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Big Earth Data 2024年第2期8卷 333-349页

作者： Luying Zhu Haifeng Tian Ni Huang Li Wang Zheng niu State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingChina College of Resources and Environment University of Chinese Academy of SciencesBeijingChina College of Geography and Environmental Science Henan UniversityKaifengChina

Called the“Water Tower”,the water resource in Qinghai Province plays a vital role in the ecological environment of northwestern ***,significant uncertainty exists regarding its spatialtemporal *** this study,the data on the surface water of Qinghai Province from 1986 to 2018 was extracted and a systemic analysis of its spatial-temporal variations and responses to climate change was conducted using the Google Earth Engine(GEE)cloud processing *** findings revealed that the surface water in Qinghai Province was primarily concentrated in the Qaidam Basin,the Hoh Xil Nature Reserve,and Qinghai *** surface water area in Qinghai Province exhibited an overall increasing trend,with the temperature and precipitation being the primary drivers of this *** results provide crucial insights into the variations of surface water variations in Qinghai Province,northwestern China,under the influence of climate change.

关键词： Qinghai Province Google Earth Engine surface water climate change

Vector field path following for a micro flapping-wing robot

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Science China(Information Sciences) 2024年第6期67卷 442-444页

作者： Haifeng HUANG Yingte LIU Tao niu Chang WANG Yao ZOU Wei HE School of Intelligence Science and Technology University of Science and Technology Beijing Institute of Artificial Intelligence University of Science and Technology Beijing Key Laboratory of Intelligent Bionic Unmanned Systems Ministry of EducationUniversity of Science and Technology Beijing

Flapping-wing robots mimic the flight patterns of natural flying creatures,granting them natural *** hold promising applications in the military reconnaissance,urban surveillance,and various other fields[1–3].However,the current limitations in size often restrict the suitability of existing bird-like flapping-wing robots,

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电动隐藏式外门把手噪声分析和优化设计

噪声与振动控制 2024年第1期44卷 205-211页

作者：牛时光左曙光同济大学汽车学院上海201804

随着新能源汽车的发展,越来越注重车辆智能化和电动化,电动隐藏式外门把手被越来越多地应用在新能源汽车上。电动隐藏式外门把手在开启与关闭时,执行器产生工作噪声,噪声过大或声品质不好会引起用户抱怨。分析电动隐藏式外门把手工作噪... 详细信息

随着新能源汽车的发展,越来越注重车辆智能化和电动化,电动隐藏式外门把手被越来越多地应用在新能源汽车上。电动隐藏式外门把手在开启与关闭时,执行器产生工作噪声,噪声过大或声品质不好会引起用户抱怨。分析电动隐藏式外门把手工作噪声产生的原因,从外门把手本体结构、结构传递路径、空气传递路径和工作控制策略等4个方面进行分析和优化设计,有效降低电动隐藏式外门把手的本体噪声及乘客舱内的辐射噪声,对汽车电动隐藏式外门把手噪声的优化设计具有一定参考价值和指导意义。

关键词：声学隐藏式外门把手新能源车噪声分析优化设计

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Fabrication of Molecularly Imprinted Electrospun Nanofibers with Mono-amidoxime Functional Ligand for Efficient Decontamination of Toxic Organophosphates

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Chinese Journal of Polymer Science 2024年第4期42卷 446-456页

作者： Lan Wang Peng Jiang Ya-Lin niu Jun-Peng Cao Tian-Ying Guo Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of Chemistry and Frontier Science Center for the Creation of New Organic SubstancesNankai UniversityTianjin300071China

There is an urgent imperative to discover practical and efficacious artificial catalysts for the expeditious decontamination of toxic organophosphates. Herein, we propose a novel molecularly imprinted approach utilizing electrospun fiber scaffolds. Specifically, an amidoxime-based functional polymer (PMAOX) has been synthesized, which contains amidoxime groups that can act as nucleophiles and ligands for the formation of catalytic active sites. This polymer was blended with polyacrylonitrile (PAN), a well-processable material, to prepare a nanofiber mat using electrospinning techniques. Then, the amidoxime side groups on fiber surface were further cross-linked after the molecular coordination of templates to complete the molecularly imprinting process. This approach can not only enhance the content of functional molecularly imprinted polymers without affecting structural stability, but also combines surface MI technology to fully expose and leverage the advantages of active sites. The as prepared molecularly imprinted electrospun nanofibers MIF-Zn-PMAOX/PAN-6/4 catalyzes the degradation of paraoxon with a half-life of 32 min, and MIF-Ag-PMAOX/PAN catalyzes the degradation of parathion with a half-life of 18 min. The maximum catalytic rate evidence rate enhancements nearly 3700-fold of the self-hydrolysis. Thus, the mono-amidoxime based molecularly imprinted fibers demonstrate the versatility and superiority as self-detoxifying for organophosphates.

