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Novel Tumor-associated Antigen of Hepatocellular Carcinoma Defined by Monoclonal Antibody E4-65

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 359-365页

作者： Ke ZOU~(1,2), Jihang JU~(1,2), and Hong XIE~~(1*)1 Institute of Biochemist13, and Cell Biology, Shanghai Institutes for Biological sciences, chinese academy of sciences, Shanghai 200031, china. 2 graduate school of the chinese academy of sciences beijing 100049, china Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of SciencesShanghai 200031 China graduate school of the chinese academy of sciencesbeijing 100049 China

A monoclonal antibody, E4-65, produced by immunizing mice with SMMC-7721 cells, a human hepatocellular carcinoma (HCC) cell line, was used to identify and characterize an unreported HCC-associated antigen. Indirect immunofluorescence studies showed that E4-65 antibody reacted with five out of eight HCC cell lines, but not with 10 non-HCC tumor cell lines or a normal liver cell line. Using immunohistochemical examination, E4-65 antigen was detected on the cell membranes and in the cytoplasm of human liver tumor tissues, but was not found in most other tumors, or normal adult or fetal tissues, except for a weakly positive reaction in tissues of the digestive system. Western blot analysis showed that E4-65 antibody bound to a 45 kDa protein in the human HCC cell line and tissue lysates. Enzyme treatment and lectin blotting did not detect the carbohydrate chain in E4-65 antigen. This HCC-associated protein represents a potentially useful target for diagnoses and immunotherapy of human HCC.

关键词： hepatocellular carcinoma immunohistochemistry monoclonal antibody neoplasm antigen

Gasdynamic characteristics of toroidal shock and detonation wave converging

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Science china(Physics,Mechanics & Astronomy) 2005年第6期48卷 739-749页

作者： TENG Honghui1,2 & JIANG Zonglin2 1. Key Laboratory of High Temperature Gas Dynamics, Institute of Mechanics, chinese academy of Sci- ences, beijing 100080, china 2. graduate University of chinese academy of sciences, beijing 100039, china Key Laboratory of High Temperature Gas Dynamics Institute of Mechanics Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China

The modified CCW relation is applied to analyzing the shock, detonation wave converging and the role of chemical reactions in the process. Results indicate that the shock wave is strengthened faster than the detonation wave in the converging at the same initial Mach number. Euler equations implemented with a detailed chemical reaction model are solved to simulate toroidal shock and detonation wave converging. Gasdynamic characteristics of the converging are investigated, including wave interaction patterns, observable discrepancies and physical phenomena behind them. By comparing wave diffractions, converging processes and pressure evolutions in the focusing area, the different effects of chemical reactions on diffracting and converging processes are discussed and the analytic conclusion is demonstrated through the observation of numerical simulations.

关键词： converging, CCW relation, shock wave, detonation wave.

Theoretical critical value curve and driving force formation of ecological migration in the arid land

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chinese Science Bulletin 2006年第A1期51卷 196-203页

作者： ZHU Zi’an & ZHANG Xiaolei Xinjiang Institute of Ecology and Geography, chinese academy of sciences, Urumqi 830011, china The graduate school of the chinese academy of sciences, beijing 100039, china Xinjiang Uygur Autonomous Region Development and Reform Commission, Urumqi 830002, china Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi China The graduate school of the chinese academy of sciences Beijing China Xinjiang Uygur Autonomous Region Development and Reform Commission Urumqi China

干旱陆地的易碎的 eco 环境的特征确定它骚乱抵抗的能力更低。在干旱陆地的自然荒芜的绿洲在在宽 Gobi 沙漠散布的马赛克补丁。人口分发是极大地依赖于水资源。人口与驱散的分发，简单生产和生活被描绘风格，和贫穷和遥远。生态的迁居... 详细信息

干旱陆地的易碎的 eco 环境的特征确定它骚乱抵抗的能力更低。在干旱陆地的自然荒芜的绿洲在在宽 Gobi 沙漠散布的马赛克补丁。人口分发是极大地依赖于水资源。人口与驱散的分发，简单生产和生活被描绘风格，和贫穷和遥远。生态的迁居被执行的原因躺在生态的问题。生态的降级是生态的迁居的主要驱动力。然后，驱动力的力量取决于生态的降级的度。因此，是否执行生态的移植取决于生态的降级的程度。理论上，为在干旱陆地的精明的生态的移植的批评的值曲线通过生态学的相对问题的全面研究被提出，经济等等，在干旱陆地与生态的移植经验结合了，并且基于干旱环境的特征。在这篇文章，与这条曲线，理论研究和生态的迁居的一些实践从不做作的行为和生态的移植的驱动力形成的政府行为的观点被做了。它分析活跃驱动力(因素) 和否定力量(因素) ，并且指出预定和在干旱陆地实现生态的迁居的步骤。理论曲线表达某些创见和适用性，它为为实现生态的迁居工程评估生态的降级和理论底的度提供一个量的方法。

