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Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture

Acta Pharmacologica Sinica 2007年第10期28卷 1597-1602页

作者： Qing-chuan LIAO~2.Zhou-sheng XIAO~(4,5),Yan-fang QIN~3,Hong-hao ZHOU~4~2.Affiliated Children's Hospital,Nanjing Medical university,Nanjing 2.0008,China,~3 Department of Pathology,School of Medicine,Jinanuniversity,Guangzhou 510632.China {2.,central south university,changsha 410078,China ated Childrenos Hospital Nanjing Medical University Nanjing 210008 China. xiaozs64@***.

Aim:To test the hypothesis that genistein stimulates the osteoblastic differentia-tion through the p38 mitogen activated protein kinase (MAPK)-core-binding fac-tor 1 (Cbfa1) ***:The activation of p38 MAPK was detected byWestern *** phosphatase (ALP) activity and calcium depositionwere assessed for osteoblastic differentiation of bone marrow-derived mesenchy-mal stem cell (BMSC) *** expression of Cbfa1 was analyzed at both themRNA and protein *** activity of Cbfa1 was detected by electrophoreticmobility shift *** sialoprotein (BSP),ALP,osteocalcin (OC),andosteopontin (OPN) gene transcription were also evaluated by either RT-PCR orNorthern ***:Genistein (0.01-1 μmol/L) dose dependently led tothe rapid and sustained activation of the p38 MAPK pathway in mouse *** with genistein (1 μmol/L) resulted in increased ALP activityand calcium deposition of BMSC cultures as a function of *** alsoenhanced Cbfa1 DNA binding activity and promoted the expressions of Cbfa1itself as well as several Cbfa1-regulated genes,including ALP,BSP,OC,and *** treatment with p38 MAPK inhibitor (SB2.3580) diminished thegenistein-induced osteoblastic maturation and p38 MAPK-Cbfa1 activation inmouse BMSC ***:These results indicated that genistein couldstimulate the osteoblastic differentiation of BMSC cultures through the p38MAPK-Cbfa1 pathway.

关键词： bone marrow-derived mesenchymal stem cells core-binding factor 1 osteoblastic differentiation genistein mitogen-activated protein kinase

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Abnormal gradient microstructure in Cr_3C_2.based cemented carbide

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Journal of central south university of Technology 2001年第4期8卷 224-227页

作者： ZHANG Li 1,CHEN Shu 2.(1. Powder Metallurgy Factory, central south university, changsha 410083, China 2. changsha Research institute of Mining and Metallurgy, changsha 410012. China) 1. Powder Metallurgy Factory Central South University 410083 Changsha China 2. changsha Research institute of Mining and Metallurgy 410012 Changsha China

With OLYMPUS PMG3 metallograph, an abnormal three-layer gradient structure, i. e. coarse grain zone, binder enrichment zone and normal structure zone from surface to inner, was observed in Cr3C2.based cemented carbide. In the binder enrichment zone, three different shapes of anomalous coarse carbides were observed. It is shown that the transverse rupture strength can be raised remarkably, up 2..7%from the alloy with abnormal gradient structure by removing the abnormal gradient structure. The results suggested that the abnormal gradient structure in the surface, especially the anomalous coarse carbides in the binder enrichment zone is the main reason for the lower strength

关键词： Cr3C2.based cermet cemented carbide gradient structure microstructure

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Polycomb group proteins and their roles in carcinogenesis

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Chinese Science Bulletin 2012年第18期57卷 2259-2264页

作者： XIAO LanBo 1,2.3,TAO YongGuang 1,2.3,LI LiLi 1,2.3,4 & CAO Ya 1,2.31 Key Laboratory of Carcinogenesis of Ministry of Health,Xiangya School of Medicine,central south university,changsha 410078,China 2.Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Xiangya School of Medicine,central south university,changsha 410078,China 3 Cancer Research institute,Xiangya School of Medicine,central south university,changsha 410078,China 4 Cancer Epigenetics Laboratory,State Key Laboratory in Oncology in south China,Chinese university of Hong Kong,Hong Kong 999077,China Key Laboratory of Carcinogenesis of Ministry of Health Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Xiangya School of Medicine Central South University Cancer Resea

In the cell nucleus,DNA is wound around histone proteins,which are then packed together to form *** can be chemically tagged by methyl and acetyl *** group (PcG) proteins attach methyl groups to genes,which block their *** is similar to the attachment of methyl groups to gene promoters by DNA methyltransferases (DNMTs).This action is directly linked with tumor initiation and metastasis via the promotion of anti-senescence and anti-apoptosis pathways,and by facilitating epithelial mesenchymal transition (EMT).Cell fate transcriptional factors (CFTFs) and long non-coding RNAs (long ncRNAs) recruit PcG proteins to the promoters of tumor suppressor genes,resulting in epigenetic gene silencing by influencing chromatin structure and DNA ***,PcG proteins are potential diagnostic markers and targets for new chemoprevention and therapeutic strategies.

