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Object use in insects

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Insect Science 2024年第4期31卷 1001-1014页

作者： Chao wen Cai Wang Xiaoli Guo Hongyu Li Haijun Xiao Junbao wen Shikui Dong School of Grassland Science Beijing Forestry UniversityBeijingChina college of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhouChina Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijingChina

Insects are the most diverse group of organisms in the animal kingdom,and some species exhibit complex social *** research on insect object use is still in its early stages,insects have already been shown to display rich object-use *** review focuses on patterns and behavioral flexibility in insect object-use behavior,and the role of cultural evolution in the development of object-use *** use in insects is not widespread but has been documented in a diverse set of *** insects can use objects flexibly and display various object-use *** mammals and birds,insects use objects in diverse activities,including foraging,predator defense,courtship,and ***,pre-existing manipulative behaviors,and anatomical structure affect innovations in object *** addition,learning and imitation are the main mechanisms underlying the spread of object-use behaviors within *** that insects are one of the major animal groups engaging in object use,studies of insect object use could provide general insights into object use in the animal kingdom.

关键词： cognition evolution insects learning object use

Suramin Inhibits the In Vitro Expression of Encephalitis B Virus Proteins NS3 and E

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Journal of Huazhong University of Science and Technology(medical Sciences) 2003年第4期23卷 375-379页

作者：徐可树任宏宇朱剑文杨昀廖芳 department of Gastroenterology department of microbiology

In this study, the mechanism by which Suramin inhibits the replication of epidemic encephalitis B virus was explored to provide a theoretical basis for its further application in clinical practice. After viral infection of HepG2 and IMR 32 cells, different concentrations of Suramin were added to the culture media, and then the cultural supernatants and infected cells were collected 48 h later. For the evaluation of the curative effect, cytopathic effect (CPE), virus titers, the expression of viral protein and viral RNA were determined by Western blot, RT PCR and in vitro RNA synthesis, respectively. At the concentration of 50 μg/ml of Suramin, HepG2 and IMR 32 infected with epidemic encephalitis B virus decreased by 51.8 % and 0.03 % respectively, as compared with controls. It was suggested that expression of encephalitis B virus proteins NS3 and E was notably reduced by Suramin. This is especially true of E protein. At RNA level, however, no difference in RNA virus was found between Suramin treated virus and non treated cells. Our results suggest that Suramin can inhibit viral replication by blocking the production of viral proteins.

关键词： Suramin antiviral activity encephalitis B virus

Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor

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Biomedical and Environmental Sciences 1999年第2期12卷 88-94页

作者： YING CHEN-JIANG YE XIAO-LEI XIE HONG YAN wen-SHENG ZHAO MEI-YING XIA TONG AND YIN SHU-YI.(department of Environmental Health, Tongji medical University, Wuhan 430030, china.department of Public Health, wenzhou medical college, wenzhou 317400, china.department of Anatomy,Tongji medical University, Wuhan 430030, china. department of Environmental Health Tongji Medical University Wuhan 430030 China department of Public Health Wenzhou Medical College Wenzhou 317400 China department of Anatomy Tongji Medical University Wuhan 430030 China

The present report evaluates the effects of formaldehyde (FA) exposure on peripheral lymphocytes by using heth genetic and immunological parameters. Twenty-three non-smoking students in the study had inhalation exposure to 0.508 ±0. 299 mg/m3 of FA for a Period of 8 weeks (3h × 3 times each week) during anatomy classes. As for composition of lymphocyte subsets after FA exposare,significant increase was found in the percentage of CD19(B cells), while sighficant decrease was observed in CD3(total T cells), CD4(T helper-inducer cells), and CD8(T cytotoxic-suppressior cells) with a P 0 .05) was reported between lymphocyte prolifendion rate and sisterchromatid exchange (SCE) at the exposure level and duration. It is suggested that the lymphocyte subsets may be most susceptible to the effects of FA, though a single immunological endpoint is rarely related with pathophysiological interpretation.

关键词： Res FA DNA Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor Heck

Network Pharmacology of Xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： ming-Xia Zhao Cheng-Lin Song Qin-Chang Zhang Hao-Jie Du Shu-Qiong Zhang Yu-Xian Shen Yang Sun Hai-Bo Cheng wen Lv department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the Xian-Lian-Jie-Du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology Xian-Lian-Jie-Du decoction

Relationship between expression p53 protein,PCNA and CEA in colorectal cancer and lymph node metastasis

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World Journal of Gastroenterology 1998年第3期4卷 38-38页

作者： XU Qingwen1, LI YanSong2 and ZHU HeGen11department of Surgery, 2department of Pathology, The Affiliated Hospital of guangdong medical college, zhanjiang 524001, guangdong Province, china.