关键词：生态迁移临界值驱动力贫瘠地

Population information extraction in Chaohu watershed based on RS and GIS

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chinese Science Bulletin 2003年第2期48卷 181-183页

作者： LIU Jianjun1,2 & LI Chunlai3 1. Institute of Geochemistry, chinese academy of sciences, Guiyang 550002, china 2. graduate school, chinese academy of sciences, beijing 100039, china 3. National Astronomical Observatories, chinese academy of sciences, beijing 100012, china Correspondence should be addressed to Liu Jianjun (e-mail: dhsliujj@ ***) Institute of Geochemistry Chinese Academy of Sciences Guiyang China graduate school Chinese Academy of Sciences Beijing China National Astronomical Observatories Chinese Academy of Sciences Beijing China

It is always difficult to extract population in-formation of small watershed during the region environment assessment. The report adopted compound areal interpola-tion to study the population in Chaohu watershed with the GIS technique and landuse interpretation data from remote sensing. The result indicated that the method is effective to extract population information of small watershed.

关键词：巢湖流域人口分布信息提取 RS GIS 小流域生态环境评价

SHRIMP zircon U-Pb geochronology of early Mesozoic felsic igneous rocks from the southern Lancangjiang and its tectonic implications

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Science china Earth sciences 2006年第10期49卷 1032-1042页

作者： PENG Touping1,2, WANG Yuejun1, FAN Weiming1, LIU Dunyi3, SHI Yuruo3 & MIAO Laicheng4 1. Key Laboratory of Isotope Geochronology and Geochemistry, Guangzhou Institute of Geochemistry, chinese academy of sciences, Guangzhou 510640, china 2. graduate University of chinese academy of sciences, beijing 100039, china 3. SHRIMP isotope Laboratory, chinese academy of Geological sciences, beijing 100037, china 4. Institute of Geology and Geophysics, chinese academy of sciences, beijing 100029, china Key Laboratory of Isotope Geochronology and Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China graduate University of chinese academy of sciences Beijing China SHRIMP isotope Laboratory Chinese Academy of Geological Sciences Beijing China Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China

The SHRIMP zircon U-Pb geochronology of three typical samples, including two monzo nitic granites from the Lincang batholith and a rhyolite from the Manghuai Formation are presented in the southern Lancangjiang, western Yunnan Province. The analyses of zircons for the biotite monzonitic granites from the northern (02DX-137) and southern (20JH-10) Lincang batholith show the single and tight clusters on the concordia, and yield the weighted mean 206Pb/238U ages of 229.4 ± 3.0 Ma and 230.4 ± 3.6 Ma, respectively, representing the crystallized ages of these granites. The zircons for the rhyolitic sample (02DX-95) from the Manghuai Formation give a weighted mean 206Pb/238U age of 231.0 ± 5.0 Ma. These data suggest that the igneous rocks from the Lincang granitic batholith and Manghuai Formation have a similar crystallized age. In combination with other data, it is inferred that both were generated at a narrow age span (~230 Ma) and were originated from the postcollisional tectonic regime. An early Proterozoic 206Pb/238U apparent age of 1977±44 Ma is additionally obtained from one zircon from the biotite monzonitic granite (southern Lincang batholith), indicative of devel- opment of the early Proterozoic Yangtze basement in the region. These precisely geochronological data provide important constraints on better understanding the Paleozoic tectonic evolution of the Tethys, western Yunnan Province.

关键词： SHRIMP zircon U-Pb dating, Middle Triassic, Lincang granitic batholith, Manghuai Formation rhyolite, southern Lancangjiang.

Strong decays of N~*(1535) in an extended chiral quark model

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Science china(Physics,Mechanics & Astronomy) 2009年第10期52卷 1452-1457页

作者： AN ChunSheng1,2,3 & ZOU BingSong1,2,3 1 Institute of High Energy Physics,chinese academy of sciences,beijing 100049,china 2 Theoretical Physics Center for Science Facilities,chinese academy of sciences,beijing 100049,china 3 graduate University of chinese academy of sciences,beijing 100049,china Institute of High Energy Physics Chinese Academy of Sciences Beijing China Theoretical Physics Center for Science Facilities Chinese Academy of Sciences Beijing China graduate University of chinese academy of sciences Beijing China

The strong decays of the N*(1535) resonance are investigated in an extended chiral quark model by including the low-lying $ qqqq\bar q $ components in addition to the qqq component. The results show that these five-quark components in N*(1535) contribute significantly to the N*(1535) → Nπ and N*(1535) → Nη decays. The contributions to the Nη decay come from both the lowest energy and the next-tolowest energy five-quarks components, while the contributions to the Nπ decay come from only the latter one. Taking these contributions into account, the description for the strong decays of N*(1535) is improved, especially for the puzzling large ratio of the decays to Nη and Nπ.