关键词：组蛋白 DNA甲基转移酶基因启动子癌变非编码RNA PEG 凋亡途径抑癌基因

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Number of zero point for a polynomial in real field

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Chinese Science Bulletin 1997年第11期42卷 886-890页

作者： LIN Liang and LIU Yirong1. Guilin institute of Technology, Guilin 541004, China 2. central south university of Technology, {2. 410083, China Guilin institute of Technology Guilin 541004 China

IT is well known that for any real coefficient polynomial f(x) of degree n,how to determineits number of real zero points is a very important problem in theory of polynomial,as well as inapplications in mathematics,mechanics,physics and other *** way to solve thisproblem by using Euclidean mutual division as pointed out by Sturm is not simple and conve-nient for us to use the theoretic analyses for the above problem because the relation

关键词： polynomial real zero point coefficients.

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Characteristic atom arranging crystallogphy of alloy phases for Au-Cu system

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Science China(Technological Sciences) 2011年第6期54卷 1560-1567页

作者： XIE YouQing1,2.3,LIU XinBi1,2.3,PENG HongJian4,NIE YaoZhuang5,LI XiaoBo6 & LI YanFen1,2.3 1 School of Materials Science and Engineering,central south university,changsha 410083,China 2.Powder Metallurgy Research {2.,central south university,changsha 410083 China 3 State Key Laboratory of Powder Metallurgy,central south university,changsha 410083,China 4 School of Chemistry and Chemical Engineering,central south university,changsha 410083,China 5 School of Physical Science and Technique,central south university,changsha,410083,China 6 College of Mechanical Engineering,Xiangtan university,Xiangtan 411105,China 1. School of Materials Science and Engineering Central South University Changsha 410083 China2. Powder Metallurgy Research Institute Central South University Changsha 410083 China3. State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China4. School of Chemistry and Chemical Engineering Central South University Changsha 410083 China5. School of Physical Science and Technique Central South University Changsha 410083 China6. College of Mechanical Engineering Xiangtan University Xiangtan 411105 China

In this paper,it is pointed out that the descriptions of alloy phase structures are dependent on structural unit *** the systematic science of alloys(SSA),the alloy phase structures are described by means of the symmetry element sequence combining with characteristic atom *** is named the characteristic atom arranging structure,which can display the characteristic atoms at the lattice sites and the micro-inhomogeneity,besides the *** characteristic atom has its own characters:neighboring configuration,potential energy,volume and electronic *** micro-inhomogeneity of alloy phases can be described by concentrations and short-range ordered parameters of characteristic *** differences between the electronic structures of alloy phases and electronic structures of characteristic atoms in the alloy phases are also discussed.

关键词： systematic science of alloys Au-Cu system alloy phase structure micro-inhomogeneity

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Survival probability and ruin probability of a risk model

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 256-264页

作者： LUO Jian-hua College of Science,central south university of Forestry and Technology,changsha 410004,China {2. of Statistics,central south university of Forestry and Technology,changsha 410004,China. College of Science Central South University of Forestry and Technology Changsha 410004 China institute of Statistics Central South University of Forestry and Technology Changsha 410004 China

In this paper, a new risk model is studied in which the rate of premium income is regarded as a random variable, the arrival of insurance policies is a Poisson process and the process of claim occurring is p-thinning process. The integral representations of the survival probability are gotten. The explicit formula of the survival probability on the infinite interval is obtained in the special casc cxponential *** Lundberg inequality and the common formula of the ruin probability are gotten in terms of some techniques from martingale theory.

关键词： risk model thinning process survival probability martingale ruin probability integral representation

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Resolution of α-cyclohexyl-mandelic acid enantiomers by two-phase (O/W) recognition chiral extraction

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Science China Chemistry 2007年第6期50卷 764-769页

作者： TANG KeWen1,2. ZHANG GuoLi2. HUANG KeLong2. LI Yuanjian3 & YI JianMin1,2.1 Department of Chemistry and Chemical Engineering, Hunan institute of Science and Technology, Yueyang 414000, China 2.College of Chemistry and Chemical Engineering, central south university, {2. 410083, China 3 College of Pharmaceutical Science, central south university, changsha 410078, China Department of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang 414000China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

This paper presents a new chiral separation technology:two-phase(O/W)recognition chiral *** behavior of alpha-cyclohexyl-mandelic acid enantiomers was studied in the extraction system with D(L)-isobutyl tartrate in 1,2.dichloroethane organic phase and beta-CD derivatives in aqueous phase,and the influence of the kind and concentration of extractant and pH on extraction performance was *** experimental results indicate that two-phase(O/W)recognition chiral extraction is of strong chiral separation ***-^-CD,HE-beta-CD and Me-beta-CD have higher recognition ability for S-CHMA than that for R-CHMA,among which HP-beta-CD has the strongest ability;whereas,D-isobutyl tartrate has reversed recognition ability for *** the extraction system containing HP-beta-CD and D-isobutyl tartrate,e.e.% of S-CHMA in aqueous phase reached 2..6% by one stage extraction,and the distribution ratio for R-CHMA(k_R)and for S-CHMA(k_S)and separation factor(alpha)are 2.44,0.89 and 2.49,***,pH and concentration of extractant have great effects on chiral separation ***-phase(O/W)recognition chiral extraction has great significance for preparative separation of racemic compounds.

