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腹膜透析患者瘦素水平及其影响因素的研究

中国实用内科杂志 2006年第S1期26卷 19-21页

作者：关欣郑红光沈阳军区总医院肾内科辽宁沈阳110016

目的探讨腹膜透析患者血清瘦素水平及其影响因素。方法选取2002—2004年沈阳军区总医院肾内科30例腹膜透析患者和30名志愿健康者为研究对象。采用 ELISA 法测定血清瘦素水平,用免疫散射比浊法测定 C 反应蛋白(CRP),同时观察体重指数(BM... 详细信息

目的探讨腹膜透析患者血清瘦素水平及其影响因素。方法选取2002—2004年沈阳军区总医院肾内科30例腹膜透析患者和30名志愿健康者为研究对象。采用 ELISA 法测定血清瘦素水平,用免疫散射比浊法测定 C 反应蛋白(CRP),同时观察体重指数(BMI),测定空腹胰岛素(FINS)及肾功能等指标。并用SGA 法评估营养状况,分析瘦素与各项参数间的关系。结果 (1)腹透患者血清瘦素水平比健康者明显增高(P2)女性腹透患者瘦素质量浓度为(42.76±3.87)g/L,明显高于男性腹透患者[(34.885±3.36)g/L。P2.04±3.76)mg/mL 明显高于营养正常者[(33.34±2.51)g/L,P0.05)。结论腹透患者存在高瘦素血症,血清瘦素水平受体脂含量(BMI)、性别、胰岛素及营养状况等多因素的影响。

关键词：腹膜透析瘦素影响因素

Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease

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Neural Regeneration Research 2006年第9期1卷 841-843页

作者： Fang Liu1,2, Xiao Sun1, Jing Wang1, Yan Kong1, Li Cui1, Xiangdang Shi2 1department of Neurology, Fengtian hospital, shenyang Medical College, shenyang 110024, Liaoning Province, china.2Medical University of South Carolina, SC, U.S.A department of Neurology Fengtian Hospital Shenyang Medical College Shenyang 110024 Liaoning Province China Medical University of South Carolina Charleston SC United States

BACKGROUND: Many researches have suggested that apolipoprotein E (APOE) and total cholesterol metabolism are closely related with dementia. In the supposed theory, 219 site of APOE promoter region is near gene coding region, so its polymorphism may result in the abnormality of APOE gene and protein expression, and finally lead to dementia. OBJECTIVE: To observe the association between APOE promoter-219G/T polymorphisms with serum total cholesterol in patients with Alzheimer disease, and compare it with non-dementia people. DESIGN: Case-control, comparative observation. SETTING: department of Neurology, Fengtian hospital of shenyang Medical College. PARTICIPANTS: Fifty-five dementia patients including 27 males and 28 females aged (66±3) years and treated in the department of Neurology, Fengtian hospital were selected from January 2002 to December 2005 as the Alzheimer disease group. They all diagnosed according to the DSM-Ⅳdiagnostic criteria of Alzheimer disease instituted by American Psychiatry Association in 1994. Meanwhile, 44 none-dementia patients including 21 males and 23 females aged (66±3) years were selected from other clinical departments of Fengtian hospital as control group. All the participants were informed the detection and agreed. METHODS: Genomic DNA was extracted from the peripheral blood of all subjects, then 'NEST'PCR, DNA sequence and enzyme digestion were adopted to detect the expression of APOE promoter-219 polymorphism, following by biomedical statistics analysis based on the clinical total cholesterol level. MAIN OUTCOME MEASURES: Polymorphism of APOE promoter-219 G/T and total cholesterol level. RESULTS: All 55 dementia patients and 44 non-dementia ones were involved in the result analysis. ①Allele and genotype frequency: The T allele frequency of the Alzheimer disease group was significantly higher than that in the control group [88.2% (97/110), 54.5% (48/88)], while G allele frequency was remarkably lower than that in the control group [1

关键词： Association between apolipoprotein E promoter-219G/T polymorphism and total cholesterol level in patients with Alzheimer disease APO DSM than

