Aedes albopictus densovirus with other parvoviruses

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Science china(Life Sciences) 2007年第1期50卷 70-74页

作者： CHENG LingPeng1,2. CHEN senXiong2. Z. H. ZHOU3 & ZHANG JingQiang2.1 department of Biomedical Engineering, School of Bioscience & Bioengineering, South {2. university of Technology, Guangzhou 510640, {2. 2.State Key Laboratory of Biocontrol, sun Yat-sen university, Guangzhou 5102.5, {2. 3 department of pathology & Laboratory Medicine, university of Texas Medical School at Houston, Houston, TX77030, USA 1. department of Biomedical Engineering School of Bioscience & Bioengineering South China University of Technology Guangzhou 510640 China 2. State Key Laboratory of Biocontrol Sun Yat-sen University Guangzhou 510275 China 3. department of pathology & Laboratory Medicine University of Texas Medical School at Houston Houston TX 77030 USA

Parvoviridae is a family of the smallest viruses known with a wide variety of hosts. The capsid structure of the Aedes albopictus C6/36 cell densovirus (C6/36 DNV) at 1.2.nm resolution was obtained by elec-tron cryomicroscopy (cryoEM) and three-dimensional (3D) image reconstruction. Structure compari-sons between the C6/36 DNV and other parvoviruses reveal that the degree of structural similarity be-tween C6/36 DNV and the human parvovirus B19 is higher than that between C6/36 DNV and other in-sect parvoviruses. The amino acid sequence comparisons of structural and non-structural proteins also reveal higher levels of similarity between C6/36 DNV and parvovirus B19 than those between C6/36 DNV and other parvoviruses. These findings indicate that C6/36 DNV is closely related to the human virus B19, and the former might evolve from the human species other than from other insect viruses.

关键词： densovirus three-dimensional structure amino acid sequence.

小型猪肝硬化模型建立过程中肝脏功能及组织病理学的改变

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上海实验动物科学 2002年第2期22卷 102-105,97页

作者：周忠信王捷罗葆明广东省江门市中心医院外科江门529000 中山医科大学孙逸仙纪念医院普外科广州510120

为观察小型猪肝硬化模型建立过程中肝功能及病理学改变 ,采用 CCl4 、苯巴比妥和无水酒精喂养小型猪共 1 2. ,辅以高脂、低蛋白和低胆碱饮食 ,动态检测猪的肝功能并取组织行病理学检查。 4个月后 ,1 2.小猪成功诱导出肝硬化 ,病理学... 详细信息

为观察小型猪肝硬化模型建立过程中肝功能及病理学改变 ,采用 CCl4 、苯巴比妥和无水酒精喂养小型猪共 1 2. ,辅以高脂、低蛋白和低胆碱饮食 ,动态检测猪的肝功能并取组织行病理学检查。 4个月后 ,1 2.小猪成功诱导出肝硬化 ,病理学检查按 Madden分级 ,7头达到级 ,5头达到级。结果提示 ,CCl4 、苯巴比妥和无水酒精喂养辅以高脂低蛋白低胆碱饮食的多因素诱导小型猪肝硬化 ,成功率高 ,死亡率低 ,病理学改变分期界限明显。

关键词：小型猪肝硬化模型肝脏功能组织病理学四氯化碳

Effects of MicroRNA-2. on Apoptosis,Tumorigenicity and Prognosis of Hepatocellular Carcinoma

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Effects of MicroRNA-29 on Apoptosis,Tumorigenicity and Progn...

中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Yu Juan-xong~(1*),Jian Hong-fang~(1*),Jing Ping-yun~(2.3),Jine yang~1,Ting zhang~(2.4),Wei-hua jia~(2.4),Shi-mei zhuang~(1,2. From the 1 Key Laboratory of Gene Engineering of the Ministry of Education,State Key Laboratory of Biocontrol,School of Life Sciences,sun Yat-sen {2.,2.State Key Laboratory of Oncology in Southern china,3 department of pathology,4 Bank of Tumor Resources,Cancer Center,sun Yat-sen {2.,Guangzhou,PR china

