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Chinese Chemical Letters 2021年第5期32卷 1755-1758页

作者： Tianlu zhang Zhiguo Lu Jianze Wang Jie Shen Qiulian Hao Yan Li Jun Yang Yunwei Niu zuobing Xiao Lei Chen Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Obstetrics and Gynecology Navy General Hospital of People Liberation ArmyBeijing 100048China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Fragrances are frequently added to a variety of products,including food,cosmetics and health ***,the high volatility and instability of essence limit its application in some *** this study,mesoporous silica nanoparticles(MSNs) were prepared to encapsulate eugenol,which could reduce the volatilization of the fragrance molecules.A facile approach was presented to synthesize MSNs with three different pore diameters for encapsulating *** addition,the properties of MSNs including mean particle size,morphology,encapsulating efficiency and release tendency were charac *** showed that the larger the pore diameters of MSNs,the more aromatic molecules were ***,the release mechanism was described as the smaller the pore diameters of MSNs,the slower the release of eugenol.

关键词： Eugenol Mesoporous silica nanoparticles Nano-fragrance Slow release of fragrance

Cationic and temperature-sensitive liposomes loaded with eugenol for the application to silk

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Chinese Chemical Letters 2020年第12期31卷 3139-3142页

作者： Zhiguo Lu Xiangyu Wang Tianlu zhang Luyao zhang Jun Yang Yan Li Jie Shen Jianze Wang Yunwei Niu zuobing Xiao Guiying Liu Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Pediatrics Capital Medical University Affiliated Beijing Anzhen HospitalBeijing 100029China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Silk has been widely used in the clothing industry due to their soft and smooth features,good biocompatibility,good heat dissipation,warmth and ultraviolet *** application of fragrance to silk can significantly improve the performance of ***,there are two key scientific problems that need to be solved:slowing down the release rate of fragrances and increasing the scent lasting time of *** this study,cationic and temperature-sensitive liposomes were designed and prepared to encapsulate *** fragrance-loaded liposomes significantly slowed down the release rate of the fragrance and controlled the release rate of the fragrance in a thermo-sensitive *** liposomes adhered to the silk through electrostatic adsorption *** positive charge on the fragranceloaded liposomes neutralized much negative charge on silk and thereby increasing the adhesion efficiency.

关键词： Eugenol Silk Cationic and temperature-sensitive liposomes Slow release of fragrance Controlled release of fragrance

Reactive mesoporous silica nanoparticles loaded with limonene for improving physical and mental health of mice at simulated microgravity condition

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Bioactive Materials 2020年第4期5卷 1127-1137页

作者： Zhiguo Lu Jianze Wang Lina Qu Guanghan Kan Tianlu zhang Jie Shen Yan Li Jun Yang Yunwei Niu zuobing Xiao Yinghui Li Xin zhang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190PR China State Key Laboratory of Space Medicine Fundamentals and Application China Astronaut Research and Training CenterBeijing100094China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049PR China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai200232PR China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai200233PR China

Astronauts are under high stress for a long time because of the microgravity condition,which leads to anxiety,affects their learning and memory abilities,and seriously impairs the health of *** can improve the physical and mental health of astronauts in a way that moisturizes them softly and ***,the strong volatility of fragrances and inconvenience of aroma treatment greatly limit their application in the field of *** this study,reactive mesoporous silica nanoparticles were prepared to encapsulate and slowly release *** limonene loaded nanoparticles were named limonene@mesoporous silica nanoparticles-cyanuric chloride(LE@MSNs-CYC).LE@MSNs-CYC were then applied to wallpaper to improve the convenience of ***@MSNs-CYC could chemically react with the wallpaper,thus firmly adsorbed on the *** the following,the mice were treated with hindlimb unloading(HU)to simulate a microgravity *** results showed that 28-day HU led to an increase in the level of anxiety and declines in learning,memory,and physical health in ***@MSNs-CYC showed significant relief effects on anxiety,learning,memory,and physical health of HU treated ***,the molecular mechanisms were explored by hypothalamic-pituitary-adrenal axis related hormones,immune-related cytokines,learning,and memory-related neurotransmitters and proteins.

关键词： Reactive mesoporous silica nanoparticles Slow release of limonene Simulated microgravity condition Improvement of physical health Improvement of mental health

Controllable Fragrance Release Mediated by Spontaneous Hydrogen Bonding with POSS–Thiourea Derivatives

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CCS Chemistry 2020年第6期2卷 478-487页

作者： Chenwei Xue Ming Liu Zhi-Ang zhang Jianwei Han Chengyun Wang Limin Wang zuobing Xiao Wei-Hong Zhu Shanghai Key Laboratory of Functional Materials Chemistry Key Laboratory for Advanced Materials and Institute of Fine ChemicalsJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringFeringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237 School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 201418

The purpose of achieving the long-lasting fragrance perception leads to nanocarrier-based profragrances in perfume ***,we report a family of novel profragrance systems based on polyhedral oligomeric silsesquioxane(POSS)derivatized thioureas(POSS thioureas)that enable linkage of volatile carbonyl fragrances with the spontaneous formation of fragile hydrogen *** profragrance platform addresses the dilemma of the volatile nature of aroma-materials on the one hand,and the desired long-lasting effects on the *** releasing performance as profragrances is investigated by headspace solid-phase microextraction(SPME)in combination with gas chromatography(GC)analysis under water as the external humidity stimulus,indicating that the fragrance concentration released from the POSS–thiourea-based profragrance is up to four times higher than the neat reference of the corresponding perfume ***,deposition of the novel profragrance system onto wallpaper results in excellent retentive capacity for volatile *** the low essential toxicity,the POSS–thiourea system has been demonstrated as a suitable profragrance for practical application to perfume delivery.

