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Multi-level decollement zones and detachment deformation of Longmenshan thrust belt,Sichuan Basin,southwest China

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Science China Earth Sciences 2008年第S2期51卷 32-43页

作者： TANG LiangJie1,2,3,YANG KeMing4,JIN WenZheng1,2,3,L ZhiZhou4 & YU YiXin1,2,3 1 State Key laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China 2 Key laboratory for Hydrocarbon Accumulation Mechanism,China University of Petroleum,Ministry of Education,Beijing 102249,China 3 Basin and Reservoir Research center,China University of Petroleum,Beijing 102249,China 4 Southwest Division Company,SINOPEC,Chengdu 610081,China State Key laboratory of Petroleum Resource and Prospecting China University of Petroleum Beijing China Key laboratory for Hydrocarbon Accumulation Mechanism China University of Petroleum Ministry of Education Beijing China Basin and Reservoir Research center China University of Petroleum Beijing China Southwest Division Company SINOPEC Chengdu China

As is well known that many decollement layers were developed in the Longmenshan thrust belt,Si-chuan Basin,China. Through field investigation,explanation of seismic profiles and analysis of the balanced sections,we can divide the decollement zones into 3 categories: (1) the deep level decolle-ment zones,including the crust-mantle decollement layer,intracrustal decollement layer,and presinian basal decollement layer. The main structural styles of their deformation are the crust-mantle decoup-ling detachment deformation,the basal ductile shear deformation,etc.; (2) the middle level decollement zones,including the Cambrian-Ordovician decollement layer,the Silurian decollement layer,etc.,the main structural styles of their deformation are the isopachous fold,the angular fold,the saddle struc-ture,and the combination styles of them; and (3) the shallow level decollement zones,including the Xujiahe Formation decollement layer of Upper Triassic and the Jurassic decollement layers,the main structural styles of their deformation are the thrust-nappe tectonic,the pop-up,the triangle zone ,the duplex,etc. Multi-level decollement zones not only made the Longmenshan thrust belt develop many different deformation styles from deep place to shallow place,but also made some local areas have the superimposition of the tectonic deformation apparently. This study indicates that the multi-level de-collement zones have a very important effect on the shaping and evolution of the Longmenshan thrust belt.

关键词： decollement layer structural styles multi-level decollement zones Longmenshan thrust belt

miRNAs modulate the drug response of tumor cells

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Science China(Life Sciences) 2009年第9期52卷 797-801页

作者： WU XueMei1,3 & XIAO HuaSheng1,2 1 center of Functional Genomics,Key laboratory of System Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China 2 National Engineering center for Biochip at Shanghai,Shanghai 201203,China 3 Graduate University of Chinese Academy of Sciences,Shanghai 200031,China center of Functional Genomics Key Laboratory of System Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China Graduate University of Chinese Academy of Sciences Shanghai China National Engineering center for Biochip at Shanghai Shanghai China

Chemotherapy is one of the major treatments of malignant carcinomas. However,its efficiency is affected by both intrinsic and acquired resistance to anticancer drugs. The cellular mechanisms of drug resistance include the overexpression of energy-dependent transporters that eject anticancer drugs from cells such as p-glycoprotein and multidrug resistance related protein (MRP),the mutation of drug targets,the activation of DNA repair pathways,the defects in cellular death pathways and so on. The genetic and epigenetic changes of these genes can lead to cancer drug resistance. Among these mechanisms,microRNAs (miRNAs) which are critical and essential for many important processes such as development,differentiation,and even carcinogenesis have been reported to regulate the chemosen-sitivity of tumor cells. In this paper we briefly review the relationship between miRNA and cancer drug resistance.

