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Top 10 Influential Events in carbon neutrality and climate change response for 2023

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Frontiers in Energy 2024年第1期18卷 1-3页

作者： Research Institute of Carbon Neutrality of shanghai Jiao Tong university Research Institute of Carbon Neutrality Shanghai Jiao Tong UniversityShanghai 200240China

In 2023, the global community intensified its efforts towards achieving carbon neutrality and addressing climate change, witnessing several impactful events. Research Institute of Carbon Neutrality, shanghai Jiao Tong university compiled the Top 10 Events (in chronological order) in the field of global carbon neutrality and climate change response for 2023, to share with readers these significant moments that document the ongoing ambition and collective efforts of human society.

关键词： neutral collective intensified

Possible Role of Histone H1 in the Regulation of Furin-dependent Proprotein Processing

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 173-180页

作者： Jinbo HAN~1 Jianxin GU~2 Chengwu CHI~(1,3*) 1 Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,Graduate school of the Chinese Academy of Sciences,shanghai 200031,china 2 Gene Research center,medical center of Fudan university,shanghai 200032,china 3 Institute of Protein Research,tongji university,shanghai 2.0092.china Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China.

Histone H1 and its C-terminal lysine rich fragments were recently found to be potent inhibitorsof furin,a mammalian proprotein ***,its role in the regulation of furin-dependent proproteinprocessing remains *** we report that histone H1 efficiently blocks furin-dependent pro-yonWillebrand factor（pro-vWF）processing in a dose-dependent *** and immunof-luorescence studies confirmed that histone H1 could interact with furin,and the interaction mainly took placeon the cell *** noted that histone H1 was released from cells undergoing necrosis and apoptosisinduced by *** findings suggested that histone H1 might be involved in extracellular and/or intracellu-lar furin regulation.

关键词： furin histone H1 pro-vWF proprotein processing

Regulation of EGF-induced ERK/MAPK Activation and EGFR Internalization by G Protein-coupled Receptor Kinase 2

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Acta Biochimica et Biophysica Sinica 2005年第8期37卷 525-531页

作者： Jingxia GAO~(1,2*) Jiali LI~1 Lan MA~(1*) ~1 Pharmacology Research center,shanghai medical College.Fudan university,shanghai 200032,china ~2 Department of Biochemistry medical College,tongji university,shanghai 2.0092.china Pharmacology Research center Shanghai Medical College Fudan UniversityShanghai 200032 China Department of Biochemistry Medical College Tongji UniversityShanghai 200092 China

G protein-coupled receptor kinases(GRKs)mediate agonist-induced phosphorylation anddesensitization of various G protein-coupled receptors(GPCRs).We investigate the role of GRK2 on epidermalgrowth factor(EGF)receptor signaling,including EGF-induced extracellular signal-regulated kinase andmitogen-activated protein kinase(ERK/MAPK)activation and EGFR *** immunofluorescence experiments show that EGF stimulates GRK2 binding to EGFR complex and GRK2translocating from cytoplasm to the plasma membrane in human embryonic kidney 293 *** assay shows that EGF-induced ERK/MAPK phosphorylation increases 1.9-fold,1.1-fold and 1.5-fold(P30,60 and 120 min,respectively when the cells were transfected with GRK2,suggesting the regulatory role of GRK2 on EGF-induced ERK/MAPK *** cytometry experimentsshow that GRK2 overexpression has no effect on EGF-induced EGFR internalization,however,it increasesagonist-induced G protein-coupled δ opioid receptor internalization by approximately 40% (P<0.01).Overall,these data suggest that GRK2 has a regulatory role in EGF-induced ERK/MAPK activation,and that themechanisms underlying the modulatory role of GRK2 in EGFR and GPCR signaling pathways are somewhatdifferent at least in receptor internalization.

关键词： G protein-coupled receptor kinase receptor tyrosine kinase epidermal growth factor receptor ERK/MAPK internalization

A New Combination of Mutated loxPs in a Vector for Construction of Phage Antibody Libraries

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Acta Biochimica et Biophysica Sinica 2005年第7期37卷 495-500页

作者： Yu GAN~(1,2) Xin-Tai ZHAO~2 1 shanghai medical College,Fudan university,shanghai 200032,china 2 Laboratory for cellular and Molecular Immunology,Cancer Institute,shanghai Jiaotong university,shanghai 200032,china shanghai medical College Fudan UniversityShanghai 200032 China Laboratory for cellular and Molecular Immunology Cancer Institute Shanghai Jiaotong UniversityShanghai 200032 China

In the construction of large antibody libraries by in vivo recombination,two non-homogeneousloxP sites are required for the exchange of V genes between phagemids to create many new *** mutated loxP511 was designed not to recombine with the wild-type loxP （loxPwt） in early studies anda combination of the two has been used to construct antibody *** recent reports have shown thatrecombination occurs between loxPwt and *** suggests that the combinational use of loxP511and loxPwt might lead to the loss of the V gene diversity of antibody ***,it is necessary tofind a new combination of loxPs to avoid the excision recombination in the antibody *** this study,we found that the excision recombination between loxP511 and loxP2272,another mutated loxP sequence,was undetectable within one phagemid,while the excision recombination between loxP511 and loxPwtoccurred at a frequency of 40%.higher than that reported ***,the in vivo recombinationof different phagemids with loxP511 and loxP2272 showed that the V gene exchange was efficiently mediatedto produce new *** was concluded that the loxP511 and loxP2272 combination wasmore favorable for reducing the excision recombination and constructing large phage antibody libraries withhigh diversity.