关键词： POSS thiourea hydrogen bond spontaneous formation profragrance precursor controllable release

Reactive nano-essential oils for sustained release of essential oils and application to wallpaper

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Chinese Chemical Letters 2022年第1期33卷 320-323页

作者： Qiulian Hao Huan Peng Ruichen Zhao Jianze Wang Zhiguo Lu Jingwen Wang Jie Shen Yunwei Niu zuobing Xiao Guiying Liu Jifu Hao Xin zhang School of Pharmaceutical Science Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271016China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Department of Pediatrics Capital Medical University Affiliated Beijing Anzhen HospitalBeijing 100029China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Research Institute of Fragrance and Flavor Industry Shanghai 200232China School of Perfume and Aroma Technology Shanghai Institute of TechnologyShanghai 200233China

Essential oils are a volatile and aromatic substance with a variety of active biological ***,the excessive volatility and inconvenience of the use of essential oils limit their *** this study,we developed a reactive mesoporous silica nanoparticle(rMSNs)based on cyanuric chloride modification for essential oil encapsulation and commodity *** large pore volume and specific surface area of rMSNs facilitate the nanoparticles adhering to a large amount of essential oil and achieve the sustained release of essential oil,thus prolonging the fragrance retention time of essential *** reactive nanoessential oils can form covalent bonds with the wallpaper,thereby remarkably improving the adhesion of the reactive nano-essential oils on the wallpaper and preventing the reactive nano-essential oil from deadhering from the *** active nano essential oil simultaneously overcomes the intense volatility of the essential oil and inconvenience in use,has a simple preparation process and low cost,and has great application potential.

关键词： Reactive nano-essential oils Reactive mesoporous silica nanoparticles Slow-release of essential oils Application to wallpaper Covalent bonds

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基于气味-滋味互作增强咸味感知研究进展

中国食品学报 2024年第5期24卷 453-464页

作者：肖作兵刘龙雪牛云蔚张静上海应用技术大学香料香精化妆品学部上海201418 上海交通大学农业与生物学院上海200240

近年来,因钠盐的过量摄入而带来的健康问题,引发人们对低盐食品的广泛关注。如何在降低钠盐摄入的同时确保食品的特色风味没有显著影响消费者可接受性已引起众多学者思考和探究。利用气味-滋味的多模态感知相互作用进行降盐增咸,是目前... 详细信息

近年来,因钠盐的过量摄入而带来的健康问题,引发人们对低盐食品的广泛关注。如何在降低钠盐摄入的同时确保食品的特色风味没有显著影响消费者可接受性已引起众多学者思考和探究。利用气味-滋味的多模态感知相互作用进行降盐增咸,是目前的研究热点。本文总结具有咸香特征的气味物质,对气味-滋味跨模态相互作用来增强咸味感知的分析方法、嗅觉和味觉之间的相互作用研究现状进行对比分析,并展望其未来发展方向,以期为今后气味诱导味觉增强方面的研究提供参考。

关键词：咸味气味-滋味相互作用增强感知

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食品功能性配料产业现状与发展趋势

中国食品学报 2024年第5期24卷 41-57页

作者：张莉莉张玉玉聂少平肖作兵孙宝国老年营养与健康教育部重点实验室(北京工商大学) 北京100048 北京工商大学中国商业联合会味科学重点实验室北京100048 南昌大学食品科学与资源挖掘全国重点实验室南昌330047 上海交通大学农业与生物学院上海200240

食品配料作为现代食品工业的重要组成部分,在提升食品色、香、味、质构等感官特性和营养价值方面发挥着重要作用。随着消费者对风味品质和健康需求的日益增长,食品产业科学“三减”与健康内涵“N加”双轮驱动格局的形成,“风味健康双导... 详细信息

食品配料作为现代食品工业的重要组成部分,在提升食品色、香、味、质构等感官特性和营养价值方面发挥着重要作用。随着消费者对风味品质和健康需求的日益增长,食品产业科学“三减”与健康内涵“N加”双轮驱动格局的形成,“风味健康双导向”食品配料逐渐成为食品工业健康转型的重要驱动力。本文回顾了我国食品配料的发展历史,并探讨其在食品工业领域的重要地位和作用。通过综合文献调研和数据可视化分析,系统梳理当前食品功能性配料研究及产业的现状。最后总结并展望食品功能性配料产业面临的挑战及未来发展趋势,旨在为我国食品配料产业发展提供思路和借鉴。