Based on microarray data,we have previously shown a significant downregulation of miR-2. in hepatocellular carcinoma(HCC) tissues(Cancer Res,69:1135-42.2.09).To date,the role of miR-2. deregulation in hepatocarcinogenesis and the signaling pathways by which miR-2. exerts its function and modulates the malignant phenotypes of HCC cells remain largely *** this study,we confirmed that reduced expression of miR-2. was a frequent event in HCC tissues using both Northern blot and real-time quantitative *** interestingly,we found that miR-2. downregulation was significantly associated with worse disease-free survival of HCC *** gain- and loss-of-function studies revealed that miR-2. could sensitize HCC cells to apoptosis that was triggered by either serum starvation or hypoxia or chemotherapeutic drugs,which mimicked the tumor growth environment in vivo and the clinical ***,introduction of miR-2. dramatically repressed the ability of HCC cells to form tumor in nude *** investigation characterized two anti-apoptotic molecules, Bcl-2.and Mcl-1,as direct targets of ***,silencing of Bcl-2.and Mcl-1 phenocopied the pro-apoptotic effect of miR-2.,whereas overexpression of these proteins attenuated the effect of miR-2.. In addition,enhanced expression of miR-2. resulted in the loss of mitochondrial potential and the release of cytochrome c to cytoplasm,suggesting that miR-2. may promote apoptosis via mitochondrial pathway that involves Mcl-1 and ***:Our data highlight an important role of miR-2. in the regulation of apoptosis and in the molecular etiology of HCC,and implicate the potential application of miR-2. in prognosis prediction and in cancer therapy.

关键词： HCC microRNA miR-2. apoptosis prognosis

Apoptosis Induction Potential by Deleted In Liver Cancer-1 (DLC-1) gene

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Apoptosis Induction Potential by Deleted In Liver Cancer-1 (...

2.08年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Xiangning Zhang~(1*) Peichun Huang~1 Chun-Ming Wong~2.Wenlin Huang~3 1 department of Pathophysiology,Guangdong Medical College,Zhanjiang Guangdong,china 2.department of pathology,Li Ka Shing Faculty of Medicine,the university of Hong Kong,Pokfulam,Hong Kong,china 3 State Key Laboratory of Oncology in South china,sun Yat sen university Cancer Center,Guangzhou,china.

DLC-1 is a bona fide tumor suppressor gene (TSG) mapped to chromosome 8p2.-p2.,a region frequently deleted in human *** and epigenetic inactivation of DLC1 is frequently found in cancers,including hepatocellular carci...

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局部复发性鼻咽癌的临床病理特征(附2.0例分析)

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实用肿瘤杂志 2004年第2期19卷 124-126页

作者：罗容珍梁小曼宗永生钟碧玲吴秋良何洁华林素暇中山大学附属肿瘤医院病理科广东广州510060 中山大学中山医学院病理学教研室广东广州510089

目的　探讨经放疗后局部复发的鼻咽癌临床和病理组织学特征。方法　收集确诊为鼻咽癌患者 2.6 10例病理资料 ,复查病历记录及活检切片。结果　 2.4 0例局部复发性鼻咽癌占 9.2.% ( 2.4 0 / 2.6 10 ) ,男女比率为 5 .32.1( 2.0 2./ 38) ... 详细信息

目的　探讨经放疗后局部复发的鼻咽癌临床和病理组织学特征。方法　收集确诊为鼻咽癌患者 2.6 10例病理资料 ,复查病历记录及活检切片。结果　 2.4 0例局部复发性鼻咽癌占 9.2.% ( 2.4 0 / 2.6 10 ) ,男女比率为 5 .32.1( 2.0 2./ 38) ,较 2.370例未经治疗的鼻咽癌者男女之比 ( 2..98∶ 1,1775 / 5 95 )为高。在有确诊到复发间隔记录的 2.37例中 ,平均间隔期为 3年 10个月。 4 8例 ( 2.0 .3% ) ,1～ 4 1例 ( 5 9.5 % ) ,5～ 2.9例 ( 12..2.% ) ,>10年才复发 19例 ( 8.0 % )。与 2.370例未经治疗的鼻咽癌相比 ,角化性鳞状细胞癌在局部复发性鼻咽癌中所占的百分率以及分化型非角化性癌在非角化性癌中所占的百分率分别为 10 .0 %与 2..3%和 18.7%与 8.9% ,均有显著增高 ( P2.)相当一部分局部复发性鼻咽癌在局部复发时 ,癌细胞的鳞化程度要较原发时为高。

关键词：局部复发性鼻咽癌病理组织治疗鼻咽肿瘤病理学放射疗法

Reassessment of the predictive role of perivesical fat invasion in invasive bladder cancer prognosis in 151 Chinese patients

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Reassessment of the predictive role of perivesical fat invas...