消胀排气汤联合中药热奄包促进剖宫产术后胃肠功能恢复临床研究

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新中医 2024年第19期56卷 106-110页

作者：冯沈阳任利容广州中医药大学第七临床医学院广东深圳518000 广州中医药大学附属宝安中医院广东深圳518000

目的:观察消胀排气汤联合中药热奄包对剖宫产术后胃肠功能恢复的增效作用与安全性。方法:将120例剖宫产术后产妇按随机数字表法分为对照组、热奄包组、联合组各40例。对照组术后予常规处理,热奄包组在对照组基础上加用中药热奄包热敷腹... 详细信息

目的:观察消胀排气汤联合中药热奄包对剖宫产术后胃肠功能恢复的增效作用与安全性。方法:将120例剖宫产术后产妇按随机数字表法分为对照组、热奄包组、联合组各40例。对照组术后予常规处理,热奄包组在对照组基础上加用中药热奄包热敷腹部穴位,联合组在热奄包组基础上予消胀排气汤治疗。比较3组产妇术后首次肠鸣音恢复时间、首次排气时间、首次排便时间、术后住院时间、腹胀发生率,术后6 h、24 h、48 h、72 h腹痛视觉模拟评分法(VAS)评分,并观察不良反应发生情况。结果:热奄包组、联合组产妇首次肠鸣音恢复时间、首次排气时间、首次排便时间及术后住院时间均短于对照组(P24 h、48 h、72 h腹痛VAS评分均低于对照组(P24 h、48 h、72 h腹痛VAS评分均低于热奄包组(P0.05)。结论:消胀排气汤联合中药热奄包对剖宫产术后胃肠功能恢复疗效确切,能减轻产妇术后腹部疼痛,促进产妇早日康复。

关键词：剖宫产消胀排气汤中药热奄包术后胃肠功能视觉模拟评分法

Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway

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Induction of apoptosis by furanodiene in HL60 leukemia cells...

两岸三地药理学与临床药理学术会议

作者： MA En-long~1 WANG Xiao-long~1 LI Yan-chun~1 TAI Wen-jiao~1 LI Te~1 GUO Tao~2 (1. department of Pharmacology, shenyang Pharmaceutical University, shenyang 110016, china.2. department of Pharmacy, general hospital of shenyang military Region, shenyang 110016, china.)

Objective Curcuma wenyujin,named Ezhu in Chinese,a traditional Chinese medicine,which has been shown to possess antiearcinogenic activity and used for the treatment of tumor in china.for example, hepatic cancer and leukemia.β-elemene,a component of Curcuma wenyujin,was largely reported as a main active component for anti-tumor effect of Curcuma ***,furanodiene,another main compo- nent of Curcuma wenyujin,was seldom investigated for its anti-tumor *** the present study,we aim to investigate the effect of furanodiene on human leukemia HL60 cells and to study the accurate molecu- lar mechanisms of its *** Trypan blue exclusion experiment was used for cell growth inhibition *** apoptotie characterizations were assessed by flow cytometry analysis,AO/EB staining assay and agarose gel electrophoresis *** expression of apoptosis-related proteins and the release of cytochrome c from mitochondrial were detected by western blotting,and the mRNA levels of TNF-αand TNFR1 were probed by *** of TNFR1 complex was analyzed by using immunoprecipitation of TNFR1 with TRRF1/2 and *** Furanodiene(10-100μM)treatment inhibited the growth of HL60 cells in a concentration-dependent *** effect of furanodiene on HL60 cells was associated with the in- duction of apoptosis,which was characterized by DNA fragmentation,cleavage of poly(ADP-ribose)poly- merase(PARP),caspase-3,caspase-8 and *** the Bcl-2 family proteins,Bid protein(a substrate of caspase-8)was activated by furanodiene,but Bcl-2,Bax and Bcl-xL proteins were not inuenced by furanodi- ene *** elicited cytochrome c release from mitochondria into the ***,fu- ranodiene treatment caused the upregulation of TNFR1,the formation of TNFR1 complex and an obvious production of TNF-αin HL60 *** soluble TNFR1 receptor effectively inhibited furanodiene-induced *** Furanodiene inhibited the growth of HL60 leuke

关键词： furanodiene apoptosis leukemia TNFR1 signaling

Effect of morphine and M-cholinoceptor blocking drugs on human sphincter of Oddi during choledochofiberscopy manometry

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Hepatobiliary & Pancreatic Diseases International 2003年第1期2卷 121-125页

作者： Shuo-Dong Wu Jing Kong Wei Wang Qiang Zhang Jun-Zhe Jin the department of Hepatobiliary, Second Affiliated hospital, china.Medical University, shenyang 110004, china department of Hepatobiliary Second Affiliated Hospital China Medical University Shenyang 110004 China.