关键词： cancer drug resistance miRNAs

Nonlinear optical properties and superluminal propagation in the ruby

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Chinese Science Bulletin 2010年第6期55卷 473-477页

作者： GAO Feng1,2,3,XU JingJun1,2,3,ZHANG GuoQuan1,2,3 & ZHANG WenDing1,2,3 1 Photonics center,College of Physics Science,Nankai University,Tianjin 300457,China 2 The Key laboratory of Advanced Technique and Fabrication for Weak-Light Nonlinear Photonics Materials of Ministry of Education,Nankai University,Tianjin 300457,China 3 Tianjin Key laboratory of Photonics Materials and Technology for Information Science,Nankai University,Tianjin 300457,China Photonics center College of Physics Science Nankai University Tianjin China The Key laboratory of Advanced Technique and Fabrication for Weak-Light Nonlinear Photonics Materials of Ministry of Education Nankai University Tianjin China Tianjin Key laboratory of Photonics Materials and Technology for Information Science Nankai University Tianjin China

In this review article,we summarized the study of the weak light nonlinear properties associated with group velocity change in the *** ruby could be reduced to a two-level system,in which population oscillations could lead to a subluminal *** the modulated TEM00 beam introduced into the ruby,self-phase modulation together with Fraunhofer diffractions and nondegenerate two-wave coupling between different spatial frequency components of the beam occurs at the same *** oscillations,self-phase modulation together with Fraunhofer diffractions and nondegenerate two-wave coupling mechanism competes with each other,which brings a new phenomenon of self-superluminal group velocity propagation in the ruby.

关键词：非线性光学性质超光速传播红宝石自相位调制 TEM00模速度变化光束耦合空间频率

Secure network coding in the presence of eavesdroppers

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Science China(Information Sciences) 2010年第3期53卷 648-658页

作者： LUO MingXing1,2,3, YANG YiXian1,2,3, WANG LiCheng1,2,3 & NIU XinXin1,2,3 1Information Security center, State Key laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing 100876, China 2Key laboratory of Network and Information Attack and Defence Technology of MOE, Beijing University of Posts and Telecommunications, Beijing 100876, China 3National Engineering laboratory for Disaster Backup and Recovery, Beijing University of Posts and Telecommunications, Beijing 100876, China Information Security center State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing China Key laboratory of Network and Information Attack and Defence Technology of MOE Beijing University of Posts and Telecommunications Beijing China National Engineering laboratory for Disaster Backup and Recovery Beijing University of Posts and Telecommunications Beijing China

Our concern, in the paper, is to construct information-theoretic secure network coding in the presence of eavesdroppers. Based on the generalized attack model and all-or-nothing transformation, the security of network coding in the generalized combination network can be characterized by the network capacity and the min-cut bound of wiretapping set from the source. Furthermore, it can be extended to any directed acyclic networks with single source. Compared with the traditional results, we construct information-theoretic secure network coding without additional encryptions and giving up any capacity.

关键词： all-or-nothing transformation secure network coding eavesdropping

Relations between thickness of UHMWPE’s wear debris and positive pressure of tribological system

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Chinese Science Bulletin 2008年第9期53卷 1435-1443页

作者： LIU HongTao1,2,3 & GE ShiRong1,3 1 Institute of Tribology and Reliability Engineering, China University of Mining & Technology, Xuzhou 221116, China 2 College of Mechanical and Electrical Engineering, China University of Mining & Technology, Xuzhou 221116, China 3 Biotribology center, State Key laboratory of Tribology, Xuzhou 221116, China Institute of Tribology and Reliability Engineering China University of Mining & Technology Xuzhou China College of Mechanical and Electrical Engineering China University of Mining & Technology Xuzhou China Biotribology center State Key Laboratory of Tribology Xuzhou China

MiaoXAM2.5X-50X Ultrahigh Precision Surface 3D Profiler is introduced to research the relations be- tween thickness of UHMWPE’s wear debris and positive pressure of tribological system. Research re- sults show that thickness of wear debris owns evident classification, and the first grade thickness math model and the second grade thickness math model are built. By the second grade thickness math model, the true force condition in the tribological system can be gotten, and the model can be used as a tool to modify simulating parameters of the tribological system, and it is an important inspecting method to the airtight system which cannot be examined in real time. The first grade thickness math model can describe the true working load and surface condition of work piece in the tribological sys- tem, and is an effective description method for the running condition of frictional pairs. The research results at different lubricating conditions testify the relations between thicknesses of wear debris and positive pressure of the tribological system. The fractal relation between maximal thickness of wear debris and positive pressure is discussed. The conceptions of the immutability principle and charac- teristic granularity of wear debris thickness are brought forward and discussed. In conclusion, as a stable tribological parameter owning mechanical theory basis, wear debris thickness will play an im- portant part in fault diagnosis, especially for the airtight system such as artificial joint.