关键词： two-phase(W/0)recognition chiral extraction alpha-cyclohexyl-mandelic acid enantiomers

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KINETICS OF LIQUID PENETRATING INTO GRAIN BOUNDARY

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中国有色金属学会会刊：英文版 1995年第3期5卷 88-92页

作者： Chen, Kanghua Huang, Baiyun (Powder Metallurgy Research institute,central south university of Technology, {2. 410083) central south Univ of Technology Changsha China

ＫＩＮＥＴＩＣＳＯＦＬＩＱＵＩＤＰＥＮＥＴＲＡＴＩＮＧＩＮＴＯＧＲＡＩＮＢＯＵＮＤＡＲＹ￥Ｃｈｅｎ，Ｋａｎｇｈｕａ；Ｈｕａｎｇ，Ｂａｉｙｕｎ（ＰｏｗｄｅｒＭｅｔａｌｌｕｒｇｙＲｅｓｅａｒｃｈｉｎｓｔｉｔｕｔｅ，Ｃｅｎ... 详细信息

ＫＩＮＥＴＩＣＳＯＦＬＩＱＵＩＤＰＥＮＥＴＲＡＴＩＮＧＩＮＴＯＧＲＡＩＮＢＯＵＮＤＡＲＹ￥Ｃｈｅｎ，Ｋａｎｇｈｕａ；Ｈｕａｎｇ，Ｂａｉｙｕｎ（ＰｏｗｄｅｒＭｅｔａｌｌｕｒｇｙＲｅｓｅａｒｃｈｉｎｓｔｉｔｕｔｅ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉ...

关键词： interface interface energy wetting penetration

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miRNA and nasopharyngeal carcinoma

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Chinese Science Bulletin 2011年第8期56卷 722-728页

作者： ZHAO LuQing1,2.3,CHEN Xue1,2.3 & CAO Ya1,2.3 1 Key Laboratory of Carcinogenesis and Invasion,Ministry of Education,changsha 410078,China 2.Key Laboratory of Carcinogenesis,Ministry of Health,changsha 410078,China 3 Cancer Research {2.,Xiangya School of Medicine,central south university,changsha 410078,China Key Laboratory of Carcinogenesis and Invasion Ministry of Education Changsha 410078 China Key Laboratory of Carcinogenesis Ministry of Health Changsha 410078 China Cancer Research institute Xiangya School of Medicine Central South University Changsha 410078 China

MicroRNAs(miRNAs) constitute a family of small non-coding RNA molecules 2.-2. nucleotides in *** control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3'-untranslated *** studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma,such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways,gene-regulatory networks,mitosis,tumor angiogenesis,invasion and *** the relationship between miRNAs and the development of nasopharyngeal carcinoma,will further the understanding of this cancer and provide new avenues for diagnosis and treatment.

关键词： miRNAs 鼻咽癌非编码RNA 小分子RNA 信号转导通路潜伏膜蛋白1 基因调控网络肿瘤血管生成

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Ti/Al_2._3 Functionally Gradient Material Prepared by the Explosive Compaction/SHS Process

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Journal of Materials Science & Technology 1999年第3期15卷 271-275页

作者： Yimin LI(Powder Metallurgy Research institute, central-{2. university of Technology, changsha 410083, China)Ziqiao ZHENG(Department of Materials Science and Engineering, central-{2. university of Technology, changsha 410083, China) Cent S Univ Technol Powder Met Res Inst Changsha 410083 Peoples R China Cent S Univ Technol Dept Mat Sci & Engn Changsha 410083 Peoples R China

Ti1Al2.3 Functionally Gradient Material (FGM) was prepared by an explosive compaction/SHS process. Ten sheets of the compounding powder were laminated and pressed to get a green body of FGM. It was then compacted explosively By burying the explosive compaction body into a stoichiometric Al/TiO2.mixture and igniting the combustion of the stoichiometric Al/TiO2.mixture, the SHS reaction of the explosive compaction body was initiated by the heat released from the combustion of the stoichiometric Al/TiO2.mixture. In this way, Ti/Al2.3 FGM was synthesized. The adiabatic temperatures of each gradient layer were calculated when the preheating temperatures were 2.8 K and 1173 K, respectively The microstructure, composition and properties of Ti/Al2.3 FGM and the reaction mechanism of each gradient layer were studied. It was found that Ti/Al2.3 FGM prepared by the explosive compaction/SHS process had a high density and a high microhardness. Its structure, composition and properties showed apparent gradient distribution. The structure of the standard stoichiometric ratio gradient layer of FGM was a network structure. Its reaction mode could be described as follows: Al powder melted first, then the molten Al penetrated into the TiO2.zone and reacted with TiO2. and big pores were left in the original positions of Al powder. The reaction of gradient layers with the addition of Al3O3 as diluents was similar to that of the standard stoichiometric ratio gradient layer, so were their structure and composition. However, the reaction of gradient layers with the addition of Ti as diluents was more complex and the composition deviated slightly from the designed one

关键词： Al SHS Ti/Al2.3 Functionally Gradient Material Prepared by the Explosive Compaction/SHS Process

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