关键词： N*(1535) strong decays five-quark components

De-interlacing technique based on total variation with spatial-temporal smoothness constraint

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Science in china(Series F) 2007年第4期50卷 561-575页

作者： YIN XueMin1,2,3, YUAN JianHua1,2, LU XiaoPeng1,2 & ZOU MouYan1,2 1 Institute of Electronics, chinese academy of sciences, beijing 100080, china 2 graduate school, chinese academy of sciences, beijing 100039, china 3 Jiuquan Satellite Launch Center, Lanzhou 732750, china Institute of Electronics Chinese Academy of Sciences Beijing China graduate school Chinese Academy of Sciences Beijing China Jiuquan Satellite Launch Center Lanzhou China

This paper introduces a new method of converting interlaced video to a progressively scanned video and image, The new method is derived from Bayesian framework with the spatial-temporal smoothness constraint and the MAP is done by minimizing the energy functional, The half-quadratic regularization method is used to solve the corresponding partial differential equations （PDEs）, This approach gives the improved results over the conventional de-interlacing methods, Two criteria are proposed in the paper, and they can be used to evaluate the performance of the de-interlacing algorithms,

关键词： video processing de-interlacing total variation spatio-temporai smoothness constraint PDEs half-quadratic regularization

Simulations for terrestrial planets formation

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Science china(Physics,Mechanics & Astronomy) 2009年第5期52卷 794-803页

作者： ZHANG Niu 1,2 &JI JiangHui 2,3 1graduate University of chinese academy of sciences,beijing 100049,china 2Purple Mountain Observatory,chinese academy of sciences,Nanjing 210008,china 3 National Astronomical Observatories,chinese academy of sciences,beijing 100012,china graduate University of chinese academy of sciences Beijing China Purple Mountain Observatory Chinese Academy of Sciences Nanjing China National Astronomical Observatories Chinese Academy of Sciences Beijing China

In this paper,the formation of terrestrial planets in the late stage of planetary formation is investigated using the two-planet *** that time,the protostar formed for about 3 Ma and the gas disk *** the model,the perturbations from Jupiter and Saturn are *** of the mass of outer planet,and the initial eccentricities and inclinations of embryos and planetesimals are also *** results show that,terrestrial planets are formed in 50 Ma,and the accretion rate is about 60%-80%.In each simulation,3-4 terrestrial planets are formed inside"Jupiter"with masses of 0.15 -3.6M⊕.In the 0.5-4 AU,when the eccentricities of planetesimals are excited,planetesimals are able to accrete material from wide radial *** plenty of water material of the terrestrial planet in the Habitable Zone may be transferred from the farther places by this *** could also happen a few times between two major planets only if the outer planet has a moderate mass and the small terrestrial planet could survive at some resonances over time scale of 10 8 *** one of our simulations,commensurability of the orbital periods of planets is very ***,a librating-circulating 3:2 configuration of mean motion resonance is found.

关键词： astrophysics exoplanet planetary formation n-body simulation

Formal Verification under Unknown Constraints

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Wuhan University Journal of Natural sciences 2005年第1期10卷 43-46页

作者： LI Guang-hui 1,2,3 , LI Xiao-wei 2,31. school of Information Engineering, Zhejiang Forestry College, Hangzhou 311300, Zhejiang, china 2. Institute of Computing Technology, chinese academy of sciences, beijing 100080, china 3. graduate school of the chinese academy of sciences, beijing 100039, china school of Information Engineering Zhejiang Forestry College Hangzhou Zhejiang China Institute of Computing Technology Chinese Academy of Sciences Beijing China graduate school of the chinese academy of sciences Beijing China

We present a formal method of verifying designs with unknown constraints (e.g., black boxes) using Boolean satisfiability (SAT). This method is based on a new encoding scheme of unknown constraints, and solves the corresponding conjunctive normal form (CNF) ***,this method can avoid the potential memory explosion, which the binary decision diagram (BDD) based techniques maybe suffer from, thus it has the capacity of verifying large designs. Experimental results demonstrate the efficiency and feasibility of the proposed method.

关键词： formal verification unknown constraints black box Boolean satisfiability Boolean comparison