关键词：摩擦学磨损面厚度分形数学模型

Study on blister of the coating on solid cantilevers of hydraulic supports for coal mining

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Science China(Technological Sciences) 2010年第12期53卷 3183-3188页

作者： MENG GuoZhe1, FU JinLiang2, SUN FeiLong1, SHAO YaWei1, ZHANG Tao1 & WANG FuHui1, 3 1 Corrosion and Protection laboratory, Key laboratory of Superlight Materials and Surface Technology (Harbin Engineering University), Ministry of Education, Harbin 150001, China 2 Technology center of Zhengzhou Coal Mining Machinery Group Co. Ltd., Zhengzhou 100049, China 3 State Key laboratory for Corrosion and Protection, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China Corrosion and Protection laboratory Key Laboratory of Superlight Materials and Surface Technology (Harbin Engineering University) Ministry of Education Harbin China Technology center of Zhengzhou Coal Mining Machinery Group Co. Ltd. Zhengzhou China State Key laboratory for Corrosion and Protection Institute of Metal Research Chinese Academy of Sciences Shenyang China

In this work, blister of the Cu-Sn plus Cr coating on solid cantilevers of hydraulic supports for coal mining was investigated by hydrogen-charging, Devanathan-Stachurski method and electrochemical impedance spectroscopy (EIS) measurement. It was found that the permeation hydrogen during the pickling process and the electroplating process was responsible for the blisters. The residual tensile stress due to the machining process would increase the permeation hydrogen amount during pickling and electroplating processes.

关键词： hydrogen blister hydrogen permeation EIS sub-surface hydrogen concentration

Isomerization of B_6,B_6^- and B_6^+ clusters

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Science China Chemistry 2010年第1期53卷 202-209页

作者： WEI GongMin1,PU ZhiFeng2,ZOU Rong3,LI GuoLiang2,3 & LUO Qiong2,3 1Department of Physics,Capital Normal University,Beijing 100048,China 2State Key laboratory of Explosion Science and Technology Beijing Institute of Technology,Beijing 100081,China 3center for Computational Quantum Chemistry,South China Normal University,Guangzhou 510631,China Department of Physics Capital Normal University Beijing China State Key laboratory of Explosion Science and Technology Beijing Institute of Technology Beijing China center for Computational Quantum Chemistry South China Normal University Guangzhou China

The interconversions between isomers with the same spin multiplicity of neutral B6 and charged B6-and B6+ clusters have been investigated at the B3LYP/6-311+G level of theory,including determination of the minimum energy pathways with transition states connecting the corresponding reactants and *** dynamic calculations,26 isomers were optimized,including 11 novel *** order to further refine the energies,single-point B3LYP/6-311+G(3df) calculations were carried out on the corresponding B3LYP/6-311+G geometries of all isomers of B6,B6-and B6+ and the corresponding isomerization transition *** stability of each isomer of B6(singlet and triplet states),B6-(doublet state) and B6+(doublet state) was analyzed from both thermodynamic and dynamic viewpoints.