关键词： Organophosphateshydrolysis Electrospinning Molecular imprinting

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Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito-borne viruses

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Insect Science 2024年第3期31卷 663-673页

作者： Zhao-Yang Wang Kai-Xiao Nie Ji-Chen niu Gong Cheng Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua UniversityBejingChina Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenGuangdongChina Department of Pathogen Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesJinanChina

Mosquito-borne viruses(MBVs)are a large class of viruses transmitted mainly through mosquito bites,including dengue virus,Zika virus,Japanese encephalitis virus,West Nile virus,and chikungunya virus,which pose a major threat to the health of people around the *** global warming and extended human activities,the incidence of many MBVs has increased *** saliva contains a variety of bioactive protein *** not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host ***,we review the physiological functions of mosquito salivary proteins(MSPs)in detail,the influence and the underlying mechanism of MSPs on the transmission of MBVs,and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV transmission blocking vaccines.

关键词： immune response mosquito-borne virus mosquito salivary protein saliva vaccine transmission

Enabling an Inorganic-Rich Interface via Cationic Surfactant for High-Performance Lithium Metal Batteries

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Nano-Micro Letters 2024年第8期16卷 1-17页

作者： Zejun Sun Jinlin Yang Hongfei Xu Chonglai Jiang Yuxiang niu Xu Lian Yuan Liu Ruiqi Su Dayu Liu Yu Long Meng Wang Jingyu Mao Haotian Yang Baihua Cui Yukun Xiao Ganwen Chen Qi Zhang Zhenxiang xing Jisheng Pan Gang Wu Wei Chen Department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore Agency for Science Technology and Research(A*STAR)Institute of High-Performance Computing1 Fusionopolis Way#16‑16 ConnexisSingapore 138632Singapore Department of Physics National University of Singapore2 Science Drive 3Singapore 117542Singapore Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207People’s Republic of China Agency for Science Technologyand Research(A*STAR)Institute of Materials Research and EngineeringInnovis2 Fusionopolis Way#08‑03Singapore 138634Singapore

An anion-rich electric double layer(EDL)region is favorable for fabricating an inorganic-rich solid-electrolyte interphase(SEI)towards stable lithium metal anode in ester ***,cetyltrimethylammonium bromide(CTAB),a cationic surfactant,is adopted to draw more anions into EDL by ionic interactions that shield the repelling force on anions during lithium *** situ electrochemical surface-enhanced Raman spectroscopy results combined with molecular dynamics simulations validate the enrichment of NO_(3)^(−)/FSI−anions in the EDL region due to the positively charged CTA^(+).In-depth analysis of SEI structure by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry results confirmed the formation of the inorganic-rich SEI,which helps improve the kinetics of Li^(+)transfer,lower the charge transfer activation energy,and homogenize Li *** a result,the Li||Li symmetric cell in the designed electrolyte displays a prolongated cycling time from 500 to 1300 h compared to that in the blank electrolyte at 0.5 mA cm^(-2) with a capacity of 1 mAh cm^(-2).Moreover,Li||LiFePO_(4) and Li||LiCoO_(2) with a high cathode mass loading of>10 mg cm^(-2) can be stably cycled over 180 cycles.

关键词： Cationic surfactant Lithium nitrate additive Solid-electrolyte interphase Electric double layer Lithium metal batteries

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Constructing a nomogram to predict overall survival of colon cancer based on computed tomography characteristics and clinicopathological factors

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4104-4114页

作者： Zhe-xing Hu Yin Li Xuan Yang Yu-Xia Li Yao-Yao He Xiao-Hui niu Ting-Ting Nie Xiao-Fang Guo Zi-Long Yuan Department of Radiology Hubei Cancer HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Department of Radiology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina College of Informatics Huazhong Agriculture UniversityWuhan 430070Hubei ProvinceChina

BACKGROUND The colon cancer prognosis is influenced by multiple factors,including clinical,pathological,and non-biological ***,only a few studies have focused on computed tomography(CT)imaging ***,this study aims to predict the prognosis of patients with colon cancer by combining CT imaging features with clinical and pathological characteristics,and establishes a nomogram to provide critical guidance for the individualized *** To establish and validate a nomogram to predict the overall survival(OS)of patients with colon *** A retrospective analysis was conducted on the survival data of 249 patients with colon cancer confirmed by surgical pathology between January 2017 and December *** patients were randomly divided into training and testing groups at a 1:1 *** and multivariate logistic regression analyses were performed to identify the independent risk factors associated with OS,and a nomogram model was constructed for the training *** curves were calculated using the Kaplan–Meier *** concordance index(C-index)and calibration curve were used to evaluate the nomogram model in the training and testing *** Multivariate logistic regression analysis revealed that lymph node metastasis on CT,perineural invasion,and tumor classification were independent prognostic factors.A nomogram incorporating these variables was constructed,and the C-index of the training and testing groups was 0.804 and 0.692,*** calibration curves demonstrated good consistency between the actual values and predicted probabilities of *** A nomogram combining CT imaging characteristics and clinicopathological factors exhibited good discrimination and *** can aid clinicians in risk stratification and postoperative monitoring and provide important guidance for the individualized treatment of patients with colon cancer.

