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Plasmacytoid Dendritic Cells Act as the Most Competent Cell Type in Linking Antiviral Innate and Adaptive Immune Responses

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Cellular & Molecular Immunology 2005年第6期2卷 411-417页

作者： Zheng Zhang~1 Fu-Sheng Wang~(1,2) ~1research Center of biological therapy,beijing 302 hospital,beijing 100039,china.~2research centre of biological therapy,beijing institute of infectious diseases,beijing 302 hospital,100 xi si huan middle road,beijing 100039,china. research Center of biological therapy Beijing 302 Hospital Beijing 100039 China.

Appropriate in vivo control of plasmacytoid dendritic cell (pDC) recruitment and activation is a fundamentalrequirement for defense against viral *** this process,a pivotal event that influences the outcome ofviral infection is the production of high levels of type I interferon by *** particular,recent research findingsshowed that pDCs not only shape the nature of innate resistance,but are also responsible for the successfultransition from innate to adaptive immunity for viral *** addition,pDCs can differentiate into antigenpresenting cells that may regulate tolerance to a given ***,in a series of recent clinical studies,pDCs appeared to be defective in number and function in conditions of chronic viral diseases such as infected withHIV-1,HBV or ***-associated clinical antiviral therapy is also *** review describes researchfindings examining the functional and antiviral properties of in vivo pDC *** & MolecularImmunology.2005;2(6):411-417.

关键词： virus plasmacytoid dendritic cell innate immunity adaptive immunity

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Current status and prospects of studies on human genetic alleles associated with hepatitis B virus infection

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World Journal of Gastroenterology 2003年第4期9卷 641-644页

作者： Fu-Sheng Wang Division of biological Engineering,beijing institute of infectious diseases,100 xi si-huan-Zhong road,beijing 100039,china Division of Bioengineering Beijing Institute of Infectious Diseases 100 Xi Si-Huan-Zhong Road Beijing 100039 China. fswang@***

Chronic hepatitis B virus (HBV) infection can cause a broad spectrum diseases, including from asymptomatic HBV carriers or cryptic hepatitis, to acute hepatitis, chronic hepatitis, Liver cirrhosis and primary hepatocellular carcinoma. The variable pattern and clinical outcome of the infection were mainly determined by virological itself factors, host immunological factors and genetic factors as well as the experimental factors. Among the human genetic factors, major candidate or identified genes involved in the process of HBV infection fall into the following categories: (1) genes that mediate the processes of viral entry into hepatocytes, induding genes involved in viral binding, fusion with cellular membrane and transportation in target cells; (2) genes that modulate or control the immune response to HBV infection; (3) genes that participate in the pathological alterations in liver tissue;(4) genes involved in the development of liver cirrhosis and hepatocellular carcinoma associated with chronic HBV infection, including genes related to mother-to-infant transmission of HBV infection; and (5) those that contribute to resistance to antiviral therapies. Most of the reports of human genes associated with HBV infection have currently focused on HLA associations. For example, some investigators reported the association of the HLA class Ⅱ alleles such as DRB1*1302 or HLA-DR13 or DQA1*0501-DQB1*0301-DQB1*1102 haplotypes with acute and/or chronic hepatitis B virus infection, respectively. Several pro-inflammatory cytokines such as Th1 cytokines (including IL-2 and IFN-γ)and TNF-α have been identified to participate the process of viral clearance and host immune response to HBV. In contrast, the Th2 cytokine IL-10 serves as a potent inhibitor of Th1 effector cells in HBV diseases. The MBP polymorphisms in its encoding region were found to be involved in chronic infection. Thus, reports from various laboratories have shown some inconsistencies with regard to the effects of

关键词：乙型肝炎病毒慢性乙型肝炎遗传学等位基因基因多态性病毒携带者

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Frequency and Absolute Number of FoxP3^+ Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection

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Virologica sinica 2007年第6期22卷 501-508页

作者： Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun xiNG Bao-yun FU Chun-bao ZHOU xi-cheng WANG Hao WU Fu-Sheng WANG research Center of biological therapy Beijing Institute of Infectious Diseases Beijing 302 Hospital 100 Xi Si Huan Middle Road Beijing 100039 China Postgraduate Team Military Postgraduate Medical CollegeBeijing 100853 China Department of infectious diseases Beijing You-An Hospital Affiliated to Capital University of Medical Science Beijing 100054 China

CD4^＋CD25^＋ Regulatory T cells （Treg） have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute counts and frequency in 75 antiviral-naive HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection, influencing the disease progression.

关键词： T-Lymphocytes HIV Infections Tolerance/Suppression/Anergy Proliferation

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