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2009年上海市医用生物材料研讨会

作者： Guangping Xie~1,jiao Sun~(1*),Gaoren Zhong~2,Changsheng Liu~3,Jie Wei~3 (1.Ninth People''s hospital,shanghai jiaotong university school of medicine,shanghai,200011 2.school of Pharmacy,Fudan university,shanghai,200037 3.school of Materials Science and Engineering,East china university of Science and Technology,shanghai,200237)

＜正＞Introduction:Recently,nanoparticles（NPs） have been extensively developed as controlled-release c arriers. Hydroxyapatite nanoparticles（HANPs） is a type of inorganic NPs that not only have the specific properties of NPs,such as small size and large surface area,but also possess superior bioactivity compared with HA micron-

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Effect of recombinant human SDF-1a on re-endothelialization after sirolimus-eluting stent implantation in rabbit aorta abdominalis

Effect of recombinant human SDF-1a on re-endothelialization ...

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第十三次全国心血管病学术会议

作者： ZHU Jin-Zhou,ZHANG Lin,DU Run,ZHU Zhen-bin,ZHANG Jing, HAN Wei,Zhang Rui-yan department of Cardiology,Rui Jin hospital,school of medicine, shanghai jiao tong university,shanghai 200025,china

Objective Although the use of drug-eluting stent(DES) has been shown to limit neointimal hyperplasia,currently available DES may adversely affect re-endothelialization(RE) and thus increase stent *** evidence has indicated the impact of circulating endothelial progenitor cells(EPCs) on RE after artery *** stromal cell derived fac-

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血管新生理论在牙周创面愈合中的应用前景

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牙体牙髓牙周病学杂志 2012年第7期22卷 419-422页

作者：丁进尹元正上海交通大学医学院附属第九人民医院牙周病科上海市口腔医学重点实验室上海200011

血管新生在牙周创面愈合和组织再生中有着重要作用,是牙周组织再生技术必须依赖的基础。本文就血管新生理论在牙周创面愈合中的应用情况进行综述,以期对牙周组织再生治疗有所裨益。

关键词：牙周再生血管新生血管内皮细胞

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颌骨放射性骨坏死研究进展

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上海口腔医学 2008年第6期17卷 659-661页

作者：贺捷何悦上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面外科上海市口腔医学研究所·上海市口腔医学重点实验室上海200011

颌骨放射性骨坏死是头颈肿瘤放疗后常见的并发症之一,以下颌骨最为常见。其发展慢、病程长,因发病机制至今未能完全明确,目前缺乏针对性治疗,多数患者需要通过手术切除病损,往往造成颌面部软硬组织缺损,给患者带来极大痛苦,严重影响肿... 详细信息

颌骨放射性骨坏死是头颈肿瘤放疗后常见的并发症之一,以下颌骨最为常见。其发展慢、病程长,因发病机制至今未能完全明确,目前缺乏针对性治疗,多数患者需要通过手术切除病损,往往造成颌面部软硬组织缺损,给患者带来极大痛苦,严重影响肿瘤患者治疗后的生存质量。本文就其发病机制、预防、诊断和治疗的研究进展作一综述。

关键词：颌骨放射性骨坏死发病机制诊断治疗

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Comparative proteomic analysis of differentially expressed proteins in an in vitro cellular carcinogenesis model of oral squamous cell carcinoma

Comparative proteomic analysis of differentially expressed p...

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海峡两岸2008口腔癌诊治与修复重建新进展研讨会

作者： Lai-ping Zhong Zhi-yuan Zhang department of Oral and Maxillofacial Surgery,Ninth People’s hospital,school of Stomatology,shanghai jiao tong university school of medicine:shanghai Key Laboratory of Stomatology & shanghai Research Institute of Stomatology

In vitro cellular model is an important tool in understanding cellular events related to

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Carto-Merge can improve the ablation accuracy for pulmonary vein isolation

Carto-Merge can improve the ablation accuracy for pulmonary ...