AIM To study the p53 protein, PCNA and CEA expression and its relationship with lymph node metastasis in colorectal cancer. METHODS SP immunohistochemical method was used to examine the positive rates of p53 protein, PCNA and the phenotype of CEA in 44 cases of colorectal cancer. RESULTS The positive rate of p53 protein expression in colorectal cancer was 523%, which was not related to sex, age, tumor location, differentiation or invasion (P>005). The frequency of lymph node metastasis in p53positive cases was significantly higher than in p53negative cases (14/23, 609% vs 6/21, 286%,P2±15 vs 396±17,P21/23, 913% vs 13/21, 619%,P20, 950% vs 15/24, 625%, P<005). CONCLUSION p53, PCNA and CEA expression is important to determine the degree of malignancy and prognosis, and predict lymph node metastasis of colorectal cancer.

关键词： colorectal metastasis

Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro

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Science china.Life Sciences) 2006年第2期49卷 158-163页

作者： PENG Bo1, CHEN Hanyang1, TAN Yadi1,2, JIN Meilin1,2, CHEN Huanchun1,2 & GUO Aizhen1,2 1. Laboratory of Animal Virology, college of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, china.2. National Key Laboratory of Agricultural microbiology, Huazhong Agricultural University, Wuhan 430070, china 1. Laboratory of Animal Virology College of Veterinary Medicine Huazhong Agricultural University Wuhan 430070 China 2. National Key Laboratory of Agricultural microbiology Huazhong Agricultural University Wuhan 430070 China

Purified avian infectious bronchitis virus (IBV) was used to screen a random phage dis-play peptide library. After the fourth panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells and blocked IBV haemagglutination. One linear peptide “GSH HRH VHS PFV” from the positive phages with the highest neutralization titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development of antiviral therapeutics for IBV and studying the determinants for viral and cell interac-tion.

关键词： avian infectious bronchitis virus, phage display, peptides.

THE STUDY OF HUMAN TRANSFER FACTOR

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Science in china.Ser.B 1985年第4期28卷 394-401页

作者：李在连 microbiology department Changwei medical college Weifang

In this paper, the study of human transfer factor is reported. We established a negative pressure dialysis method instead of ordinary dialysis for treatment of the crude leukocyte extract. Dialysate is rapidly obtained in only 5h so that a large volume of preparation is easier to handle and the chance of contamination avoided. When humau TF was incubated With human cord blood T-lymphocytes and pig lymphocytes, a very high biological activity on SRBC rosette enhancement and an increase in electrophoresis rate appeared. It suggests that these assays may be used as in vitro method of evaluation of TF activity. In our clinic, TF has been in clinical trials for 5 years and has now been administered to a large number of patients with a variety of diseases, in which cell-mediated immune responses have been compromised. We observe that TF has served an efficient immunopotentiating or immunemodulation agent.

关键词： THE STUDY OF HUMAN TRANSFER FACTOR TF RFC

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling wen Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE wen-wen LIANG Qing-shun HUANG Yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan wen Ze-huai LI Chun-ji OUYANG wen-wei LI Geng WU ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K Paul TANG Xian-yu FAN Guan-jie department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical college of Guangzhou University of Chinese Medicine Guangzhou510120China department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China guangdong Provincial Academy of Chinese medical Sciences Guangzhou510120China department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(P2 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(P0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

Multifunctional carbon materials from rugose rose for energy storage and water purification

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Frontiers of Chemical Science and Engineering 2024年第9期18卷 1-13页

作者： Peng-Hui Li Hui Zhou wen-Juan Wu Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China college of Light Industry and Food Engineering Nanjing Forestry UniversityNanjing 210037China college of Chemical Engineering East China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering Shanghai 200237China

With the advancement of social process,the resource problem is becoming more prominent,biomass materials come into being,and it is becoming more and more important to explore and prepare efficient and multifunctional biomass materials to alleviate the problems of energy storage and water *** this paper,nitrogen-doped hierarchical porous carbon materials(NRRC)were produced by one-step carbonization of withered rose as raw material and melamine as nitrogen source with KOH-activated *** resulting nitrogen-doped porous carbon material had the most abundant pores and the best microspherical graded pore structure,with a specific surface area of up to 1393 m2·g^(-1),a pore volume of 0.68 cm3·g^(-1),and a nitrogen-doped content of 5.52%.Electrochemical tests showed that the maximum specific capacitance of NRRC in the three-electrode system was 346.4 F·g^(-1)(0.5 A·g^(-1)),which was combined with favorable capacitance retention performance and cycling *** NRRC//NRRC symmetric supercapacitors were further assembled,and the maximum energy density of a single device was 23.88 Wh·kg^(-1),which still maintains excellent capacitance retention and cyclic charging/discharging *** example,the capacitance retention rate was always close to 96.27%with almost negligible capacitance loss after 10000 consecutive charge/discharge cycles(current density:10 A·g^(-1)).Regardless of the three-electrode or two-electrode system,the super capacitive performance of NRRC porous carbon materials was comparable to the electrochemical performance of many reported biomass porous carbon materials,which showed better energy storage advantages and practical application *** addition,NRRC porous carbon materials had excellent water purification *** dye adsorption test confirmed that NRRC had a high adsorption capacity(491.47 mg·g^(-1))for methylene *** undoubtedly also showed a potential and promising avenue for high value-added utilization

关键词： rose carbon adsorption electrode material electrochemical performance