OBJECTIVE: To evaluate the effects of morphine on the human sphincter of Oddi pressure and the antagonism of anticholinergic agents against morphine. METHODS: The action of these drugs on the sphincter of Oddi (SO) was evaluated by means of choledochofiberscopy manometry in 40 operated patients with T-tube. The patients were divided randomly into 4 groups: anisodamine, atropine, buscopan, and control. The following data were recorded: duodenal pressure (DP), basal pressure of the sphincter of Oddi (BPSO), contractive amplitude of the sphincter of Oddi (CASO), contractive frequency of the sphincter of Oddi (CFSO), contractive duration of the sphincter of Oddi (CDSO), and pressure of the common bile duct (PCBD). Both morphine and anticholinergic agents were given intramuscularly. RESULTS: After injection of 10 mg morphine, BPSO, CASO, CFSO, and PCBD increased significantly. After injection of 15 mg anisodamine or 0.75 mg atropine, CASO, BPSO declined obviously, and after injection of 20 mg buscopan, CASO, BPSO, CFSO declined obviously, but in anisodamine, atropine and buscopan groups, they differed insignificantly. CONCLUSIONS: The results illustrate that SO manometry via choledochofiberscopy is a new method for SO dynamic study. Morphine can increase DP, BPSO, CASO, PCBD, but anisodamine atropine and buscopan can antagonize the effect of morphine.

关键词： biliary manometry via choledochofiberscopy morphine anisodamine atropine buscopan contractive amplitude basal pressure sphincter of Oddi

Safety and feasibility of transradial coronary intervention in Chinese elderly patients

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Journal of Geriatric Cardiology 2007年第1期4卷 14-16页

作者： Quanmin JING Yaling HAN Shouli WANG Yingyan MA Bo LUAN Huiquan ZHAO department of Cardiology Shenyang General Hospital of Chinese PLAShenyang 110016China The Liaoyang Third hospital Liaoyang 110000China

Objective To assess the feasibility and safety of transradial approach in Chinese elderly patients undergoing coronary *** In this prospective study,764 elderly patients with coronary artery disease received percutaneous coronary intervention via either a transradial approach(TRA group)or a transfemoral approach(TFA group).The procedural success rate,success rate of artery access,puncture time,fluoroscopy time,dose of contrast,local complications and post-procedural pulmonary embolism were recorded and compared between 2 *** There was no significant difference of the procedural success rate between the TRA group and the TRF group(96.3%vs.98.2%,P>0.05);there were also no differences of success rate of cannulation,mean fluoroscopy time and mean dose of contrast between the 2 *** mean puncture time was longer in the TRA group than in the TFA group(3.8±2.1 min vs.2.0±3.4 min,P2 patients in the TFA group but none in the TRA *** Transradial coronary intervention was feasible and safe in most Chinese elderly patients when performed by experienced operators.

关键词： percutaneous coronary intervention radial artery stent elderly Chinese

Comparative study on the effect of integrin αvβ3 on secretion of matrix metalloproteinases in human normal and carcinoma trophoblasts

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Progress in Natural Science:Materials International 2005年第11期15卷 982-987页

作者： BAI Suxia, FU Yayuan, KONG Gang and WANG Yanling (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, china.The Second hospital of Chinese Medicine College, shenyang 110003, china. State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100080 China The Second hospital of Chinese Medicine College Shenyang 110003 China

The invasion of cytotrophoblast cells into the maternal endometrium during embryonic implantation is very similar to the metastasis of carcinoma cells. However, the significant difference is that the former is a highly controlled process. In this report, the effects of integnn αvβ3 on the secretion of matrix metalloproteinase (MMP) were compared between normal cytotrophoblast cells and chorio-carcinoma cells by RT-PCR, gelatin zymography and immunocytochemistry. The results reveal that both normal cytotrophobiast cells and choriocarcinoma cells can express integrin αvβ3. The secretion of MMPs in normal cytotrophoblast cells is up-regulated by anti-αvβ3 antibody, whereas, decreased in choriocarcmoma cells. It was suggested that αvβ3 can modulate the expression of MMPs in trophoblasts, and this action is carried out through distinct mechanisms in normal and carcinoma cytotrophoblast cells.