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中华医学会心电生理和起搏分会第十次全国学术年会

作者： Songwen Chen,Gang Chen,Ying Zhuge,Feng Zhang,Shaowen Liu department of Cardiology,shanghai First People’s hospital,school of medicine,shanghai jiao tong university 200000

Objective To quantify the superiority of performing AF ablation guided by Carto-Merge. Methods Forty-eight consecutive AF patients,with four discrete pulmonary veins(PVs),were *** the four separate PVs and the two ipsilateral PVs of each patient,three types of p lanes were defined respectively at the PV *** fluoroscopy planes(FPs) were labeled in t he Carto under the guidance of contrast PVs *** procedure,the ablation planes(A Ps) were defined with the ablation *** image planes(IPs) were labeled in the CT image. Results The angle between the APs and the IPs was significantly smaller than that between the FPs and the IPs with regard to the left inferior PV planes(15.80±7.64°vs.20.69±13.91°,p =0.040) and the left superior PV planes(15.17±7.20°vs.23.21±12.97°,p=0.001).Moreover,com pared to that between the FPs and the IPs,less difference of angle and distance between the AP s and the IPs was demonstrated in the left PV planes(1.36±1.27mmvs.2.89±2.49mm,p3.91±6.20°vs.30.52±20.97°,p3.51±2.46m m,p3.58±8.01°vs.17.94±8.89°,p=0.014),the right superior PV planes(2.10±1.80mmvs. 3.47±2.97mm,p=0.009;11.20±6.75°vs.33.38±15.86°,p33±1.7 lmmvs.4.13±3.47mm,p=0.002;13.27±6.14°vs.26.40±18.89°,p<0.001). Conclusions Navigation by Carto-Merge,less difference of angle and distance between the ablation lesions and the actual PV ostia can be achieved,compared with the guidance of contrast PV angiography.

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An Essential Role for RIG-I in Phagocytosis by Macrophages

An Essential Role for RIG-I in Phagocytosis by Macrophages

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中国细胞生物学学会第九次会员代表大会暨青年学术大会

作者： Ling Kong~(1,3) Hongxin Zhang~2 Linhua Qin~1 Jun-Hao Hu~(1,3) Zi-Heng Zhuang~(1,3) Lei Sun~(1,3) Ming-Can Yu~1 Jing-Wu Zang~1 Zhu-Gang Wang~2 Bao-Xue Ge~(1,3) 1 Joint Immunologic Laboratory of Institute of Health Science and shanghai Institute of Immunology,shanghai jiao tong university school of medicine and shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,shanghai 200025,china 2 Laboratory of Genetic Engineering,shanghai jiao tong university school of medicine,shanghai 200025,china 3 Graduate school of Chinese Academy of Sciences

Retinoic acid-inducible gene-Ⅰ(RIG-Ⅰ)plays an important role in antiviral response by recognizing double- stranded RNA(dsRNA).Here we demonstrate an unanticipated role of RIG-Ⅰ in bacterial *** of lipopolysaccharid...

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Journal of Zhejiang university-Science B(Biomedicine & Biotechnology) 2013年第1期14卷 84-84页

作者： Li-jun PU, Ying SHEN, Wei-feng SHEN (department of Cardiology, Ruijin hospital, shanghai jiao tong university school of medicine, shanghai 200025, china) department of Cardiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

We are grateful for the constructive commentsgiven by Babic et al.(2013)on our article recentlypublished in the Journal of Zhejiang university-SCIENCE B(Biomedicine&Biotechnology)(Pu et al.,2012).The aim of this study... 详细信息

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Tc-99m uptake in hepatoma cells induced by tissue-specific human sodium/iodide symporter gene expression

Tc-99m uptake in hepatoma cells induced by tissue-specific h...