关键词： B6 transition state intrinsic reaction coordinate barrier height

Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel,flavopiridol,and 5-fluorouracil

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Acta Pharmacologica Sinica 2006年第10期27卷 1375-1381页

作者： Jun GUO~2 an-wu ZHOU~2 Yu-cai FU~3 Udit N VERMA~2 Debu TRIPATHY~2 Eugene P FRENKEL~(2,5) Carlos R BECERRA~4 ~2Harold C.Simmons Cancer center,Division of Hematology-Oncology,Department of Medicine,University of Texas Southwestern Medical Centel.Dallas,Texas 75390,USA ~3laboratory of Cell Senescence,Shantou University Medical College,Shantou 515041,China ~4Sammons Cancer center,Baylor University Medical center,TOPA-US Oncology,Dallas,Texas 75246,USA Division of Hematology-Oncology Department of Medicine Harold C. Simmons Cancer Center University of Texas Southwestern Medical Center Dallas USA laboratory of Cell Senescence Shantou University Medical College Shantou China Sammons Cancer center Baylor University Medical Center TOPA-US Oncology Dallas USA

Aim:Clinical treatment of solid tumors with docetaxel,flavopiridol,or 5-fluorou-racil(5-FU)often encounters undesirable side effects and drug *** aims to evaluate the potential role of combination therapy with docetaxel,flavopiridol,or 5-FU in modulating chemosensitivity and better understand howthey might be used ***:HCT116 colon cancer cells were treatedwith docetaxel,flavopiridol,and 5-FU in several different administrative sche-dules in vitro,either sequentially or *** survival was measuredby MTT *** activity of caspase-3 was determined by caspase-3 assaysand the soft agar colony assay was used to test the colony formation of HCT116cells in soft *** also established xenograft models to extend in vitro obser-vations to an in vivo ***:The maximum cytotoxicity was found whenhuman colon cancer HCT116 cells were treated with docetaxel for 1 h followed byflavopiridol for 24 h and 5-FU for another 24 *** sequential combinationtherapy not only inhibits tumor cell growth more strongly compared to othercombination therapies but also significantly reduces colony formation in soft agarand augments apoptosis of HCT116 *** of docetaxel followed 1 hlater by flavopiridol,followed 24 h later by 5-FU in xenograft models,also resultedin delayed tumor growth and higher survival ***:These resultshighlight the importance of an administrative schedule when combining docetaxelwith flavopiridol and 5-FU,providing a rationale explanation for its developmentin clinical trials.

关键词： combination drug therapy docetaxel flavopiridol fluorouracil colonic neoplasms

Friction behavior of coupling motion for natural articular cartilage by reciprocating rotation

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Chinese Science Bulletin 2009年第4期54卷 576-583页

作者： QIAN ShanHua1,2,3 & GE ShiRong1,3 1 College of Mechano-electronic Engineering, China University of Mining & Technology, Xuzhou 221116, China 2 Institute of Tribology and Reliability Engineering, China University of Mining & Technology, Xuzhou 221116, China 3 Biotribology center, State Key laboratory of Tribology, Xuzhou 221116, China College of Mechano-electronic Engineering China University of Mining & Technology Xuzhou China Institute of Tribology and Reliability Engineering China University of Mining & Technology Xuzhou China Biotribology center State Key Laboratory of Tribology Xuzhou China

Based on the irregular surface of natural cartilage configurations, the tribological characteristics of coupling motion between natural cartilage pairs were investigated by the variation of rotated offset and velocity. Contact displacement, contact load, friction force and coefficient of friction from natural cartilage pairs were measured by a UMT-2 testing machine. In order to obtain the steady part and wavy part, the contact load and contact displacement were decompounded by the five-point sliding average method. These results showed that the contact load was composed of steady load and wavy load. And the contact displacement was composed of cartilage deformation and surface outline. The steady load was similar to exterior load while natural cartilage deformation increased nonlinearly with the sliding time. Wavy load had the correlative coefficient 0.235 with surface outline due to the irregular surface of friction configurations. The coefficient of friction from cartilage friction configurations was less influenced by smaller magnitude in rotated parameters. A few strange summits were obtained in the area of coef-ficient of friction, and significantly related with local minimal values corresponding to the contact loads. The rotated offsets had clear impact on contact load and a slight impact on contact displacement. Larger offset produced higher wavy magnitude of the contact load. The rotated velocities played an evident role in cartilage deformation, but had a less influence on contact load. Lower velocity brought larger cartilage deformation.

关键词：软骨构造关节软骨摩擦系数软骨变形接触装