关键词：食品配料风味健康双导向产业现状未来趋势

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香气增甜的作用机制及评价方法研究进展

食品科学技术学报 2022年第6期40卷 1-12页

作者：肖作兵胡雨梦牛云蔚朱建才张凤梅张静上海应用技术大学食品香料香精技术与工程学院上海201418 上海交通大学农业与生物学院上海200240 云南中烟工业有限责任公司技术中心云南昆明650231

食品减糖比较常见的方法是使用非营养性甜味剂,但非营养性甜味剂会带来不受欢迎的苦味或金属味及安全风险。研究表明,在某些食物中加入香气物质可以增强人体对食品的甜味感知,即利用香气增甜作用达到食品减糖效果。从气味物质种类、甜... 详细信息

食品减糖比较常见的方法是使用非营养性甜味剂,但非营养性甜味剂会带来不受欢迎的苦味或金属味及安全风险。研究表明,在某些食物中加入香气物质可以增强人体对食品的甜味感知,即利用香气增甜作用达到食品减糖效果。从气味物质种类、甜味剂浓度2个方面总结了对香气增甜作用有重要影响的因素;从正鼻途径和后鼻途径的嗅觉感受机制、脑神经及味觉感受机制、心理感受机制3个方面阐述了香气增甜的作用机制,总结了分子模拟在分析甜味剂与味觉受体结合、释放过程的应用;归纳了评价香气增甜作用大小的感官分析方法,并比较描述性感官分析法、时间强度法和感觉时间支配分析法3种感官分析方法的差异性;对香气增甜作用在食品工业中的应用现状进行了汇总;对香气增甜研究方向以及分析气味增强味觉作用机制的方法提出展望,以期为香气减糖的研究提供新思路。

关键词：香气增甜减糖评价方法感知相互作用

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光敏纳米香料应用于壁纸及香气缓控释的研究

中国科学：化学 2019年第4期49卷 613-618页

作者：沈洁卢红霞卢治国张田露肖作兵张欣中国科学院过程工程研究所生化工程国家重点实验室北京100190 中国科学院大学北京100049 青岛科技大学化工学院青岛266042 上海香料研究所上海200232 上海应用技术大学香料香精技术与工程学院上海200233

利用简单的溶胶-凝胶法制备了介孔二氧化硅纳米棒,并偶联小分子光敏剂ICPES-AZO.通过介孔二氧化硅吸附能力,对檀香803进行载香,制备出光敏性纳米香料.随后,将纳米香料附着在壁纸上,形成芳香壁纸.最后,对芳香壁纸上檀香803的释放进行了检... 详细信息

利用简单的溶胶-凝胶法制备了介孔二氧化硅纳米棒,并偶联小分子光敏剂ICPES-AZO.通过介孔二氧化硅吸附能力,对檀香803进行载香,制备出光敏性纳米香料.随后,将纳米香料附着在壁纸上,形成芳香壁纸.最后,对芳香壁纸上檀香803的释放进行了检测.研究表明,光照条件下香料可以持续释放,黑暗条件下缓慢释放,具有显著的缓控释效果.

关键词：檀香803 介孔二氧化硅缓控释芳香壁纸纳米香料

血浆降钙素基因相关肽和内皮素水平与烧伤后消化道溃疡的相关性

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武汉大学学报（医学版） 2010年第6期31卷 836-837页

作者：张勇王佐兵可国安余秀文湖北省黄石市第五医院湖北黄石435005 湖北省黄石市第一医院湖北黄石435000

目的:探讨烧伤患者血浆降钙素基因相关肽(CGRP)和内皮素(ET)水平与烧伤后消化道溃疡的相关性。方法:采用放射免疫法测定61例烧伤患者、51例烧伤后消化道溃疡患者和30例对照组血浆CGRP、ET水平。结果:烧伤患者血浆CGRP水平为(27.18±11.2... 详细信息

目的:探讨烧伤患者血浆降钙素基因相关肽(CGRP)和内皮素(ET)水平与烧伤后消化道溃疡的相关性。方法:采用放射免疫法测定61例烧伤患者、51例烧伤后消化道溃疡患者和30例对照组血浆CGRP、ET水平。结果:烧伤患者血浆CGRP水平为(27.18±11.21)ng/L、烧伤后消化道溃疡患者血浆CGRP水平为(22.64±10.42)ng/L,显著低于正常对照组(60.31±26.17)ng/L(P<0.01);烧伤患者血浆ET水平为(103.31±38.51)ng/L、烧伤后消化道溃疡患者血浆ET水平为(290.34±57.10)ng/L,显著高于正常对照组(40.61±11.51)ng/L(P<0.01)。结论:血浆CGRP/ET之间平衡紊乱可能在烧伤后消化道溃疡的发生机制中具有重要作用。

关键词：烧伤消化道溃疡内皮素降钙素基因相关肽