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首届全国分子核医学暨分子影像学学术交流会

作者： CHEN Li-bo, LUO Quan-yong, YU Yong-li, et al. department of Nuclear medicine, shanghai Sixth People’s hospital, shanghai jiao tong university,200233 shanghai, china

Objective The sodium/iodide symporter gene could be used as an ideal reporter gene as well as a promising therapeutic gene. Tc-99m has proven to be more advantageous than 131I-iodide, with respect to image quality, procedure and radiation dose in examination of thyroid uptake and scintigraphy. Herein, we investigated the feasibility of monitoring human sodium iodide symporter (hNIS) gene expression with Tc-99m in hepatoma cells (MH3924A) following tissue-specific expression. Methods MH3924A cells were stably fransfected with the recombinant retroviral vector, in which hNIS cDNA was driven by murine albumin enhancer/promoter (mAlb) and coupled to hygromycin resistance gene using an internal ribosomal entry site (IRES). Functional NIS expression in hepatoma cells was confirmed by an 125I- uptake assay. The dynamic uptake and efflux of Tc-99m was determined both in vitro and in vivo. Results The Tc-99m was up to 254-fold higher in stably transfected MH3924A cells than in wild-type cells. However, the in vitro efflux of Tc-99m out of recombinant cells was rapid with a half time of less than 2 minutes. Further, the in vivo studies yielded clear images and quantitative data of mAlbhNIS-infected tumor xenografts using Tc-99m and gamma camera. Conclusion The current study demonstrates enhanced Tc-99m uptake in hepatoma cells in vitro and in vivo following tissue-specific gene transfer using a recombinant retrovirus with the albumin enhancer/promoter and the hNIS gene. It is feasible to monitor hNIS gene expression non-invasively and quantitatively using conventional gamma camera and Tc-99m.

关键词： Sodium/iodide symporter (NIS) Tc-99m Uptake Hepatoma Tissue-specific expression

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Production of Cloned Miniature Pigs by Enucleation using the Spindle View System

Production of Cloned Miniature Pigs by Enucleation using the...

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第九届中国实验动物科学年会（2010新疆）

作者： YLil,3,4,JLiul,4,J Dai2,F Xing1,Z Fang1,T Zhang2,Z Shi3,D Zhang2 and XChen1,4 1 department of Laboratory Animal Science,school of medicine,shanghai jiao tong university,shanghai 2 Institute of Animal Sci and Veterinary medicine,shanghai Municipal Key Laboratory of Agri-Genetics and Breeding,shanghai 3College of Animal Science,South china Agricultural university,Guangzhou,Guangdong 4 Center of Developmental Biology,Xinhua hospital,shanghai jiao tong university,shanghai,china

Objectivc Cloned animals in several species,including sheep(Schnieke et al.1997),cattle(Bordignon et al. 2003),mice(Wakayama et al.1998),goats(Baguisi et al.1999),cats(Shin et al.2002),horses(Galli et al.2003),dogs(Lee et al.2005) and rabbits(Li et al.2006c),have been successfully produced by somatic cell nuclear transfer(NT).Although several groups have conducted NT with pigs(Betthauser et al.2000;Onishi et al.2000;Polejaeva et al.2000;Boquest et al. 2002),the efficiency is extremely low,with3). Therefore,it is particularly important to improve the efficiency of cloning in *** recent years,Du et *** the blastocyst rate with the handmade cloning method to be 50-80%with ten piglets delivered(Du et al.2007).In the field of medicine,miniature pigs are the preferred animals for pulmonary drugs toxicity tests and metabolic *** is well known that many human diseases can be treated by organ allotransplantation,but the shortage of human organ sources presents a significant barrier for *** of organs from miniature pigs has been considered as a suitable option because it has many advantages,such as compatibility in terms of size and physiology and a potentially large supply(Cozzi et al.2000).Multiple factors render pig cloning *** regard to the technique,pig oocytes are difficult to enucleate because their cytoplasm contains many lipid *** ’blind’ enucleation method involves removal of the nucleus through the first polar body and the adjacent cytoplasm(Onishi et al.2000).Yet,the inner development environment of oocytes is cytoplasm and its main functions are metabolism and maintain structure of oocytes *** to the oocytes occurs by removal of most of the cytoplasm during the ’blind’ method and it cannot be clearly confirmed whether the karyon in the oocytes has been ***,some investigators have used the centrifugal

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