关键词： Colon cancer Nomogram Prognosis Overall survival Computed tomography Clinicopathology

Learnable digital signal processing:a new benchmark of linearity compensation for optical fiber communications

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Light(Science & Applications) 2024年第9期13卷 1931-1943页

作者： Zekun niu Hang Yang Lyu Li Minghui Shi Guozhi Xu Weisheng Hu Lilin Yi State Key Lab of Advanced Optical Communication Systems and Networks School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China

The surge in interest regarding the next generation of optical fiber transmission has stimulated the development of digital signal processing(DSP)schemes that are highly cost-effective with both high performance and low *** benchmarks for nonlinear compensation methods,however,traditional DSP designed with block-by-block modules for linear compensations,could exhibit residual linear effects after compensation,limiting the nonlinear compensation *** we propose a high-efficient design thought for DSP based on the learnable perspectivity,called learnable DSP(LDSP).LDSP reuses the traditional DSP modules,regarding the whole DSP as a deep learning framework and optimizing the DSP parameters adaptively based on backpropagation algorithm from a global *** method not only establishes new standards in linear DSP performance but also serves as a critical benchmark for nonlinear DSP *** comparison to traditional DSP with hyperparameter optimization,a notable enhancement of approximately 1.21 dB in the Q factor for 400 Gb/s signal after 1600 km fiber transmission is experimentally demonstrated by combining LDSP and perturbation-based nonlinear compensation *** from the learnable model,LDSP can learn the best configuration adaptively with low complexity,reducing dependence on initial *** proposed approach implements a symbol-rate DSP with a small bit error rate(BER)cost in exchange for a 48%complexity reduction compared to the conventional 2 samples/symbol *** believe that LDSP represents a new and highly efficient paradigm for DSP design,which is poised to attract considerable attention across various domains of optical communications.

关键词： fiber signal optical

Time-dependent deviation of bridge pile foundations caused by adjacent large-area surcharge loads in soft soils and its preventive measures

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Frontiers of Structural and Civil Engineering 2024年第2期18卷 184-201页

作者： Shuanglong LI Limin WEI Jingtai niu Zhiping DENG Bangbin WU Wuwen QIAN Feifei HE School of Hydraulic Engineering Nanchang Institute of TechnologyNanchang 330099China School of Civil Engineering Central South UniversityChangsha 410075China

Time-dependent characteristics(TDCs)have been neglected in most previous studies investigating the deviation mechanisms of bridge pile foundations and evaluating the effectiveness of preventive *** this study,the stress-strain-time characteristics of soft soils were illustrated by consolidation-creep tests based on a typical engineering *** extended Koppejan model was developed and then embedded in a finite element(FE)model via a user-material subroutine(UMAT).Based on the validated FE model,the time-dependent deformation mechanism of the pile foundation was revealed,and the preventive effect of applying micropiles and stress-release holes to control the deviation was *** results show that the calculated maximum lateral displacement of the cap differs from the measured one by 6.5%,indicating that the derived extended Koppejan model reproduced the deviation process of the bridge cap-pile foundation with *** additional load acting on the pile side caused by soil lateral deformation was mainly concentrated within the soft soil layer and increased with the increase in load *** with t=3 d(where t is surcharge time),the maximum lateral additional pressure acting on Pile 2#increased by approximately 47.0%at t=224 *** bridge pile foundation deviation in deep soft soils,stress-release holes can provide better prevention compared to micropiles and are therefore recommended.

关键词： bridge pile foundation surcharge load soft soil time-dependent deformation interaction mechanism preventive measure

Fc receptor-like 5(FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma

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Signal Transduction and Targeted Therapy 2024年第2期9卷 724-737页

作者： Zhengyu Yu Hexian Li Qizhong Lu Zongliang Zhang Aiping Tong Ting niu Department of Hematology State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Multiple myeloma(MM)remains a challenging hematologic malignancy despite advancements in chimeric antigen receptor T-cell(CAR-T)*** targets of CAR-T cells used in MM immunotherapy have limitations,with a subset of patients experiencing antigen loss resulting in ***,novel targets for enhancing CAR-T cell therapy in MM remain *** receptor-like 5(FCRL5)is a protein marker with considerably upregulated expression in MM and has emerged as a promising target for CAR-T cell therapeutic interventions,offering an alternative treatment for *** further explore this option,we designed FCRL5-directed CAR-T cells and assessed their cytotoxicity in vitro using a co-culture system and in vivo using MM cell-derived xenograft models,specifically focusing on MM with gain of chromosome *** the challenges in CAR-T therapies arising from limited T cell persistence,our approach incorporates interleukin-15(IL-15),which enhances the functionality of central memory T(TCM)cells,into the design of FCRL5-directed CAR-T cells,to improve cytotoxicity and reduce T-cell dysfunction,thereby promoting greater CAR-T cell survival and *** in vitro and xenograft models displayed that FCRL5 CAR-T cells incorporating IL-15 exhibited potent antitumor efficacy,effectively inhibiting the proliferation of MM cells and leading to remarkable tumor *** results highlight the capacity of FCRL5-specific CAR-T cells with the integration of IL-15 to improve the therapeutic potency,suggesting a potential novel immunotherapeutic strategy for MM treatment.

关键词： directed thereby offering