关键词： mutated loxP excision recombination phage antibody library

An accessibility measure for the combined travel demand model

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Science china(Information Sciences) 2010年第2期53卷 299-306页

作者： YANG Chao & HE ShuLin school of Transportation Engineering, tongji university, shanghai 201804, china school of Transportation Engineering Tongji University Shanghai China

The accessibility-oriented transport planning method is critical for many high population density cities in china. Most definitions of accessibility only consider spatial separation and ignore the influence of traveler choice on accessibility. In this paper, the combined travel demand model is employed in transport planning. The travelers’ choice behavior of the model is based on the random utility theory. The model overcomes inconsistence problem of the sequential four-step model on travel behavior and congestion effects. Based on the same random utility theory, an accessibility measure is proposed, which can be integrated into the combined travel demand model. The accessibility measure can reflect the traveler’s choices at different stages (travel choice, destination choice, mode choice and route choice). The properties of the accessibility measure are discussed through a numerical example.

关键词： accessibility random utility theory combined travel demand model urban transport planning

Fold-Hopf bifurcation in a simplified four-neuron BAM (bidirectional associative memory) neural network with two delays

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Science china(Technological Sciences) 2010年第3期53卷 633-644页

作者： GE JuHong & XU Jian school of Aerospace Engineering and Applied Mechanics,tongji university,shanghai 2.0092.china school of Aerospace Engineering and Applied Mechanics Tongji University Shanghai China

The bidirectional associative memory (BAM) neural network with four neurons and two delays is considered in the present paper.A linear stability analysis for the trivial equilibrium is firstly employed to provide a possible critical point at which a zero and a pair of pure imaginary eigenvalues occur in the corresponding characteristic equation.A fold-Hopf bifurcation is proved to happen at this critical point by the nonlinear *** coupling strength and the delay are considered as bifurcation parameters to investigate the dynamical behaviors derived from the fold-Hopf *** dynamical behaviours are qualitatively classified in the neighbourhood of the fold-Hopf bifurcation point by using the center manifold reduction (CMR) together with the normal *** bifurcating periodic solutions are expressed analytically in an approximate *** validity of the results is shown by their consistency with the numerical simulation.

关键词： codimension-two bifurcation time delay solution classification unfolding centre manifold

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Explicit Analytical Solutions for the Shearingand Radial Stresses in Curved Beams

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Communications in Nonlinear Science and Numerical Simulation 1999年第2期4卷 151-156页

作者： Aiming YU+ Xiangrong LI+++ (tongji university, shanghai 2.0092, china)++ (shanghai university, shanghai 200072, china) tongji university Shanghai 200092 China shanghai university Shanghai 200072 China

The shearing stresses in curved beams can be solved explicitly from anintegral equation, which is obtained by differentiation & integral manipulations. Twonovel formulae for shearing & radial stresses are also presented in the paper. The resultsof an example reveal that the shearing & radial stresses arrive at their maximum valuesslightly below the centroid of the section.

关键词： curved beam shearing stress radial stress integral equation

Inhibitory Effect of CT120B,an Alternative Splice Variant of CT120A,on Lung Cancer Cell Growth

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Acta Biochimica et Biophysica Sinica 2005年第9期37卷 588-592页

作者： Dong-Ning PAN~(1,2) Jin-Jun LI~(2,3) Lin WEI~2 Ming YAO~(2,3) Da-Fang WAN~(2,3*) Jian-Ren GU~(1,2,3*) 1 shanghai medical College,Fudan university,shanghai 200032,china 2 National Laboratory for Oncogenes and Related Genes,shanghai Cancer Institute,shanghai 200032,china 3 medical school of shanghai Jiaotong university,shanghai 200032,china shanghai medical College Fudan UniversityShanghai 200032 China National Laboratory for Oncogenes and Related Genes Shanghai Cancer InstituteShanghai 200032 China medical school of shanghai Jiaotong universityshanghai 200032 China

The expression product of ct120a,a novel gene isolated from human chromosome 17p13.3in our laboratory,was predicted to have seven transmembrane domains and could cause malignanttransformation of mouse NIH3T3 *** existed an mRNA splicing variant of ct120a,namely ct120b,which had a 96-nucleotide deletion and produced an in-frame loss of 32 amino acids from codon 136 tocodon 167 of *** CT120B protein was predicted to have six transmembrane *** thisstudy,we observed that the green fluorescent protein-tagged CT120B was localized on plasma membraneand in cytoplasm in SPC-A-1 *** expression of CT120B/A in normal lung tissue and in lung cancercells was also *** showed that the stable CT120B overexpression in SPC-A-1 cells resultedin a reduction of cell growth rate,and inhibited tumorigenecity and anchorage-independent growth in *** functions of CT120A and CT120B for cell growth appeared *** suggested that thedelayed G1/S phase transition might contribute to the inhibitory activities of CT120B on cell growth and thatthe deleted 32 amino acids missing in CT120B might be essential for the oncogenetic activities of CT120A.

关键词： CT120B alternative splicing cell growth lung cancer

Chinese expert consensus on refined diagnosis,treatment,and management of advanced primary liver cancer(2023 edition)

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