第十七届全国泌尿外科学术会议

作者： Zhang Zhiling~1,Li Yonghong~1,Hou Guoliang~1, Liu Zhuowei~1,Han Hui~1,Qin Zike~1,Yun Jingping~2. Zhou Fangjian~1 1.department of Urology,Cancer Center,sun Yat-{2. university 2.department of pathology,Cancer Center,sun Yat-{2. university

Objective To assess the predictive value of perivesical fat invasion for prognoses of T2.and T3 bladder cancer in Chinese patients. Materials and Methods 151 patients who underwent radical cystectomy for pT2.3N0M0 inv...

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胃口服超声造影在腹部体检中的实用价值

中国超声医学杂志 2021年第5期37卷 560-563页

作者：袁帆钟清连傅绢郭建敏邓凤平赖建慧潘轩李建国中山大学附属第八医院(深圳福田)超声科中山大学附属第八医院(深圳福田)消化内科中山大学附属第八医院(深圳福田)体检科北京大学人民医院超声科

目的探讨胃增强超声造影检查在腹部体检中的应用及诊断价值。方法选我院有消化道症状的体检者。口服胃超声造影行胃、十二指肠球部超声检查。观察胃各部管腔充盈情况,仔细观察黏膜有无中断、胃壁有无增厚或肿块以及胃壁蠕动等,对发现的... 详细信息

目的探讨胃增强超声造影检查在腹部体检中的应用及诊断价值。方法选我院有消化道症状的体检者。口服胃超声造影行胃、十二指肠球部超声检查。观察胃各部管腔充盈情况,仔细观察黏膜有无中断、胃壁有无增厚或肿块以及胃壁蠕动等,对发现的异常图像回放分析。以病理组织诊断为金标准。结果胃超声造影1 885例,经胃镜或手术病理证实114例。符合率分别为:胃息肉93.86%,慢性活动性胃炎94.74%,溃疡性病变、胃间质瘤、胃癌等的符合率98.2.%。对胃良恶性疾病的诊断,超声与胃镜的吻合度较高（χ2.63.670,K=0.806,P=0.000）,对胃黏膜下层疾病的检出率优于胃镜（χ2.6.050,P=0.014）。结论胃超声造影对胃十二指肠疾病的诊断与病理结果符合率较高,与胃镜结合可提高胃十二指肠疾病的检出率。对胃黏膜下病变,胃肠超声造影检出率优于胃镜。胃肠超声在健康体检人群的初筛值得推广和普及。

关键词：胃增强超声造影胃十二指肠疾病胃癌胃间质瘤

上皮型钙黏素β-链接素在鼻咽原发癌和淋巴结转移癌组织中的表达差异

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实用肿瘤杂志 2003年第6期18卷 448-452页

作者：李智林素暇梁英杰中山大学中山医学院病理学教研室广东广州510089

目的　研究鼻咽原发癌和淋巴结转移癌组织中上皮型钙黏素 (E- cadherin)和β-链接素 (β- catenin)蛋白水平和 m RNA水平表达的差异性 ,探讨鼻咽癌癌细胞侵袭转移的机制。方法　采用蛋白印迹法、免疫组化法和反转录聚合酶链反应 (RT- P... 详细信息

目的　研究鼻咽原发癌和淋巴结转移癌组织中上皮型钙黏素 (E- cadherin)和β-链接素 (β- catenin)蛋白水平和 m RNA水平表达的差异性 ,探讨鼻咽癌癌细胞侵袭转移的机制。方法　采用蛋白印迹法、免疫组化法和反转录聚合酶链反应 (RT- PCR)法检测 2.1例鼻咽原发癌和 2.1例淋巴结转移癌组织中上皮型钙黏素和β-链接素蛋白和m RNA的表达水平。结果　 (1) 2.1例淋巴结转移癌组织中 ,癌细胞的上皮型钙黏素蛋白表达率 (5 0 % )和蛋白印迹相对强度 (6 5 .0± 15 .9)均明显低于 2.1例原发癌组织中的表达水平 (80 %和 2.0 6 .7± 32..7) ,且淋巴结转移癌组织中的上皮型钙黏素 m RNA表达水平也低于原发癌组织 ,差异有显著性 (P2.)β-链接素在鼻咽原发癌和淋巴结转移癌组织中均有较高的蛋白表达量 ,其 m RNA表达水平在不同组织中的表达也相似 ,均未显示有差异性 (P>0 .0 5 ) ;(3)鼻咽原发癌和淋巴结转移癌组织中癌细胞表达上皮型钙黏素和β-链接素未显示相关性 (P>0 .0 5 )。结论　 (1)在鼻咽癌组织中 ,导致癌细胞侵袭转移的一个重要因素可能是上皮型钙黏素的表达下调。 (2.)

关键词：上皮型钙黏素 β—链接素鼻咽原发癌淋巴结转移癌组织表达差异肿瘤浸润