关键词： cytotrophoblast cells choriocarcinoma cells integrfn αvβ3 matrix metalloproteinase.

The Gamma Fuzzy Reliability Design of Vehicle parts

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The Gamma Fuzzy Reliability Design of Vehicle parts

2009中国控制与决策会议

作者： Tie Wang~1,Gaonan Wang~2,Jianyang Lin~3 1.School of Vehicle,shenyang Ligong University,shenyang 110168,china. 2.School of Mechanical Engineering,Tsinghua University,Beijing 100084,china. 3.The first affiliated hospital,china.Medical University,shenyang 110001,china

With considering lightening and safety of strength,integrations of both distribution’s density and function’s density,the normal fussy reliability formulas about vehicle parts that forces,strengths are gamma distribution and subordinate is parabola of exponential k was gotten;First integral change was achieved according to initial data and function imported and extent of integrated,second this number result with VB program in the computer was achieved by using middle-points integral calculus and romberg integration. This program can be used in design of vehicle parts for rising up level of design.

关键词： Vehicle parts Reliability design Gamma distribution Fussy mathematics

Impact of postoperative QRS duration on effect of cardiac resynchronization therapy

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Impact of postoperative QRS duration on effect of cardiac re...

第14届中国南方国际心血管病学术会议(南方会)

作者： Dong-mei Wang~1,Hai-bo Yu~2,Shu-ying Qi~1,Chao Ding~1, Gang Wang~1,Ya-ling Han~2 (1.department of Cardiology,Peace hospital,Shijiazhuang 0500822,china.2.department of Cardiology,The general hospital of shenyang military Region,shenyang 110016, china.

＜正＞Objectives To analyze the factors which affect the QRS duration（QRSD）after cardiac resynchronization therapy（CRT）and evaluate the affection of postoperative different QRSDs on effect of CRT in patients with heart failure （HF）.Methods 145 patients with HF[115 men;mean age 58.02±10.48 years,NYHA classⅢin 72 orⅣin 73, left ventricular ejection fraction（LVEF）≤35%]for implantation of CRT device were studied between April 2001 and June *** patients were divided into 3 groups according to postoperative QRSD change:GroupⅠ:93 cases,preoperative QRSD（164.11±72.62ms）＞postoperative QRSD（125.78+ 28.99ms）,GroupⅡ:29 cases,preoperative QRSD（121.97±17.26ms）postoperative QRSD（156.38±14.75ms）,GroupⅠ:23 cases(preoperative QRSD（136.96±19.18ms）= postoperative QRSD（136.96±19.18ms）.Follow-up was more than 6 months.3 groups had no statistical difference in preoperative basal *** During 6 months follow-up,there were 5（5.37%）deaths（sudden death in 1,worsening HF in 1,stroke in 2 and cancer in 1）in GroupsⅠ.There were 2（6.89%）sudden deaths in GroupⅡ,And there were 2 deaths（8.69%）（sudden death in 1 and renal failure in 1） in Group *** with GroupⅡ,The NYHA class and LVEF were improved significantly and LVEDD were decreased significantly in GroupⅠand GroupⅢ（p＜/span＞＜0.05-0.01）.The NYHA class and LVEF were improved significantly, but LVEDD were not decreased significantly in GroupⅡ（Table）.Conclusions There was better outcome in postoperative QRSDs narrowed or unchanged than QRSD *** QRSD changes after CRT were relative with the durations of preoperative *** preoperative QRSD＜130ms was the main factor which made QRSD *** function parameters were improved significant in patients （QRSD＜130 ms）with left ventricular dyssynchrony,but there was not left ventricular reverse remodeling in patients （QRSD＜130ms）.

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